-
1
-
-
84890203965
-
A bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp
-
Aakre, C. D., Phung, T. N., Huang, D., and Laub, M. T. (2013). A bacterial toxin inhibits DNA replication elongation through a direct interaction with the β sliding clamp. Mol. Cell 52, 617-628. doi: 10.1016/j.molcel.2013.10.014
-
(2013)
Mol. Cell
, vol.52
, pp. 617-628
-
-
Aakre, C.D.1
Phung, T.N.2
Huang, D.3
Laub, M.T.4
-
2
-
-
0034987056
-
Bacillus subtilis locus encoding a killer protein and its antidote
-
Adler, E., Barák, I., and Stragier, P. (2001). Bacillus subtilis locus encoding a killer protein and its antidote. J. Bacteriol. 183, 3574-3581. doi: 10.1128/JB.183.12.3574-3581.2001
-
(2001)
J. Bacteriol
, vol.183
, pp. 3574-3581
-
-
Adler, E.1
Barák, I.2
Stragier, P.3
-
3
-
-
77951214558
-
PemK toxin of Bacillus anthracis is a ribonuclease: an insight into its active site, structure, and function
-
Agarwal, S., Mishra, N. K., Bhatnagar, S., and Bhatnagar, R. (2010). PemK toxin of Bacillus anthracis is a ribonuclease: an insight into its active site, structure, and function. J. Biol. Chem. 285, 7254-7270. doi: 10.1074/jbc. M109.073387
-
(2010)
J. Biol. Chem
, vol.285
, pp. 7254-7270
-
-
Agarwal, S.1
Mishra, N.K.2
Bhatnagar, S.3
Bhatnagar, R.4
-
4
-
-
79959669820
-
VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins
-
Ahidjo, B. A., Kuhnert, D., McKenzie, J. L., Machowski, E. E., Gordhan, B. G., Arcus, V., et al. (2011). VapC toxins from Mycobacterium tuberculosis are ribonucleases that differentially inhibit growth and are neutralized by cognate VapB antitoxins. PLoS ONE 6:e21738. doi: 10.1371/journal.pone.0021738
-
(2011)
PLoS ONE
, vol.6
-
-
Ahidjo, B.A.1
Kuhnert, D.2
McKenzie, J.L.3
Machowski, E.E.4
Gordhan, B.G.5
Arcus, V.6
-
5
-
-
0030008368
-
An Escherichia coli chromosomal "addiction module" regulated by guanosine 3', 5'-bispyrophosphate: a model for programmed bacterial cell death
-
Aizenman, E., Engelberg-Kulka, H., and Glaser, G. (1996). An Escherichia coli chromosomal "addiction module" regulated by guanosine 3', 5'-bispyrophosphate: a model for programmed bacterial cell death. Proc. Natl. Acad. Sci. U.S.A. 93, 6059-6063. doi: 10.1073/pnas.93.12.6059
-
(1996)
Proc. Natl. Acad. Sci. U.S.A
, vol.93
, pp. 6059-6063
-
-
Aizenman, E.1
Engelberg-Kulka, H.2
Glaser, G.3
-
6
-
-
84955183951
-
An ADP-ribosyltransferase Alt of bacteriophage T4 negatively regulates the Escherichia coli MazF toxin of a toxin-antitoxin module
-
Alawneh, A. M., Qi, D., Yonesaki, T., and Otsuka, Y. (2016). An ADP-ribosyltransferase Alt of bacteriophage T4 negatively regulates the Escherichia coli MazF toxin of a toxin-antitoxin module. Mol. Microbiol. 99, 188-198. doi: 10.1111/mmi.13225
-
(2016)
Mol. Microbiol
, vol.99
, pp. 188-198
-
-
Alawneh, A.M.1
Qi, D.2
Yonesaki, T.3
Otsuka, Y.4
-
7
-
-
67651103123
-
'Bacterial toxin-antitoxin systems as targets for the development of novel antibiotics'
-
eds M. E. Tolmasky and R. A. Bonomo (Washington DC: American Society of Microbiology)
-
Alonso, J. C., Balsa, D., Cherny, I., Christensen, S. K., Espinosa, M., Francuski, D., et al. (2007). "Bacterial toxin-antitoxin systems as targets for the development of novel antibiotics". in Enzyme-Mediated Resistance to Antibiotics, eds M. E. Tolmasky and R. A. Bonomo (Washington DC: American Society of Microbiology), 313-329
-
(2007)
Enzyme-Mediated Resistance to Antibiotics
, pp. 313-329
-
-
Alonso, J.C.1
Balsa, D.2
Cherny, I.3
Christensen, S.K.4
Espinosa, M.5
Francuski, D.6
-
8
-
-
63449138496
-
Escherichia coli MazF leads to the simultaneous selective synthesis of both "Death Proteins" and "Survival Proteins."
-
Amitai, S., Kolodkin-Gal, I., Hananya-Meltabashi, M., Sacher, A., and Engelberg-Kulka, H. (2009). Escherichia coli MazF leads to the simultaneous selective synthesis of both "Death Proteins" and "Survival Proteins." PLoS Genet. 5:e1000390. doi: 10.1371/journal.pgen.1000390
-
(2009)
PLoS Genet
, vol.5
-
-
Amitai, S.1
Kolodkin-Gal, I.2
Hananya-Meltabashi, M.3
Sacher, A.4
Engelberg-Kulka, H.5
-
9
-
-
77955504694
-
Crystal structures of Phd-Doc, HigA, and YeeU establish multiple evolutionary links between microbial growth-regulating toxin-antitoxin systems
-
Arbing, M. A., Handelman, S. K., Kuzin, A. P., Verdon, G., Wang, C., Su, M., et al. (2010). Crystal structures of Phd-Doc, HigA, and YeeU establish multiple evolutionary links between microbial growth-regulating toxin-antitoxin systems. Structure 18, 996-1010. doi: 10.1016/j.str.2010.04.018
-
(2010)
Structure
, vol.18
, pp. 996-1010
-
-
Arbing, M.A.1
Handelman, S.K.2
Kuzin, A.P.3
Verdon, G.4
Wang, C.5
Su, M.6
-
10
-
-
84857963742
-
Characterization of Escherichia coli dinJ-yafQ toxin-antitoxin system using insights from mutagenesis data
-
Armalyte, J., Jurenaite, M., Beinoraviciûte, G., Teiserskas, J., and Suziedeliene, E. (2012). Characterization of Escherichia coli dinJ-yafQ toxin-antitoxin system using insights from mutagenesis data. J. Bacteriol. 194, 1523-1532. doi: 10.1128/JB.06104-11
-
(2012)
J. Bacteriol
, vol.194
, pp. 1523-1532
-
-
Armalyte, J.1
Jurenaite, M.2
Beinoraviciûte, G.3
Teiserskas, J.4
Suziedeliene, E.5
-
11
-
-
63449088634
-
Influence of operator site geometry on transcriptional control by the YefM-YoeB toxin-antitoxin complex
-
Bailey, S. E. S., and Hayes, F. (2009). Influence of operator site geometry on transcriptional control by the YefM-YoeB toxin-antitoxin complex. J. Bacteriol. 191, 762-772. doi: 10.1128/JB.01331-08
-
(2009)
J. Bacteriol
, vol.191
, pp. 762-772
-
-
Bailey, S.E.S.1
Hayes, F.2
-
12
-
-
84922057098
-
BtoxDB: a comprehensive database of protein structural data on toxin-antitoxin systems
-
Barbosa, L. C. B., Garrido, S. S., and Marchetto, R. (2015). BtoxDB: a comprehensive database of protein structural data on toxin-antitoxin systems. Comput. Biol. Med. 58, 146-153. doi: 10.1016/j.compbiomed.2015.01.010
-
(2015)
Comput. Biol. Med
, vol.58
, pp. 146-153
-
-
Barbosa, L.C.B.1
Garrido, S.S.2
Marchetto, R.3
-
13
-
-
0026728290
-
Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes
-
Bernard, P., and Couturier, M. (1992). Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes. J. Mol. Biol. 226, 735-745. doi: 10.1016/0022-2836(92)90629-X
-
(1992)
J. Mol. Biol
, vol.226
, pp. 735-745
-
-
Bernard, P.1
Couturier, M.2
-
14
-
-
84907161111
-
Post-transcriptional regulation of gene expression in bacterial pathogens by toxin-antitoxin systems
-
Bertram, R., and Schuster, C. F. (2014). Post-transcriptional regulation of gene expression in bacterial pathogens by toxin-antitoxin systems. Front. Cell. Infect. Microbiol. 4:6. doi: 10.3389/fcimb.2014.00006
-
(2014)
Front. Cell. Infect. Microbiol
, vol.4
, pp. 6
-
-
Bertram, R.1
Schuster, C.F.2
-
15
-
-
84907842145
-
Functional and structural analysis of HicA3-HicB3, a novel toxin-antitoxin system of Yersinia pestis
-
Bibi-Triki, S., Li de la Sierra-Gallay, I., Lazar, N., Leroy, A., Van Tilbeurgh, H., Sebbane, F., et al. (2014). Functional and structural analysis of HicA3-HicB3, a novel toxin-antitoxin system of Yersinia pestis. J. Bacteriol. 196, 3712-3723. doi: 10.1128/JB.01932-14
-
(2014)
J. Bacteriol
, vol.196
, pp. 3712-3723
-
-
Bibi-Triki, S.1
Li de la Sierra-Gallay, I.2
Lazar, N.3
Leroy, A.4
Van Tilbeurgh, H.5
Sebbane, F.6
-
16
-
-
79551671757
-
Balancing at survival's edge: The structure and adaptive benefits of prokaryotic toxin-antitoxin partners
-
Blower, T. R., Salmond, G. P. C., and Luisi, B. F. (2011). Balancing at survival's edge: The structure and adaptive benefits of prokaryotic toxin-antitoxin partners. Curr. Opin. Struct. Biol. 21, 109-118. doi: 10.1016/j.sbi.2010.10.009
-
(2011)
Curr. Opin. Struct. Biol
, vol.21
, pp. 109-118
-
-
Blower, T.R.1
Salmond, G.P.C.2
Luisi, B.F.3
-
17
-
-
26844537302
-
Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins
-
Bobay, B. G., Andreeva, A., Mueller, G. A., Cavanagh, J., and Murzin, A. G. (2005). Revised structure of the AbrB N-terminal domain unifies a diverse superfamily of putative DNA-binding proteins. FEBS Lett. 579, 5669-5674. doi: 10.1016/j.febslet.2005.09.045
-
(2005)
FEBS Lett
, vol.579
, pp. 5669-5674
-
-
Bobay, B.G.1
Andreeva, A.2
Mueller, G.A.3
Cavanagh, J.4
Murzin, A.G.5
-
18
-
-
84867404222
-
The crystal structure of the intact E. coli RelBE toxin-antitoxin complex provides the structural basis for conditional cooperativity
-
Bøggild, A., Sofos, N., Andersen, K. R., Feddersen, A., Easter, A. D., Passmore, L. A., et al. (2012). The crystal structure of the intact E. coli RelBE toxin-antitoxin complex provides the structural basis for conditional cooperativity. Structure 20, 1641-1648. doi: 10.1016/j.str.2012.08.017
-
(2012)
Structure
, vol.20
, pp. 1641-1648
-
-
Bøggild, A.1
Sofos, N.2
Andersen, K.R.3
Feddersen, A.4
Easter, A.D.5
Passmore, L.A.6
-
19
-
-
84883336034
-
The axe-txe complex of Enterococcus faecium presents a multilayered mode of toxin-antitoxin gene expression regulation
-
Boss, L., Labudda, L., Wêgrzyn, G., Hayes, F., and Kêdzierska, B. (2013). The axe-txe complex of Enterococcus faecium presents a multilayered mode of toxin-antitoxin gene expression regulation. PLoS ONE 8:e73569. doi: 10.1371/journal.pone.0073569
-
(2013)
PLoS ONE
, vol.8
-
-
Boss, L.1
Labudda, L.2
Wêgrzyn, G.3
Hayes, F.4
Kêdzierska, B.5
-
20
-
-
84874981938
-
Characterization of Myxococcus xanthus MazF and implications for a new point of regulation
-
Boynton, T. O., Mcmurry, J. L., and Shimkets, L. J. (2013). Characterization of Myxococcus xanthus MazF and implications for a new point of regulation. Mol. Microbiol. 87, 1267-1276. doi: 10.1111/mmi.12165
-
(2013)
Mol. Microbiol
, vol.87
, pp. 1267-1276
-
-
Boynton, T.O.1
Mcmurry, J.L.2
Shimkets, L.J.3
-
21
-
-
0024199426
-
Killing of Escherichia coli cells modulated by components of the stability system ParD of plasmid R1
-
Bravo, A., Ortega, S., de Torrontegui, G., and Díaz, R. (1988). Killing of Escherichia coli cells modulated by components of the stability system ParD of plasmid R1. Mol. Gen. Genet. 215, 146-151. doi: 10.1007/BF00331316
-
(1988)
Mol. Gen. Genet
, vol.215
, pp. 146-151
-
-
Bravo, A.1
Ortega, S.2
de Torrontegui, G.3
Díaz, R.4
-
22
-
-
0024571640
-
The Helix-Turn-Helix DNA binding motif
-
Brennan, R. G., and Matthews, B. W. (1989). The Helix-Turn-Helix DNA binding motif. J. Biol. Chem. 264, 1903-1906
-
(1989)
J. Biol. Chem
, vol.264
, pp. 1903-1906
-
-
Brennan, R.G.1
Matthews, B.W.2
-
23
-
-
74549170423
-
Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties
-
Brown, B. L., Grigoriu, S., Kim, Y., Arruda, J. M., Davenport, A., Wood, T. K., et al. (2009). Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties. PLoS Pathog. 5:e1000706. doi: 10.1371/journal.ppat.1000706
-
(2009)
PLoS Pathog
, vol.5
-
-
Brown, B.L.1
