Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice

Journal of Biological Chemistry

Volumn 281, Issue 14, 2006, Pages 9152-9162

  Xu, Jian ^a   Gong, Nanling L ^b,c   Bodi, Ilona ^a   Aronow, Bruce J ^a   Backx, Peter H ^b,c   Molkentin, Jeffery D ^a,d  

^a UNIVERSITY OF CINCINNATI   (United States)

^b UNIVERSITY OF TORONTO   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOLOGY; DISEASES; GENES; IONS; METABOLITES; PROTEINS;

CARDIAC HYPERTROPHY; METABOLIC GENES; TRANSGENIC MICE;

ENZYME KINETICS;

CALCINEURIN; MYOCYTE ENHANCER FACTOR 2; MYOCYTE ENHANCER FACTOR 2A; MYOCYTE ENHANCER FACTOR 2C; UNCLASSIFIED DRUG; MADS DOMAIN PROTEIN; MEF2A PROTEIN, HUMAN; MEF2A PROTEIN, MOUSE; MEF2C PROTEIN, HUMAN; MYOGENIC FACTOR; POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARDIOMYOPATHY; CONTROLLED STUDY; EXTRACELLULAR MATRIX; GENE EXPRESSION; HEART MUSCLE CELL; HISTOPATHOLOGY; MOUSE; MUSCLE CELL; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ADENOVIRUS; ANIMAL; BIOSYNTHESIS; GENE EXPRESSION PROFILING; GENETIC TRANSFECTION; GENETICS; HEART VENTRICLE; HUMAN; HYPERTROPHIC CARDIOMYOPATHY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; ULTRASTRUCTURE;

MUS MUSCULUS;

ADENOVIRIDAE; ANIMALS; CALCINEURIN; CARDIOMYOPATHY, HYPERTROPHIC; GENE EXPRESSION PROFILING; HEART VENTRICLES; HUMANS; MADS DOMAIN PROTEINS; MICE; MICE, TRANSGENIC; MYOCYTES, CARDIAC; MYOGENIC REGULATORY FACTORS; PHENOTYPE; POTASSIUM CHANNELS; SIGNAL TRANSDUCTION; TRANSFECTION;

EID: 33646942503     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M510217200     Document Type: Article

References (70)

