메뉴 건너뛰기




Volumn 39, Issue 2, 2012, Pages 200-208

Unmasking the janus faces of autophagy in obesity-associated insulin resistance and cardiac dysfunction

Author keywords

Autophagy; Cardiovascular disease; Heart; Insulin resistance; Obesity

Indexed keywords

ACYL COENZYME A DESATURASE 1; MAMMALIAN TARGET OF RAPAMYCIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; STEROL REGULATORY ELEMENT BINDING PROTEIN; THIOREDOXIN INTERACTING PROTEIN;

EID: 84863081685     PISSN: 03051870     EISSN: 14401681     Source Type: Journal    
DOI: 10.1111/j.1440-1681.2011.05638.x     Document Type: Article
Times cited : (37)

References (80)
  • 1
    • 68449091999 scopus 로고    scopus 로고
    • Pharmacotherapy of obesity: Benefit, bias and hyperbole
    • Nair RP, Ren J. Pharmacotherapy of obesity: Benefit, bias and hyperbole. Curr. Med. Chem. 2009; 16: 1888-97.
    • (2009) Curr. Med. Chem. , vol.16 , pp. 1888-1897
    • Nair, R.P.1    Ren, J.2
  • 2
    • 11144240071 scopus 로고    scopus 로고
    • Diabetes: Outfoxing insulin resistance?
    • Montminy M, Koo SH. Diabetes: Outfoxing insulin resistance?Nature 2004; 432: 958-9.
    • (2004) Nature , vol.432 , pp. 958-959
    • Montminy, M.1    Koo, S.H.2
  • 4
    • 2342430250 scopus 로고    scopus 로고
    • Obesity, insulin resistance, and cardiovascular disease
    • Reaven G, Abbasi F, McLaughlin T. Obesity, insulin resistance, and cardiovascular disease. Recent Prog. Horm. Res. 2004; 59: 207-23.
    • (2004) Recent Prog. Horm. Res. , vol.59 , pp. 207-223
    • Reaven, G.1    Abbasi, F.2    McLaughlin, T.3
  • 5
    • 0035890294 scopus 로고    scopus 로고
    • + currents in Type 1 and Type 2 diabetes
    • + currents in Type 1 and Type 2 diabetes. J. Physiol. 2001; 537: 83-92.
    • (2001) J. Physiol. , vol.537 , pp. 83-92
    • Shimoni, Y.1
  • 6
    • 55449091223 scopus 로고    scopus 로고
    • The crosstalk between insulin and renin-angiotensin-aldosterone signaling systems and its effect on glucose metabolism and diabetes prevention
    • Muscogiuri G, Chavez AO, Gastaldelli Aet al.The crosstalk between insulin and renin-angiotensin-aldosterone signaling systems and its effect on glucose metabolism and diabetes prevention. Curr. Vasc. Pharmacol. 2008; 6: 301-12.
    • (2008) Curr. Vasc. Pharmacol. , vol.6 , pp. 301-312
    • Muscogiuri, G.1    Chavez, A.O.2    Gastaldelli, A.3
  • 8
    • 33645641438 scopus 로고    scopus 로고
    • Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: Interactions with genotype and equol production
    • Hall WL, Vafeiadou K, Hallund Jet al.Soy-isoflavone-enriched foods and markers of lipid and glucose metabolism in postmenopausal women: Interactions with genotype and equol production. Am. J. Clin. Nutr. 2006; 83: 592-600.
    • (2006) Am. J. Clin. Nutr. , vol.83 , pp. 592-600
    • Hall, W.L.1    Vafeiadou, K.2    Hallund, J.3
  • 9
    • 61649124031 scopus 로고    scopus 로고
    • The role of autophagy in pancreatic beta-cell and diabetes
    • Fujitani Y, Kawamori R, Watada H. The role of autophagy in pancreatic beta-cell and diabetes. Autophagy 2009; 5: 280-2.
    • (2009) Autophagy , vol.5 , pp. 280-282
    • Fujitani, Y.1    Kawamori, R.2    Watada, H.3
  • 10
    • 79954583401 scopus 로고    scopus 로고
    • Autophagic degradation of mitochondria in white adipose tissue differentiation
    • Goldman SJ, Zhang Y, Jin S. Autophagic degradation of mitochondria in white adipose tissue differentiation. Antioxid. Redox Signal. 2011; 14: 1971-8.
