Autophagy Plays an Essential Role in Mediating Regression of Hypertrophy during Unloading of the Heart

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Hariharan, Nirmala ^a   Ikeda, Yoshiyuki ^a   Hong, Chull ^a   Alcendor, Ralph R ^a   Usui, Soichiro ^a   Gao, Shumin ^a   Maejima, Yasuhiro ^a   Sadoshima, Junichi ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; BECLIN 1; CELL PROTEIN; GREEN FLUORESCENT PROTEIN; PROTEIN LC3 II; PROTEIN P62; SHORT HAIRPIN RNA; TRANSCRIPTION FACTOR FKHR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA CONSTRICTION; ARTICLE; AUTOPHAGY; BODY WEIGHT; CONTROLLED STUDY; DOWN REGULATION; GENETIC TRANSDUCTION; HEART HYPERTROPHY; HEART LEFT VENTRICLE MASS; HEART MUSCLE CELL; HEART SIZE; HEART VENTRICLE PRESSURE; IN VITRO STUDY; IN VIVO STUDY; MECHANICAL STRESS; MOUSE; NEWBORN; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REMISSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TISSUE SPECIFICITY; TRANSGENIC MOUSE; UPREGULATION;

ANIMALS; AUTOPHAGY; CARDIOMEGALY; CELL SIZE; CELLS, CULTURED; FORKHEAD TRANSCRIPTION FACTORS; HEART; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYOCARDIUM; MYOCYTES, CARDIAC; RATS; UP-REGULATION; WEIGHT-BEARING;

MUS; MUS MUSCULUS;

EID: 84872043533     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0051632     Document Type: Article

References (24)

1. Sadoshima J, Izumo S, (1997) The cellular and molecular response of cardiac myocytes to mechanical stress. Annu Rev Physiol 59: 551-571.
2. Morisco C, Sadoshima J, Trimarco B, Arora R, Vatner DE, et al. (2003) Is treating cardiac hypertrophy salutary or detrimental: the two faces of Janus. Am J Physiol (Heart Circ Physiol) 284: H1043-H1047.
3. Zafeiridis A, Jeevanandam V, Houser SR, Margulies KB, (1998) Regression of cellular hypertrophy after left ventricular assist device support. Circulation 98: 656-662.
4. Depre C, Shipley GL, Chen W, Han Q, Doenst T, et al. (1998) Unloaded heart in vivo replicates fetal gene expression of cardiac hypertrophy. Nat Med 4: 1269-1275.
5. Friddle CJ, Koga T, Rubin EM, Bristow J, (2000) Expression profiling reveals distinct sets of genes altered during induction and regression of cardiac hypertrophy. Proc Natl Acad Sci U S A 97: 6745-6750.
6. Mizushima N, Komatsu M, (2011) Autophagy: renovation of cells and tissues. Cell 147: 728-741.
7. Nakai A, Yamaguchi O, Takeda T, Higuchi Y, Hikoso S, et al. (2007) The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat Med 13: 619-624.
8. Zhu H, Tannous P, Johnstone JL, Kong Y, Shelton JM, et al. (2007) Cardiac autophagy is a maladaptive response to hemodynamic stress. J Clin Invest 117: 1782-1793.
9. Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA, et al. (2010) Deacetylation of FoxO by Sirt1 Plays an Essential Role in Mediating Starvation-Induced Autophagy in Cardiac Myocytes. Circ Res 107: 1470-1482.
10. Sengupta A, Molkentin JD, Yutzey KE, (2009) FoxO transcription factors promote autophagy in cardiomyocytes. J Biol Chem 284: 28319-28331.
11. Mammucari C, Milan G, Romanello V, Masiero E, Rudolf R, et al. (2007) FoxO3 controls autophagy in skeletal muscle in vivo. Cell Metab 6: 458-471.
12. Sandri M, Sandri C, Gilbert A, Skurk C, Calabria E, et al. (2004) Foxo transcription factors induce the atrophy-related ubiquitin ligase atrogin-1 and cause skeletal muscle atrophy. Cell 117: 399-412.
13. Zhao J, Brault JJ, Schild A, Cao P, Sandri M, et al. (2007) FoxO3 coordinately activates protein degradation by the autophagic/lysosomal and proteasomal pathways in atrophying muscle cells. Cell Metab 6: 472-483.
14. Ni YG, Berenji K, Wang N, Oh M, Sachan N, et al. (2006) Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling. Circulation 114: 1159-1168.
15. Skurk C, Izumiya Y, Maatz H, Razeghi P, Shiojima I, et al. (2005) The FOXO3a transcription factor regulates cardiac myocyte size downstream of AKT signaling. J Biol Chem 280: 20814-20823.
16. Matsuda T, Zhai P, Maejima Y, Hong C, Gao S, et al. (2008) Phosphorylation of GSK-3α is essential for myocyte proliferation in the heart under pressure overload. Proc Natl Acad Sci U S A 105: 20900-20905.
17. Nakae J, Kitamura T, Silver DL, Accili D, (2001) The forkhead transcription factor Foxo1 (Fkhr) confers insulin sensitivity onto glucose-6-phosphatase expression. J Clin Invest 108: 1359-1367.
18. Matsui Y, Takagi H, Qu X, Abdellatif M, Sakoda H, et al. (2007) Distinct Roles of Autophagy in the Heart During Ischemia and Reperfusion. Roles of AMP-Activated Protein Kinase and Beclin 1 in Mediating Autophagy. Circ Res 100: 914-922.
19. Mizushima N, Yamamoto A, Matsui M, Yoshimori T, Ohsumi Y, (2004) In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker. Mol Biol Cell 15: 1101-1111.
20. Zhai P, Gao S, Holle E, Yu X, Yatani A, et al. (2007) Glycogen synthase kinase-3alpha reduces cardiac growth and pressure overload-induced cardiac hypertrophy by inhibition of extracellular signal-regulated kinases. J Biol Chem 282: 33181-33191.
21. Iwai-Kanai E, Yuan H, Huang C, Sayen MR, Perry-Garza CN, et al. (2008) A method to measure cardiac autophagic flux in vivo. Autophagy 4: 322-329.
22. Bjorkoy G, Lamark T, Brech A, Outzen H, Perander M, et al. (2005) p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J Cell Biol 171: 603-614.
23. Su H, Wang X, (2010) The ubiquitin-proteasome system in cardiac proteinopathy: a quality control perspective. Cardiovasc Res 85: 253-262.
24. Evans-Anderson HJ, Alfieri CM, Yutzey KE, (2008) Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors. Circ Res 102: 686-694.