1. Gossett, L. A., Kelvin, D. J., Sternberg, E. A., and Olson, E. N. (1989) Mol. Cell. Biol. 9, 5022-5033
2. Black, B. L., and Olson, E. N. (1998) Annu. Rev. Cell Dev. Biol. 14, 167-196
3. Molkentin, J. D., and Olson, E. N. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 9366-9373
4. Rao, S., Karray, S., Gackstetter, E. R., and Koshland, M. E. (1998) J. Biol. Chem. 273, 26123-26129
5. Han, J., Jiang, Y., Li, Z., Kravchenko, V. V., and Ulevitch, R. J. (1997) Nature 386, 296-299
6. Skerjanc, I. S., and Wilton, S. (2000) FEBS Lett. 472, 53-56
7. Lin, Q., Schwarz, J., Bucana, C., and Olson, E. N. (1997) Science 276, 1404-1407
8. Shore, P., and Sharrocks, A. D. (1995) Eur. J. Biochem. 229, 1-13
9. Molkentin, J. D., and Markham, B. E. (1993) J. Biol. Chem. 268, 19512-19520
10. Kolodziejczyk, S. M., Wang, L., Balazsi, K., DeRepentigny, Y., Kothary, R., and Megeney, L. A. (1999) Curr. Biol. 9, 1203-1206
11. Naya, F. J., Black, B. L., Wu, H., Bassel-Duby, R., Richardson, J. A., Hill, J. A., and Olson, E. N. (2002) Nat. Med. 8, 1303-1309
12. Molkentin, J. D., and Dorn, G. W., II (2001) Annu. Rev. Physiol. 63, 391-426
13. Balke, C. W., and Shorofsky, S. R. (1998) Cardiovasc. Res. 37, 290-299
14. Mao, Z., and Wiedmann, M. (1999) J. Biol. Chem. 274, 31102-31107
15. Youn, H. D., Sun, L., Prywes, R., and Liu, J. O. (1999) Science 286, 790-793
16. Youn, H. D., Grozinger, C. M., and Liu, J. O. (2000) J. Biol. Chem. 275, 22563-22567
17. Lu, J., McKinsey, T. A., Nicol, R. L., and Olson, E. N. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 4070-4075
18. Pan, F., Ye, Z., Cheng, L., and Liu, J. O. (2004) J. Biol. Chem. 279, 14477-14480
19. Wu, H., Naya, F. J., McKinsey, T. A., Mercer, B., Shelton, J. M., Chin, E. R., Simard, A. R., Michel, R. N., Bassel-Duby, R., Olson, E. N., and Williams, R. S. (2000) EMBO J. 19, 1963-1973
20. Lin, J., Wu, H., Tarr, P. T., Zhang, C. Y., Wu, Z., Boss, O., Michael, L. F., Puigserver, P., Isotani, E., Olson, E. N., Lowell, B. B., Bassel-Duby, R., and Spiegelman, B. M. (2002) Nature 418, 797-801
21. Handschin, C., Rhee, J., Lin, J., Tarr, P. T., and Spiegelman, B. M. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 7111-7116
22. Cox, D. M., Du, M., Marback, M., Yang, E. C., Chan, J., Siu, K. W., and McDermott, J. C. (2003) J. Biol. Chem. 278, 15297-15303
23. Zhao, M., New, L., Kravchenko, V. V., Kato, Y., Gram, H., di Padova, F., Olson, E. N., Ulevitch, R. J., and Han, J. (1999) Mol. Cell. Biol. 19, 21-30
24. Yang, S.-H., Galanis, A., and Sharrocks, A. D. (1999) Mol. Cell. Biol. 19, 4028-4038
25. Ornatsky, O. I., Cox, D. M., Tangirala, P., Adnreeucci, J. J., Quinn, Z. A., Wrana, J. L., Prywes, R., Yu, Y. T., and McDermott, J. C. (1999) Nucleic Acids Res. 27, 2646-2654
26. Marrinissen, M. J., Chiariello, M., Pallante, M., and Gutkind, J. S. (1999) Mol. Cell. Biol. 19, 4289-4301
27. Kato, Y., Kravchenko, V. V., Tapping, R. I., Han, J., Ulevitch, R. J., and Lee, J.-D. (1997) EMBO J. 16, 7054-7066
28. Passier, R., Zeng, H., Frey, N., Naya, F. J., Nicol, R. L., McKinsey, T. A., Overbeek, P., Richardson, J. A., Grant, S. R., and Olson, E. N. (2000) J. Clin. Investig. 105, 1395-1406
29. Miska, E. A., Karlsson, C., Langley, E., Nielsen, S. J., Pines, J., and Kouzarides, T. (1999) EMBO J. 18, 5099-5107
30. Sparrow, D. B., Miska, E. A., Langley, E., Reynaud-Deonauth, S., Kotecha, S., Towers, N., Spohr, G., Kouzarides, T., and Mohun, T. J. (1999) EMBO J. 18, 5085-5098
31. Wang, A. H., Bertos, N. R., Vezmar, M., Pelletier, N., Crosato, M., Heng, H. H., Th'ng, J., Han, J., and Yang, X. J. (1999) Mol. Cell. Biol. 19, 7816-7827
32. McKinsey, T. A., Zhang, C. L., and Olson, E. N. (2001) Mol. Cell. Biol. 21, 6312-6321
33. Lu, J., McKinsey, T. A., Zhang, C. L., and Olson, E. N. (2000) Mol. Cell 6, 233-244
34. McKinsey, T. A., Zhang, C. L., Lu, J., and Olson, E. N. (2000) Nature 408, 106-111
35. Zhang, C. L., McKinsey, T. A., Chang, S., Antos, C. L., Hill, J. A., and Olson, E. N. (2002) Cell 110, 479-488
36. Naya, F. J., Wu, C., Richardson, J. A., Overbeek, P., and Olson, E. N. (1999) Development (Camb.) 126, 2045-2052
37. Palermo, J., Gulick, J., Colbert, M., Fewell, J., and Robbins, J. (1996) Circ. Res. 78, 504-509
38. Wilkins, B. J., Dai, Y.-S., Bueno, O. F., Parsons, S. A., Xu, J., Plank, D. M., Jones, F., Kimball, T. R., and Molkentin, J. D. (2004) Circ. Res. 94, 110-118
39. Molkentin, J. D., Lu, J. R., Antos, C. L., Markham, B., Richardson, J., Robbins, J., Grant, S. R., and Olson, E. N. (1999) Cell 93, 215-228