    • (2011) Antioxid. Redox Signal. , vol.14 , pp. 1971-1978
    • Goldman, S.J.1    Zhang, Y.2    Jin, S.3
  • 11
    • 0004279664 scopus 로고
    • National Academy Press, Washington, DC
    • Thomas PR Weighing the Options. National Academy Press, Washington, DC. 1995.
    • (1995) Weighing the Options
    • Thomas, P.R.1
  • 12
    • 2542548063 scopus 로고    scopus 로고
    • Obesity and the metabolic syndrome in children and adolescents
    • Weiss R, Dziura J, Burgert TSet al.Obesity and the metabolic syndrome in children and adolescents. N. Engl. J. Med. 2004; 350: 2362-74.
    • (2004) N. Engl. J. Med. , vol.350 , pp. 2362-2374
    • Weiss, R.1    Dziura, J.2    Burgert, T.S.3
  • 13
    • 0032474427 scopus 로고    scopus 로고
    • American Heart Association call to action: Obesity as a major risk factor for coronary heart disease. AHA Nutrition Committee
    • Eckel RH, Krauss RM. American Heart Association call to action: Obesity as a major risk factor for coronary heart disease. AHA Nutrition Committee. Circulation 1998; 97: 2099-100.
    • (1998) Circulation , vol.97 , pp. 2099-2100
    • Eckel, R.H.1    Krauss, R.M.2
  • 14
    • 0033824123 scopus 로고    scopus 로고
    • Obesity and cardiovascular disease. Pathogenetic role of the metabolic syndrome and therapeutic implications
    • Abate N Obesity and cardiovascular disease. Pathogenetic role of the metabolic syndrome and therapeutic implications. J. Diabetes Complicat. 2000; 14: 154-74.
    • (2000) J. Diabetes Complicat. , vol.14 , pp. 154-174
    • Abate, N.1
  • 15
    • 0025292829 scopus 로고
    • The response to long-term overfeeding in identical twins
    • Bouchard C, Tremblay A, Despres JPet al.The response to long-term overfeeding in identical twins. N. Engl. J. Med. 1990; 322: 1477-82.
    • (1990) N. Engl. J. Med. , vol.322 , pp. 1477-1482
    • Bouchard, C.1    Tremblay, A.2    Despres, J.P.3
  • 17
    • 77955594299 scopus 로고    scopus 로고
    • Physiological insights gained from gene expression analysis in obesity and diabetes
    • Keller MP, Attie AD. Physiological insights gained from gene expression analysis in obesity and diabetes. Annu. Rev. Nutr. 2010; 30: 341-64.
    • (2010) Annu. Rev. Nutr. , vol.30 , pp. 341-364
    • Keller, M.P.1    Attie, A.D.2
  • 18
    • 79953755370 scopus 로고    scopus 로고
    • AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    • Li Y, Xu S, Mihaylova MMet al.AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab. 2011; 13: 376-88.
    • (2011) Cell Metab. , vol.13 , pp. 376-388
    • Li, Y.1    Xu, S.2    Mihaylova, M.M.3
  • 19
    • 77957121400 scopus 로고    scopus 로고
    • Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing beta-cells
    • Thorn K, Hovsepyan M, Bergsten P. Reduced levels of SCD1 accentuate palmitate-induced stress in insulin-producing beta-cells. Lipids Health Dis. 2010; 9: 108-15.
    • (2010) Lipids Health Dis. , vol.9 , pp. 108-115
    • Thorn, K.1    Hovsepyan, M.2    Bergsten, P.3
  • 20
    • 0023851885 scopus 로고
    • Reduced rate of energy expenditure as a risk factor for body-weight gain
    • Ravussin E, Lillioja S, Knowler WCet al.Reduced rate of energy expenditure as a risk factor for body-weight gain. N. Engl. J. Med. 1988; 318: 467-72.
    • (1988) N. Engl. J. Med. , vol.318 , pp. 467-472
    • Ravussin, E.1    Lillioja, S.2    Knowler, W.C.3
  • 21
    • 72549095406 scopus 로고    scopus 로고
    • Regulation mechanisms and signaling pathways of autophagy
    • He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu. Rev. Genet. 2009; 43: 67-93.