Grigoriu, S.2
Kim, Y.3
Arruda, J.M.4
Davenport, A.5
Wood, T.K.6
-
24
-
-
84872361771
-
The Escherichia coli toxin MqsR destabilizes the transcriptional repression complex formed between the antitoxin MqsA and the mqsRA operon promoter
-
Brown, B. L., Lord, D. M., Grigoriu, S., Peti, W., and Page, R. (2013). The Escherichia coli toxin MqsR destabilizes the transcriptional repression complex formed between the antitoxin MqsA and the mqsRA operon promoter. J. Biol. Chem. 288, 1286-1294. doi: 10.1074/jbc. M112.421008
-
(2013)
J. Biol. Chem
, vol.288
, pp. 1286-1294
-
-
Brown, B.L.1
Lord, D.M.2
Grigoriu, S.3
Peti, W.4
Page, R.5
-
25
-
-
78751504273
-
Structure of the Escherichia coli antitoxin MqsA (YgiT/b3021) bound to its gene promoter reveals extensive domain rearrangements and the specificity of transcriptional regulation
-
Brown, B. L., Wood, T. K., Peti, W., and Page, R. (2011). Structure of the Escherichia coli antitoxin MqsA (YgiT/b3021) bound to its gene promoter reveals extensive domain rearrangements and the specificity of transcriptional regulation. J. Biol. Chem. 286, 2285-2296. doi: 10.1074/jbc. M110.172643
-
(2011)
J. Biol. Chem
, vol.286
, pp. 2285-2296
-
-
Brown, B.L.1
Wood, T.K.2
Peti, W.3
Page, R.4
-
26
-
-
1342344954
-
A locus contained within a variable region of pneumococcal pathogenicity Island 1 contributes to virulence in mice
-
Brown, J. S., Gilliland, S. M., Spratt, B. G., and Holden, D. W. (2004). A locus contained within a variable region of pneumococcal pathogenicity Island 1 contributes to virulence in mice. Infect. Immun. 72, 1587-1593. doi: 10.1128/IAI.72.3.1587-1593.2004
-
(2004)
Infect. Immun
, vol.72
, pp. 1587-1593
-
-
Brown, J.S.1
Gilliland, S.M.2
Spratt, B.G.3
Holden, D.W.4
-
27
-
-
84887997250
-
The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu
-
Castro-Roa, D., Garcia-Pino, A., De Gieter, S., van Nuland, N. A. J., Loris, R., and Zenkin, N. (2013). The Fic protein Doc uses an inverted substrate to phosphorylate and inactivate EF-Tu. Nat. Chem. Biol. 9, 811-817. doi: 10.1038/nchembio.1364
-
(2013)
Nat. Chem. Biol
, vol.9
, pp. 811-817
-
-
Castro-Roa, D.1
Garcia-Pino, A.2
De Gieter, S.3
van Nuland, N.A.J.4
Loris, R.5
Zenkin, N.6
-
28
-
-
84883401486
-
Conditional cooperativity of toxin-antitoxin regulation can mediate bistability between growth and dormancy
-
Cataudella, I., Sneppen, K., Gerdes, K., and Mitarai, N. (2013). Conditional cooperativity of toxin-antitoxin regulation can mediate bistability between growth and dormancy. PLoS Comput. Biol. 9:e1003174. doi: 10.1371/journal.pcbi.1003174
-
(2013)
PLoS Comput. Biol
, vol.9
-
-
Cataudella, I.1
Sneppen, K.2
Gerdes, K.3
Mitarai, N.4
-
29
-
-
84864950352
-
Conditional cooperativity in toxin-antitoxin regulation prevents random toxin activation and promotes fast translational recovery
-
Cataudella, I., Trusina, A., Sneppen, K., Gerdes, K., and Mitarai, N. (2012). Conditional cooperativity in toxin-antitoxin regulation prevents random toxin activation and promotes fast translational recovery. Nucleic Acids Res. 40, 6424-6434. doi: 10.1093/nar/gks297
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 6424-6434
-
-
Cataudella, I.1
Trusina, A.2
Sneppen, K.3
Gerdes, K.4
Mitarai, N.5
-
30
-
-
0027771641
-
Analysis of the stabilization system of pSM19035-derived plasmid pBT233 in Bacillus subtilis
-
Ceglowski, P., Boitsov, A., Chai, S., and Alonso, J. C. (1993). Analysis of the stabilization system of pSM19035-derived plasmid pBT233 in Bacillus subtilis. Gene 136, 1-12. doi: 10.1016/0378-1119(93)90441-5
-
(1993)
Gene
, vol.136
, pp. 1-12
-
-
Ceglowski, P.1
Boitsov, A.2
Chai, S.3
Alonso, J.C.4
-
31
-
-
84940007260
-
One cannot rule them all: are bacterial toxins-antitoxins druggable?
-
Chan, W. T., Balsa, D., and Espinosa, M. (2015). One cannot rule them all: are bacterial toxins-antitoxins druggable? FEMS Microbiol. Rev. 39, 522-540. doi: 10.1093/femsre/fuv002
-
(2015)
FEMS Microbiol. Rev
, vol.39
, pp. 522-540
-
-
Chan, W.T.1
Balsa, D.2
Espinosa, M.3
-
32
-
-
84870719244
-
Toxin-antitoxin genes of the gram-positive pathogen Streptococcus pneumoniae: so few and yet so many
-
Chan, W. T., Moreno-Córdoba, I., Yeo, C. C., and Espinosa, M. (2012). Toxin-antitoxin genes of the gram-positive pathogen Streptococcus pneumoniae: so few and yet so many. Microbiol. Mol. Biol. Rev. 76, 773-791. doi: 10.1128/MMBR.00030-12
-
(2012)
Microbiol. Mol. Biol. Rev
, vol.76
, pp. 773-791
-
-
Chan, W.T.1
Moreno-Córdoba, I.2
Yeo, C.C.3
Espinosa, M.4
-
33
-
-
80052548515
-
Genetic regulation of the yefM-yoeB toxin-antitoxin locus of Streptococcus pneumoniae
-
Chan, W. T., Nieto, C., Harikrishna, J. A., Khoo, S. K., Othman, R. Y., Espinosa, M., et al. (2011). Genetic regulation of the yefM-yoeB toxin-antitoxin locus of Streptococcus pneumoniae. J. Bacteriol. 193, 4612-4625. doi: 10.1128/JB.05187-11
-
(2011)
J. Bacteriol
, vol.193
, pp. 4612-4625
-
-
Chan, W.T.1
Nieto, C.2
Harikrishna, J.A.3
Khoo, S.K.4
Othman, R.Y.5
Espinosa, M.6
-
34
-
-
84920669889
-
Functional validation of putative toxin-antitoxin genes from the Gram-positive pathogen Streptococcus pneumoniae: phd-doc is the fourth bona-fide operon
-
Chan, W. T., Yeo, C. C., Sadowy, E., and Espinosa, M. (2014). Functional validation of putative toxin-antitoxin genes from the Gram-positive pathogen Streptococcus pneumoniae: phd-doc is the fourth bona-fide operon. Front. Microbiol. 5:677. doi: 10.3389/fmicb.2014.00677
-
(2014)
Front. Microbiol
, vol.5
, pp. 677
-
-
Chan, W.T.1
Yeo, C.C.2
Sadowy, E.3
Espinosa, M.4
-
35
-
-
85028130078
-
Toxin GhoT of the GhoT/GhoS toxin/antitoxin system damages the cell membrane to reduce adenosine triphosphate and to reduce growth under stress
-
Cheng, H.-Y., Soo, V. W. C., Islam, S., McAnulty, M. J., Benedik, M. J., and Wood, T. K. (2014). Toxin GhoT of the GhoT/GhoS toxin/antitoxin system damages the cell membrane to reduce adenosine triphosphate and to reduce growth under stress. Environ. Microbiol. 16, 1741-1754. doi: 10.1111/1462-2920.12373
-
(2014)
Environ. Microbiol
, vol.16
, pp. 1741-1754
-
-
Cheng, H.-Y.1
Soo, V.W.C.2
Islam, S.3
McAnulty, M.J.4
Benedik, M.J.5
Wood, T.K.6
-
36
-
-
24044497249
-
The YoeB Toxin is a folded protein that forms a physical complex with the Unfolded YefM antitoxin: implications for a structural-based differential stability of toxin-antitoxin systems
-
Cherny, I., Rockah, L., and Gazit, E. (2005). The YoeB Toxin is a folded protein that forms a physical complex with the Unfolded YefM antitoxin: implications for a structural-based differential stability of toxin-antitoxin systems. J. Biol. Chem. 280, 30063-30072. doi: 10.1074/jbc. M506220200
-
(2005)
J. Biol. Chem
, vol.280
, pp. 30063-30072
-
-
Cherny, I.1
Rockah, L.2
Gazit, E.3
-
37
-
-
79951867941
-
Acquisition of HIV-1 resistance in T lymphocytes using an ACA-specific E. coli mRNA interferase
-
Chono, H., Matsumoto, K., Tsuda, H., Saito, N., Lee, K., Kim, S., et al. (2011). Acquisition of HIV-1 resistance in T lymphocytes using an ACA-specific E. coli mRNA interferase. Hum. Gene Ther. 22, 35-43. doi: 10.1089/hum.2010.001
-
(2011)
Hum. Gene Ther
, vol.22
, pp. 35-43
-
-
Chono, H.1
Matsumoto, K.2
Tsuda, H.3
Saito, N.4
Lee, K.5
Kim, S.6
-
38
-
-
0038797797
-
RelE toxins from bacteria and Archaea cleave mRNAs on translating ribosomes, which are rescued by tmRNA
-
Christensen, S. K., and Gerdes, K. (2003). RelE toxins from bacteria and Archaea cleave mRNAs on translating ribosomes, which are rescued by tmRNA. Mol. Microbiol. 48, 1389-1400. doi: 10.1046/j.1365-2958.2003.03512.x
-
(2003)
Mol. Microbiol
, vol.48
, pp. 1389-1400
-
-
Christensen, S.K.1
Gerdes, K.2
-
39
-
-
1642483754
-
Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: involvement of the yefM-yoeB toxin-antitoxin system
-
Christensen, S. K., Maenhaut-Michel, G., Mine, N., Gottesman, S., Gerdes, K., and Van Melderen, L. (2004). Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: involvement of the yefM-yoeB toxin-antitoxin system. Mol. Microbiol. 51, 1705-1717. doi: 10.1046/j.1365-2958.2003.03941.x
-
(2004)
Mol. Microbiol
, vol.51
, pp. 1705-1717
-
-
Christensen, S.K.1
Maenhaut-Michel, G.2
Mine, N.3
Gottesman, S.4
Gerdes, K.5
Van Melderen, L.6
-
40
-
-
0035807805
-
RelE, a global inhibitor of translation, is activated during nutritional stress
-
Christensen, S. K., Mikkelsen, M., Pedersen, K., and Gerdes, K. (2001). RelE, a global inhibitor of translation, is activated during nutritional stress. Proc. Natl. Acad. Sci. U.S.A. 98, 14328-14333. doi: 10.1073/pnas.251327898
-
(2001)
Proc. Natl. Acad. Sci. U.S.A
, vol.98
, pp. 14328-14333
-
-
Christensen, S.K.1
Mikkelsen, M.2
Pedersen, K.3
Gerdes, K.4
-
41
-
-
0041825422
-
Toxin-antitoxin loci as stress-response-elements: ChpAK/MazF and ChpBK cleave translated RNAs and are counteracted by tmRNA
-
Christensen, S. K., Pedersen, K., Hansen, F. G., and Gerdes, K. (2003). Toxin-antitoxin loci as stress-response-elements: ChpAK/MazF and ChpBK cleave translated RNAs and are counteracted by tmRNA. J. Mol. Biol. 332, 809-819. doi: 10.1016/S0022-2836(03)00922-7
-
(2003)
J. Mol. Biol
, vol.332
, pp. 809-819
-
-
Christensen, S.K.1
Pedersen, K.2
Hansen, F.G.3
Gerdes, K.4
-
42
-
-
74349123303
-
Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses
-
Christensen-Dalsgaard, M., Jørgensen, M. G., and Gerdes, K. (2010). Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses. Mol. Microbiol. 75, 333-348. doi: 10.1111/j.1365-2958.2009.06969.x
-
(2010)
Mol. Microbiol
, vol.75
, pp. 333-348
-
-
Christensen-Dalsgaard, M.1
Jørgensen, M.G.2
Gerdes, K.3
-
43
-
-
58249094401
-
RNA decay by messenger RNA interferases
-
Christensen-Dalsgaard, M., Overgaard, M., Winther, K. S., and Gerdes, K. (2008). RNA decay by messenger RNA interferases. Methods Enzymol. 447, 521-535. doi: 10.1016/S0076-6879(08)02225-8
-
(2008)
Methods Enzymol
, vol.447
, pp. 521-535
-
-
Christensen-Dalsgaard, M.1
Overgaard, M.2
Winther, K.S.3
Gerdes, K.4
-
44
-
-
84858128637
-
Regulation of the vapBC-1 toxin-antitoxin locus in nontypeable Haemophilus influenzae
-
Cline, S. D., Saleem, S., and Daines, D. A. (2012). Regulation of the vapBC-1 toxin-antitoxin locus in nontypeable Haemophilus influenzae. PLoS ONE 7:e32199. doi: 10.1371/journal.pone.0032199
-
(2012)
PLoS ONE
, vol.7
-
-
Cline, S.D.1
Saleem, S.2
Daines, D.A.3
-
45
-
-
84896282895
-
Doc toxin is a kinase that inactivates elongation factor Tu
-
Cruz, J. W., Rothenbacher, F. P., Maehigashi, T., Lane, W. S., Dunham, C. M., and Woychik, N. A. (2014). Doc toxin is a kinase that inactivates elongation factor Tu. J. Biol. Chem. 289, 7788-7798. doi: 10.1074/jbc. M113.544429
-
(2014)
J. Biol. Chem
, vol.289
, pp. 7788-7798
-
-
Cruz, J.W.1
Rothenbacher, F.P.2
Maehigashi, T.3
Lane, W.S.4
Dunham, C.M.5
