-
1
-
-
35448981935
-
Autophagy: from phenomenology to molecular understanding in less than a decade
-
Klionsky DJ (2007) Autophagy: from phenomenology to molecular understanding in less than a decade. Nat. Rev. Mol. Cell Biol. 8, 931-937.
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 931-937
-
-
Klionsky, D.J.1
-
2
-
-
84892569830
-
An overview of autophagy: morphology, mechanism, and regulation
-
Parzych KR, Klionsky DJ (2014) An overview of autophagy: morphology, mechanism, and regulation. Antioxid. Redox Signal. 20, 460-473.
-
(2014)
Antioxid. Redox Signal.
, vol.20
, pp. 460-473
-
-
Parzych, K.R.1
Klionsky, D.J.2
-
3
-
-
37649005234
-
Autophagy in the pathogenesis of disease
-
Levine B, Kroemer G (2008) Autophagy in the pathogenesis of disease. Cell 132, 27-42.
-
(2008)
Cell
, vol.132
, pp. 27-42
-
-
Levine, B.1
Kroemer, G.2
-
4
-
-
84887486465
-
Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer
-
Liu B, Wen X, Cheng Y (2013) Survival or death: disequilibrating the oncogenic and tumor suppressive autophagy in cancer. Cell Death Dis. 4, e892.
-
(2013)
Cell Death Dis.
, vol.4
, pp. e892
-
-
Liu, B.1
Wen, X.2
Cheng, Y.3
-
5
-
-
77956363593
-
Autophagic pathways as new targets for cancer drug development
-
Liu B, Cheng Y, Liu Q, Bao JK, Yang JM (2010) Autophagic pathways as new targets for cancer drug development. Acta Pharmacol. Sin. 31, 1154-1164.
-
(2010)
Acta Pharmacol. Sin.
, vol.31
, pp. 1154-1164
-
-
Liu, B.1
Cheng, Y.2
Liu, Q.3
Bao, J.K.4
Yang, J.M.5
-
6
-
-
34548265278
-
Autophagy and human disease
-
Huang J, Klionsky DJ (2007) Autophagy and human disease. Cell Cycle 6, 1837-1849.
-
(2007)
Cell Cycle
, vol.6
, pp. 1837-1849
-
-
Huang, J.1
Klionsky, D.J.2
-
7
-
-
78649704325
-
Autophagy and metabolism
-
Rabinowitz JD, White E (2010) Autophagy and metabolism. Science 330, 1344-1348.
-
(2010)
Science
, vol.330
, pp. 1344-1348
-
-
Rabinowitz, J.D.1
White, E.2
-
8
-
-
57649184088
-
Control of autophagy by oncogenes and tumor suppressor genes
-
Maiuri MC, Tasdemir E, Criollo A, Morselli E, Vicencio JM, Carnuccio R et al. (2009) Control of autophagy by oncogenes and tumor suppressor genes. Cell Death Differ. 16, 87-93.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 87-93
-
-
Maiuri, M.C.1
Tasdemir, E.2
Criollo, A.3
Morselli, E.4
Vicencio, J.M.5
Carnuccio, R.6
-
9
-
-
84891747382
-
The machinery of macroautophagy
-
Feng Y, He D, Yao Z, Klionsky DJ (2014) The machinery of macroautophagy. Cell Res. 1, 24-41.
-
(2014)
Cell Res.
, vol.1
, pp. 24-41
-
-
Feng, Y.1
He, D.2
Yao, Z.3
Klionsky, D.J.4
-
10
-
-
43149090064
-
FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells
-
Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL et al. (2008) FIP200, a ULK-interacting protein, is required for autophagosome formation in mammalian cells. J. Cell Biol. 181, 497-510.
-
(2008)
J. Cell Biol.
, vol.181
, pp. 497-510
-
-
Hara, T.1
Takamura, A.2
Kishi, C.3
Iemura, S.4
Natsume, T.5
Guan, J.L.6
-
11
-
-
65249176304
-
ULK-Atg13-FIP200 complexes mediate mTORC1 signaling to the autophagy machinery
-
Jung CH, Jun CB, Ro SH, Kim YM, Otto NM, Cao J et al. (2009) ULK-Atg13-FIP200 complexes mediate mTORC1 signaling to the autophagy machinery. Mol. Biol. Cell 20, 1992-2003.
-
(2009)
Mol. Biol. Cell
, vol.20
, pp. 1992-2003
-
-
Jung, C.H.1
Jun, C.B.2
Ro, S.H.3
Kim, Y.M.4
Otto, N.M.5
Cao, J.6
-
12
-
-
70349644856
-
Atg101, a novel mammalian autophagy protein interacting with Atg13
-
Hosokawa N, Sasaki T, Iemura S, Natsume T, Hara T, Mizushima N (2009) Atg101, a novel mammalian autophagy protein interacting with Atg13. Autophagy 5, 973-979.
-
(2009)
Autophagy
, vol.5
, pp. 973-979
-
-
Hosokawa, N.1
Sasaki, T.2
Iemura, S.3
Natsume, T.4
Hara, T.5
Mizushima, N.6
-
13
-
-
84864874958
-
MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB
-
Martina JA, Chen Y, Gucek M, Puertollano R (2012) MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB. Autophagy 8, 903-914.
