The role of autophagy in cardiac hypertrophy

Acta Biochimica et Biophysica Sinica

Volumn 48, Issue 6, 2016, Pages 491-500

  Li, Lanfang ^a   Xu, Jin ^a   He, Lu ^a   Peng, Lijun ^a   Zhong, Qiaoqing ^a   Chen, Linxi ^a   Jiang, Zhisheng ^a  

^a UNIVERSITY OF SOUTH CHINA   (China)

Author keywords

Autophagic flux; Autophagy; Cardiac function; Cardiac hypertrophy; Cell signaling

Indexed keywords

ANIMAL; AUTOPHAGY; BIOLOGICAL MODEL; CARDIAC MUSCLE CELL; CARDIOMEGALY; DISEASE MODEL; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALS; AUTOPHAGY; CARDIOMEGALY; DISEASE MODELS, ANIMAL; MODELS, CARDIOVASCULAR; MYOCYTES, CARDIAC; SIGNAL TRANSDUCTION;

EID: 84979263303     PISSN: 16729145     EISSN: 17457270     Source Type: Journal    
DOI: 10.1093/abbs/gmw025     Document Type: Review

References (115)

1. Mathew J, Sleight P, Lonn E, Johnstone D, Pogue J, Yi Q, Bosch J, et al. Reduction of cardiovascular risk by regression of electrocardiographic markers of left ventricular hypertrophy by the angiotensin-converting enzyme inhibitor ramipril. Circulation 2001, 104: 1615-1621.
2. Wang ZV, Ferdous A, Hill JA. Cardiomyocyte autophagy: metabolic profit and loss. Heart Fail Rev 2013, 18: 585-594.
3. Nemchenko A, Chiong M, Turer A, Lavandero S, Hill JA. Autophagy as a therapeutic target in cardiovascular disease. J Mol Cell Cardiol 2011, 51: 584-593.
4. Yang Z, Klionsky DJ. Eaten alive: a history of macroautophagy. Nat Cell Biol 2010, 12: 814-822.
5. Rothermel BA, Hill JA. Myocyte autophagy in heart disease: friend or foe? Autophagy 2007, 3: 632-634.
6. Lavandero S, Troncoso R, Rothermel BA, Martinet W, Sadoshima J, Hill JA. Cardiovascular autophagy: concepts, controversies, and perspectives. Autophagy 2013, 9: 1455-1466.
7. Singh R, Cuervo AM. Autophagy in the cellular energetic balance. Cell Metab 2011, 13: 495-504.
8. Gurusamy N, Das DK. Autophagy, redox signaling, and ventricular remodeling. Antioxid Redox Signal 2009, 11: 1975-1988.
9. Uchiyama Y, Shibata M, Koike M, Yoshimura K, Sasaki M. Autophagyphysiology and pathophysiology. Histochem Cell Biol 2008, 129: 407-420.
10. Pedrozo Z, Torrealba N, Fernandez C, Gatica D, Toro B, Quiroga C, Rodriguez AE, et al. Cardiomyocyte ryanodine receptor degradation by chaperone-mediated autophagy. Cardiovasc Res 2013, 98: 277-285.
11. Gottlieb RA, Mentzer RM. Autophagy during cardiac stress: joys and frustrations of autophagy. Annu Rev Physiol 2010, 72: 45-59.
12. Mijaljica D, Prescott M, Devenish RJ. Microautophagy in mammalian cells: revisiting a 40-year-old conundrum. Autophagy 2011, 7: 673-682.
13. Arias E, Cuervo AM. Chaperone-mediated autophagy in protein quality control. Curr Opin Cell Biol 2011, 23: 184-189.
14. Mizushima N, Levine B. Autophagy in mammalian development and differentiation. Nat Cell Biol 2010, 12: 823-830.
15. Chen Y, Klionsky DJ. The regulation of autophagy - unanswered questions. J Cell Sci 2011, 124: 161-170.
16. Kroemer G, Marino G, Levine B. Autophagy and the integrated stress response. Mol Cell 2010, 40: 280-293.
17. Nair U, Jotwani A, Geng J, Gammoh N, Richerson D, Yen WL, Griffith J, et al. SNARE proteins are required for macroautophagy. Cell 2011, 146: 290-302.
18. Yang Z, Klionsky DJ. Mammalian autophagy: core molecular machinery and signaling regulation. Curr Opin Cell Biol 2010, 22: 124-131.
19. Galluzzi L, Pietrocola F, Levine B, Kroemer G. Metabolic control of autophagy. Cell 2014, 159: 1263-1276.