Woychik, N.A.6
-
46
-
-
77949367813
-
A conserved mode of protein recognition and binding in a ParD-ParE toxin-antitoxin complex
-
Dalton, K. M., and Crosson, S. (2010). A conserved mode of protein recognition and binding in a ParD-ParE toxin-antitoxin complex. Biochemistry 49, 2205-2215. doi: 10.1021/bi902133s
-
(2010)
Biochemistry
, vol.49
, pp. 2205-2215
-
-
Dalton, K.M.1
Crosson, S.2
-
47
-
-
84918574813
-
Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin-antitoxin assembly
-
Das, U., Pogenberg, V., Subhramanyam, U. K. T., Wilmanns, M., Gourinath, S., and Srinivasan, A. (2014). Crystal structure of the VapBC-15 complex from Mycobacterium tuberculosis reveals a two-metal ion dependent PIN-domain ribonuclease and a variable mode of toxin-antitoxin assembly. J. Struct. Biol. 188, 249-258. doi: 10.1016/j.jsb.2014.10.002
-
(2014)
J. Struct. Biol
, vol.188
, pp. 249-258
-
-
Das, U.1
Pogenberg, V.2
Subhramanyam, U.K.T.3
Wilmanns, M.4
Gourinath, S.5
Srinivasan, A.6
-
48
-
-
67651091627
-
Rejuvenation of CcdB-poisoned gyrase by an intrinsically disordered protein domain
-
De Jonge, N., Garcia-Pino, A., Buts, L., Haesaerts, S., Charlier, D., Zangger, K., et al. (2009). Rejuvenation of CcdB-poisoned gyrase by an intrinsically disordered protein domain. Mol. Cell 35, 154-163. doi: 10.1016/j.molcel.2009.05.025
-
(2009)
Mol. Cell
, vol.35
, pp. 154-163
-
-
De Jonge, N.1
Garcia-Pino, A.2
Buts, L.3
Haesaerts, S.4
Charlier, D.5
Zangger, K.6
-
49
-
-
77949331925
-
Structural and thermodynamic characterization of Vibrio fischeri CcdB
-
De Jonge, N., Hohlweg, W., Garcia-Pino, A., Respondek, M., Buts, L., Haesaerts, S., et al. (2010). Structural and thermodynamic characterization of Vibrio fischeri CcdB. J. Biol. Chem. 285, 5606-5013. doi: 10.1074/jbc. M109.068429
-
(2010)
J. Biol. Chem
, vol.285
, pp. 5606-5013
-
-
De Jonge, N.1
Hohlweg, W.2
Garcia-Pino, A.3
Respondek, M.4
Buts, L.5
Haesaerts, S.6
-
50
-
-
0037439267
-
Regulatable killing of eukaryotic cells by the prokaryotic proteins Kid and Kis
-
de la Cueva-Méndez, G., Mills, A. D., Clay-Farrace, L., Díaz-Orejas, R., and Laskey, R. A. (2003). Regulatable killing of eukaryotic cells by the prokaryotic proteins Kid and Kis. EMBO J. 22, 246-251. doi: 10.1093/emboj/cdg026
-
(2003)
EMBO J
, vol.22
, pp. 246-251
-
-
de la Cueva-Méndez, G.1
Mills, A.D.2
Clay-Farrace, L.3
Díaz-Orejas, R.4
Laskey, R.A.5
-
51
-
-
84930248633
-
'Biotechnological and medical exploitation of toxin-antitoxin genes and their components'
-
ed. K. Gerdes (Berlin, Heidelberg: Springer Berlin Heidelberg)
-
de la Cueva-Méndez, G., and Pimentel, B. (2013). "Biotechnological and medical exploitation of toxin-antitoxin genes and their components". in Prokaryotic Toxin-Antitoxins, ed K. Gerdes (Berlin, Heidelberg: Springer Berlin Heidelberg), 341-360
-
(2013)
Prokaryotic Toxin-Antitoxins
, pp. 341-360
-
-
de la Cueva-Méndez, G.1
Pimentel, B.2
-
52
-
-
0034681134
-
Plasmid copy-number control and better-than-random segregation genes of pSM19035 share a common regulator
-
de la Hoz, A. B., Ayora, S., Sitkiewicz, I., Fernández, S., Pankiewicz, R., Alonso, J. C., et al. (2000). Plasmid copy-number control and better-than-random segregation genes of pSM19035 share a common regulator. Proc. Natl. Acad. Sci. U.S.A. 97, 728-733. doi: 10.1073/pnas.97.2.728
-
(2000)
Proc. Natl. Acad. Sci. U.S.A
, vol.97
, pp. 728-733
-
-
de la Hoz, A.B.1
Ayora, S.2
Sitkiewicz, I.3
Fernández, S.4
Pankiewicz, R.5
Alonso, J.C.6
-
53
-
-
1642341084
-
Plasmid evolution and interaction between the plasmid addiction stability systems of two related broad-host-range IncQ-like plasmids
-
Deane, S. M., and Rawlings, D. E. (2004). Plasmid evolution and interaction between the plasmid addiction stability systems of two related broad-host-range IncQ-like plasmids. J. Bacteriol. 186, 2123-2133. doi: 10.1128/JB.186.7.2123-2133.2004
-
(2004)
J. Bacteriol
, vol.186
, pp. 2123-2133
-
-
Deane, S.M.1
Rawlings, D.E.2
-
54
-
-
77954694584
-
ParD toxin-antitoxin system of plasmid R1-Basic contributions, biotechnological applications and relationships with closely-related toxin-antitoxin systems
-
Diago-Navarro, E., Hernandez-Arriaga, A. M., López-Villarejo, J., Muñoz-Gómez, A. J., Kamphuis, M. B., Boelens, R., et al. (2010). ParD toxin-antitoxin system of plasmid R1-Basic contributions, biotechnological applications and relationships with closely-related toxin-antitoxin systems. FEBS J. 277, 3097-3117. doi: 10.1111/j.1742-4658.2010.07722.x
-
(2010)
FEBS J
, vol.277
, pp. 3097-3117
-
-
Diago-Navarro, E.1
Hernandez-Arriaga, A.M.2
López-Villarejo, J.3
Muñoz-Gómez, A.J.4
Kamphuis, M.B.5
Boelens, R.6
-
55
-
-
82555168246
-
Crystal structure of the VapBC toxin-antitoxin complex from Shigella flexneri reveals a hetero-octameric DNA-binding assembly
-
Dienemann, C., Bøggild, A., Winther, K. S., Gerdes, K., and Brodersen, D. E. (2011). Crystal structure of the VapBC toxin-antitoxin complex from Shigella flexneri reveals a hetero-octameric DNA-binding assembly. J. Mol. Biol. 414, 713-722. doi: 10.1016/j.jmb.2011.10.024
-
(2011)
J. Mol. Biol
, vol.414
, pp. 713-722
-
-
Dienemann, C.1
Bøggild, A.2
Winther, K.S.3
Gerdes, K.4
Brodersen, D.E.5
-
56
-
-
69949170096
-
Fratricide in Streptococcus pneumoniae: contributions and role of the cell wall hydrolases CbpD, LytA and LytC
-
Eldholm, V., Johnsborg, O., Haugen, K., Ohnstad, H. S., and Håvarstein, L. S. (2009). Fratricide in Streptococcus pneumoniae: contributions and role of the cell wall hydrolases CbpD, LytA and LytC. Microbiology 155, 2223-2234. doi: 10.1099/mic.0.026328-0
-
(2009)
Microbiology
, vol.155
, pp. 2223-2234
-
-
Eldholm, V.1
Johnsborg, O.2
Haugen, K.3
Ohnstad, H.S.4
Håvarstein, L.S.5
-
57
-
-
33750489399
-
Bacterial programmed cell death and multicellular behavior in bacteria
-
Engelberg-Kulka, H., Amitai, S., Kolodkin-Gal, I., and Hazan, R. (2006). Bacterial programmed cell death and multicellular behavior in bacteria. PLoS Genet. 2:e135. doi: 10.1371/journal.pgen.0020135
-
(2006)
PLoS Genet
, vol.2
, pp. e135
-
-
Engelberg-Kulka, H.1
Amitai, S.2
Kolodkin-Gal, I.3
Hazan, R.4
-
58
-
-
0032696759
-
Addiction modules and programmed cell death and antideath in bacterial cultures
-
Engelberg-Kulka, H., and Glaser, G. (1999). Addiction modules and programmed cell death and antideath in bacterial cultures. Annu. Rev. Microbiol. 53, 43-70. doi: 10.1146/annurev.micro.53.1.43
-
(1999)
Annu. Rev. Microbiol
, vol.53
, pp. 43-70
-
-
Engelberg-Kulka, H.1
Glaser, G.2
-
59
-
-
84890072129
-
YoeB-ribosome structure: a canonical RNase that requires the ribosome for its specific activity
-
Feng, S., Chen, Y., Kamada, K., Wang, H., Tang, K., Wang, M., et al. (2013). YoeB-ribosome structure: a canonical RNase that requires the ribosome for its specific activity. Nucleic Acids Res. 41, 9549-9556. doi: 10.1093/nar/gkt742
-
(2013)
Nucleic Acids Res
, vol.41
, pp. 9549-9556
-
-
Feng, S.1
Chen, Y.2
Kamada, K.3
Wang, H.4
Tang, K.5
Wang, M.6
-
60
-
-
70349845295
-
Crystal structure of the antitoxin-toxin protein complex RelB-RelE from Methanococcus jannaschii
-
Francuski, D., and Saenger, W. (2009). Crystal structure of the antitoxin-toxin protein complex RelB-RelE from Methanococcus jannaschii. J. Mol. Biol. 393, 898-908. doi: 10.1016/j.jmb.2009.08.048
-
(2009)
J. Mol. Biol
, vol.393
, pp. 898-908
-
-
Francuski, D.1
Saenger, W.2
-
61
-
-
77954256912
-
Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity
-
Garcia-Pino, A., Balasubramanian, S., Wyns, L., Gazit, E., De Greve, H., Magnuson, R. D., et al. (2010). Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity. Cell 142, 101-111. doi: 10.1016/j.cell.2010.05.039
-
(2010)
Cell
, vol.142
, pp. 101-111
-
-
Garcia-Pino, A.1
Balasubramanian, S.2
Wyns, L.3
Gazit, E.4
De Greve, H.5
Magnuson, R.D.6
-
62
-
-
57649155916
-
Doc of Prophage P1 is inhibited by its antitoxin partner phd through fold complementation
-
Garcia-Pino, A., Christensen-Dalsgaard, M., Wyns, L., Yarmolinsky, M., Magnuson, R. D., Gerdes, K., et al. (2008). Doc of Prophage P1 is inhibited by its antitoxin partner phd through fold complementation. J. Biol. Chem. 283, 30821-30827. doi: 10.1074/jbc. M805654200
-
(2008)
J. Biol. Chem
, vol.283
, pp. 30821-30827
-
-
Garcia-Pino, A.1
Christensen-Dalsgaard, M.2
Wyns, L.3
Yarmolinsky, M.4
Magnuson, R.D.5
Gerdes, K.6
-
63
-
-
84883350971
-
A general model for toxin-antitoxin module dynamics can explain persister cell formation in E. coli
-
Gelens, L., Hill, L., Vandervelde, A., Danckaert, J., and Loris, R. (2013). A general model for toxin-antitoxin module dynamics can explain persister cell formation in E. coli. PLoS Comput. Biol. 9:e1003190. doi: 10.1371/journal.pcbi.1003190
-
(2013)
PLoS Comput. Biol
, vol.9
-
-
Gelens, L.1
Hill, L.2
Vandervelde, A.3
Danckaert, J.4
Loris, R.5
-
64
-
-
0022764432
-
Mechanism of postsegregational killing by the hok gene product of the parB system of plasmid R1 and its homology with the relF gene product of the E. coli relB operon
-
Gerdes, K., Bech, F. W., Jørgensen, S. T., Løbner-Olesen, A., Rasmussen, P. B., Atlung, T., et al. (1986). Mechanism of postsegregational killing by the hok gene product of the parB system of plasmid R1 and its homology with the relF gene product of the E. coli relB operon. EMBO J. 5, 2023-2029
-
(1986)
EMBO J
, vol.5
, pp. 2023-2029
-
-
Gerdes, K.1
Bech, F.W.2
Jørgensen, S.T.3
Løbner-Olesen, A.4
Rasmussen, P.B.5
Atlung, T.6
-
65
-
-
17844370503
-
Prokaryotic toxin-antitoxin stress response loci
-
Gerdes, K., Christensen, S. K., and Løbner-Olesen, A. (2005). Prokaryotic toxin-antitoxin stress response loci. Nat. Rev. Microbiol. 3, 371-382. doi: 10.1038/nrmicro1147
-
(2005)
Nat. Rev. Microbiol
, vol.3
, pp. 371-382
-
-
Gerdes, K.1
Christensen, S.K.2
Løbner-Olesen, A.3
-
66
-
-
84886290812
-
Molecular mechanism of bacterial persistence by HipA
-
Germain, E., Castro-Roa, D., Zenkin, N., and Gerdes, K. (2013). Molecular mechanism of bacterial persistence by HipA. Mol. Cell 52, 248-254. doi: 10.1016/j.molcel.2013.08.045
-
(2013)
Mol. Cell
, vol.52
, pp. 248-254
-
-
Germain, E.1
Castro-Roa, D.2
Zenkin, N.3
Gerdes, K.4
-
67
-
-
0039985836
-
The structure of plasmid-encoded transcriptional repressor CopG unliganded and bound to its operator
-
Gomis-Rüth, F. X., Solá, M., Acebo, P., Párraga, A., Guasch, A., Eritja, R., et al. (1998). The structure of plasmid-encoded transcriptional repressor CopG unliganded and bound to its operator. EMBO J. 17, 7404-7415. doi: 10.1093/emboj/17.24.7404
-
(1998)
EMBO J
, vol.17
, pp. 7404-7415
-
-
Gomis-Rüth, F.X.1
Solá, M.2
Acebo, P.3
Párraga, A.4
Guasch, A.5
Eritja, R.6
-
68
-
-
30744444010
-
Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022)
-