-
(2012)
Autophagy
, vol.8
, pp. 903-914
-
-
Martina, J.A.1
Chen, Y.2
Gucek, M.3
Puertollano, R.4
-
14
-
-
59249089394
-
Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG
-
Itakura E, Kishi C, Inoue K, Mizushima N (2008) Beclin 1 forms two distinct phosphatidylinositol 3-kinase complexes with mammalian Atg14 and UVRAG. Mol. Biol. Cell 19, 5360-5372.
-
(2008)
Mol. Biol. Cell
, vol.19
, pp. 5360-5372
-
-
Itakura, E.1
Kishi, C.2
Inoue, K.3
Mizushima, N.4
-
15
-
-
84874598403
-
Beclin-1: autophagic regulator and therapeutic target in cancer
-
Fu LL, Cheng Y, Liu B (2013) Beclin-1: autophagic regulator and therapeutic target in cancer. Int. J. Biochem. Cell Biol. 45, 921-924.
-
(2013)
Int. J. Biochem. Cell Biol.
, vol.45
, pp. 921-924
-
-
Fu, L.L.1
Cheng, Y.2
Liu, B.3
-
16
-
-
84883235992
-
mTOR, AMBRA1, and autophagy: an intricate relationship
-
Nazio F, Cecconi F (2013) mTOR, AMBRA1, and autophagy: an intricate relationship. Cell Cycle 12, 2524-2525.
-
(2013)
Cell Cycle
, vol.12
, pp. 2524-2525
-
-
Nazio, F.1
Cecconi, F.2
-
17
-
-
79952628267
-
The Beclin 1 network regulates autophagy and apoptosis
-
Kang R, Zeh HJ, Lotze MT, Tang D (2011) The Beclin 1 network regulates autophagy and apoptosis. Cell Death Differ. 18, 571-580.
-
(2011)
Cell Death Differ.
, vol.18
, pp. 571-580
-
-
Kang, R.1
Zeh, H.J.2
Lotze, M.T.3
Tang, D.4
-
18
-
-
0032563798
-
A protein conjugation system essential for autophagy
-
Mizushima N, Noda T, Yoshimori T, Tanaka Y, Ishii T, George MD et al. (1998) A protein conjugation system essential for autophagy. Nature 395, 395-398.
-
(1998)
Nature
, vol.395
, pp. 395-398
-
-
Mizushima, N.1
Noda, T.2
Yoshimori, T.3
Tanaka, Y.4
Ishii, T.5
George, M.D.6
-
19
-
-
0038325675
-
Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate
-
Mizushima N, Kuma A, Kobayashi Y, Yamamoto A, Matsubae M, Takao T et al. (2003) Mouse Apg16L, a novel WD-repeat protein, targets to the autophagic isolation membrane with the Apg12-Apg5 conjugate. J. Cell Sci. 116, 1679-1688.
-
(2003)
J. Cell Sci.
, vol.116
, pp. 1679-1688
-
-
Mizushima, N.1
Kuma, A.2
Kobayashi, Y.3
Yamamoto, A.4
Matsubae, M.5
Takao, T.6
-
20
-
-
51049118332
-
The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy
-
Geng J, Klionsky DJ (2008) The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy. EMBO Rep. 9, 859-864.
-
(2008)
EMBO Rep.
, vol.9
, pp. 859-864
-
-
Geng, J.1
Klionsky, D.J.2
-
21
-
-
0346503885
-
The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure
-
Reggiori F, Tucker KA, Stromhaug PE, Klionsky DJ (2004) The Atg1-Atg13 complex regulates Atg9 and Atg23 retrieval transport from the pre-autophagosomal structure. Dev. Cell 6, 79-90.
-
(2004)
Dev. Cell
, vol.6
, pp. 79-90
-
-
Reggiori, F.1
Tucker, K.A.2
Stromhaug, P.E.3
Klionsky, D.J.4
-
22
-
-
65649136884
-
The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy
-
Satoo K, Noda NN, Kumeta H, Fujioka Y, Mizushima N, Ohsumi Y et al. (2009) The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy. EMBO J. 28, 1341-1350.
-
(2009)
EMBO J.
, vol.28
, pp. 1341-1350
-
-
Satoo, K.1
Noda, N.N.2
Kumeta, H.3
Fujioka, Y.4
Mizushima, N.5
Ohsumi, Y.6
-
23
-
-
0042592913
-
Deletion of the SNARE vti1b in mice results in the loss of a single SNARE partner, syntaxin 8
-
Atlashkin V, Kreykenbohm V, Eskelinen E-L, Wenzel D, Fayyazi A, Fischer von Mollard G (2003) Deletion of the SNARE vti1b in mice results in the loss of a single SNARE partner, syntaxin 8. Mol. Cell. Biol. 23, 5198-5207.
-
(2003)
Mol. Cell. Biol.
, vol.23
, pp. 5198-5207
-
-
Atlashkin, V.1
Kreykenbohm, V.2
Eskelinen, E.-L.3
Wenzel, D.4
Fayyazi, A.5
Fischer von Mollard, G.6
-
24
-
-
77949448601
-
Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes
-
Furuta N, Fujita N, Noda T, Yoshimori T, Amano A (2010) Combinational soluble N-ethylmaleimide-sensitive factor attachment protein receptor proteins VAMP8 and Vti1b mediate fusion of antimicrobial and canonical autophagosomes with lysosomes. Mol. Biol. Cell 21, 1001-1010.