    • (2009) Annu. Rev. Genet. , vol.43 , pp. 67-93
    • He, C.1    Klionsky, D.J.2
  • 22
    • 39849109338 scopus 로고    scopus 로고
    • Autophagy fights disease through cellular self-digestion
    • Mizushima N, Levine B, Cuervo AM, Klionsky DJ. Autophagy fights disease through cellular self-digestion. Nature 2008; 451: 1069-75.
    • (2008) Nature , vol.451 , pp. 1069-1075
    • Mizushima, N.1    Levine, B.2    Cuervo, A.M.3    Klionsky, D.J.4
  • 23
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: Molecular mechanisms and biological functions of autophagy
    • Levine B, Klionsky DJ. Development by self-digestion: Molecular mechanisms and biological functions of autophagy. Dev. Cell 2004; 6: 463-77.
    • (2004) Dev. Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 24
    • 34848886914 scopus 로고    scopus 로고
    • Autophagosome formation. Core machinery and adaptations
    • Xie Z, Klionsky DJ. Autophagosome formation. Core machinery and adaptations. Nat. Cell Biol. 2007; 9: 1102-9.
    • (2007) Nat. Cell Biol. , vol.9 , pp. 1102-1109
    • Xie, Z.1    Klionsky, D.J.2
  • 25
    • 12944303650 scopus 로고    scopus 로고
    • Growth factor regulation of autophagy and cell survival in the absence of apoptosis
    • Lum JJ, Bauer DE, Kong Met al.Growth factor regulation of autophagy and cell survival in the absence of apoptosis. Cell 2005; 120: 237-48.
    • (2005) Cell , vol.120 , pp. 237-248
    • Lum, J.J.1    Bauer, D.E.2    Kong, M.3
  • 27
    • 77951924231 scopus 로고    scopus 로고
    • The FoxO family in cardiac function and dysfunction
    • Ronnebaum SM, Patterson C. The FoxO family in cardiac function and dysfunction. Annu. Rev. Physiol. 2010; 72: 81-94.
    • (2010) Annu. Rev. Physiol. , vol.72 , pp. 81-94
    • Ronnebaum, S.M.1    Patterson, C.2
  • 28
    • 33847404337 scopus 로고    scopus 로고
    • Autophagy gene-dependent clearance of apoptotic cells during embryonic development
    • Qu X, Zou Z, Sun Qet al.Autophagy gene-dependent clearance of apoptotic cells during embryonic development. Cell 2007; 128: 931-46.
    • (2007) Cell , vol.128 , pp. 931-946
    • Qu, X.1    Zou, Z.2    Sun, Q.3
  • 29
    • 4344583901 scopus 로고    scopus 로고
    • Role of mitochondrial permeability transition pores in mitochondrial autophagy
    • Rodriguez-Enriquez S, He L, Lemasters JJ. Role of mitochondrial permeability transition pores in mitochondrial autophagy. Int. J. Biochem. Cell Biol. 2004; 36: 2463-72.
    • (2004) Int. J. Biochem. Cell Biol. , vol.36 , pp. 2463-2472
    • Rodriguez-Enriquez, S.1    He, L.2    Lemasters, J.J.3
  • 30
    • 33947386684 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress: A new pathway to induce autophagy
    • Yorimitsu T, Klionsky DJ. Endoplasmic reticulum stress: A new pathway to induce autophagy. Autophagy 2007; 3: 160-2.
    • (2007) Autophagy , vol.3 , pp. 160-162
    • Yorimitsu, T.1    Klionsky, D.J.2
  • 32
    • 17044440789 scopus 로고    scopus 로고
    • Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease)
    • Nishino I, Fu J, Tanji Ket al.Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease). Nature 2000; 406: 906-10.
    • (2000) Nature , vol.406 , pp. 906-910
    • Nishino, I.1    Fu, J.2    Tanji, K.3
  • 33
    • 27644467802 scopus 로고    scopus 로고
    • Autophagy in cardiac myocyte homeostasis, aging, and pathology
    • Terman A, Brunk UT. Autophagy in cardiac myocyte homeostasis, aging, and pathology. Cardiovasc. Res. 2005; 68: 355-65.