20. Li TY, Lin SY, Lin SC. Mechanism and physiological significance of growth factor-related autophagy. Physiology (Bethesda) 2013, 28: 423-431.
21. Qi D, Young LH. AMPK: energy sensor and survival mechanism in the ischemic heart. Trends Endocrinol Metab 2015, 26: 422-429.
22. Szatmari Z, Sass M. The autophagic roles of Rab small GTPases and their upstream regulators: a review. Autophagy 2014, 10: 1154-1166.
23. Webb AE, Brunet A. FOXO transcription factors: key regulators of cellular quality control. Trends Biochem Sci 2014, 39: 159-169.
24. Xu J, Wang Y, Tan X, Jing H. MicroRNAs in autophagy and their emerging roles in crosstalk with apoptosis. Autophagy 2012, 8: 873-882.
25. Su Z, Yang Z, Xu Y, Chen Y, Yu Q. Apoptosis, autophagy, necroptosis, and cancer metastasis. Mol Cancer 2015, 14: 48.
26. Tong XP, Chen Y, Zhang SY, Xie T, Tian M, Guo MR, Kasimu R, et al. Key autophagic targets and relevant small-molecule compounds in cancer therapy. Cell Prolif 2015, 48: 7-16.
27. Gros F, Muller S. Pharmacological regulators of autophagy and their link with modulators of lupus disease. Br J Pharmacol 2014, 171: 4337-4359.
28. Kim YC, Guan KL. mTOR: a pharmacologic target for autophagy regulation. J Clin Invest 2015, 125: 25-32.
29. Zhang Y, Xu X, Ren J. MTOR overactivation and interrupted autophagy flux in obese hearts: a dicey assembly? Autophagy 2013, 9: 939-941.
30. Decuypere JP, Monaco G, Bultynck G, Missiaen L, De Smedt H, Parys JB. The IP(3) receptor-mitochondria connection in apoptosis and autophagy. Biochim Biophys Acta 2011, 1813: 1003-1013.
31. O'Farrell F, Rusten TE, Stenmark H. Phosphoinositide 3-kinases as accelerators and brakes of autophagy. FEBS J 2013, 280: 6322-6337.
32. Weng LQ, Zhang WB, Ye Y, Yin PP, Yuan J, Wang XX, Kang L, et al. Aliskiren ameliorates pressure overload-induced heart hypertrophy and fibrosis in mice. Acta Pharmacol Sin 2014, 35: 1005-1014.
33. Oka T, Hikoso S, Yamaguchi O, Taneike M, Takeda T, Tamai T, Oyabu J, et al. Mitochondrial DNA that escapes from autophagy causes inflammation and heart failure. Nature 2012, 485: 251-255.
34. Yin X, Peng C, Ning W, Li C, Ren Z, Zhang J, Gao H, et al. miR-30a downregulation aggravates pressure overload-induced cardiomyocyte hypertrophy. Mol Cell Biochem 2013, 379: 1-6.
35. Pan W, Zhong Y, Cheng C, Liu B, Wang L, Li A, Xiong L, et al. MiR-30-regulated autophagy mediates angiotensin II-induced myocardial hypertrophy. PLoS One 2013, 8: e53950.
36. An L, Zhao X, Wu J, Jia J, Zou Y, Guo X, He L, et al. Involvement of autophagy in cardiac remodeling in transgenic mice with cardiac specific over-expression of human programmed cell death 5. PLoS One 2012, 7: e30097.
37. Jeffery TK, Morrell NW. Molecular and cellular basis of pulmonary vascular remodeling in pulmonary hypertension. Prog Cardiovasc Dis 2002, 45: 173-202.
38. Long L, Yang X, Southwood M, Lu J, Marciniak SJ, Dunmore BJ, Morrell NW. Chloroquine prevents progression of experimental pulmonary hypertension via inhibition of autophagy and lysosomal bone morphogenetic protein type II receptor degradation. Circ Res 2013, 112: 1159-1170.
39. Rawat DK, Alzoubi A, Gupte R, Chettimada S, Watanabe M, Kahn AG, Okada T, et al. Increased reactive oxygen species, metabolic maladaptation, and autophagy contribute to pulmonary arterial hypertensioninduced ventricular hypertrophy and diastolic heart failure. Hypertension 2014, 64: 1266-1274.
40. Zhang X, Li ZL, Crane JA, Jordan KL, Pawar AS, Textor SC, Lerman A, et al. Valsartan regulates myocardial autophagy and mitochondrial turnover in experimental hypertension. Hypertension 2014, 64: 87-93.