-
(2010)
Mol. Biol. Cell
, vol.21
, pp. 1001-1010
-
-
Furuta, N.1
Fujita, N.2
Noda, T.3
Yoshimori, T.4
Amano, A.5
-
25
-
-
84870880174
-
The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes
-
Itakura E, Kishi-Itakura C, Mizushima N (2012) The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell 151, 1256-1269.
-
(2012)
Cell
, vol.151
, pp. 1256-1269
-
-
Itakura, E.1
Kishi-Itakura, C.2
Mizushima, N.3
-
26
-
-
79960925702
-
Core signaling pathways of survival/death in autophagy-related cancer networks
-
Wang SY, Yu QJ, Zhang RD, Liu B (2011) Core signaling pathways of survival/death in autophagy-related cancer networks. Int. J. Biochem. Cell Biol. 43, 1263-1266.
-
(2011)
Int. J. Biochem. Cell Biol.
, vol.43
, pp. 1263-1266
-
-
Wang, S.Y.1
Yu, Q.J.2
Zhang, R.D.3
Liu, B.4
-
27
-
-
69349087479
-
Anti- and pro-tumor functions of autophagy
-
Morselli E, Galluzzi L, Kepp O, Vicencio JM, Criollo A, Maiuri MC et al. (2009) Anti- and pro-tumor functions of autophagy. Biochim. Biophys. Acta 1793, 1524-1532.
-
(2009)
Biochim. Biophys. Acta
, vol.1793
, pp. 1524-1532
-
-
Morselli, E.1
Galluzzi, L.2
Kepp, O.3
Vicencio, J.M.4
Criollo, A.5
Maiuri, M.C.6
-
28
-
-
84894594752
-
Autophagy: directed development
-
McCarthy N (2014) Autophagy: directed development. Nat. Rev. Cancer 14, 74-75.
-
(2014)
Nat. Rev. Cancer
, vol.14
, pp. 74-75
-
-
McCarthy, N.1
-
29
-
-
84900423162
-
Activation of the PI3K/mTOR pathway is involved in cystic proliferation of cholangiocytes of the PCK rat
-
Ren XS, Sato Y, Harada K, Sasaki M, Furubo S, Song JY et al. (2014) Activation of the PI3K/mTOR pathway is involved in cystic proliferation of cholangiocytes of the PCK rat. PLoS One 9, e87660.
-
(2014)
PLoS One
, vol.9
, pp. e87660
-
-
Ren, X.S.1
Sato, Y.2
Harada, K.3
Sasaki, M.4
Furubo, S.5
Song, J.Y.6
-
30
-
-
84902162904
-
AKT/mTOR and C- N-terminal kinase (JNK) signaling pathways are required for chrysotile asbestos-induced autophagy
-
Lin Z, Liu T, Kamp DW, Wang Y, He H, Zhou X et al. (2014) AKT/mTOR and C- N-terminal kinase (JNK) signaling pathways are required for chrysotile asbestos-induced autophagy. Free Radic. Biol. Med. 72, 296-307.
-
(2014)
Free Radic. Biol. Med.
, vol.72
, pp. 296-307
-
-
Lin, Z.1
Liu, T.2
Kamp, D.W.3
Wang, Y.4
He, H.5
Zhou, X.6
-
31
-
-
84899639570
-
IPF fibroblasts are desensitized to type I collagen matrix-induced cell death by suppressing low autophagy via aberrant Akt/mTOR kinases
-
Nho RS, Hergert P (2014) IPF fibroblasts are desensitized to type I collagen matrix-induced cell death by suppressing low autophagy via aberrant Akt/mTOR kinases. PLoS One 9, e94616.
-
(2014)
PLoS One
, vol.9
, pp. e94616
-
-
Nho, R.S.1
Hergert, P.2
-
32
-
-
78650510609
-
mTOR: from growth signal integration to cancer, diabetes and ageing
-
Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 12, 21-35.
-
(2011)
Nat. Rev. Mol. Cell Biol.
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
33
-
-
77956511880
-
The mTOR pathway: a new target in cancer therapy
-
Ciuffreda L, Di Sanza C, Incani UC, Milella M (2010) The mTOR pathway: a new target in cancer therapy. Curr. Cancer Drug Targets 10, 484-495.
-
(2010)
Curr. Cancer Drug Targets
, vol.10
, pp. 484-495
-
-
Ciuffreda, L.1
Di Sanza, C.2
Incani, U.C.3
Milella, M.4
-
34
-
-
34548700597
-
Rapamycin: something old, something new, sometimes borrowed and now renewed
-
Hartford CM, Ratain MJ (2007) Rapamycin: something old, something new, sometimes borrowed and now renewed. Clin. Pharmacol. Ther. 82, 381-388.
-
(2007)
Clin. Pharmacol. Ther.
, vol.82
, pp. 381-388
-
-
Hartford, C.M.1
Ratain, M.J.2
-
35
-
-
77957870285
-
mTOR mediated anti-cancer drug discovery
-
Liu Q, Thoreen C, Wang J, Sabatini D, Gray NS (2009) mTOR mediated anti-cancer drug discovery. Drug Discov. Today Ther. Strateg. 6, 47-55.