    • (2005) Cardiovasc. Res. , vol.68 , pp. 355-365
    • Terman, A.1    Brunk, U.T.2
  • 34
    • 34249714158 scopus 로고    scopus 로고
    • The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress
    • Nakai A, Yamaguchi O, Takeda Tet al.The role of autophagy in cardiomyocytes in the basal state and in response to hemodynamic stress. Nat. Med. 2007; 13: 619-24.
    • (2007) Nat. Med. , vol.13 , pp. 619-624
    • Nakai, A.1    Yamaguchi, O.2    Takeda, T.3
  • 35
    • 34447133404 scopus 로고    scopus 로고
    • Cardiac autophagy is a maladaptive response to hemodynamic stress
    • Zhu H, Tannous P, Johnstone JLet al.Cardiac autophagy is a maladaptive response to hemodynamic stress. J. Clin. Invest. 2007; 117: 1782-94.
    • (2007) J. Clin. Invest. , vol.117 , pp. 1782-1794
    • Zhu, H.1    Tannous, P.2    Johnstone, J.L.3
  • 36
    • 33744536558 scopus 로고    scopus 로고
    • Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury
    • Valentim L, Laurence KM, Townsend PAet al.Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury. J. Mol. Cell. Cardiol. 2006; 40: 846-52.
    • (2006) J. Mol. Cell. Cardiol. , vol.40 , pp. 846-852
    • Valentim, L.1    Laurence, K.M.2    Townsend, P.A.3
  • 37
    • 34147168105 scopus 로고    scopus 로고
    • Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy
    • Matsui Y, Takagi H, Qu Xet al.Distinct roles of autophagy in the heart during ischemia and reperfusion: Roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy. Circ. Res. 2007; 100: 914-22.
    • (2007) Circ. Res. , vol.100 , pp. 914-922
    • Matsui, Y.1    Takagi, H.2    Qu, X.3
  • 38
    • 75749122303 scopus 로고    scopus 로고
    • Methods in mammalian autophagy research
    • Mizushima N, Yoshimori T, Levine B. Methods in mammalian autophagy research. Cell 2010; 140: 313-26.
    • (2010) Cell , vol.140 , pp. 313-326
    • Mizushima, N.1    Yoshimori, T.2    Levine, B.3
  • 39
    • 33847652900 scopus 로고    scopus 로고
    • Autophagy and neurodegeneration: When the cleaning crew goes on strike
    • Martinez-Vicente M, Cuervo AM. Autophagy and neurodegeneration: When the cleaning crew goes on strike. Lancet Neurol. 2007; 6: 352-61.
    • (2007) Lancet Neurol. , vol.6 , pp. 352-361
    • Martinez-Vicente, M.1    Cuervo, A.M.2
  • 40
    • 78650691023 scopus 로고    scopus 로고
    • Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes
    • Hariharan N, Maejima Y, Nakae J, Paik J, Depinho RA, Sadoshima J. Deacetylation of FoxO by Sirt1 plays an essential role in mediating starvation-induced autophagy in cardiac myocytes. Circ. Res. 2010; 107: 1470-82.
    • (2010) Circ. Res. , vol.107 , pp. 1470-1482
    • Hariharan, N.1    Maejima, Y.2    Nakae, J.3    Paik, J.4    Depinho, R.A.5    Sadoshima, J.6
  • 41
    • 34249817899 scopus 로고    scopus 로고
    • The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco/endoplasmic reticulum calcium stores
    • Brady NR, Hamacher-Brady A, Yuan H, Gottlieb RA. The autophagic response to nutrient deprivation in the hl-1 cardiac myocyte is modulated by Bcl-2 and sarco/endoplasmic reticulum calcium stores. FEBS J. 2007; 274: 3184-97.
    • (2007) FEBS J. , vol.274 , pp. 3184-3197
    • Brady, N.R.1    Hamacher-Brady, A.2    Yuan, H.3    Gottlieb, R.A.4
  • 42
    • 27944504351 scopus 로고    scopus 로고
    • p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death
    • Bjorkoy G, Lamark T, Brech Aet al.p62/SQSTM1 forms protein aggregates degraded by autophagy and has a protective effect on huntingtin-induced cell death. J. Cell Biol. 2005; 171: 603-14.