González Barrios, A. F., Zuo, R., Hashimoto, Y., Yang, L., Bentley, W. E., and Wood, T. K. (2006). Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022). J. Bacteriol. 188, 305-316. doi: 10.1128/JB.188.1.305-316.2006
-
(2006)
J. Bacteriol
, vol.188
, pp. 305-316
-
-
González Barrios, A.F.1
Zuo, R.2
Hashimoto, Y.3
Yang, L.4
Bentley, W.E.5
Wood, T.K.6
-
69
-
-
79953323267
-
Cannibalism: a social behavior in sporulating Bacillus subtilis
-
González-Pastor, J. E. (2011). Cannibalism: a social behavior in sporulating Bacillus subtilis. FEMS Microbiol. Rev. 35, 415-424. doi: 10.1111/j.1574-6976.2010.00253.x
-
(2011)
FEMS Microbiol. Rev
, vol.35
, pp. 415-424
-
-
González-Pastor, J.E.1
-
70
-
-
0031816179
-
The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family
-
Gotfredsen, M., and Gerdes, K. (1998). The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family. Mol. Microbiol. 29, 1065-1076. doi: 10.1046/j.1365-2958.1998.00993.x
-
(1998)
Mol. Microbiol
, vol.29
, pp. 1065-1076
-
-
Gotfredsen, M.1
Gerdes, K.2
-
71
-
-
0037338682
-
Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by a multidrug-resistant, clinical isolate of Enterococcus faecium
-
Grady, R., and Hayes, F. (2003). Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by a multidrug-resistant, clinical isolate of Enterococcus faecium. Mol. Microbiol. 47, 1419-1432. doi: 10.1046/j.1365-2958.2003.03387.x
-
(2003)
Mol. Microbiol
, vol.47
, pp. 1419-1432
-
-
Grady, R.1
Hayes, F.2
-
72
-
-
33645057206
-
MazG-A regulator of programmed cell death in Escherichia coli
-
Gross, M., Marianovsky, I., and Glaser, G. (2006). MazG-A regulator of programmed cell death in Escherichia coli. Mol. Microbiol. 59, 590-601. doi: 10.1111/j.1365-2958.2005.04956.x
-
(2006)
Mol. Microbiol
, vol.59
, pp. 590-601
-
-
Gross, M.1
Marianovsky, I.2
Glaser, G.3
-
73
-
-
84883428186
-
Crystallization of the HigBA2 toxin-antitoxin complex from Vibrio cholerae
-
Hadži, S., Garcia-Pino, A., Martinez-Rodriguez, S., Verschueren, K., Christensen-Dalsgaard, M., Gerdes, K., et al. (2013). Crystallization of the HigBA2 toxin-antitoxin complex from Vibrio cholerae. Acta Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 69, 1052-1059. doi: 10.1107/S1744309113021490
-
(2013)
Acta Crystallogr. Sect. F. Struct. Biol. Cryst. Commun
, vol.69
, pp. 1052-1059
-
-
Hadži, S.1
Garcia-Pino, A.2
Martinez-Rodriguez, S.3
Verschueren, K.4
Christensen-Dalsgaard, M.5
Gerdes, K.6
-
74
-
-
77951555583
-
New toxins homologous to ParE belonging to three-component toxin-antitoxin systems in Escherichia coli O157:H7
-
Hallez, R., Geeraerts, D., Sterckx, Y., Mine, N., Loris, R., and Van Melderen, L. (2010). New toxins homologous to ParE belonging to three-component toxin-antitoxin systems in Escherichia coli O157:H7. Mol. Microbiol. 76, 719-732. doi: 10.1111/j.1365-2958.2010.07129.x
-
(2010)
Mol. Microbiol
, vol.76
, pp. 719-732
-
-
Hallez, R.1
Geeraerts, D.2
Sterckx, Y.3
Mine, N.4
Loris, R.5
Van Melderen, L.6
-
75
-
-
67049145664
-
The Chromosomal Toxin Gene yafQ is a determinant of multidrug tolerance for Escherichia coli growing in a biofilm
-
Harrison, J. J., Wade, W. D., Akierman, S., Vacchi-Suzzi, C., Stremick, C. A., Turner, R. J., et al. (2009). The Chromosomal Toxin Gene yafQ is a determinant of multidrug tolerance for Escherichia coli growing in a biofilm. Antimicrob. Agents Chemother. 53, 2253-2258. doi: 10.1128/AAC.00043-09
-
(2009)
Antimicrob. Agents Chemother
, vol.53
, pp. 2253-2258
-
-
Harrison, J.J.1
Wade, W.D.2
Akierman, S.3
Vacchi-Suzzi, C.4
Stremick, C.A.5
Turner, R.J.6
-
76
-
-
79955848787
-
A variable region within the genome of Streptococcus pneumoniae contributes to strain-strain variation in virulence
-
Harvey, R. M., Stroeher, U. H., Ogunniyi, A. D., Smith-Vaughan, H. C., Leach, A. J., and Paton, J. C. (2011). A variable region within the genome of Streptococcus pneumoniae contributes to strain-strain variation in virulence. PLoS ONE 6:e19650. doi: 10.1371/journal.pone.0019650
-
(2011)
PLoS ONE
, vol.6
-
-
Harvey, R.M.1
Stroeher, U.H.2
Ogunniyi, A.D.3
Smith-Vaughan, H.C.4
Leach, A.J.5
Paton, J.C.6
-
77
-
-
84892880242
-
Regulating toxin-antitoxin expression: controlled detonation of intracellular molecular timebombs
-
Hayes, F., and Kêdzierska, B. (2014). Regulating toxin-antitoxin expression: controlled detonation of intracellular molecular timebombs. Toxins (Basel). 6, 337-358. doi: 10.3390/toxins6010337
-
(2014)
Toxins (Basel)
, vol.6
, pp. 337-358
-
-
Hayes, F.1
Kêdzierska, B.2
-
78
-
-
80053474881
-
Toxins-antitoxins: diversity, evolution and function
-
Hayes, F., and Van Melderen, L. (2011). Toxins-antitoxins: diversity, evolution and function. Crit. Rev. Biochem. Mol. Biol. 46, 386-408. doi: 10.3109/10409238.2011.600437
-
(2011)
Crit. Rev. Biochem. Mol. Biol
, vol.46
, pp. 386-408
-
-
Hayes, F.1
Van Melderen, L.2
-
79
-
-
84958811591
-
Conditional activation of toxin-antitoxin systems: postsegregational killing and beyond
-
Hernández-Arriaga, A. M., Chan, W. T., Espinosa, M., and Díaz-Orejas, R. (2014). Conditional activation of toxin-antitoxin systems: postsegregational killing and beyond. Microbiol. Spectr. 2:PLAS-0009-2013. doi: 10.1128/microbiolspec. PLAS-0009-2013
-
(2014)
Microbiol. Spectr
, vol.2
-
-
Hernández-Arriaga, A.M.1
Chan, W.T.2
Espinosa, M.3
Díaz-Orejas, R.4
-
80
-
-
67650517830
-
Bacterial toxin HigB associates with ribosomes and mediates translation-dependent mRNA cleavage at A-rich sites
-
Hurley, J. M., and Woychik, N. A. (2009). Bacterial toxin HigB associates with ribosomes and mediates translation-dependent mRNA cleavage at A-rich sites. J. Biol. Chem. 284, 18605-18613. doi: 10.1074/jbc. M109.008763
-
(2009)
J. Biol. Chem
, vol.284
, pp. 18605-18613
-
-
Hurley, J.M.1
Woychik, N.A.2
-
81
-
-
84893490136
-
Nucleotide sequence analysis of integrative conjugative element Tn5253 of Streptococcus pneumoniae
-
Iannelli, F., Santoro, F., Oggioni, M. R., and Pozzi, G. (2014). Nucleotide sequence analysis of integrative conjugative element Tn5253 of Streptococcus pneumoniae. Antimicrob. Agents Chemother. 58, 1235-1239. doi: 10.1128/AAC.01764-13
-
(2014)
Antimicrob. Agents Chemother
, vol.58
, pp. 1235-1239
-
-
Iannelli, F.1
Santoro, F.2
Oggioni, M.R.3
Pozzi, G.4
-
82
-
-
0022390750
-
Effects of the ccd function of the F plasmid on bacterial growth
-
Jaffe, A., Ogura, T., and Hiraga, S. (1985). Effects of the ccd function of the F plasmid on bacterial growth. J. Bacteriol. 163, 841-849
-
(1985)
J. Bacteriol
, vol.163
, pp. 841-849
-
-
Jaffe, A.1
Ogura, T.2
Hiraga, S.3
-
83
-
-
60849121408
-
HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea
-
Jørgensen, M. G., Pandey, D. P., Jaskolska, M., and Gerdes, K. (2009). HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea. J. Bacteriol. 191, 1191-1199. doi: 10.1128/JB.01013-08
-
(2009)
J. Bacteriol
, vol.191
, pp. 1191-1199
-
-
Jørgensen, M.G.1
Pandey, D.P.2
Jaskolska, M.3
Gerdes, K.4
-
84
-
-
84880000324
-
Identification and characterization of type II toxin-antitoxin systems in the opportunistic pathogen Acinetobacter baumannii
-
Jurenaite, M., Markuckas, A., and Suziedeliene, E. (2013). Identification and characterization of type II toxin-antitoxin systems in the opportunistic pathogen Acinetobacter baumannii. J. Bacteriol. 195, 3165-3172. doi: 10.1128/JB.00237-13
-
(2013)
J. Bacteriol
, vol.195
, pp. 3165-3172
-
-
Jurenaite, M.1
Markuckas, A.2
Suziedeliene, E.3
-
85
-
-
23744463273
-
Conformational change in the catalytic site of the ribonuclease YoeB toxin by YefM antitoxin
-
Kamada, K., and Hanaoka, F. (2005). Conformational change in the catalytic site of the ribonuclease YoeB toxin by YefM antitoxin. Mol. Cell 19, 497-509. doi: 10.1016/j.molcel.2005.07.004
-
(2005)
Mol. Cell
, vol.19
, pp. 497-509
-
-
Kamada, K.1
Hanaoka, F.2
-
86
-
-
0037738520
-
Crystal Structure of the MazE/MazF Complex
-
Kamada, K., Hanaoka, F., and Burley, S. K. (2003). Crystal Structure of the MazE/MazF Complex. Mol. Cell 11, 875-884. doi: 10.1016/S1097-2765(03)00097-2
-
(2003)
Mol. Cell
, vol.11
, pp. 875-884
-
-
Kamada, K.1
Hanaoka, F.2
Burley, S.K.3
-
87
-
-
33846967840
-
Structure and function of bacterial kid-kis and related toxin-antitoxin systems
-
Kamphuis, M., Chiara Monti, M. H., van den Heuvel, R., Lopez-Villarejo, J., Diaz-Orejas, R., and Boelens, R. (2007b). Structure and function of bacterial kid-kis and related toxin-antitoxin systems. Protein Pept. Lett. 14, 113-124. doi: 10.2174/092986607779816096
-
(2007)
Protein Pept. Lett
, vol.14
, pp. 113-124
-
-
Kamphuis, M.1
Chiara Monti, M.H.2
van den Heuvel, R.3
Lopez-Villarejo, J.4
Diaz-Orejas, R.5
Boelens, R.6
-
88
-
-
33644766097
-
Model for RNA binding and the catalytic site of the RNase Kid of the bacterial parD toxin-antitoxin system
-
Kamphuis, M. B., Bonvin, A. M., Monti, M. C., Lemonnier, M., Muñoz-Gómez, A., Van Den Heuvel, R. H., et al. (2006). Model for RNA binding and the catalytic site of the RNase Kid of the bacterial parD toxin-antitoxin system. J. Mol. Biol. 357, 115-126. doi: 10.1016/j.jmb.2005.12.033
-
(2006)
J. Mol. Biol
, vol.357
, pp. 115-126
-
-
Kamphuis, M.B.1
Bonvin, A.M.2
Monti, M.C.3
Lemonnier, M.4
Muñoz-Gómez, A.5
Van Den Heuvel, R.H.6
-
89
-
-
33847367709
-
Interactions between the toxin Kid of the bacterial parD system and the antitoxins Kis and MazE
-
Kamphuis, M. B., Monti, M. C., van den Heuvel, R. H. H., Santos-Sierra, S., Folkers, G. E., Lemonnier, M., et al. (2007a). Interactions between the toxin Kid of the bacterial parD system and the antitoxins Kis and MazE. Proteins 67, 219-231. doi: 10.1002/prot.21254
-
(2007)
Proteins
, vol.67
, pp. 219-231
-
-
Kamphuis, M.B.1
Monti, M.C.2
van den Heuvel, R.H.H.3
Santos-Sierra, S.4
Folkers, G.E.5
Lemonnier, M.6
-
90
-
-
77952567720
-
The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair
-
Kasari, V., Kurg, K., Margus, T., Tenson, T., and Kaldalu, N. (2010). The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair. J. Bacteriol. 192, 2908-2919. doi: 10.1128/JB.01266-09
-
(2010)
J. Bacteriol
, vol.192
, pp. 2908-2919
-
-
Kasari, V.1
Kurg, K.2
Margus, T.3
Tenson, T.4
Kaldalu, N.5
-
91
-
-
33846680128
-
Toxin-antitoxin regulation: bimodal interaction of YefM-YoeB with paired DNA palindromes exerts transcriptional autorepression
-
Kedzierska, B., Lian, L.-Y., and Hayes, F. (2007). Toxin-antitoxin regulation: bimodal interaction of YefM-YoeB with paired DNA palindromes exerts transcriptional autorepression. Nucleic Acids Res. 35, 325-339. doi: 10.1093/nar/gkl1028
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 325-339
-
-
Kedzierska, B.1
Lian, L.-Y.2
Hayes, F.3
-
92
-
-
85018220243
-
'Transcriptional control of toxin-antitoxin expression: keeping toxins under wraps until the time is right'
-
ed. F. J. de Bruijin (Hoboken, NJ: John Wiley & Sons, Inc.)