-
(2009)
Drug Discov. Today Ther. Strateg.
, vol.6
, pp. 47-55
-
-
Liu, Q.1
Thoreen, C.2
Wang, J.3
Sabatini, D.4
Gray, N.S.5
-
36
-
-
80052227050
-
Autophagy as a target for anticancer therapy
-
Ku F, McConkey DJ, Hong DS, Kurzrock R (2011) Autophagy as a target for anticancer therapy. Nat. Rev. Clin. Oncol. 8, 528-539.
-
(2011)
Nat. Rev. Clin. Oncol.
, vol.8
, pp. 528-539
-
-
Ku, F.1
McConkey, D.J.2
Hong, D.S.3
Kurzrock, R.4
-
37
-
-
84866122688
-
Autophagy modulation as a potential therapeutic target for diverse diseases
-
Rubinsztein DC, Codogno P, Levine B (2012) Autophagy modulation as a potential therapeutic target for diverse diseases. Nat. Rev. Drug Discov. 11, 709-730.
-
(2012)
Nat. Rev. Drug Discov.
, vol.11
, pp. 709-730
-
-
Rubinsztein, D.C.1
Codogno, P.2
Levine, B.3
-
38
-
-
70349616273
-
Screen for chemical modulators of autophagy reveals el therapeutic inhibitors of mTORC1 signaling
-
Balgi AD, Fonseca BD, Donohue E, Tsang TC, Lajoie P, Proud CG et al. (2009) Screen for chemical modulators of autophagy reveals el therapeutic inhibitors of mTORC1 signaling. PLoS One 4, e7124.
-
(2009)
PLoS One
, vol.4
, pp. e7124
-
-
Balgi, A.D.1
Fonseca, B.D.2
Donohue, E.3
Tsang, T.C.4
Lajoie, P.5
Proud, C.G.6
-
39
-
-
54249162351
-
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
-
Apsel B, Blair JA, Gonzalez B, Nazif TM, Feldman ME, Aizenstein B et al. (2008) Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. Nat. Chem. Biol. 4, 691-699.
-
(2008)
Nat. Chem. Biol.
, vol.4
, pp. 691-699
-
-
Apsel, B.1
Blair, J.A.2
Gonzalez, B.3
Nazif, T.M.4
Feldman, M.E.5
Aizenstein, B.6
-
40
-
-
65949086045
-
Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells
-
Bomeddy A, Hahm ER, Xiao D, Powolny AA, Fisher AL, Jiang Y et al. (2009) Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells. Cancer Res. 69, 3704-3712.
-
(2009)
Cancer Res.
, vol.69
, pp. 3704-3712
-
-
Bomeddy, A.1
Hahm, E.R.2
Xiao, D.3
Powolny, A.A.4
Fisher, A.L.5
Jiang, Y.6
-
41
-
-
0038364056
-
Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by reasing mTOR phosphorylation and inducing autophagy
-
Raviku B, Stewart A, Kita H, Kato K, Duden R, Rubinsztein DC (2003) Raised intracellular glucose concentrations reduce aggregation and cell death caused by mutant huntingtin exon 1 by reasing mTOR phosphorylation and inducing autophagy. Hum. Mol. Genet. 12, 985-994.
-
(2003)
Hum. Mol. Genet.
, vol.12
, pp. 985-994
-
-
Raviku, B.1
Stewart, A.2
Kita, H.3
Kato, K.4
Duden, R.5
Rubinsztein, D.C.6
-
42
-
-
66449115318
-
Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
-
Salazar M, Carracedo A, Salanueva IJ, Hernández-Tiedra S, Lorente M, Egia A et al. (2009) Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells. J. Clin. Invest. 119, 1359-1372.
-
(2009)
J. Clin. Invest.
, vol.119
, pp. 1359-1372
-
-
Salazar, M.1
Carracedo, A.2
Salanueva, I.J.3
Hernández-Tiedra, S.4
Lorente, M.5
Egia, A.6
-
43
-
-
47249094223
-
Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells
-
Scarlatti F, Maffei R, Beau I, Codogno P, Ghidoni R (2008) Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells. Cell Death Differ. 15, 1318-1329.
-
(2008)
Cell Death Differ.
, vol.15
, pp. 1318-1329
-
-
Scarlatti, F.1
Maffei, R.2
Beau, I.3
Codogno, P.4
Ghidoni, R.5
-
44
-
-
79960410571
-
Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells
-
Bareford MD, Park MA, Yacoub A, Hamed HA, Tang Y, Cruickshanks N et al. (2011) Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells. Cancer Res. 71, 4955-4967.
-
(2011)
Cancer Res.
, vol.71
, pp. 4955-4967
-
-
Bareford, M.D.1
Park, M.A.2
Yacoub, A.3
Hamed, H.A.4
Tang, Y.5
Cruickshanks, N.6
-
45
-
-
68849091778
-
NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas
-
Liu TJ, Koul D, LaFortune T, Tiao N, Shen RJ, Maira SM et al. (2009) NVP-BEZ235, a novel dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor, elicits multifaceted antitumor activities in human gliomas. Mol. Cancer Ther. 8, 2204-2210.
-
(2009)
Mol. Cancer Ther.