    • (2005) J. Cell Biol. , vol.171 , pp. 603-614
    • Bjorkoy, G.1    Lamark, T.2    Brech, A.3
  • 43
    • 58149344946 scopus 로고    scopus 로고
    • Midbody ring disposal by autophagy is a post-abscission event of cytokinesis
    • Pohl C, Jentsch S. Midbody ring disposal by autophagy is a post-abscission event of cytokinesis. Nat. Cell Biol. 2009; 11: 65-70.
    • (2009) Nat. Cell Biol. , vol.11 , pp. 65-70
    • Pohl, C.1    Jentsch, S.2
  • 44
    • 19444382327 scopus 로고    scopus 로고
    • The dynamics of autophagy visualized in live cells: From autophagosome formation to fusion with endo/lysosomes
    • Bampton ET, Goemans CG, Niranjan D, Mizushima N, Tolkovsky AM. The dynamics of autophagy visualized in live cells: From autophagosome formation to fusion with endo/lysosomes. Autophagy 2005; 1: 23-36.
    • (2005) Autophagy , vol.1 , pp. 23-36
    • Bampton, E.T.1    Goemans, C.G.2    Niranjan, D.3    Mizushima, N.4    Tolkovsky, A.M.5
  • 46
    • 79960342396 scopus 로고    scopus 로고
    • Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes
    • Pattison JS, Osinska H, Robbins J. Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes. Circ. Res. 2011; 109: 151-60.
    • (2011) Circ. Res. , vol.109 , pp. 151-160
    • Pattison, J.S.1    Osinska, H.2    Robbins, J.3
  • 47
    • 79961022260 scopus 로고    scopus 로고
    • Autophagy and p62 in cardiac proteinopathy
    • Zheng Q, Su H, Ranek MJ, Wang X. Autophagy and p62 in cardiac proteinopathy. Circ. Res. 2011; 109: 296-308.
    • (2011) Circ. Res. , vol.109 , pp. 296-308
    • Zheng, Q.1    Su, H.2    Ranek, M.J.3    Wang, X.4
  • 48
    • 33746108329 scopus 로고    scopus 로고
    • Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy
    • Tanida I, Minematsu-Ikeguchi N, Ueno T, Kominami E. Lysosomal turnover, but not a cellular level, of endogenous LC3 is a marker for autophagy. Autophagy 2005; 1: 84-91.
    • (2005) Autophagy , vol.1 , pp. 84-91
    • Tanida, I.1    Minematsu-Ikeguchi, N.2    Ueno, T.3    Kominami, E.4
  • 49
    • 79958030075 scopus 로고    scopus 로고
    • Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase
    • Ouimet M, Franklin V, Mak E, Liao X, Tabas I, Marcel YL. Autophagy regulates cholesterol efflux from macrophage foam cells via lysosomal acid lipase. Cell Metab. 2011; 13: 655-67.
    • (2011) Cell Metab. , vol.13 , pp. 655-667
    • Ouimet, M.1    Franklin, V.2    Mak, E.3    Liao, X.4    Tabas, I.5    Marcel, Y.L.6
  • 50
    • 52749093177 scopus 로고    scopus 로고
    • Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet
    • Ebato C, Uchida T, Arakawa Met al.Autophagy is important in islet homeostasis and compensatory increase of beta cell mass in response to high-fat diet. Cell Metab. 2008; 8: 325-32.
    • (2008) Cell Metab. , vol.8 , pp. 325-332
    • Ebato, C.1    Uchida, T.2    Arakawa, M.3
  • 51
    • 77957299576 scopus 로고    scopus 로고
    • Role of autophagy in beta-cell function and mass
    • Hur KY, Jung HS, Lee MS. Role of autophagy in beta-cell function and mass. Diabetes Obes Metab. 2010; 12 (Suppl. 2): 20-26.
    • (2010) Diabetes Obes Metab. , vol.12 , Issue.SUPPL. 2 , pp. 20-26
    • Hur, K.Y.1    Jung, H.S.2    Lee, M.S.3
  • 52
    • 75149123563 scopus 로고    scopus 로고
    • Autophagy and adipogenesis. Implications in obesity and type II diabetes
    • Goldman S, Zhang Y, Jin S. Autophagy and adipogenesis. Implications in obesity and type II diabetes. Autophagy 2010; 6: 179-81.
