Impaired mitochondrial energy production causes light-induced photoreceptor degeneration independent of oxidative stress

PLoS Biology

Volumn 13, Issue 7, 2015, Pages

  Jaiswal, Manish ^a,b   Haelterman, Nele A ^c   Sandoval, Hector ^a   Xiong, Bo ^c   Donti, Taraka ^a   Kalsotra, Auinash ^a,e   Yamamoto, Shinya ^a,c,d   Cooper, Thomas A ^a,c   Graham, Brett H ^a   Bellen, Hugo J ^a,b,c,d  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c BCM   (United States)

^d TEXAS CHILDREN S HOSPITAL   (United States)

^e UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CITRATE SYNTHASE; COMPLEMENTARY DNA; MITOCHONDRIAL DNA; MITOCHONDRIAL RNA; PYRUVATE DEHYDROGENASE; RHODOPSIN; BICOID STABILITY FACTOR, DROSOPHILA; DROSOPHILA PROTEIN; LRPPRC2 PROTEIN, DROSOPHILA; MITOCHONDRIAL PROTEIN; PYRUVATE DEHYDROGENASE COMPLEX; REACTIVE OXYGEN METABOLITE; RNA BINDING PROTEIN;

ARTICLE; CONTROLLED STUDY; DEGENERATION; DISORDERS OF MITOCHONDRIAL FUNCTIONS; DROSOPHILA; ELECTRON TRANSPORT; ELECTRORETINOGRAM; ENDOCYTOSIS; ENERGY YIELD; FLUORESCENCE; GENE MAPPING; GENE MUTATION; LIGHT EXPOSURE; MEMBRANE DEPOLARIZATION; MITOCHONDRIAL GENE; MUTAGENESIS; MUTANT; NONHUMAN; OXIDATIVE STRESS; PHOTORECEPTOR; PHOTOTRANSDUCTION; PPR GENE; TRANSMISSION ELECTRON MICROSCOPY; ANIMAL; BIOSYNTHESIS; ELECTRORETINOGRAPHY; GENETICS; METABOLISM; MITOCHONDRION; PHOTORECEPTOR CELL; RADIATION RESPONSE; RETINA DISEASE; VISION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CITRATE (SI)-SYNTHASE; DROSOPHILA; DROSOPHILA PROTEINS; ELECTRORETINOGRAPHY; ENDOCYTOSIS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXIDATIVE STRESS; PHOTORECEPTOR CELLS, INVERTEBRATE; PYRUVATE DEHYDROGENASE COMPLEX; REACTIVE OXYGEN SPECIES; RETINAL DISEASES; RHODOPSIN; RNA-BINDING PROTEINS; VISION, OCULAR;

EID: 84938702402     PISSN: 15449173     EISSN: 15457885     Source Type: Journal    
DOI: 10.1371/journal.pbio.1002197     Document Type: Article

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