41. Li L, Zeng H, Chen JX. Apelin-13 increases myocardial progenitor cells and improves repair postmyocardial infarction. Am J Physiol Heart Circ Physiol 2012, 303: H605-H618.
42. Li F, Li L, Qin X, Pan W, Feng F, Chen F, Zhu B, et al. Apelin-induced vascular smooth muscle cell proliferation: the regulation of cyclin D1. Front Biosci 2008, 13: 3786-3792.
43. Li L, Zeng H, Hou X, He X, Chen JX. Myocardial injection of apelin-overexpressing bone marrow cells improves cardiac repair via upregulation of Sirt3 after myocardial infarction. PLoS One 2013, 8: e71041.
44. Xie F, Liu W, Feng F, Li X, Yang L, Lv D, Qin X, et al. A static pressure sensitive receptor APJ promote H9c2 cardiomyocyte hypertrophy via PI3K-autophagy pathway. Acta Biochim Biophys Sin 2014, 46: 699-708.
45. Lin L, Tang C, Xu J, Ye Y, Weng L, Wei W, Ge J, et al. Mechanical stress triggers cardiomyocyte autophagy through angiotensin II type 1 receptormediated p38MAP kinase independently of angiotensin II. PLoS One 2014, 9: e89629.
46. Zhu H, Tannous P, Johnstone JL, Kong Y, Shelton JM, Richardson JA, Le V, et al. Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest 2007, 117: 1782-1793.
47. Lu S, Xu D. Cold stress accentuates pressure overload-induced cardiac hypertrophy and contractile dysfunction: role of TRPV1/AMPK-mediated autophagy. Biochem Biophys Res Commun 2013, 442: 8-15.
48. Chou IP, Chiu YP, Ding ST, Liu BH, Lin YY, Chen CY. Adiponectin receptor 1 overexpression reduces lipid accumulation and hypertrophy in the heart of diet-induced obese mice-possible involvement of oxidative stress and autophagy. Endocr Res 2014, 39: 173-179.
49. Guo R, Hu N, Kandadi MR, Ren J. Facilitated ethanol metabolism promotes cardiomyocyte contractile dysfunction through autophagy in murine hearts. Autophagy 2012, 8: 593-608.
50. Willis MS, Min JN, Wang S, McDonough H, Lockyer P, Wadosky KM, Patterson C. Carboxyl terminus of Hsp70-interacting protein (CHIP) is required to modulate cardiac hypertrophy and attenuate autophagy during exercise. Cell Biochem Funct 2013, 31: 724-735.
51. Sun M, Ouzounian M, de Couto G, Chen M, Yan R, Fukuoka M, Li G, et al. Cathepsin-L ameliorates cardiac hypertrophy through activation of the autophagy-lysosomal dependent protein processing pathways. J Am Heart Assoc 2013, 2: e000191.
52. Dennemarker J, Lohmuller T, Muller S, Aguilar SV, Tobin DJ, Peters C, Reinheckel T. Impaired turnover of autophagolysosomes in cathepsin L deficiency. Biol Chem 2010, 391: 913-922.
53. Rothermel BA, Hill JA. Autophagy in load-induced heart disease. Circ Res 2008, 103: 1363-1369.
54. Fidzianska A, Bilinska ZT, Walczak E, Witkowski A, Chojnowska L. Autophagy in transition from hypertrophic cardiomyopathy to heart failure. J Electron Microsc (Tokyo) 2010, 59: 181-183.
55. Hug C, Wang J, Ahmad NS, Bogan JS, Tsao TS, Lodish HF. T-cadherin is a receptor for hexameric and high-molecular-weight forms of Acrp30/adiponectin. Proc Natl Acad Sci USA 2004, 101: 10308-10313.
56. Redout EM, Wagner MJ, Zuidwijk MJ, Boer C, Musters RJ, van Hardeveld C, Paulus WJ, et al. Right-ventricular failure is associated with increased mitochondrial complex II activity and production of reactive oxygen species. Cardiovasc Res 2007, 75: 770-781.
57. Qipshidze N, Tyagi N, Metreveli N, Lominadze D, Tyagi SC. Autophagy mechanism of right ventricular remodeling in murine model of pulmonary artery constriction. Am J Physiol Heart Circ Physiol 2012, 302: H688-H696.