, vol.8
, pp. 2204-2210
-
-
Liu, T.J.1
Koul, D.2
LaFortune, T.3
Tiao, N.4
Shen, R.J.5
Maira, S.M.6
-
46
-
-
78149475478
-
Akt and autophagy cooperate to promote survival of drug-resistant glioma
-
Fan QW, Cheng C, Hackett C, Feldman M, Houseman BT, Nicolaides T et al. (2010) Akt and autophagy cooperate to promote survival of drug-resistant glioma. Sci. Signal. 3, ra81.
-
(2010)
Sci. Signal.
, vol.3
, pp. ra81
-
-
Fan, Q.W.1
Cheng, C.2
Hackett, C.3
Feldman, M.4
Houseman, B.T.5
Nicolaides, T.6
-
47
-
-
67650312583
-
Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR)
-
García-tínez JM, Moran J, Clarke RG, Gray A, Cosulich SC, Chresta CM et al. (2009) Ku-0063794 is a specific inhibitor of the mammalian target of rapamycin (mTOR). Biochem. J. 421, 29-42.
-
(2009)
Biochem. J.
, vol.421
, pp. 29-42
-
-
García-tínez, J.M.1
Moran, J.2
Clarke, R.G.3
Gray, A.4
Cosulich, S.C.5
Chresta, C.M.6
-
48
-
-
67549135481
-
Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy
-
Laane E, Tamm KP, Buentke E, Ito K, Kharaziha P, Oscarsson J et al. (2009) Cell death induced by dexamethasone in lymphoid leukemia is mediated through initiation of autophagy. Cell Death Differ. 16, 1018-1029.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 1018-1029
-
-
Laane, E.1
Tamm, K.P.2
Buentke, E.3
Ito, K.4
Kharaziha, P.5
Oscarsson, J.6
-
49
-
-
38049125764
-
Magnolol-induced H460 cells death via autophagy but not apoptosis
-
Li HB, Yi X, Gao JM, Ying XX, Guan HQ, Li JC (2007) Magnolol-induced H460 cells death via autophagy but not apoptosis. Arch. Pharm. Res. 30, 1566-1574.
-
(2007)
Arch. Pharm. Res.
, vol.30
, pp. 1566-1574
-
-
Li, H.B.1
Yi, X.2
Gao, J.M.3
Ying, X.X.4
Guan, H.Q.5
Li, J.C.6
-
50
-
-
67549135655
-
The inositol 1, 4, 5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1
-
Vicencio JM, Ortiz C, Criollo A, Jones AW, Kepp O, Galluzzi L et al. (2009) The inositol 1, 4, 5-trisphosphate receptor regulates autophagy through its interaction with Beclin 1. Cell Death Differ. 16, 1006-1017.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 1006-1017
-
-
Vicencio, J.M.1
Ortiz, C.2
Criollo, A.3
Jones, A.W.4
Kepp, O.5
Galluzzi, L.6
-
51
-
-
79956144655
-
Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1
-
Li H, Wang P, Sun Q, Ding WX, Yin XM, Sobol RW et al. (2011) Following cytochrome c release, autophagy is inhibited during chemotherapy-induced apoptosis by caspase 8-mediated cleavage of Beclin 1. Cancer Res. 71, 3625-3634.
-
(2011)
Cancer Res.
, vol.71
, pp. 3625-3634
-
-
Li, H.1
Wang, P.2
Sun, Q.3
Ding, W.X.4
Yin, X.M.5
Sobol, R.W.6
-
52
-
-
84907210432
-
Beclin 1, an essential component and master regulator of PI3K-III in health and disease
-
McKnight NC, Zhenyu Y (2013) Beclin 1, an essential component and master regulator of PI3K-III in health and disease. Curr. Pathobiol. Rep. 1, 231-238.
-
(2013)
Curr. Pathobiol. Rep.
, vol.1
, pp. 231-238
-
-
McKnight, N.C.1
Zhenyu, Y.2
-
53
-
-
84862023791
-
Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG
-
Li X, He L, Che KH, Funderburk SF, Pan L, Pan N et al. (2012) Imperfect interface of Beclin1 coiled-coil domain regulates homodimer and heterodimer formation with Atg14L and UVRAG. Nat. Commun. 3, 662.
-
(2012)
Nat. Commun.
, vol.3
, pp. 662
-
-
Li, X.1
He, L.2
Che, K.H.3
Funderburk, S.F.4
Pan, L.5
Pan, N.6
-
54
-
-
77957728513
-
The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy
-
Di Bartolomeo S, Corazzari M, Nazio F, Oliverio S, Lisi G, Antonioli M et al. (2010) The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy. J. Cell Biol. 19, 155-168.
-
(2010)
J. Cell Biol.
, vol.19
, pp. 155-168
-
-
Di Bartolomeo, S.1
Corazzari, M.2
Nazio, F.3
Oliverio, S.4
Lisi, G.5
Antonioli, M.6
-
55
-
-
77956386515
-
Endogenous HMGB1 regulates autophagy
-
Tang D, Kang R, Livesey KM, Cheh CW, Farkas A, Loughran P et al. (2010) Endogenous HMGB1 regulates autophagy. J. Cell Biol. 190, 881-892.