    • (2010) Autophagy , vol.6 , pp. 179-181
    • Goldman, S.1    Zhang, Y.2    Jin, S.3
  • 53
    • 70449448312 scopus 로고    scopus 로고
    • Autophagy regulates adipose mass and differentiation in mice
    • Singh R, Xiang Y, Wang Yet al.Autophagy regulates adipose mass and differentiation in mice. J. Clin. Invest. 2009; 119: 3329-39.
    • (2009) J. Clin. Invest. , vol.119 , pp. 3329-3339
    • Singh, R.1    Xiang, Y.2    Wang, Y.3
  • 54
    • 73949124173 scopus 로고    scopus 로고
    • Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis
    • Zhang Y, Goldman S, Baerga R, Zhao Y, Komatsu M, Jin S. Adipose-specific deletion of autophagy-related gene 7 (atg7) in mice reveals a role in adipogenesis. Proc. Natl Acad. Sci. USA 2009; 106: 19860-5.
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , pp. 19860-19865
    • Zhang, Y.1    Goldman, S.2    Baerga, R.3    Zhao, Y.4    Komatsu, M.5    Jin, S.6
  • 56
    • 73449117508 scopus 로고    scopus 로고
    • Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice
    • Baerga R, Zhang Y, Chen PH, Goldman S, Jin S. Targeted deletion of autophagy-related 5 (atg5) impairs adipogenesis in a cellular model and in mice. Autophagy 2009; 5: 1118-30.
    • (2009) Autophagy , vol.5 , pp. 1118-1130
    • Baerga, R.1    Zhang, Y.2    Chen, P.H.3    Goldman, S.4    Jin, S.5
  • 57
    • 77956834462 scopus 로고    scopus 로고
    • Autophagy: A potential link between obesity and insulin resistance
    • Codogno P, Meijer AJ. Autophagy: A potential link between obesity and insulin resistance. Cell Metab. 2010; 11: 449-51.
    • (2010) Cell Metab. , vol.11 , pp. 449-451
    • Codogno, P.1    Meijer, A.J.2
  • 58
    • 77951464621 scopus 로고    scopus 로고
    • Autophagy in health and disease. Regulation of lipid metabolism and storage by autophagy: Pathophysiological implications
    • Czaja MJ Autophagy in health and disease. Regulation of lipid metabolism and storage by autophagy: Pathophysiological implications. Am. J. Physiol. Cell Physiol. 2010; 298: C973-8.
    • (2010) Am. J. Physiol. Cell Physiol. , vol.298
    • Czaja, M.J.1
  • 59
    • 65949095803 scopus 로고    scopus 로고
    • Autophagy regulates lipid metabolism
    • Singh R, Kaushik S, Wang Yet al.Autophagy regulates lipid metabolism. Nature 2009; 458: 1131-5.
    • (2009) Nature , vol.458 , pp. 1131-1135
    • Singh, R.1    Kaushik, S.2    Wang, Y.3
  • 60
    • 77956400005 scopus 로고    scopus 로고
    • Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance
    • Yang L, Li P, Fu S, Calay ES, Hotamisligil GS. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 2010; 11: 467-78.
    • (2010) Cell Metab. , vol.11 , pp. 467-478
    • Yang, L.1    Li, P.2    Fu, S.3    Calay, E.S.4    Hotamisligil, G.S.5
  • 61
    • 79952229430 scopus 로고    scopus 로고
    • Pancreatic cancers require autophagy for tumor growth
    • Yang S, Wang X, Contino Get al.Pancreatic cancers require autophagy for tumor growth. Genes Dev. 2011; 25: 717-29.
    • (2011) Genes Dev. , vol.25 , pp. 717-729
    • Yang, S.1    Wang, X.2    Contino, G.3
  • 62
    • 79959952405 scopus 로고    scopus 로고
    • Liver autophagy contributes to the maintenance of blood glucose and amino acid levels
    • Ezaki J, Matsumoto N, Takeda-Ezaki Met al.Liver autophagy contributes to the maintenance of blood glucose and amino acid levels. Autophagy 2011; 7: 727-36.