58. Kong Y, Tannous P, Lu G, Berenji K, Rothermel BA, Olson EN, Hill JA. Suppression of class I and II histone deacetylases blunts pressureoverload cardiac hypertrophy. Circulation 2006, 113: 2579-2588.
59. Granger A, Abdullah I, Huebner F, Stout A, Wang T, Huebner T, Epstein JA, et al. Histone deacetylase inhibition reduces myocardial ischemia-reperfusion injury in mice. FASEB J 2008, 22: 3549-3560.
60. Cao DJ, Wang ZV, Battiprolu PK, Jiang N, Morales CR, Kong Y, Rothermel BA, et al. Histone deacetylase (HDAC) inhibitors attenuate cardiac hypertrophy by suppressing autophagy. Proc Natl Acad Sci USA 2011, 108: 4123-4128.
61. Yitzhaki S, Huang C, Liu W, Lee Y, Gustafsson AB, Mentzer RM Jr, Gottlieb RA. Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA. Basic Res Cardiol 2009, 104: 157-167.
62. Boengler K, Buechert A, Heinen Y, Roeskes C, Hilfiker-Kleiner D, Heusch G, Schulz R. Cardioprotection by ischemic postconditioning is lost in aged and STAT3-deficient mice. Circ Res 2008, 102: 131-135.
63. Boengler K, Schulz R, Heusch G. Loss of cardioprotection with ageing. Cardiovasc Res 2009, 83: 247-261.
64. Hua Y, Zhang Y, Ceylan-Isik AF, Wold LE, Nunn JM, Ren J. Chronic Akt activation accentuates aging-induced cardiac hypertrophy and myocardial contractile dysfunction: role of autophagy. Basic Res Cardiol 2011, 106: 1173-1191.
65. Kawano J, Arora R. The role of adiponectin in obesity, diabetes, and cardiovascular disease. J Cardiometab Syndr 2009, 4: 44-49.
66. Fujita K, Maeda N, Sonoda M, Ohashi K, Hibuse T, Nishizawa H, Nishida M, et al. Adiponectin protects against angiotensin II-induced cardiac fibrosis through activation of PPAR-alpha. Arterioscler Thromb Vasc Biol 2008, 28: 863-870.
67. Lopaschuk GD, Folmes CD, Stanley WC. Cardiac energy metabolism in obesity. Circ Res 2007, 101: 335-347.
68. Guo R, Zhang Y, Turdi S, Ren J. Adiponectin knockout accentuates high fat diet-induced obesity and cardiac dysfunction: role of autophagy. Biochim Biophys Acta 2013, 1832: 1136-1148.
69. Valencia-Sanchez MA, Liu J, Hannon GJ, Parker R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 2006, 20: 515-524.
70. Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009, 136: 215-233.
71. Su M, Wang J, Wang C, Wang X, Dong W, Qiu W, Wang Y, et al. MicroRNA-221 inhibits autophagy and promotes heart failure by modulating the p27/CDK2/mTOR axis. Cell Death Differ 2015, 22: 986-999.
72. Ucar A, Gupta SK, Fiedler J, Erikci E, Kardasinski M, Batkai S, Dangwal S, et al. The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy. Nat Commun 2012, 3: 1078.
73. Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, Taniike M, Omiya S, et al. The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 2007, 13: 619-624.
74. Bhuiyan MS, Pattison JS, Osinska H, James J, Gulick J, McLendon PM, Hill JA, et al. Enhanced autophagy ameliorates cardiac proteinopathy. J Clin Invest 2013, 123: 5284-5297.
75. Mughal W, Dhingra R, Kirshenbaum LA. Striking a balance: autophagy, apoptosis, and necrosis in a normal and failing heart. Curr Hypertens Rep 2012, 14: 540-547.
76. Xu X, Ren J. Unmasking the janus faces of autophagy in obesityassociated insulin resistance and cardiac dysfunction. Clin Exp Pharmacol Physiol 2012, 39: 200-208.
77. Roe ND, Xu X, Kandadi MR, Hu N, Pang J, Weiser-Evans MC, Ren J. Targeted deletion of PTEN in cardiomyocytes renders cardiac contractile dysfunction through interruption of Pink1-AMPK signaling and autophagy. Biochim Biophys Acta 2015, 1852: 290-298.