-
(2010)
J. Cell Biol.
, vol.190
, pp. 881-892
-
-
Tang, D.1
Kang, R.2
Livesey, K.M.3
Cheh, C.W.4
Farkas, A.5
Loughran, P.6
-
56
-
-
84893930312
-
Survivin as a preferential target for cancer therapy
-
Mobahat M, Narendran A, Riabowol K (2014) Survivin as a preferential target for cancer therapy. Int. J. Mol. Sci. 15, 2494-2516.
-
(2014)
Int. J. Mol. Sci.
, vol.15
, pp. 2494-2516
-
-
Mobahat, M.1
Narendran, A.2
Riabowol, K.3
-
57
-
-
77952242572
-
The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy
-
Michiorri S, Gelmetti V, Giarda E, Lombardi F, Romano F, Marongiu R et al. (2010) The Parkinson-associated protein PINK1 interacts with Beclin1 and promotes autophagy. Cell Death Differ. 17, 962-974.
-
(2010)
Cell Death Differ.
, vol.17
, pp. 962-974
-
-
Michiorri, S.1
Gelmetti, V.2
Giarda, E.3
Lombardi, F.4
Romano, F.5
Marongiu, R.6
-
58
-
-
25144457455
-
Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy
-
Pattingre S, Tassa A, Qu X, Garuti R, Liang XH, Mizushima N et al. (2005) Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122, 927-939.
-
(2005)
Cell
, vol.122
, pp. 927-939
-
-
Pattingre, S.1
Tassa, A.2
Qu, X.3
Garuti, R.4
Liang, X.H.5
Mizushima, N.6
-
59
-
-
78650936005
-
The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression
-
Sun Q, Zhang J, Fan W, Wong KN, Ding X, Chen S et al. (2011) The RUN domain of rubicon is important for hVps34 binding, lipid kinase inhibition, and autophagy suppression. J. Biol. Chem. 286, 185-191.
-
(2011)
J. Biol. Chem.
, vol.286
, pp. 185-191
-
-
Sun, Q.1
Zhang, J.2
Fan, W.3
Wong, K.N.4
Ding, X.5
Chen, S.6
-
60
-
-
80053501671
-
Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13
-
Liu J, Xia H, Kim M, Xu L, Li Y, Zhang L et al. (2011) Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13. Cell 147, 223-234.
-
(2011)
Cell
, vol.147
, pp. 223-234
-
-
Liu, J.1
Xia, H.2
Kim, M.3
Xu, L.4
Li, Y.5
Zhang, L.6
-
61
-
-
80052714034
-
BH3 mimetics activate multiple pro-autophagic pathways
-
Malik SA, Orhon I, Morselli E, Criollo A, Shen S, Mariño G et al. (2011) BH3 mimetics activate multiple pro-autophagic pathways. Oncogene 30, 3918-3929.
-
(2011)
Oncogene
, vol.30
, pp. 3918-3929
-
-
Malik, S.A.1
Orhon, I.2
Morselli, E.3
Criollo, A.4
Shen, S.5
Mariño, G.6
-
62
-
-
27144503701
-
Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death
-
Hoyer-Hansen M, Bastholm L, Mathiasen IS, Elling F, Jaattela M (2005) Vitamin D analog EB1089 triggers dramatic lysosomal changes and Beclin 1-mediated autophagic cell death. Cell Death Differ. 12, 1297-1309.
-
(2005)
Cell Death Differ.
, vol.12
, pp. 1297-1309
-
-
Hoyer-Hansen, M.1
Bastholm, L.2
Mathiasen, I.S.3
Elling, F.4
Jaattela, M.5
-
63
-
-
78650170269
-
A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum
-
Lian J, Wu X, He F, Karnak D, Tang W, Meng Y et al. (2011) A natural BH3 mimetic induces autophagy in apoptosis-resistant prostate cancer via modulating Bcl-2-Beclin1 interaction at endoplasmic reticulum. Cell Death Differ. 18, 60-71.
-
(2011)
Cell Death Differ.
, vol.18
, pp. 60-71
-
-
Lian, J.1
Wu, X.2
He, F.3
Karnak, D.4
Tang, W.5
Meng, Y.6
-
64
-
-
33747608873
-
Antitumoral activity of rapamycin in renal angiomyolipoma associated with tuberous sclerosis complex
-
Wienecke R, Fackler I, Linsenmaier U, Linsenmaier U, Mayer K, Licht T et al. (2006) Antitumoral activity of rapamycin in renal angiomyolipoma associated with tuberous sclerosis complex. Am. J. Kidney Dis. 48, e27-e29.
-
(2006)
Am. J. Kidney Dis.
, vol.48
, pp. e27-e29
-
-
Wienecke, R.1
Fackler, I.2
Linsenmaier, U.3
Linsenmaier, U.4
Mayer, K.5
Licht, T.6
-
65
-
-
67650252764
-
RAD001 (Everolimus) induces autophagy in acute lymphoblastic leukemia
-
Crazzolara R, Bradstock KF, Bendall LJ (2009) RAD001 (Everolimus) induces autophagy in acute lymphoblastic leukemia. Autophagy 5, 727-728.
-
(2009)
Autophagy
, vol.5
, pp. 727-728
-
-
Crazzolara, R.1
Bradstock, K.F.2
Bendall, L.J.3
-
66
-
-
8044257699
-
The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes
-
Blommaart EF, Krause U, Schellens JP, Vreeling-Sindelarova H, Meijer AJ (1997) The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes. Eur. J. Biochem. 243, 240-246.