-
Kedzierska, B., and Hayes, F. (2016). "Transcriptional control of toxin-antitoxin expression: keeping toxins under wraps until the time is right". in Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria, ed F. J. de Bruijin (Hoboken, NJ: John Wiley & Sons, Inc.), 463-472
-
(2016)
Stress and Environmental Regulation of Gene Expression and Adaptation in Bacteria
, pp. 463-472
-
-
Kedzierska, B.1
Hayes, F.2
-
93
-
-
34547126009
-
Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae
-
Khoo, S. K., Loll, B., Chan, W. T., Shoeman, R. L., Ngoo, L., Yeo, C. C., et al. (2007). Molecular and structural characterization of the PezAT chromosomal toxin-antitoxin system of the human pathogen Streptococcus pneumoniae. J. Biol. Chem. 282, 19606-19618. doi: 10.1074/jbc. M701703200
-
(2007)
J. Biol. Chem
, vol.282
, pp. 19606-19618
-
-
Khoo, S.K.1
Loll, B.2
Chan, W.T.3
Shoeman, R.L.4
Ngoo, L.5
Yeo, C.C.6
-
94
-
-
77953551929
-
Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD
-
Kim, Y., Wang, X., Zhang, X.-S., Grigoriu, S., Page, R., Peti, W., et al. (2010). Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD. Environ. Microbiol. 12, 1105-1121. doi: 10.1111/j.1462-2920.2009.02147.x
-
(2010)
Environ. Microbiol
, vol.12
, pp. 1105-1121
-
-
Kim, Y.1
Wang, X.2
Zhang, X.-S.3
Grigoriu, S.4
Page, R.5
Peti, W.6
-
95
-
-
78951480425
-
Escherichia coli rnlA and rnlB compose a novel toxin-antitoxin system
-
Koga, M., Otsuka, Y., Lemire, S., and Yonesaki, T. (2011). Escherichia coli rnlA and rnlB compose a novel toxin-antitoxin system. Genetics 187, 123-130. doi: 10.1534/genetics.110.121798
-
(2011)
Genetics
, vol.187
, pp. 123-130
-
-
Koga, M.1
Otsuka, Y.2
Lemire, S.3
Yonesaki, T.4
-
96
-
-
35548944074
-
A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli
-
Kolodkin-Gal, I., Hazan, R., Gaathon, A., Carmeli, S., and Engelberg-Kulka, H. (2007). A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli. Science 318, 652-655. doi: 10.1126/science.1147248
-
(2007)
Science
, vol.318
, pp. 652-655
-
-
Kolodkin-Gal, I.1
Hazan, R.2
Gaathon, A.3
Carmeli, S.4
Engelberg-Kulka, H.5
-
97
-
-
84937514611
-
Expression of the toxin-antitoxin genes yefMLrh, yoeBLrh in human Lactobacillus rhamnosus isolates
-
Krügel, H., Klimina, K. M., Mrotzek, G., Tretyakov, A., Schöfl, G., Saluz, H.-P., et al. (2015). Expression of the toxin-antitoxin genes yefMLrh, yoeBLrh in human Lactobacillus rhamnosus isolates. J. Basic Microbiol. 55, 982-991. doi: 10.1002/jobm.201400904
-
(2015)
J. Basic Microbiol
, vol.55
, pp. 982-991
-
-
Krügel, H.1
Klimina, K.M.2
Mrotzek, G.3
Tretyakov, A.4
Schöfl, G.5
Saluz, H.-P.6
-
98
-
-
53149133857
-
Crystal structure of Mycobacterium tuberculosis YefM antitoxin reveals that it is not an intrinsically unstructured protein
-
Kumar, P., Issac, B., Dodson, E. J., Turkenburg, J. P., and Mande, S. C. (2008). Crystal structure of Mycobacterium tuberculosis YefM antitoxin reveals that it is not an intrinsically unstructured protein. J. Mol. Biol. 383, 482-493. doi: 10.1016/j.jmb.2008.08.067
-
(2008)
J. Mol. Biol
, vol.383
, pp. 482-493
-
-
Kumar, P.1
Issac, B.2
Dodson, E.J.3
Turkenburg, J.P.4
Mande, S.C.5
-
99
-
-
84864020098
-
Myxococcus xanthus developmental cell fate production: heterogeneous accumulation of developmental regulatory proteins and reexamination of the Role of MazF in developmental lysis
-
Lee, B., Holkenbrink, C., Treuner-lange, A., and Higgs, P. I. (2012). Myxococcus xanthus developmental cell fate production: heterogeneous accumulation of developmental regulatory proteins and reexamination of the Role of MazF in developmental lysis. J. Bacteriol. 194, 3058-3068. doi: 10.1128/JB.06756-11
-
(2012)
J. Bacteriol
, vol.194
, pp. 3058-3068
-
-
Lee, B.1
Holkenbrink, C.2
Treuner-Lange, A.3
Higgs, P.I.4
-
100
-
-
84941254072
-
Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides
-
Lee, I.-G., Lee, S. J., Chae, S., Lee, K.-Y., Kim, J.-H., and Lee, B.-J. (2015). Structural and functional studies of the Mycobacterium tuberculosis VapBC30 toxin-antitoxin system: implications for the design of novel antimicrobial peptides. Nucleic Acids Res. 43, 7624-7637. doi: 10.1093/nar/gkv689
-
(2015)
Nucleic Acids Res
, vol.43
, pp. 7624-7637
-
-
Lee, I.-G.1
Lee, S.J.2
Chae, S.3
Lee, K.-Y.4
Kim, J.-H.5
Lee, B.-J.6
-
101
-
-
0027372158
-
Plasmid addiction genes of bacteriophage P1: doc, which causes cell death on curing of prophage, and phd, which prevents host death when prophage is retained
-
Lehnherr, H., Maguin, E., Jafri, S., and Yarmolinsky, M. B. (1993). Plasmid addiction genes of bacteriophage P1: doc, which causes cell death on curing of prophage, and phd, which prevents host death when prophage is retained. J. Mol. Biol. 233, 414-428. doi: 10.1006/jmbi.1993.1521
-
(1993)
J. Mol. Biol
, vol.233
, pp. 414-428
-
-
Lehnherr, H.1
Maguin, E.2
Jafri, S.3
Yarmolinsky, M.B.4
-
102
-
-
0028985596
-
Addiction protein Phd of plasmid prophage P1 is a substrate of the ClpXP serine protease of Escherichia coli
-
Lehnherr, H., and Yarmolinsky, M. B. (1995). Addiction protein Phd of plasmid prophage P1 is a substrate of the ClpXP serine protease of Escherichia coli. Proc. Natl. Acad. Sci. U.S.A. 92, 3274-3277. doi: 10.1073/pnas.92.8.3274
-
(1995)
Proc. Natl. Acad. Sci. U.S.A
, vol.92
, pp. 3274-3277
-
-
Lehnherr, H.1
Yarmolinsky, M.B.2
-
103
-
-
80052196405
-
Diversity of bacterial type II toxin-antitoxin systems: a comprehensive search and functional analysis of novel families
-
Leplae, R., Geeraerts, D., Hallez, R., Guglielmini, J., Drze, P., and Van Melderen, L. (2011). Diversity of bacterial type II toxin-antitoxin systems: a comprehensive search and functional analysis of novel families. Nucleic Acids Res. 39, 5513-5525. doi: 10.1093/nar/gkr131
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 5513-5525
-
-
Leplae, R.1
Geeraerts, D.2
Hallez, R.3
Guglielmini, J.4
Drze, P.5
Van Melderen, L.6
-
104
-
-
77955628762
-
Persister cells
-
Lewis, K. (2010). Persister cells. Annu. Rev. Microbiol. 64, 357-372. doi: 10.1146/annurev.micro.112408.134306
-
(2010)
Annu. Rev. Microbiol
, vol.64
, pp. 357-372
-
-
Lewis, K.1
-
105
-
-
67649794729
-
Inhibitory mechanism of Escherichia coli RelE-RelB toxin-antitoxin module involves a helix displacement near an mRNA interferase active site
-
Li, G.-Y., Zhang, Y., Inouye, M., and Ikura, M. (2009). Inhibitory mechanism of Escherichia coli RelE-RelB toxin-antitoxin module involves a helix displacement near an mRNA interferase active site. J. Biol. Chem. 284, 14628-14636. doi: 10.1074/jbc. M809656200
-
(2009)
J. Biol. Chem
, vol.284
, pp. 14628-14636
-
-
Li, G.-Y.1
Zhang, Y.2
Inouye, M.3
Ikura, M.4
-
106
-
-
84905394780
-
Structural and functional characterization of Escherichia coli toxin-antitoxin complex DinJ-YafQ
-
Liang, Y., Gao, Z., Wang, F., Zhang, Y., Dong, Y., and Liu, Q. (2014). Structural and functional characterization of Escherichia coli toxin-antitoxin complex DinJ-YafQ. J. Biol. Chem. 289, 21191-21202. doi: 10.1074/jbc. M114.559773
-
(2014)
J. Biol. Chem
, vol.289
, pp. 21191-21202
-
-
Liang, Y.1
Gao, Z.2
Wang, F.3
Zhang, Y.4
Dong, Y.5
Liu, Q.6
-
107
-
-
84856259348
-
The ζ toxin induces a set of protective responses and dormancy
-
Lioy, V. S., Machon, C., Tabone, M., Gonzalez-Pastor, J. E., Daugelavicius, R., Ayora, S., et al. (2012). The ζ toxin induces a set of protective responses and dormancy. PLoS ONE 7:e30282. doi: 10.1371/journal.pone.0030282
-
(2012)
PLoS ONE
, vol.7
-
-
Lioy, V.S.1
Machon, C.2
Tabone, M.3
Gonzalez-Pastor, J.E.4
Daugelavicius, R.5
Ayora, S.6
-
108
-
-
44449119912
-
Bacterial addiction module toxin Doc inhibits translation elongation through its association with the 30S ribosomal subunit
-
Liu, M., Zhang, Y., Inouye, M., and Woychik, N. A. (2008). Bacterial addiction module toxin Doc inhibits translation elongation through its association with the 30S ribosomal subunit. Proc. Natl. Acad. Sci. U.S.A. 105, 5885-5890. doi: 10.1073/pnas.0711949105
-
(2008)
Proc. Natl. Acad. Sci. U.S.A
, vol.105
, pp. 5885-5890
-
-
Liu, M.1
Zhang, Y.2
Inouye, M.3
Woychik, N.A.4
-
109
-
-
0042346293
-
Crystal structure of the intrinsically flexible addiction antidote MazE
-
Loris, R., Marianovsky, I., Lah, J., Laeremans, T., Engelberg-Kulka, H., Glaser, G., et al. (2003). Crystal structure of the intrinsically flexible addiction antidote MazE. J. Biol. Chem. 278, 28252-28257. doi: 10.1074/jbc. M302336200
-
(2003)
J. Biol. Chem
, vol.278
, pp. 28252-28257
-
-
Loris, R.1
Marianovsky, I.2
Lah, J.3
Laeremans, T.4
Engelberg-Kulka, H.5
Glaser, G.6
-
110
-
-
33750443632
-
Structural basis for nucleic acid and toxin recognition of the bacterial antitoxin CcdA
-
Madl, T., Van Melderen, L., Mine, N., Respondek, M., Oberer, M., Keller, W., et al. (2006). Structural basis for nucleic acid and toxin recognition of the bacterial antitoxin CcdA. J. Mol. Biol. 364, 170-185. doi: 10.1016/j.jmb.2006.08.082
-
(2006)
J. Mol. Biol
, vol.364
, pp. 170-185
-
-
Madl, T.1
Van Melderen, L.2
Mine, N.3
Respondek, M.4
Oberer, M.5
Keller, W.6
-
111
-
-
84883342218
-
(p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity
-
Maisonneuve, E., Castro-Camargo, M., and Gerdes, K. (2013). (p)ppGpp controls bacterial persistence by stochastic induction of toxin-antitoxin activity. Cell 154, 1140-1150. doi: 10.1016/j.cell.2013.07.048
-
(2013)
Cell
, vol.154
, pp. 1140-1150
-
-
Maisonneuve, E.1
Castro-Camargo, M.2
Gerdes, K.3
-
112
-
-
80055028227
-
Defense Islands in bacterial and archaeal genomes and prediction of novel defense systems
-
Makarova, K. S., Wolf, Y. I., Snir, S., and Koonin, E. V. (2011). Defense Islands in bacterial and archaeal genomes and prediction of novel defense systems. J. Bacteriol. 193, 6039-6056. doi: 10.1128/JB.05535-11
-
(2011)
J. Bacteriol
, vol.193
, pp. 6039-6056
-
-
Makarova, K.S.1
Wolf, Y.I.2
Snir, S.3
Koonin, E.V.4
-
113
-
-
0035937194
-
The Regulation of the Escherichia coli mazEF promoter involves an unusual alternating palindrome
-
Marianovsky, I., Aizenman, E., Engelberg-Kulka, H., and Glaser, G. (2001). The Regulation of the Escherichia coli mazEF promoter involves an unusual alternating palindrome. J. Biol. Chem. 276, 5975-5984. doi: 10.1074/jbc. M008832200
-
(2001)
J. Biol. Chem
, vol.276
, pp. 5975-5984
-
-
Marianovsky, I.1
Aizenman, E.2
Engelberg-Kulka, H.3
Glaser, G.4
-
114
-
-
84890181690
-
Preventing bacterial suicide: a novel toxin-antitoxin strategy
-
