Intermedin Suppresses Pressure Overload Cardiac Hypertrophy through Activation of Autophagy

PLoS ONE

Volumn 8, Issue 5, 2013, Pages

  Chen, HuaLi ^a   Wang, Xue ^a   Tong, MingMing ^a   Wu, Dan ^a   Wu, Sisi ^a   Chen, JiaXiang ^a   Wang, XiaoXiao ^a   Wang, XuLei ^a,b   Kang, Yu ^a,c   Tang, Hong ^a   Tang, ChaoShu ^d   Jiang, Wei ^a  

^a SICHUAN UNIVERSITY   (China)

^b SOUTHWEST JIAOTONG UNIVERSITY   (China)

^c CHENGDU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^d PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; ANGIOTENSIN II; ATRIAL NATRIURETIC FACTOR; BRAIN NATRIURETIC PEPTIDE; CALCITONIN RECEPTOR LIKE RECEPTOR; COLLAGEN; CYCLIC AMP DEPENDENT PROTEIN KINASE; INTERMEDIN; ISOPRENALINE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHOSPHATIDYLINOSITOL 3 KINASE; RECEPTOR ACTIVITY MODIFYING PROTEIN 1; RECEPTOR ACTIVITY MODIFYING PROTEIN 3; WORTMANNIN; CYCLIC AMP; INTERMEDIN PROTEIN, MOUSE; NEUROPEPTIDE; RECEPTOR ACTIVITY MODIFYING PROTEIN;

ANGIOGENESIS; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL CULTURE; CELL SIZE; CONTROLLED STUDY; ENZYME INHIBITION; HEART LEFT VENTRICLE OVERLOAD; HEART MUSCLE CELL; HEART MUSCLE NECROSIS; HEART PROTECTION; HEART SIZE; HEART VENTRICLE HYPERTROPHY; HEART VENTRICLE REMODELING; HEART WEIGHT; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SUPPLEMENTATION; ANIMAL; BIOSYNTHESIS; CELL LINE; DRUG EFFECTS; ECHOCARDIOGRAPHY; ETIOLOGY; FIBROSIS; GENETICS; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE; HEART VENTRICLE; HYPERTROPHY, LEFT VENTRICULAR; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY;

ANIMALS; APOPTOSIS; AUTOPHAGY; CELL LINE; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ECHOCARDIOGRAPHY; FIBROSIS; HEART VENTRICLES; HYPERTROPHY, LEFT VENTRICULAR; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MYOCARDIUM; MYOCYTES, CARDIAC; NEUROPEPTIDES; RECEPTOR ACTIVITY-MODIFYING PROTEINS; VENTRICULAR DYSFUNCTION, LEFT; VENTRICULAR REMODELING;

EID: 84878459996     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0064757     Document Type: Article

References (38)