-
(1997)
Eur. J. Biochem.
, vol.243
, pp. 240-246
-
-
Blommaart, E.F.1
Krause, U.2
Schellens, J.P.3
Vreeling-Sindelarova, H.4
Meijer, A.J.5
-
67
-
-
77951217000
-
Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase
-
Wu YT, Tan HL, Shui G, Bauvy C, Huang Q, Wenk MR et al. (2010) Dual role of 3-methyladenine in modulation of autophagy via different temporal patterns of inhibition on class I and III phosphoinositide 3-kinase. J. Biol. Chem. 285, 10850-10861.
-
(2010)
J. Biol. Chem.
, vol.285
, pp. 10850-10861
-
-
Wu, Y.T.1
Tan, H.L.2
Shui, G.3
Bauvy, C.4
Huang, Q.5
Wenk, M.R.6
-
68
-
-
79961118336
-
AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation
-
Shang LB, Wang XD (2011) AMPK and mTOR coordinate the regulation of Ulk1 and mammalian autophagy initiation. Autophagy 7, 924-926.
-
(2011)
Autophagy
, vol.7
, pp. 924-926
-
-
Shang, L.B.1
Wang, X.D.2
-
70
-
-
78650418176
-
P53 and autophagy in cancer: guardian of the genome meets guardian of the proteome
-
Ryan KM (2011) P53 and autophagy in cancer: guardian of the genome meets guardian of the proteome. Eur. J. Cancer 47, 44-50.
-
(2011)
Eur. J. Cancer
, vol.47
, pp. 44-50
-
-
Ryan, K.M.1
-
71
-
-
20444363122
-
The coordinate regulation of the p53 and mTOR pathways in cells
-
Feng Z, Zhang H, Levine AJ, Jin S (2005) The coordinate regulation of the p53 and mTOR pathways in cells. Proc. Natl. Acad. Sci. USA 102, 8204-8209.
-
(2005)
Proc. Natl. Acad. Sci. USA
, vol.102
, pp. 8204-8209
-
-
Feng, Z.1
Zhang, H.2
Levine, A.J.3
Jin, S.4
-
72
-
-
33745885329
-
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
-
Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR et al. (2006) DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 126, 121-134.
-
(2006)
Cell
, vol.126
, pp. 121-134
-
-
Crighton, D.1
Wilkinson, S.2
O'Prey, J.3
Syed, N.4
Smith, P.5
Harrison, P.R.6
-
73
-
-
69349100455
-
Linking the p53 tumour suppressor pathway to somatic cell reprogramming
-
Kawamura T, Suzuki J, Wang YV, Menendez S, Morera LB, Raya A et al. (2009) Linking the p53 tumour suppressor pathway to somatic cell reprogramming. Nature 460, 1140-1144.
-
(2009)
Nature
, vol.460
, pp. 1140-1144
-
-
Kawamura, T.1
Suzuki, J.2
Wang, Y.V.3
Menendez, S.4
Morera, L.B.5
Raya, A.6
-
74
-
-
67650745428
-
PUMA and Bax-induced autophagy contributes to apoptosis
-
Yee KS, Wilkinson S, James J, Ryan KM, Vousden KH (2009) PUMA and Bax-induced autophagy contributes to apoptosis. Cell Death Differ. 16, 1135-1145.
-
(2009)
Cell Death Differ.
, vol.16
, pp. 1135-1145
-
-
Yee, K.S.1
Wilkinson, S.2
James, J.3
Ryan, K.M.4
Vousden, K.H.5
-
75
-
-
79957895563
-
P53 signaling and autophagy in cancer: a revolutionary strategy could be developed for cancer treatment
-
Sui X, Jin L, Huang X, Geng S, He C, Hu X (2011) P53 signaling and autophagy in cancer: a revolutionary strategy could be developed for cancer treatment. Autophagy 7, 565-571.
-
(2011)
Autophagy
, vol.7
, pp. 565-571
-
-
Sui, X.1
Jin, L.2
Huang, X.3
Geng, S.4
He, C.5
Hu, X.6
-
76
-
-
44649141966
-
Regulation of autophagy by cytoplasmic p53
-
Tasdemir E, Maiuri MC, Galluzzi L, Vitale I, Djavaheri-Mergny M, D'Amelio M et al. (2008) Regulation of autophagy by cytoplasmic p53. Nat. Cell Biol. 10, 676-687.
-
(2008)
Nat. Cell Biol.
, vol.10
, pp. 676-687
-
-
Tasdemir, E.1
Maiuri, M.C.2
Galluzzi, L.3
Vitale, I.4
Djavaheri-Mergny, M.5
D'Amelio, M.6
-
77
-
-
53649086181
-
Mutant p53 protein localized in the cytoplasm inhibits autophagy
-
Morselli E, Tasdemir E, Maiuri MC, Galluzzi L, Kepp O, Criollo A et al. (2008) Mutant p53 protein localized in the cytoplasm inhibits autophagy. Cell Cycle 19, 3056-3061.
-
(2008)
Cell Cycle
, vol.19
, pp. 3056-3061
-
-
Morselli, E.1
Tasdemir, E.2
Maiuri, M.C.3
Galluzzi, L.4
Kepp, O.5
Criollo, A.6
-
78
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R et al. (2006) TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 126, 107-120.