Markovski, M., and Wickner, S. (2013). Preventing bacterial suicide: a novel toxin-antitoxin strategy. Mol. Cell 52, 611-612. doi: 10.1016/j.molcel.2013.11.018
-
(2013)
Mol. Cell
, vol.52
, pp. 611-612
-
-
Markovski, M.1
Wickner, S.2
-
115
-
-
84861347512
-
YeeU enhances the bundling of cytoskeletal polymers of MreB and FtsZ, antagonizing the CbtA (YeeV) toxicity in Escherichia coli
-
Masuda, H., Tan, Q., Awano, N., Wu, K.-P., and Inouye, M. (2012). YeeU enhances the bundling of cytoskeletal polymers of MreB and FtsZ, antagonizing the CbtA (YeeV) toxicity in Escherichia coli. Mol. Microbiol. 84, 979-989. doi: 10.1111/j.1365-2958.2012.08068.x
-
(2012)
Mol. Microbiol
, vol.84
, pp. 979-989
-
-
Masuda, H.1
Tan, Q.2
Awano, N.3
Wu, K.-P.4
Inouye, M.5
-
116
-
-
84860196578
-
Crystal structure of the DNA-bound VapBC2 antitoxin/toxin pair from Rickettsia felis
-
Maté, M. J., Vincentelli, R., Foos, N., Raoult, D., Cambillau, C., and Ortiz-Lombardía, M. (2012). Crystal structure of the DNA-bound VapBC2 antitoxin/toxin pair from Rickettsia felis. Nucleic Acids Res. 40, 3245-3258. doi: 10.1093/nar/gkr1167
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 3245-3258
-
-
Maté, M.J.1
Vincentelli, R.2
Foos, N.3
Raoult, D.4
Cambillau, C.5
Ortiz-Lombardía, M.6
-
117
-
-
33846011436
-
Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs
-
Mattison, K., Wilbur, J. S., So, M., and Brennan, R. G. (2006). Structure of FitAB from Neisseria gonorrhoeae bound to DNA reveals a tetramer of toxin-antitoxin heterodimers containing pin domains and ribbon-helix-helix motifs. J. Biol. Chem. 281, 37942-37951. doi: 10.1074/jbc. M605198200
-
(2006)
J. Biol. Chem
, vol.281
, pp. 37942-37951
-
-
Mattison, K.1
Wilbur, J.S.2
So, M.3
Brennan, R.G.4
-
118
-
-
84861397933
-
Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry
-
McKenzie, J. L., Duyvestyn, J. M., Smith, T., Bendak, K., Mackay, J., Cursons, R., et al. (2012). Determination of ribonuclease sequence-specificity using Pentaprobes and mass spectrometry. RNA 18, 1267-1278. doi: 10.1261/rna.031229.111
-
(2012)
RNA
, vol.18
, pp. 1267-1278
-
-
McKenzie, J.L.1
Duyvestyn, J.M.2
Smith, T.3
Bendak, K.4
Mackay, J.5
Cursons, R.6
-
119
-
-
0037452810
-
Crystal structure of the plasmid maintenance system ε/ζ?: functional mechanism of toxin ζ and inactivation by e2ζ2 complex formation
-
Meinhart, A., Alonso, J. C., Sträter, N., and Saenger, W. (2003). Crystal structure of the plasmid maintenance system ε/ζ?: functional mechanism of toxin ζ and inactivation by e2ζ2 complex formation. Proc. Natl. Acad. Sci. U.S.A. 100, 1661-1666. doi: 10.1073/pnas.0434325100
-
(2003)
Proc. Natl. Acad. Sci. U.S.A
, vol.100
, pp. 1661-1666
-
-
Meinhart, A.1
Alonso, J.C.2
Sträter, N.3
Saenger, W.4
-
120
-
-
84941003568
-
Analysis of the Bacillus cereus SpoIIS antitoxin-toxin system reveals its three-component nature
-
Melnicáková, J., Beèárová, Z., Makroczyová, J., and Barák, I. (2015). Analysis of the Bacillus cereus SpoIIS antitoxin-toxin system reveals its three-component nature. Front. Microbiol. 6:808. doi: 10.3389/fmicb.2015.00808
-
(2015)
Front. Microbiol
, vol.6
, pp. 808
-
-
Melnicáková, J.1
Beèárová, Z.2
Makroczyová, J.3
Barák, I.4
-
121
-
-
58649099643
-
Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems VapBC-5 from Mycobacterium tuberculosis
-
Miallau, L., Faller, M., Chiang, J., Arbing, M., Guo, F., Cascio, D., et al. (2009). Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. J. Biol. Chem. 284, 276-83. doi: 10.1074/jbc. M805061200
-
(2009)
J. Biol. Chem
, vol.284
, pp. 276-283
-
-
Miallau, L.1
Faller, M.2
Chiang, J.3
Arbing, M.4
Guo, F.5
Cascio, D.6
-
122
-
-
0028882589
-
P22 Arc repressor: transition state properties inferred from mutational effects on the rates of protein unfolding and refolding
-
Milla, M. E., Brown, B. M., Waldburger, C. D., and Sauer, R. T. (1995). P22 Arc repressor: transition state properties inferred from mutational effects on the rates of protein unfolding and refolding. Biochemistry 34, 13914-13919. doi: 10.1021/bi00042a024
-
(1995)
Biochemistry
, vol.34
, pp. 13914-13919
-
-
Milla, M.E.1
Brown, B.M.2
Waldburger, C.D.3
Sauer, R.T.4
-
123
-
-
84867679061
-
The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg2+ ion in the active site and a putative RNA-binding site
-
Min, A. B., Miallau, L., Sawaya, M. R., Habel, J., Cascio, D., and Eisenberg, D. (2012). The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg2+ ion in the active site and a putative RNA-binding site. Protein Sci. 21, 1754-1767. doi: 10.1002/pro.2161
-
(2012)
Protein Sci
, vol.21
, pp. 1754-1767
-
-
Min, A.B.1
Miallau, L.2
Sawaya, M.R.3
Habel, J.4
Cascio, D.5
Eisenberg, D.6
-
124
-
-
67650299651
-
The decay of the chromosomally encoded ccdO157 toxin-antitoxin system in the Escherichia coli species
-
Mine, N., Guglielmini, J., Wilbaux, M., and Van Melderen, L. (2009). The decay of the chromosomally encoded ccdO157 toxin-antitoxin system in the Escherichia coli species. Genetics 181, 1557-1566. doi: 10.1534/genetics.108.095190
-
(2009)
Genetics
, vol.181
, pp. 1557-1566
-
-
Mine, N.1
Guglielmini, J.2
Wilbaux, M.3
Van Melderen, L.4
-
125
-
-
34247133389
-
Interactions of Kid-Kis toxin-antitoxin complexes with the parD operator-promoter region of plasmid R1 are piloted by the Kis antitoxin and tuned by the stoichiometry of Kid-Kis oligomers
-
Monti, M. C., Hernández-Arriaga, A. M., Kamphuis, M. B., López-Villarejo, J., Heck, A. J. R., Boelens, R., et al. (2007). Interactions of Kid-Kis toxin-antitoxin complexes with the parD operator-promoter region of plasmid R1 are piloted by the Kis antitoxin and tuned by the stoichiometry of Kid-Kis oligomers. Nucleic Acids Res. 35, 1737-1749. doi: 10.1093/nar/gkm073
-
(2007)
Nucleic Acids Res
, vol.35
, pp. 1737-1749
-
-
Monti, M.C.1
Hernández-Arriaga, A.M.2
Kamphuis, M.B.3
López-Villarejo, J.4
Heck, A.J.R.5
Boelens, R.6
-
126
-
-
84862184967
-
The toxin-antitoxin proteins relBE2Spn of Streptococcus pneumoniae: characterization and association to their DNA target
-
Moreno-Córdoba, I., Diago-Navarro, E., Barendregt, A., Heck, A. J. R., Alfonso, C., Díaz-Orejas, R., et al. (2012). The toxin-antitoxin proteins relBE2Spn of Streptococcus pneumoniae: characterization and association to their DNA target. Proteins 80, 1834-1846. doi: 10.1002/prot.24081
-
(2012)
Proteins
, vol.80
, pp. 1834-1846
-
-
Moreno-Córdoba, I.1
Diago-Navarro, E.2
Barendregt, A.3
Heck, A.J.R.4
Alfonso, C.5
Díaz-Orejas, R.6
-
127
-
-
0035824885
-
Crystal structure of omega transcriptional repressor encoded by Streptococcus pyogenes plasmid pSM19035 at 1.5 A resolution
-
Murayama, K., Orth, P., de la Hoz, A. B., Alonso, J. C., and Saenger, W. (2001). Crystal structure of omega transcriptional repressor encoded by Streptococcus pyogenes plasmid pSM19035 at 1.5 A resolution. J. Mol. Biol. 314, 789-796. doi: 10.1006/jmbi.2001.5157
-
(2001)
J. Mol. Biol
, vol.314
, pp. 789-796
-
-
Murayama, K.1
Orth, P.2
de la Hoz, A.B.3
Alonso, J.C.4
Saenger, W.5
-
128
-
-
79953708539
-
A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis
-
Mutschler, H., Gebhardt, M., Shoeman, R. L., and Meinhart, A. (2011). A novel mechanism of programmed cell death in bacteria by toxin-antitoxin systems corrupts peptidoglycan synthesis. PLoS Biol. 9:e1001033. doi: 10.1371/journal.pbio.1001033
-
(2011)
PLoS Biol
, vol.9
-
-
Mutschler, H.1
Gebhardt, M.2
Shoeman, R.L.3
Meinhart, A.4
-
129
-
-
84655169530
-
e/ζ systems: their role in resistance, virulence, and their potential for antibiotic development
-
Mutschler, H., and Meinhart, A. (2011). e/ζ systems: their role in resistance, virulence, and their potential for antibiotic development. J. Mol. Med. 89, 1183-1194. doi: 10.1007/s00109-011-0797-4
-
(2011)
J. Mol. Med
, vol.89
, pp. 1183-1194
-
-
Mutschler, H.1
Meinhart, A.2
-
130
-
-
84930257639
-
'Type II Toxin-antitoxin loci: the epsilon/zeta family'
-
ed. K. Gerdes (Berlin, Heidelberg: Springer Berlin Heidelberg)
-
Mutschler, H., and Meinhart, A. (2013). "Type II Toxin-antitoxin loci: the epsilon/zeta family". in Prokaryotic Toxin-Antitoxins, ed K. Gerdes (Berlin, Heidelberg: Springer Berlin Heidelberg), 205-223
-
(2013)
Prokaryotic Toxin-Antitoxins
, pp. 205-223
-
-
Mutschler, H.1
Meinhart, A.2
-
131
-
-
37649005671
-
MazF, an mRNA Interferase, mediates programmed cell death during multicellular myxococcus development
-
Nariya, H., and Inouye, M. (2008). MazF, an mRNA Interferase, mediates programmed cell death during multicellular myxococcus development. Cell 132, 55-66. doi: 10.1016/j.cell.2007.11.044
-
(2008)
Cell
, vol.132
, pp. 55-66
-
-
Nariya, H.1
Inouye, M.2
-
132
-
-
84857683425
-
Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis
-
Nicolas, P., Mäder, U., Dervyn, E., Rochat, T., Leduc, A., Pigeonneau, N., et al. (2012). Condition-dependent transcriptome reveals high-level regulatory architecture in Bacillus subtilis. Science 335, 1103-1106. doi: 10.1126/science.1206848
-
(2012)
Science
, vol.335
, pp. 1103-1106
-
-
Nicolas, P.1
Mäder, U.2
Dervyn, E.3
Rochat, T.4
Leduc, A.5
Pigeonneau, N.6
-
133
-
-
33846897363
-
The yefM-yoeB toxin-antitoxin systems of Escherichia coli and Streptococcus pneumoniae: functional and structural correlation
-
Nieto, C., Cherny, I., Khoo, S. K., De Lacoba, M. G., Chan, W. T., Yeo, C. C., et al. (2007). The yefM-yoeB toxin-antitoxin systems of Escherichia coli and Streptococcus pneumoniae: functional and structural correlation. J. Bacteriol. 189, 1266-1278. doi: 10.1128/JB.01130-06
-
(2007)
J. Bacteriol
, vol.189
, pp. 1266-1278
-
-
Nieto, C.1
Cherny, I.2
Khoo, S.K.3
De Lacoba, M.G.4
Chan, W.T.5
Yeo, C.C.6
-
134
-
-
84881250387
-
Two paralogous yefM-yoeB loci from Staphylococcus equorum encode functional toxin-antitoxin systems
-
Nolle, N., Schuster, C. F., and Bertram, R. (2013). Two paralogous yefM-yoeB loci from Staphylococcus equorum encode functional toxin-antitoxin systems. Microbiology 159, 1575-1585. doi: 10.1099/mic.0.068049-0
-
(2013)
Microbiology
, vol.159
, pp. 1575-1585
-
-
Nolle, N.1
Schuster, C.F.2
Bertram, R.3
-
135
-
-
84868113986
-
Toxin-antitoxin systems are important for niche-specific colonization and stress resistance of uropathogenic Escherichia coli
-
Norton, J. P., and Mulvey, M. A. (2012). Toxin-antitoxin systems are important for niche-specific colonization and stress resistance of uropathogenic Escherichia coli. PLoS Pathog. 8:e1002954. doi: 10.1371/journal.ppat.1002954
-
