JNK modulates FOXO3a for the expression of the mitochondrial death and mitophagy marker BNIP3 in pathological hypertrophy and in heart failure

Cell Death and Disease

Volumn 3, Issue 2, 2012, Pages

  Chaanine, A H ^a   Jeong, D ^a   Liang, L ^a   Chemaly, E R ^a   Fish, K ^a   Gordon, R E ^a   Hajjar, R J ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

BNIP3; FOXO3a; Heart failure; JNK; Mitochondrial apoptosis; Mitophagy

Indexed keywords

3 METHYLADENINE; DOBUTAMINE; GREEN FLUORESCENT PROTEIN; MUSCLE RING FINGER 1 PROTEIN; PLACEBO; PROTEIN BNIP3; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR FKHRL1; BIOLOGICAL MARKER; BNIP3 PROTEIN, RAT; FORKHEAD TRANSCRIPTION FACTOR; FOXO3A PROTEIN, RAT; MEMBRANE PROTEIN; MITOCHONDRIAL PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; ONCOPROTEIN; PROTEIN KINASE B;

ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; AUTOPHAGOSOME; CELL DEATH; CONTROLLED STUDY; ENZYME ACTIVITY; HEART FAILURE; HEART FUNCTION; HEART HYPERTROPHY; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART MUSCLE CELL; HEART VENTRICLE OVERLOAD; HEART VENTRICLE REMODELING; HEART WEIGHT; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MALE; MITOCHONDRION; MITOPHAGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEIN PHOSPHORYLATION; RAT; SARCOPLASMIC RETICULUM; SIGNAL TRANSDUCTION; TRANSTHORACIC ECHOCARDIOGRAPHY; UPREGULATION; VIRAL GENE DELIVERY SYSTEM; ANIMAL; AUTOPHAGY; DISEASE MODEL; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION; GENETICS; HEART; HEART MITOCHONDRION; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; PRESSURE; SPRAGUE DAWLEY RAT;

RATTUS;

ANIMALS; APOPTOSIS; AUTOPHAGY; BIOLOGICAL MARKERS; DISEASE MODELS, ANIMAL; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION; HEART; HEART FAILURE; MALE; MAP KINASE KINASE 4; MEMBRANE PROTEINS; MITOCHONDRIA, HEART; MITOCHONDRIAL PROTEINS; MYOCYTES, CARDIAC; PRESSURE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; VENTRICULAR REMODELING;

EID: 84857874320     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2012.5     Document Type: Article

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