Loss of frataxin induces iron toxicity, sphingolipid synthesis, and Pdk1/Mef2 activation, leading to neurodegeneration

eLife

Volumn 5, Issue JUN2016, 2016, Pages

  Chen, Kuchuan ^a   Lin, Guang ^a   Haelterman, Nele A ^a   Ho, Tammy Szu Yu ^a   Li, Tongchao ^a   Li, Zhihong ^a   Duraine, Lita ^a   Graham, Brett H ^a   Jaiswal, Manish ^a   Yamamoto, Shinya ^a,b   Rasband, Matthew N ^a   Bellen, Hugo J ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b Texas Children's Hospital   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FRATAXIN; MYOCYTE ENHANCER FACTOR 2; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; REACTIVE OXYGEN METABOLITE; SPHINGANINE; THERMOZYMOCIDIN; 3 PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE; DROSOPHILA PROTEIN; IRON; IRON BINDING PROTEIN; MEF2 PROTEIN, DROSOPHILA; MYOGENIC FACTOR; PDK1 PROTEIN, DROSOPHILA; SPHINGOLIPID;

ADULT; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DROSOPHILA; ELECTRORETINOGRAPHY; FEMALE; IMMUNOFLUORESCENCE TEST; IRON OVERLOAD; MASS SPECTROMETRY; METABOLIC ACTIVITY ASSAY; MOLECULAR CLONING; MOUSE; MUTANT; NERVE CELL; NERVE DEGENERATION; NONHUMAN; PROTEIN DEPLETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPHINGOLIPID METABOLISM; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; BIOSYNTHESIS; DISEASE MODEL; FRIEDREICH ATAXIA; GENETICS; METABOLISM; PATHOPHYSIOLOGY;

3-PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASES; ANIMALS; DISEASE MODELS, ANIMAL; DROSOPHILA; DROSOPHILA PROTEINS; FRIEDREICH ATAXIA; IRON; IRON-BINDING PROTEINS; MYOGENIC REGULATORY FACTORS; SPHINGOLIPIDS;

EID: 84979698328     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.16043     Document Type: Article

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