78. Xu X, Hua Y, Nair S, Bucala R, Ren J. Macrophage migration inhibitory factor deletion exacerbates pressure overload-induced cardiac hypertrophy through mitigating autophagy. Hypertension 2014, 63: 490-499.
79. Kaushik S, Cuervo AM. Autophagy as a cell-repair mechanism: activation of chaperone-mediated autophagy during oxidative stress. Mol Aspects Med 2006, 27: 444-454.
80. Bauml MA, Underwood DA. Left ventricular hypertrophy: an overlooked cardiovascular risk factor. Cleve Clin J Med 2010, 77: 381-387.
81. Lang CH, Korzick DH. Chronic alcohol consumption disrupts myocardial protein balance and function in aged, but not adult, female F344 rats. Am J Physiol Regul Integr Comp Physiol 2014, 306: R23-R33.
82. Liu C, Xue R, Wu D, Wu L, Chen C, Tan W, Chen Y, et al. REDD1 attenuates cardiac hypertrophy via enhancing autophagy. Biochem Biophys Res Commun 2014, 454: 215-220.
83. Chen H, Wang X, Tong M, Wu D, Wu S, Chen J, Wang X, et al. Intermedin suppresses pressure overload cardiac hypertrophy through activation of autophagy. PLoS One 2013, 8: e64757.
84. Li Y, Chen C, Yao F, Su Q, Liu D, Xue R, Dai G, et al. AMPK inhibits cardiac hypertrophy by promoting autophagy via mTORC1. Arch Biochem Biophys 2014, 558: 79-86.
85. Liang L, Shou XL, Zhao HK, Ren GQ, Wang JB, Wang XH, Ai WT, et al. Antioxidant catalase rescues against high fat diet-induced cardiac dysfunction via an IKKbeta-AMPK-dependent regulation of autophagy. Biochim Biophys Acta 2015, 1852: 343-352.
86. Korolchuk VI, Saiki S, Lichtenberg M, Siddiqi FH, Roberts EA, Imarisio S, Jahreiss L, et al. Lysosomal positioning coordinates cellular nutrient responses. Nat Cell Biol 2011, 13: 453-460.
87. Buss SJ, Muenz S, Riffel JH, Malekar P, Hagenmueller M, Weiss CS, Bea F, et al. Beneficial effects of Mammalian target of rapamycin inhibition on left ventricular remodeling after myocardial infarction. J Am Coll Cardiol 2009, 54: 2435-2446.
88. Soesanto W, Lin HY, Hu E, Lefler S, Litwin SE, Sena S, Abel ED, et al. Mammalian target of rapamycin is a critical regulator of cardiac hypertrophy in spontaneously hypertensive rats. Hypertension 2009, 54: 1321-1327.
89. Bishu K, Ogut O, Kushwaha S, Mohammed SF, Ohtani T, Xu X, Brozovich FV, et al. Anti-remodeling effects of rapamycin in experimental heart failure: dose response and interaction with angiotensin receptor blockade. PLoS One 2013, 8: e81325.
90. Li MH, Zhang YJ, Yu YH, Yang SH, Iqbal J, Mi QY, Li B, et al. Berberine improves pressure overload-induced cardiac hypertrophy and dysfunction through enhanced autophagy. Eur J Pharmacol 2014, 728: 67-76.
91. Hariharan N, Ikeda Y, Hong C, Alcendor RR, Usui S, Gao S, Maejima Y, et al. Autophagy plays an essential role in mediating regression of hypertrophy during unloading of the heart. PLoS One 2013, 8: e51632.
92. Oyabu J, Yamaguchi O, Hikoso S, Takeda T, Oka T, Murakawa T, Yasui H, et al. Autophagy-mediated degradation is necessary for regression of cardiac hypertrophy during ventricular unloading. Biochem Biophys Res Commun 2013, 441: 787-792.
93. Zhu H, Sun X, Wang D, Hu N, Zhang Y. Doxycycline ameliorates aggregation of collagen and atrial natriuretic peptide in murine postinfarction heart. Eur J Pharmacol 2015, 754: 66-72.
94. Georgescu SP, Aronovitz MJ, Iovanna JL, Patten RD, Kyriakis JM, Goruppi S. Decreased metalloprotease 9 induction, cardiac fibrosis, and higher autophagy after pressure overload in mice lacking the transcriptional regulator p8. Am J Physiol Cell Physiol 2011, 301: C1046-C1056.