(2012)
PLoS Pathog
, vol.8
-
-
Norton, J.P.1
Mulvey, M.A.2
-
136
-
-
34547564386
-
The solution structure of ParD, the antidote of the ParDE toxin antitoxin module, provides the structural basis for DNA and toxin binding
-
Oberer, M., Zangger, K., Gruber, K., and Keller, W. (2007). The solution structure of ParD, the antidote of the ParDE toxin antitoxin module, provides the structural basis for DNA and toxin binding. Protein Sci. 16, 1676-1688. doi: 10.1110/ps.062680707
-
(2007)
Protein Sci
, vol.16
, pp. 1676-1688
-
-
Oberer, M.1
Zangger, K.2
Gruber, K.3
Keller, W.4
-
137
-
-
84954408638
-
Prokaryotic toxin-antitoxin systems: novel regulations of the toxins
-
[Epub ahead of print]
-
Otsuka, Y. (2016). Prokaryotic toxin-antitoxin systems: novel regulations of the toxins. Curr. Genet. doi: 10.1007/s00294-015-0557-z. [Epub ahead of print]
-
(2016)
Curr. Genet
-
-
Otsuka, Y.1
-
138
-
-
70350552019
-
RelB and RelE of Escherichia coli form a tight complex that represses transcription via the ribbon-helix-helix motif in RelB
-
Overgaard, M., Borch, J., and Gerdes, K. (2009). RelB and RelE of Escherichia coli form a tight complex that represses transcription via the ribbon-helix-helix motif in RelB. J. Mol. Biol. 394, 183-196. doi: 10.1016/j.jmb.2009.09.006
-
(2009)
J. Mol. Biol
, vol.394
, pp. 183-196
-
-
Overgaard, M.1
Borch, J.2
Gerdes, K.3
-
139
-
-
47749089764
-
Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity
-
Overgaard, M., Borch, J., Jørgensen, M. G., and Gerdes, K. (2008). Messenger RNA interferase RelE controls relBE transcription by conditional cooperativity. Mol. Microbiol. 69, 841-857. doi: 10.1111/j.1365-2958.2008.06313.x
-
(2008)
Mol. Microbiol
, vol.69
, pp. 841-857
-
-
Overgaard, M.1
Borch, J.2
Jørgensen, M.G.3
Gerdes, K.4
-
140
-
-
19244372639
-
Variable structures of Fis-DNA complexes determined by flanking DNA-protein contacts
-
Pan, C. Q., Finkel, S. E., Cramton, S. E., Feng, J. A., Sigman, D. S., and Johnson, R. C. (1996). Variable structures of Fis-DNA complexes determined by flanking DNA-protein contacts. J. Mol. Biol. 264, 675-695. doi: 10.1006/jmbi.1996.0669
-
(1996)
J. Mol. Biol
, vol.264
, pp. 675-695
-
-
Pan, C.Q.1
Finkel, S.E.2
Cramton, S.E.3
Feng, J.A.4
Sigman, D.S.5
Johnson, R.C.6
-
141
-
-
14244266086
-
Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes
-
Pandey, D. P., and Gerdes, K. (2005). Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes. Nucleic Acids Res. 33, 966-976. doi: 10.1093/nar/gki201
-
(2005)
Nucleic Acids Res
, vol.33
, pp. 966-976
-
-
Pandey, D.P.1
Gerdes, K.2
-
142
-
-
0037428226
-
The bacterial toxin RelE displays codon-specific cleavage of mRNAs in the ribosomal A site
-
Pedersen, K., Zavialov, A. V., Pavlov, M. Y., Elf, J., Gerdes, K., and Ehrenberg, M. (2003). The bacterial toxin RelE displays codon-specific cleavage of mRNAs in the ribosomal A site. Cell 112, 131-140. doi: 10.1016/S0092-8674(02)01248-5
-
(2003)
Cell
, vol.112
, pp. 131-140
-
-
Pedersen, K.1
Zavialov, A.V.2
Pavlov, M.Y.3
Elf, J.4
Gerdes, K.5
Ehrenberg, M.6
-
143
-
-
27144544573
-
Kid cleaves specific mRNAs at UUACU sites to rescue the copy number of plasmid R1
-
Pimentel, B., Madine, M. A., and de la Cueva-Méndez, G. (2005). Kid cleaves specific mRNAs at UUACU sites to rescue the copy number of plasmid R1. EMBO J. 24, 3459-3469. doi: 10.1038/sj.emboj.7600815
-
(2005)
EMBO J
, vol.24
, pp. 3459-3469
-
-
Pimentel, B.1
Madine, M.A.2
de la Cueva-Méndez, G.3
-
144
-
-
84886599842
-
Amino acid residues crucial for specificity of toxin-antitoxin interactions in the homologous Axe-Txe and YefM-YoeB complexes
-
Polom, D., Boss, L., Wêgrzyn, G., Hayes, F., and Kêdzierska, B. (2013). Amino acid residues crucial for specificity of toxin-antitoxin interactions in the homologous Axe-Txe and YefM-YoeB complexes. FEBS J. 280, 5906-5918. doi: 10.1111/febs.12517
-
(2013)
FEBS J
, vol.280
, pp. 5906-5918
-
-
Polom, D.1
Boss, L.2
Wêgrzyn, G.3
Hayes, F.4
Kêdzierska, B.5
-
145
-
-
0035664175
-
Genetic organization of the Francisella plasmid pFNL10
-
Pomerantsev, A. P., Golovliov, I. R., Ohara, Y., Mokrievich, A. N., Obuchi, M., Norqvist, A., et al. (2001). Genetic organization of the Francisella plasmid pFNL10. Plasmid 46, 210-222. doi: 10.1006/plas.2001.1548
-
(2001)
Plasmid
, vol.46
, pp. 210-222
-
-
Pomerantsev, A.P.1
Golovliov, I.R.2
Ohara, Y.3
Mokrievich, A.N.4
Obuchi, M.5
Norqvist, A.6
-
146
-
-
84978476493
-
Repurposing a prokaryotic Toxin-Antitoxin system for the selective killing of oncogenically stressed human cells
-
[Epub ahead of print]
-
Preston, M. A., Pimentel, B., Bermejo-Rodríguez, C., Dionne, I., Turnbull, A., and de la Cueva-Méndez, G. (2015). Repurposing a prokaryotic Toxin-Antitoxin system for the selective killing of oncogenically stressed human cells. ACS Synth. Biol. doi: 10.1021/acssynbio.5b00096. [Epub ahead of print]
-
(2015)
ACS Synth. Biol
-
-
Preston, M.A.1
Pimentel, B.2
Bermejo-Rodríguez, C.3
Dionne, I.4
Turnbull, A.5
de la Cueva-Méndez, G.6
-
147
-
-
74249084586
-
Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution
-
Ramage, H. R., Connolly, L. E., and Cox, J. S. (2009). Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. PLoS Genet. 5:e1000767. doi: 10.1371/journal.pgen.1000767
-
(2009)
PLoS Genet
, vol.5
-
-
Ramage, H.R.1
Connolly, L.E.2
Cox, J.S.3
-
148
-
-
0033062929
-
Proteic toxin-antitoxin, bacterial plasmid addiction systems and their evolution withs special reference to the pas system of pTF-FC2
-
Rawlings, D. E. (1999). Proteic toxin-antitoxin, bacterial plasmid addiction systems and their evolution withs special reference to the pas system of pTF-FC2. FEMS Microbiol. Lett. 176, 269-277. doi: 10.1111/j.1574-6968.1999.tb13672.x
-
(1999)
FEMS Microbiol. Lett
, vol.176
, pp. 269-277
-
-
Rawlings, D.E.1
-
149
-
-
4644277087
-
Stationary-phase quorum-sensing signals affect autoinducer-2 and gene expression in Escherichia coli
-
Ren, D., Bedzyk, L. A., Ye, R. W., Thomas, S. M., and Wood, T. K. (2004). Stationary-phase quorum-sensing signals affect autoinducer-2 and gene expression in Escherichia coli. Appl. Environ. Microbiol. 70, 2038-2043. doi: 10.1128/AEM.70.4.2038-2043.2004
-
(2004)
Appl. Environ. Microbiol
, vol.70
, pp. 2038-2043
-
-
Ren, D.1
Bedzyk, L.A.2
Ye, R.W.3
Thomas, S.M.4
Wood, T.K.5
-
150
-
-
84924340107
-
Transcription factor MrpC binds to promoter regions of hundreds of developmentally-regulated genes in Myxococcus xanthus
-
Robinson, M., Son, B., Kroos, D., and Kroos, L. (2014). Transcription factor MrpC binds to promoter regions of hundreds of developmentally-regulated genes in Myxococcus xanthus. BMC Genomics 15:1123. doi: 10.1186/1471-2164-15-1123
-
(2014)
BMC Genomics
, vol.15
, pp. 1123
-
-
Robinson, M.1
Son, B.2
Kroos, D.3
Kroos, L.4
-
151
-
-
67449100648
-
The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation
-
Robson, J., McKenzie, J. L., Cursons, R., Cook, G. M., and Arcus, V. L. (2009). The vapBC operon from Mycobacterium smegmatis is an autoregulated toxin-antitoxin module that controls growth via inhibition of translation. J. Mol. Biol. 390, 353-367. doi: 10.1016/j.jmb.2009.05.006
-
(2009)
J. Mol. Biol
, vol.390
, pp. 353-367
-
-
Robson, J.1
McKenzie, J.L.2
Cursons, R.3
Cook, G.M.4
Arcus, V.L.5
-
152
-
-
84937953165
-
A cis-acting antitoxin domain within the chromosomal toxin-antitoxin module EzeT of Escherichia coli quenches toxin activity
-
Rocker, A., and Meinhart, A. (2015a). A cis-acting antitoxin domain within the chromosomal toxin-antitoxin module EzeT of Escherichia coli quenches toxin activity. Mol. Microbiol. 97, 589-604. doi: 10.1111/mmi.13051
-
(2015)
Mol. Microbiol
, vol.97
, pp. 589-604
-
-
Rocker, A.1
Meinhart, A.2
-
153
-
-
84947931596
-
Type II toxin: antitoxin systems More than small selfish entities
-
[Epub ahead of print]
-
Rocker, A., and Meinhart, A. (2015b). Type II toxin: antitoxin systems. More than small selfish entities? Curr. Genet. doi: 10.1007/s00294-015-0541-7. [Epub ahead of print]
-
(2015)
Curr. Genet
-
-
Rocker, A.1
Meinhart, A.2
-
154
-
-
0037350819
-
Comparative analysis of superintegrons: engineering extensive genetic diversity in the Vibrionaceae
-
Rowe-Magnus, D. A., Guerout, A.-M., Biskri, L., Bouige, P., and Mazel, D. (2003). Comparative analysis of superintegrons: engineering extensive genetic diversity in the Vibrionaceae. Genome Res. 13, 428-442. doi: 10.1101/gr.617103
-
(2003)
Genome Res
, vol.13
, pp. 428-442
-
-
Rowe-Magnus, D.A.1
Guerout, A.-M.2
Biskri, L.3
Bouige, P.4
Mazel, D.5
-
155
-
-
84905387098
-
Mechanisms of toxin inhibition and transcriptional repression by Escherichia coli DinJ-YafQ
-
Ruangprasert, A., Maehigashi, T., Miles, S. J., Giridharan, N., Liu, J. X., and Dunham, C. M. (2014). Mechanisms of toxin inhibition and transcriptional repression by Escherichia coli DinJ-YafQ. J. Biol. Chem. 289, 20559-20569. doi: 10.1074/jbc. M114.573006
-
(2014)
J. Biol. Chem
, vol.289
, pp. 20559-20569
-
-
Ruangprasert, A.1
Maehigashi, T.2
Miles, S.J.3
Giridharan, N.4
Liu, J.X.5
Dunham, C.M.6
-
156
-
-
46049106335
-
Chromosomal toxin-antitoxin systems may act as antiaddiction modules
-
Saavedra De Bast, M., Mine, N., and Van Melderen, L. (2008). Chromosomal toxin-antitoxin systems may act as antiaddiction modules. J. Bacteriol. 190, 4603-4809. doi: 10.1128/JB.00357-08
-
(2008)
J. Bacteriol
, vol.190
, pp. 4603-4809
-
-
Saavedra De Bast, M.1
Mine, N.2
Van Melderen, L.3
-
157
-
-
58449087611
-
Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB
-
Schumacher, M. A., Piro, K. M., Xu, W., Hansen, S., Lewis, K., and Brennan, R. G. (2009). Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science 323, 396-401. doi: 10.1126/science.1163806
-
(2009)
Science
, vol.323
, pp. 396-401
-
-
Schumacher, M.A.1
Piro, K.M.2
Xu, W.3
Hansen, S.4
Lewis, K.5
Brennan, R.G.6
-
158
-
-
84891938260
-
Structure of the Proteus vulgaris HigB-(HigA)2-HigB toxin-antitoxin complex
-
Schureck, M. A., Maehigashi, T., Miles, S. J., Marquez, J., Cho, S. E., Erdman, R., et al. (2014). Structure of the Proteus vulgaris HigB-(HigA)2-HigB toxin-antitoxin complex. J. Biol. Chem. 289, 1060-1070. doi: 10.1074/jbc. M113.512095
-
(2014)
J. Biol. Chem
, vol.289
, pp. 1060-1070
-
-
Schureck, M.A.1
Maehigashi, T.2
Miles, S.J.3
Marquez, J.4
Cho, S.E.5
Erdman, R.6
-
159
-
-
84858201601
-
Identification of the first functional toxin-antitoxin system in Streptomyces
-