1. Frey N, Olson EN, (2003) Cardiac hypertrophy: the good, the bad, and the ugly. Annu Rev Physiol 65: 45-79.
2. Oparil S, (1985) Pathogenesis of ventricular hypertrophy. J Am Coll Cardiol 5: 57B-65B.
3. Barry SP, Davidson SM, Townsend PA, (2008) Molecular regulation of cardiac hypertrophy. Int J Biochem Cell Biol 40: 2023-2039.
4. Cingolani HE, Ennis IL, Aiello EA, Perez NG, (2011) Role of autocrine/paracrine mechanisms in response to myocardial strain. Pflugers Arch 462: 29-38.
5. Doroudgar S, Glembotski CC, (2011) The cardiokine story unfolds: ischemic stress-induced protein secretion in the heart. Trends Mol Med 17: 207-214.
6. Finckenberg P, Mervaala E, (2010) Novel regulators and drug targets of cardiac hypertrophy. J Hypertens 28Suppl 1: S33-38.
7. Hong Y, Hay DL, Quirion R, Poyner DR, (2012) The pharmacology of adrenomedullin 2/intermedin. Br J Pharmacol 166: 110-120.
8. Bell D, McDermott BJ, (2008) Intermedin (adrenomedullin-2): a novel counter-regulatory peptide in the cardiovascular and renal systems. Br J Pharmacol 153Suppl 1: S247-262.
9. Lin Chang C, Roh J, Park JI, Klein C, Cushman N, et al. (2005) Intermedin functions as a pituitary paracrine factor regulating prolactin release. Mol Endocrinol 19: 2824-2838.
10. Yang JH, Ma CG, Cai Y, Pan CS, Zhao J, et al. (2010) Effect of intermedin1-53 on angiotensin II-induced hypertrophy in neonatal rat ventricular myocytes. J Cardiovasc Pharmacol 56: 45-52.
11. Gottlieb RA, Mentzer RM, (2010) Autophagy during cardiac stress: joys and frustrations of autophagy. Annu Rev Physiol 72: 45-59.
12. Terman A, Brunk UT, (2005) Autophagy in cardiac myocyte homeostasis, aging, and pathology. Cardiovasc Res 68: 355-365.
13. Goswami SK, Das DK, (2006) Autophagy in the myocardium: Dying for survival? Exp Clin Cardiol 11: 183-188.
14. Hurtado O, Serrano J, Sobrado M, Fernandez AP, Lizasoain I, et al. (2010) Lack of adrenomedullin, but not complement factor H, results in larger infarct size and more extensive brain damage in a focal ischemia model. Neuroscience 171: 885-892.
15. Roh J, Chang CL, Bhalla A, Klein C, Hsu SY, (2004) Intermedin is a calcitonin/calcitonin gene-related peptide family peptide acting through the calcitonin receptor-like receptor/receptor activity-modifying protein receptor complexes. J Biol Chem 279: 7264-7274.
16. Shibata R, Ouchi N, Ito M, Kihara S, Shiojima I, et al. (2004) Adiponectin-mediated modulation of hypertrophic signals in the heart. Nat Med 10: 1384-1389.
17. Jiang W, Hall SR, Moos MP, Cao RY, Ishii S, et al. (2008) Endothelial cysteinyl leukotriene 2 receptor expression mediates myocardial ischemia-reperfusion injury. Am J Pathol 172: 592-602.
18. Kim Y, Phan D, van Rooij E, Wang DZ, McAnally J, et al. (2008) The MEF2D transcription factor mediates stress-dependent cardiac remodeling in mice. J Clin Invest 118: 124-132.
19. Shiojima I, Sato K, Izumiya Y, Schiekofer S, Ito M, et al. (2005) Disruption of coordinated cardiac hypertrophy and angiogenesis contributes to the transition to heart failure. J Clin Invest 115: 2108-2118.
20. Hescheler J, Meyer R, Plant S, Krautwurst D, Rosenthal W, et al. (1991) Morphological, biochemical, and electrophysiological characterization of a clonal cell (H9c2) line from rat heart. Circ Res 69: 1476-1486.
21. Lopez-Andres N, Inigo C, Gallego I, Diez J, Fortuno MA, (2008) Aldosterone induces cardiotrophin-1 expression in HL-1 adult cardiomyocytes. Endocrinology 149: 4970-4978.
22. Li J, Liu R, Lei Y, Wang K, Lau QC, et al. (2010) Proteomic analysis revealed association of aberrant ROS signaling with suberoylanilide hydroxamic acid-induced autophagy in Jurkat T-leukemia cells. Autophagy 6: 711-724.
23. Tomanek RJ, (1990) Response of the coronary vasculature to myocardial hypertrophy. J Am Coll Cardiol 15: 528-533.
24. Kamalov G, Bhattacharya SK, Weber KT, (2010) Congestive heart failure: where homeostasis begets dyshomeostasis. J Cardiovasc Pharmacol 56: 320-328.
25. Bell D, Zhao YY, Devine AB, McDermott BJ, (2008) Influence of atenolol and nifedipine on nitric-oxide deficient cardiomyocyte hypertrophy and expression of the cardio-endocrine peptide intermedin and its receptor components. Cell Physiol Biochem 21: 203-214.
26. McQueen AP, Zhang D, Hu P, Swenson L, Yang Y, et al. (2005) Contractile dysfunction in hypertrophied hearts with deficient insulin receptor signaling: possible role of reduced capillary density. J Mol Cell Cardiol 39: 882-892.
27. Dong F, Taylor MM, Samson WK, Ren J, (2006) Intermedin (adrenomedullin-2) enhances cardiac contractile function via a protein kinase C- and protein kinase A-dependent pathway in murine ventricular myocytes. J Appl Physiol 101: 778-784.
28. Song JQ, Teng X, Cai Y, Tang CS, Qi YF, (2009) Activation of Akt/GSK-3beta signaling pathway is involved in intermedin(1-53) protection against myocardial apoptosis induced by ischemia/reperfusion. Apoptosis 14: 1299-1307.
29. Rothermel BA, Hill JA, (2008) Autophagy in load-induced heart disease. Circ Res 103: 1363-1369.
30. Zou Y, Liang Y, Gong H, Zhou N, Ma H, et al. (2011) Ryanodine receptor type 2 is required for the development of pressure overload-induced cardiac hypertrophy. Hypertension 58: 1099-1110.
31. Porrello ER, D'Amore A, Curl CL, Allen AM, Harrap SB, et al. (2009) Angiotensin II type 2 receptor antagonizes angiotensin II type 1 receptor-mediated cardiomyocyte autophagy. Hypertension 53: 1032-1040.
32. Pfeifer U, Fohr J, Wilhelm W, Dammrich J, (1987) Short-term inhibition of cardiac cellular autophagy by isoproterenol. J Mol Cell Cardiol 19: 1179-1184.
33. Pires AL, Pinho M, Alves BS, Pinho S, Sena C, et al. (2013) Reverse myocardial effects of intermedin in pressure-overloaded hearts: role of endothelial nitric oxide synthase activity. J Physiol 591: 677-687.
34. Thekkumkara TJ, Du J, Zwaagstra C, Conrad KM, Krupinski J, et al. (1995) A role for cAMP in angiotensin II mediated inhibition of cell growth in AT1A receptor-transfected CHO-K1 cells. Mol Cell Biochem 152: 77-86.
35. Uchida H, Shishido K, Nomiya M, Yamaguchi O, (2005) Involvement of cyclic AMP-dependent and-independent mechanisms in the relaxation of rat detrusor muscle via beta-adrenoceptors. Eur J Pharmacol 518: 195-202.
36. Smith RS Jr, Gao L, Bledsoe G, Chao L, Chao J, (2009) Intermedin is a new angiogenic growth factor. Am J Physiol Heart Circ Physiol 297: H1040-1047.
37. Das S, Otani H, Maulik N, Das DK, (2006) Redox regulation of angiotensin II preconditioning of the myocardium requires MAP kinase signaling. J Mol Cell Cardiol 41: 248-255.
38. Shizukuda Y, Buttrick PM, (2002) Subtype specific roles of beta-adrenergic receptors in apoptosis of adult rat ventricular myocytes. J Mol Cell Cardiol 34: 823-831.