-
(2006)
Cell
, vol.126
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.4
Nakano, K.5
Bartrons, R.6
-
79
-
-
77951243028
-
Autophagy regulation by p53
-
Maiuri MC, Galluzzi L, Morselli E, Kepp O, Malik SA, Kroemer G (2010) Autophagy regulation by p53. Cur. Opin. Cell Biol. 22, 181-185.
-
(2010)
Cur. Opin. Cell Biol.
, vol.22
, pp. 181-185
-
-
Maiuri, M.C.1
Galluzzi, L.2
Morselli, E.3
Kepp, O.4
Malik, S.A.5
Kroemer, G.6
-
80
-
-
84864720584
-
Oridonin induces apoptosis and autophagy in murine fibrosarcoma L929 cells partly via NO-ERK-p53 positive-feedback loop signaling pathway
-
Ye YC, Wang HJ, Xu L (2012) Oridonin induces apoptosis and autophagy in murine fibrosarcoma L929 cells partly via NO-ERK-p53 positive-feedback loop signaling pathway. Acta Pharmacol. Sin. 33, 1055-1061.
-
(2012)
Acta Pharmacol. Sin.
, vol.33
, pp. 1055-1061
-
-
Ye, Y.C.1
Wang, H.J.2
Xu, L.3
-
81
-
-
84864643231
-
Activation of ERK-p53 and ERK-mediated phosphorylation of Bcl-2 are involved in autophagic cell death induced by the c-Met inhibitor SU11274 in human lung cancer A549 cells
-
Liu Y, Yang Y, Ye YC, Shi QF, Chai K, Tashiro S et al. (2012) Activation of ERK-p53 and ERK-mediated phosphorylation of Bcl-2 are involved in autophagic cell death induced by the c-Met inhibitor SU11274 in human lung cancer A549 cells. J. Pharmacol. Sci. 118, 423-432.
-
(2012)
J. Pharmacol. Sci.
, vol.118
, pp. 423-432
-
-
Liu, Y.1
Yang, Y.2
Ye, Y.C.3
Shi, Q.F.4
Chai, K.5
Tashiro, S.6
-
82
-
-
84859729838
-
Galangin induces autophagy through upregulation of p53 in HepG2 cells
-
Wen M, Wu J, Luo H, Zhang H (2012) Galangin induces autophagy through upregulation of p53 in HepG2 cells. Pharmacology 89, 247-255.
-
(2012)
Pharmacology
, vol.89
, pp. 247-255
-
-
Wen, M.1
Wu, J.2
Luo, H.3
Zhang, H.4
-
83
-
-
81155162505
-
In vitro and in vivo anti-melanoma action of metformin
-
Janjetovic K, Harhaji-Trajkovic L, Misirkic-Marjanovic M, Vucicevic L, Stevanovic D, Zogovic N et al. (2011) In vitro and in vivo anti-melanoma action of metformin. Eur. J. Pharmacol. 668, 373-382.
-
(2011)
Eur. J. Pharmacol.
, vol.668
, pp. 373-382
-
-
Janjetovic, K.1
Harhaji-Trajkovic, L.2
Misirkic-Marjanovic, M.3
Vucicevic, L.4
Stevanovic, D.5
Zogovic, N.6
-
84
-
-
80052227790
-
Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells
-
Wang N, Pan W, Zhu M, Zhang M, Hao X, Liang G et al. (2011) Fangchinoline induces autophagic cell death via p53/sestrin2/AMPK signalling in human hepatocellular carcinoma cells. Br. J. Pharmacol. 164, 731-742.
-
(2011)
Br. J. Pharmacol.
, vol.164
, pp. 731-742
-
-
Wang, N.1
Pan, W.2
Zhu, M.3
Zhang, M.4
Hao, X.5
Liang, G.6
-
85
-
-
79961167902
-
Prazosin induces p53-mediated autophagic cell death in H9C2 cells
-
Yang YF, Wu CC, Chen WP, Chen YL, Su MJ (2011) Prazosin induces p53-mediated autophagic cell death in H9C2 cells. Naunyn Schmiedebergs Arch. Pharmacol. 384, 209-216.
-
(2011)
Naunyn Schmiedebergs Arch. Pharmacol.
, vol.384
, pp. 209-216
-
-
Yang, Y.F.1
Wu, C.C.2
Chen, W.P.3
Chen, Y.L.4
Su, M.J.5
-
86
-
-
79851515032
-
Dihydroptychantol A, a macrocyclic bisbibenzyl derivative, induces autophagy and following apoptosis associated with p53 pathway in human osteosarcoma U2OS cells
-
Li X, Wu WK, Sun B, Cui M, Liu S, Gao J et al. (2011) Dihydroptychantol A, a macrocyclic bisbibenzyl derivative, induces autophagy and following apoptosis associated with p53 pathway in human osteosarcoma U2OS cells. Toxicol. Appl. Pharmacol. 251, 146-154.
-
(2011)
Toxicol. Appl. Pharmacol.
, vol.251
, pp. 146-154
-
-
Li, X.1
Wu, W.K.2
Sun, B.3
Cui, M.4
Liu, S.5
Gao, J.6
|