40. De Windt, L. J., Lim, H. W., Haq, S., Force, T., and Molkentin, J. D. (2000) J. Biol. Chem. 275, 13571-13579
41. Parsons, S. A., Millay, D. P., Wilkins, B. J., Bueno, O. F., Tsika, G. L., Neilson, J. R., Liberatore, C. M., Yutzey, K. E., Crabtree, G. R., Tsika, R. W., and Molkentin, J. D. (2004) J. Biol. Chem. 279, 26192-26200
42. Taigen, T., De Windt, L. J., Lim, H. W., and Molkentin, J. D. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 1196-1201
43. Cho, R. J., Huang, M., Campbell, M. J., Dong, H., Steinmetz, L., Sapinoso, L., Hampton, G., Elledge, S. J., Davis, R. W., and Lockhart, D. J. (2001) Nat. Genet. 27, 48-54
44. Notterman, D. A., Alon, U., Sierk, A. J., and Levine, A. J. (2001) Cancer Res. 61, 3124-3130
45. Wickenden, A. D., Kaprielian, R., Parker, T. G., Jones, O. T., and Backx, P. H. (1997) J. Physiol. (Lond.) 504, 271-286
46. Zobel, C., Kassiri, Z., Nguyen, T. T., Meng, Y., and Backx, P. H. (2002) Circulation 106, 2385-2391
47. Petrashevskaya, N. N., Bodi, I., Rubio, M., Molkentin, J. D., and Schwartz, A. (2002) Cardiovasc. Res. 54, 117-132
48. Zhang, X., Azhar, G., Chai, J., Sheridan, P., Nagano, K., Brown, T., Yang, J., Khrapko, K., Borras, A. M., Lawitts, J., Misra, R. P., and Wei, J. Y. (2001) Am. J. Physiol. 280, H1782-H1792
49. Liang, Q., and Molkentin, J. D. (2003) J. Mol. Cell. Cardiol. 35, 1385-1394
50. Braz, J. C., Bueno, O. F., Liang, Q., Wilkins, B. J., Dai, Y.-S., Parsons, S., Braunwart, J., Glascock, B. J., Klevitsky, R., Kimball, T. F., Hewett, T. E., and Molkentin, J. D. (2003) J. Clin. Investig. 111, 1475-1486
51. Zhang, S., Weinheimer, C., Courtois, M., Kovacs, A., Zhang, C. E., Cheng, A. M., Wang, Y., and Muslin, A. J. (2003) J. Clin. Investig. 111, 833-841
52. Nishida, K., Yamaguchi, O., Hirotani, S., Hikoso, S., Higuchi, Y., Watanabe, T., Takeda, T., Osuka, S., Morita, T., Kondoh, G., Uno, Y., Kashiwase, K., Taniike, M., Nakai, A., Matsumura, Y., Miyazaki, J., Sudo, T., Hongo, K., Kusakari, Y., Kurihara, S., Chien, K. R., Takeda, J., Hori, M., and Otsu, K. (2004) Mol. Cell. Biol. 24, 10611-10620
53. Liao, P., Georgakopoulos, D., Kovacs, A., Zheng, M., Lerner, D., Pu, H., Saffitz, J., Chien, K., Xiao, R. P., Kass, D. A., and Wang, Y. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 12283-12288
54. Wu, H., Rothermel, B., Kanatous, S., Rosenberg, P., Naya, F. J., Shelton, J. M., Hutcheson, K. A., DiMaio, J. M., Olson, E. N., Bassel-Duby, R., and Williams, R. S. (2001) EMBO J. 20, 6414-6423
55. Karasseva, N., Tsika, G., Ji, J., Zhang, A., Mao, X., and Tsika, R. (2003) Mol. Cell. Biol. 23, 5143-5164
56. Karns, L. R., Kariya, K., and Simpson, P. C. (1995) J. Biol. Chem. 270, 410-417
57. Vega, R. B., Harrison, B. C., Meadows, E., Roberts, C. R., Papst, P. J., Olson, E. N., and McKinsey, T. A. (2004) Mol. Cell. Biol. 24, 8374-8385
58. Dai, Y.-S., Xu, J., and Molkentin, J. D. (2005) Mol. Cell. Biol. 25, 9936-9948
59. Nicol, R. L., Frey, N., Pearson, G., Cobb, M., Richardson, J., and Olson, E. N. (2001) EMBO J. 20, 2757-2767
60. Liu, W., Youn, H. D., and Liu, J. O. (2001) Eur. J. Immunol. 31, 1757-1764
61. Mao, Z., Bonni, A., Xia, F., Nadal-Vicens, M., and Greenberg, M. E. (1999) Science 286, 785-790
62. Okamoto, S., Krainc, D., Sherman, K., and Lipton, S. A. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 7561-7566
63. Gong, X., Tang, X., Wiedmann, M., Wang, X., Peng, J., Zheng, D., Blair, L. A., Marshall, J., and Mao, Z. (2003) Neuron 38, 33-46
64. Linseman, D. A., Cornejo, B. J., Le, S. S., Meintzer, M. K., Laessig, T. A., Bouchard, R. J., and Heidenreich, K. A. (2003) J. Neurochem. 85, 1488-1499
65. Sah, R., Ramirez, R. J., Oudit, G. Y., Gidrewicz, D., Trivieri, M. G., Zobel, C., and Backx, P. H. (2003) J. Physiol. (Lond.) 546, 5-18
66. Harris, D. M., Mills, G. D., Chen, X., Kubo, H., Berretta, R. M., Votaw, V. S., Santana, L. F., and Houser, S. R. (2005) Circ. Res. 96, 543-550
67. Tessier, S., Karczewski, P., Krause, E. G., Pansard, Y., Acar, C., Lang-Lazdunski, M., Mercadier, J. J., and Hatem, S. N. (1999) Circ. Res. 85, 810-819
68. Wickenden, A. D., Lee, P., Sah, R., Huang, Q., Fishman, G. I., and Backx, P. H. (1999) Circ. Res. 85, 1067-1076
69. Kassiri, Z., Zobel, C., Nguyen, T. T., Molkentin, J. D., and Backx, P. H. (2002) Circ. Res. 90, 578-585
70. Lebeche, D., Kaprielian, R., del Monte, F., Tomaselli, G., Gwathmey, J. K., Schwartz, A., and Hajjar, R. J. (2004) Circulation 110, 3435-3443