95. Wang EY, Biala AK, Gordon JW, Kirshenbaum LA. Autophagy in the heart: too much of a good thing? J Cardiovasc Pharmacol 2012, 60: 110-117.
96. McMullen JR, Sherwood MC, Tarnavski O, Zhang L, Dorfman AL, Shioi T, Izumo S. Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation 2004, 109: 3050-3055.
97. Halapas A, Armakolas A, Koutsilieris M. Autophagy: a target for therapeutic interventions in myocardial pathophysiology. Expert Opin Ther Targets 2008, 12: 1509-1522.
98. Maejima Y, Chen Y, Isobe M, Gustafsson AB, Kitsis RN, Sadoshima J. Recent progress in research on molecular mechanisms of autophagy in the heart. Am J Physiol Heart Circ Physiol 2015, 308: H259-H268.
99. Zhang XJ, Chen S, Huang KX, Le WD. Why should autophagic flux be assessed?. Acta Pharmacol Sin 2013, 34: 595-599.
100. Schiattarella GG, Hill JA. Therapeutic targeting of autophagy in cardiovascular disease. J Mol Cell Cardiol 2015, pii: S0022-2828(15)30124-3.
101. Hyttinen JM, Amadio M, Viiri J, Pascale A, Salminen A, Kaarniranta K. Clearance of misfolded and aggregated proteins by aggrephagy and implications for aggregation diseases. Ageing Res Rev 2014, 18: 16-28.
102. Vasquez-Trincado C, Garcia-Carvajal I, Pennanen C, Parra V, Hill JA, Rothermel BA, Lavandero S. Mitochondrial dynamics, mitophagy and cardiovascular disease. J Physiol 2016, 594: 509-525.
103. Chaanine AH, Jeong D, Liang L, Chemaly ER, Fish K, Gordon RE, Hajjar RJ. JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart failure. Cell Death Dis 2012, 3: 265.
104. Bhandari P, Song M, Chen Y, Burelle Y, Dorn GW II . Mitochondrial contagion induced by Parkin deficiency in Drosophila hearts and its containment by suppressing mitofusin. Circ Res 2014, 114: 257-265.
105. Mizumura K, Choi AM, Ryter SW. Emerging role of selective autophagy in human diseases. Front Pharmacol 2014, 5: 244.
106. Ossareh-Nazari B, Nino CA, Bengtson MH, Lee JW, Joazeiro CA, Dargemont C. Ubiquitylation by the Ltn1 E3 ligase protects 60S ribosomes from starvation-induced selective autophagy. J Cell Biol 2014, 204: 909-917.
107. Carloni S, Albertini MC, Galluzzi L, Buonocore G, Proietti F, Balduini W. Increased autophagy reduces endoplasmic reticulum stress after neonatal hypoxia-ischemia: role of protein synthesis and autophagic pathways. Exp Neurol 2014, 255: 103-112.
108. Wang X, Li S, Liu Y, Ma C. Redox regulated peroxisome homeostasis. Redox Biol 2015, 4: 104-108.
109. Manjithaya R, Nazarko TY, Farre JC, Subramani S. Molecular mechanism and physiological role of pexophagy. FEBS Lett 2010, 584: 1367-1373.
110. Shaid S, Brandts CH, Serve H, Dikic I. Ubiquitination and selective autophagy. Cell Death Differ 2013, 20: 21-30.
111. Dorn GW II, Kitsis RN. The mitochondrial dynamism-mitophagy-cell death interactome: multiple roles performed by members of a mitochondrial molecular ensemble. Circ Res 2015, 116: 167-182.
112. Kubli DA, Gustafsson AB. Mitochondria and mitophagy: the yin and yang of cell death control. Circ Res 2012, 111: 1208-1221.
113. Gottlieb RA, Mentzer RM Jr. Autophagy: an affair of the heart. Heart Fail Rev 2013, 18: 575-584.
114. Rifki OF, Hill JA. Cardiac autophagy: good with the bad. J Cardiovasc Pharmacol 2012, 60: 248-252.
115. Xie M, Morales CR, Lavandero S, Hill JA. Tuning flux: autophagy as a target of heart disease therapy. Curr Opin Cardiol 2011, 26: 216-222