    • (2011) Autophagy , vol.7 , pp. 727-736
    • Ezaki, J.1    Matsumoto, N.2    Takeda-Ezaki, M.3
  • 63
    • 0018746575 scopus 로고
    • Glucagon-induced autophagy and proteolysis in rat liver: Mediation by selective deprivation of intracellular amino acids
    • Schworer CM, Mortimore GE. Glucagon-induced autophagy and proteolysis in rat liver: Mediation by selective deprivation of intracellular amino acids. Proc. Natl Acad. Sci. USA 1979; 76: 3169-73.
    • (1979) Proc. Natl Acad. Sci. USA , vol.76 , pp. 3169-3173
    • Schworer, C.M.1    Mortimore, G.E.2
  • 64
    • 0014691192 scopus 로고
    • Effects of glucagon on amino acid transport and utilization in the perfused rat ler
    • Mallette LE, Exton JH, Park CR. Effects of glucagon on amino acid transport and utilization in the perfused rat ler. J. Biol. Chem. 1969; 244: 5724-8.
    • (1969) J. Biol. Chem. , vol.244 , pp. 5724-5728
    • Mallette, L.E.1    Exton, J.H.2    Park, C.R.3
  • 65
    • 65949083995 scopus 로고    scopus 로고
    • Cell biology: Another way to get rid of fat
    • Zechner R, Madeo F. Cell biology: Another way to get rid of fat. Nature 2009; 458: 1118-9.
    • (2009) Nature , vol.458 , pp. 1118-1119
    • Zechner, R.1    Madeo, F.2
  • 67
    • 33749570745 scopus 로고    scopus 로고
    • Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes
    • Hamacher-Brady A, Brady NR, Gottlieb RA. Enhancing macroautophagy protects against ischemia/reperfusion injury in cardiac myocytes. J. Biol. Chem. 2006; 281: 29776-87.
    • (2006) J. Biol. Chem. , vol.281 , pp. 29776-29787
    • Hamacher-Brady, A.1    Brady, N.R.2    Gottlieb, R.A.3
  • 68
    • 77957308659 scopus 로고    scopus 로고
    • The role of autophagy in beta-cell lipotoxicity and Type 2 diabetes
    • Las G, Shirihai OS. The role of autophagy in beta-cell lipotoxicity and Type 2 diabetes. Diabetes Obes. Metab. 2010; 12 (Suppl. 2): 15-19.
    • (2010) Diabetes Obes. Metab. , vol.12 , Issue.SUPPL. 2 , pp. 15-19
    • Las, G.1    Shirihai, O.S.2
  • 69
    • 66749130276 scopus 로고    scopus 로고
    • Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling
    • Glazer HP, Osipov RM, Clements RT, Sellke FW, Bianchi C. Hypercholesterolemia is associated with hyperactive cardiac mTORC1 and mTORC2 signaling. Cell Cycle 2009; 8: 1738-46.
    • (2009) Cell Cycle , vol.8 , pp. 1738-1746
    • Glazer, H.P.1    Osipov, R.M.2    Clements, R.T.3    Sellke, F.W.4    Bianchi, C.5
  • 70
    • 84863059911 scopus 로고    scopus 로고
    • Markers and mediators of autophagy are increased in the hearts of two murine models of type 2 diabetes irrespective of cardiac function
    • Wellnitz KA, Lombardi R, Salazar RL, Taegtmeyer H. Markers and mediators of autophagy are increased in the hearts of two murine models of type 2 diabetes irrespective of cardiac function. Circulation 2009; 120: S490.
    • (2009) Circulation , vol.120
    • Wellnitz, K.A.1    Lombardi, R.2    Salazar, R.L.3    Taegtmeyer, H.4
  • 71
    • 79955658311 scopus 로고    scopus 로고
    • Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice
    • Mellor KM, Bell JR, Young MJ, Ritchie RH, Delbridge LM. Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice. J. Mol. Cell. Cardiol. 2011; 50: 1035-44.
    • (2011) J. Mol. Cell. Cardiol. , vol.50 , pp. 1035-1044
    • Mellor, K.M.1    Bell, J.R.2    Young, M.J.3    Ritchie, R.H.4    Delbridge, L.M.5
  • 72
    • 34548434021 scopus 로고    scopus 로고
    • Metallothionein prevents high-fat diet induced cardiac contractile dysfunction: Role of peroxisome proliferator activated receptor gamma coactivator 1alpha and mitochondrial biogenesis
    • Dong F, Li Q, Sreejayan N, Nunn JM, Ren J. Metallothionein prevents high-fat diet induced cardiac contractile dysfunction: Role of peroxisome proliferator activated receptor gamma coactivator 1alpha and mitochondrial biogenesis. Diabetes 2007; 56: 2201-12.
