Breaking Cryo-EM Resolution Barriers to Facilitate Drug Discovery

Cell

Volumn 165, Issue 7, 2016, Pages 1698-1707

  Merk, Alan ^a   Bartesaghi, Alberto ^a   Banerjee, Soojay ^a   Falconieri, Veronica ^a   Rao, Prashant ^a   Davis, Mindy I ^b   Pragani, Rajan ^b   Boxer, Matthew B ^b   Earl, Lesley A ^a   Milne, Jacqueline L S ^a   Subramaniam, Sriram ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b National Center for Advancing Translational Science   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE; ISOCITRATE DEHYDROGENASE 1; LACTATE DEHYDROGENASE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; POLYPEPTIDE; PYRUVIC ACID; TENIDAP; TETRAMER; AMINOQUINOLINE DERIVATIVE; GSK2837808A; SULFONAMIDE;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CANCER CELL; CITRIC ACID CYCLE; CONTROLLED STUDY; CRYOELECTRON MICROSCOPY; CRYSTAL STRUCTURE; ENZYME STRUCTURE; GLYCOLYSIS; HUMAN; MITOCHONDRION; MOLECULE; MUSCLE CELL; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; SINGLE PARTICLE CRYOELECTRON MICROSCOPY; X RAY CRYSTALLOGRAPHY; ANIMAL; ANTAGONISTS AND INHIBITORS; BOVINE; CHEMISTRY; CHICKEN; DRUG DEVELOPMENT; MOLECULAR MODEL; PROTEIN CONFORMATION; ULTRASTRUCTURE;

AMINOQUINOLINES; ANIMALS; CATTLE; CHICKENS; CRYOELECTRON MICROSCOPY; CRYSTALLOGRAPHY, X-RAY; DRUG DISCOVERY; GLUTAMATE DEHYDROGENASE; HUMANS; ISOCITRATE DEHYDROGENASE; L-LACTATE DEHYDROGENASE; MODELS, MOLECULAR; PROTEIN CONFORMATION; SULFONAMIDES;

EID: 84969983828     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2016.05.040     Document Type: Article

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