The 3.8 Å structure of the U4/U6.U5 tri-snRNP: Insights into spliceosome assembly and catalysis

Science

Volumn 351, Issue 6272, 2016, Pages 466-475

  Wan, Ruixue ^a   Yan, Chuangye ^a   Bai, Rui ^a   Wang, Lin ^a   Huang, Min ^b   Wong, Catherine C L ^b   Shi, Yigong ^a  

^a Tsinghua University   (China)

^b INSTITUTE OF BIOCHEMISTRY AND CELL BIOLOGY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA PRECURSOR; NUCLEOTIDE; SMALL NUCLEAR RIBONUCLEOPROTEIN; SMALL NUCLEAR RNA; MESSENGER RNA; RNA PRECURSOR; SACCHAROMYCES CEREVISIAE PROTEIN; U4 SMALL NUCLEAR RNA; U5 SMALL NUCLEAR RNA; U6 SMALL NUCLEAR RNA;

AMINO ACID; CATALYSIS; MOLECULAR ANALYSIS; MUTATION; PROTEIN; RNA; YEAST;

ARTICLE; BASE PAIRING; CATALYSIS; CONFORMATIONAL TRANSITION; CRYOELECTRON MICROSCOPY; INTERACTIONS WITH RNA; MOLECULAR RECOGNITION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; RNA ANALYSIS; RNA CONFORMATION; RNA ISOLATION; RNA SPLICING; RNA STRUCTURE; SACCHAROMYCES CEREVISIAE; SPLICEOSOME; CHEMISTRY; CONFORMATION; METABOLISM; PROTEIN CONFORMATION; ULTRASTRUCTURE;

SACCHAROMYCES CEREVISIAE;

CATALYSIS; CRYOELECTRON MICROSCOPY; NUCLEIC ACID CONFORMATION; PROTEIN CONFORMATION; RIBONUCLEOPROTEIN, U4-U6 SMALL NUCLEAR; RIBONUCLEOPROTEIN, U5 SMALL NUCLEAR; RNA PRECURSORS; RNA SPLICING; RNA, MESSENGER; RNA, SMALL NUCLEAR; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SPLICEOSOMES;

EID: 84956686435     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aad6466     Document Type: Article

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