    • (2007) Diabetes , vol.56 , pp. 2201-2212
    • Dong, F.1    Li, Q.2    Sreejayan, N.3    Nunn, J.M.4    Ren, J.5
  • 73
    • 54049155806 scopus 로고    scopus 로고
    • Hypertrophic cardiomyopathy in high-fat diet-induced obesity: Role of suppression of forkhead transcription factor and atrophy gene transcription
    • Fang CX, Dong F, Thomas DP, Ma H, He L, Ren J. Hypertrophic cardiomyopathy in high-fat diet-induced obesity: Role of suppression of forkhead transcription factor and atrophy gene transcription. Am. J. Physiol. Heart Circ. Physiol. 2008; 295: H1206-15.
    • (2008) Am. J. Physiol. Heart Circ. Physiol. , vol.295
    • Fang, C.X.1    Dong, F.2    Thomas, D.P.3    Ma, H.4    He, L.5    Ren, J.6
  • 74
    • 55249127504 scopus 로고    scopus 로고
    • High-fat diet-induced obesity leads to resistance to leptin-induced cardiomyocyte contractile response
    • Ren J, Zhu BH, Relling DP, Esberg LB, Ceylan-Isik AF. High-fat diet-induced obesity leads to resistance to leptin-induced cardiomyocyte contractile response. Obesity 2008; 16: 2417-23.
    • (2008) Obesity , vol.16 , pp. 2417-2423
    • Ren, J.1    Zhu, B.H.2    Relling, D.P.3    Esberg, L.B.4    Ceylan-Isik, A.F.5
  • 75
    • 78049425280 scopus 로고    scopus 로고
    • High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila
    • Birse RT, Choi J, Reardon Ket al.High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. Cell Metab. 2010; 12: 533-44.
    • (2010) Cell Metab. , vol.12 , pp. 533-544
    • Birse, R.T.1    Choi, J.2    Reardon, K.3
  • 76
    • 80053393865 scopus 로고    scopus 로고
    • AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy
    • Xie Z, He C, Zou MH. AMP-activated protein kinase modulates cardiac autophagy in diabetic cardiomyopathy. Autophagy 2011; 7: 1254-5.
    • (2011) Autophagy , vol.7 , pp. 1254-1255
    • Xie, Z.1    He, C.2    Zou, M.H.3
  • 77
    • 79959385996 scopus 로고    scopus 로고
    • Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice
    • Xie Z, Lau K, Eby Bet al.Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes 2011; 60: 1770-8.
    • (2011) Diabetes , vol.60 , pp. 1770-1778
    • Xie, Z.1    Lau, K.2    Eby, B.3
  • 78
    • 79953033875 scopus 로고    scopus 로고
    • Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice
    • Shende P, Plaisance I, Morandi Cet al.Cardiac raptor ablation impairs adaptive hypertrophy, alters metabolic gene expression, and causes heart failure in mice. Circulation 2011; 123: 1073-82.
    • (2011) Circulation , vol.123 , pp. 1073-1082
    • Shende, P.1    Plaisance, I.2    Morandi, C.3
  • 79
    • 77955290360 scopus 로고    scopus 로고
    • AmTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice
    • Zhang D, Contu R, Latronico MVet al.AmTORC1 regulates cardiac function and myocyte survival through 4E-BP1 inhibition in mice. J. Clin. Invest. 2010; 120: 2805-16.
    • (2010) J. Clin. Invest. , vol.120 , pp. 2805-2816
    • Zhang, D.1    Contu, R.2    Latronico, M.V.3
  • 80
    • 3042608187 scopus 로고    scopus 로고
    • Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload
    • McMullen JR, Sherwood MC, Tarnavski Oet al.Inhibition of mTOR signaling with rapamycin regresses established cardiac hypertrophy induced by pressure overload. Circulation 2004; 109: 3050-5.
    • (2004) Circulation , vol.109 , pp. 3050-3055
    • McMullen, J.R.1    Sherwood, M.C.2    Tarnavski, O.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.