Sevillano, L., Díaz, M., Yamaguchi, Y., Inouye, M., and Santamaría, R. I. (2012). Identification of the first functional toxin-antitoxin system in Streptomyces. PLoS ONE 7:e32977. doi: 10.1371/journal.pone.0032977
-
(2012)
PLoS ONE
, vol.7
-
-
Sevillano, L.1
Díaz, M.2
Yamaguchi, Y.3
Inouye, M.4
Santamaría, R.I.5
-
160
-
-
78651266381
-
TADB: a web-based resource for Type 2 toxin-antitoxin loci in bacteria and archaea
-
Shao, Y., Harrison, E. M., Bi, D., Tai, C., He, X., Ou, H.-Y., et al. (2011). TADB: a web-based resource for Type 2 toxin-antitoxin loci in bacteria and archaea. Nucleic Acids Res. 39, D606-D611. doi: 10.1093/nar/gkq908
-
(2011)
Nucleic Acids Res
, vol.39
, pp. D606-D611
-
-
Shao, Y.1
Harrison, E.M.2
Bi, D.3
Tai, C.4
He, X.5
Ou, H.-Y.6
-
161
-
-
84908568144
-
Regression of solid tumors by induction of MazF, a bacterial mRNA endoribonuclease
-
Shimazu, T., Mirochnitchenko, O., Phadtare, S., and Inouye, M. (2014). Regression of solid tumors by induction of MazF, a bacterial mRNA endoribonuclease. J. Mol. Microbiol. Biotechnol. 24, 228-233. doi: 10.1159/000365509
-
(2014)
J. Mol. Microbiol. Biotechnol
, vol.24
, pp. 228-233
-
-
Shimazu, T.1
Mirochnitchenko, O.2
Phadtare, S.3
Inouye, M.4
-
162
-
-
0030709394
-
The poison-antidote stability system of the broad-host-range Thiobacillus ferrooxidans plasmid pTF-FC2
-
Smith, A. S., and Rawlings, D. E. (1997). The poison-antidote stability system of the broad-host-range Thiobacillus ferrooxidans plasmid pTF-FC2. Mol. Microbiol. 26, 961-970. doi: 10.1046/j.1365-2958.1997.6332000.x
-
(1997)
Mol. Microbiol
, vol.26
, pp. 961-970
-
-
Smith, A.S.1
Rawlings, D.E.2
-
163
-
-
0031656595
-
Autoregulation of the pTF-FC2 proteic poison-antidote plasmid addiction system (pas) is essential for plasmid stabilization
-
Smith, A. S., and Rawlings, D. E. (1998a). Autoregulation of the pTF-FC2 proteic poison-antidote plasmid addiction system (pas) is essential for plasmid stabilization. J. Bacteriol. 180, 5463-5465
-
(1998)
J. Bacteriol
, vol.180
, pp. 5463-5465
-
-
Smith, A.S.1
Rawlings, D.E.2
-
164
-
-
0031690672
-
Efficiency of the pTF-FC2 pas poison-antidote stability system in Escherichia coli is affected by the host strain, and antidote degradation requires the lon protease
-
Smith, A. S., and Rawlings, D. E. (1998b). Efficiency of the pTF-FC2 pas poison-antidote stability system in Escherichia coli is affected by the host strain, and antidote degradation requires the lon protease. J. Bacteriol. 180, 5458-5462
-
(1998)
J. Bacteriol
, vol.180
, pp. 5458-5462
-
-
Smith, A.S.1
Rawlings, D.E.2
-
165
-
-
84887850298
-
Antitoxin MqsA represses curli formation through the master biofilm regulator CsgD
-
Soo, V. W. C., and Wood, T. K. (2013). Antitoxin MqsA represses curli formation through the master biofilm regulator CsgD. Sci. Rep. 3, 3186. doi: 10.1038/srep03186
-
(2013)
Sci. Rep
, vol.3
, pp. 3186
-
-
Soo, V.W.C.1
Wood, T.K.2
-
166
-
-
54349109072
-
The art of selective killing: plasmid toxin/antitoxin systems and their technological applications
-
Stieber, D., Gabant, P., and Szpirer, C. Y. (2008). The art of selective killing: plasmid toxin/antitoxin systems and their technological applications. Biotechniques 45, 344-346. doi: 10.2144/000112955
-
(2008)
Biotechniques
, vol.45
, pp. 344-346
-
-
Stieber, D.1
Gabant, P.2
Szpirer, C.Y.3
-
167
-
-
33947330447
-
Chromosomal toxin-antitoxin loci can diminish large-scale genome reductions in the absence of selection
-
Szekeres, S., Dauti, M., Wilde, C., Mazel, D., and Rowe-Magnus, D. A. (2007). Chromosomal toxin-antitoxin loci can diminish large-scale genome reductions in the absence of selection. Mol. Microbiol. 63, 1588-1605. doi: 10.1111/j.1365-2958.2007.05613.x
-
(2007)
Mol. Microbiol
, vol.63
, pp. 1588-1605
-
-
Szekeres, S.1
Dauti, M.2
Wilde, C.3
Mazel, D.4
Rowe-Magnus, D.A.5
-
168
-
-
84929941876
-
Toxin ζ reversible induces dormancy and reduces the UDP-N-acetylglucosamine pool as one of the protective responses to cope with stress
-
Tabone, M., Ayora, S., and Alonso, J. C. (2014). Toxin ζ reversible induces dormancy and reduces the UDP-N-acetylglucosamine pool as one of the protective responses to cope with stress. Toxins (Basel). 6, 2787-2803. doi: 10.3390/toxins6092787
-
(2014)
Toxins (Basel)
, vol.6
, pp. 2787-2803
-
-
Tabone, M.1
Ayora, S.2
Alonso, J.C.3
-
169
-
-
18744409067
-
Crystal structure of archaeal toxin-antitoxin RelE-RelB complex with implications for toxin activity and antitoxin effects
-
Takagi, H., Kakuta, Y., Okada, T., Yao, M., Tanaka, I., and Kimura, M. (2005). Crystal structure of archaeal toxin-antitoxin RelE-RelB complex with implications for toxin activity and antitoxin effects. Nat. Struct. Mol. Biol. 12, 327-331. doi: 10.1038/nsmb911
-
(2005)
Nat. Struct. Mol. Biol
, vol.12
, pp. 327-331
-
-
Takagi, H.1
Kakuta, Y.2
Okada, T.3
Yao, M.4
Tanaka, I.5
Kimura, M.6
-
170
-
-
84890282338
-
A moderate toxin, GraT, modulates growth rate and stress tolerance of Pseudomonas putida
-
Tamman, H., Ainelo, A., Ainsaar, K., and Hõrak, R. (2014). A moderate toxin, GraT, modulates growth rate and stress tolerance of Pseudomonas putida. J. Bacteriol. 196, 157-169. doi: 10.1128/JB.00851-13
-
(2014)
J. Bacteriol
, vol.196
, pp. 157-169
-
-
Tamman, H.1
Ainelo, A.2
Ainsaar, K.3
Hõrak, R.4
-
171
-
-
84878457598
-
Programmed cell death in bacteria and implications for antibiotic therapy
-
Tanouchi, Y., Lee, A. J., Meredith, H., and You, L. (2013). Programmed cell death in bacteria and implications for antibiotic therapy. Trends Microbiol. 21, 265-270. doi: 10.1016/j.tim.2013.04.001
-
(2013)
Trends Microbiol
, vol.21
, pp. 265-270
-
-
Tanouchi, Y.1
Lee, A.J.2
Meredith, H.3
You, L.4
-
172
-
-
0029876244
-
A new plasmid-encoded proteic killer gene system: cloning, sequencing, and analyzing hig locus of plasmid Rts1
-
Tian, Q. B., Ohnishi, M., Tabuchi, A., and Terawaki, Y. (1996). A new plasmid-encoded proteic killer gene system: cloning, sequencing, and analyzing hig locus of plasmid Rts1. Biochem. Biophys. Res. Commun. 220, 280-284. doi: 10.1006/bbrc.1996.0396
-
(1996)
Biochem. Biophys. Res. Commun
, vol.220
, pp. 280-284
-
-
Tian, Q.B.1
Ohnishi, M.2
Tabuchi, A.3
Terawaki, Y.4
-
173
-
-
84892872968
-
Toxin-antitoxin systems: biology, identification, and application
-
Unterholzner, S. J., Poppenberger, B., and Rozhon, W. (2013). Toxin-antitoxin systems: biology, identification, and application. Mob. Genet. Elements 3:e26219. doi: 10.4161/mge.26219
-
(2013)
Mob. Genet. Elements
, vol.3
-
-
Unterholzner, S.J.1
Poppenberger, B.2
Rozhon, W.3
-
174
-
-
63449102873
-
Bacterial toxin-antitoxin systems: more than selfish entities?
-
Van Melderen, L., and Saavedra De Bast, M. (2009). Bacterial toxin-antitoxin systems: more than selfish entities? PLoS Genet. 5:e1000437. doi: 10.1371/journal.pgen.1000437
-
(2009)
PLoS Genet
, vol.5
-
-
Van Melderen, L.1
Saavedra De Bast, M.2
-
175
-
-
78649649439
-
Toxin-antitoxin systems: why so many, what for?
-
Van Melderen, L. (2010). Toxin-antitoxin systems: why so many, what for? Curr. Opin. Microbiol. 13, 781-785. doi: 10.1016/j.mib.2010.10.006
-
(2010)
Curr. Opin. Microbiol
, vol.13
, pp. 781-785
-
-
Van Melderen, L.1
-
176
-
-
80053563668
-
Selective translation of leaderless mRNAs by specialized ribosomes generated by MazF in Escherichia coli
-
Vesper, O., Amitai, S., Belitsky, M., Byrgazov, K., Kaberdina, A. C., Engelberg-Kulka, H., et al. (2011). Selective translation of leaderless mRNAs by specialized ribosomes generated by MazF in Escherichia coli. Cell 147, 147-157. doi: 10.1016/j.cell.2011.07.047
-
(2011)
Cell
, vol.147
, pp. 147-157
-
-
Vesper, O.1
Amitai, S.2
Belitsky, M.3
Byrgazov, K.4
Kaberdina, A.C.5
Engelberg-Kulka, H.6
-
177
-
-
84959440300
-
The interaction of ω2 with the RNA polymerase β' subunit functions as an activation to repression switch
-
Volante, A., Carrasco, B., Tabone, M., and Alonso, J. C. (2015). The interaction of ω2 with the RNA polymerase β' subunit functions as an activation to repression switch. Nucleic Acids Res. 43, 9249-9261. doi: 10.1093/nar/gkv788
-
(2015)
Nucleic Acids Res
, vol.43
, pp. 9249-9261
-
-
Volante, A.1
Carrasco, B.2
Tabone, M.3
Alonso, J.C.4
-
178
-
-
84958794169
-
The interplay between different stability systems contributes to faithful segregation: Streptococcus pyogenes pSM19035 as a Model
-
Volante, A., Soberón, N. E., Ayora, S., and Alonso, J. C. (2014). The interplay between different stability systems contributes to faithful segregation: Streptococcus pyogenes pSM19035 as a Model. Microbiol. Spectr. 2:PLAS-0007-2013. doi: 10.1128/microbiolspec. PLAS-0007-2013
-
(2014)
Microbiol. Spectr
, vol.2
-
-
Volante, A.1
Soberón, N.E.2
Ayora, S.3
Alonso, J.C.4
-
179
-
-
79956074557
-
Antitoxin MqsA helps mediate the bacterial general stress response
-
Wang, X., Kim, Y., Hong, S. H., Ma, Q., Brown, B. L., Pu, M., et al. (2011). Antitoxin MqsA helps mediate the bacterial general stress response. Nat. Chem. Biol. 7, 359-366. doi: 10.1038/nchembio.560
-
(2011)
Nat. Chem. Biol
, vol.7
, pp. 359-366
-
-
Wang, X.1
Kim, Y.2
Hong, S.H.3
Ma, Q.4
Brown, B.L.5
Pu, M.6
-
180
-
-
84870279994
-
A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS
-
Wang, X., Lord, D. M., Cheng, H.-Y., Osbourne, D. O., Hong, S. H., Sanchez-Torres, V., et al. (2012). A new type V toxin-antitoxin system where mRNA for toxin GhoT is cleaved by antitoxin GhoS. Nat. Chem. Biol. 8, 855-861. doi: 10.1038/nchembio.1062
-
(2012)
Nat. Chem. Biol
, vol.8
, pp. 855-861
-
-
Wang, X.1
Lord, D.M.2
Cheng, H.-Y.3
Osbourne, D.O.4
Hong, S.H.5
Sanchez-Torres, V.6
-
181
-
-
84878629593
-
Type II toxin/antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS
-
Wang, X., Lord, D. M., Hong, S. H., Peti, W., Benedik, M. J., Page, R., et al. (2013). Type II toxin/antitoxin MqsR/MqsA controls type V toxin/antitoxin GhoT/GhoS. Environ. Microbiol. 15, 1734-1744. doi: 10.1111/1462-2920.12063
-
(2013)
Environ. Microbiol
, vol.15
, pp. 1734-1744
-
-
Wang, X.1
Lord, D.M.2
Hong, S.H.3
Peti, W.4
Benedik, M.J.5
Page, R.6
-
182
-
-
33645528243
-
Structures of omega repressors bound to direct and inverted DNA repeats explain modulation of transcription
-
Weihofen, W. A., Cicek, A., Pratto, F., Alonso, J. C., and Saenger, W. (2006). Structures of omega repressors bound to direct and inverted DNA repeats explain modulation of transcription. Nucleic Acids Res. 34, 1450-1458. doi: 10.1093/nar/gkl015
-
(2006)
Nucleic Acids Res
, vol.34
, pp. 1450-1458
-
-
Weihofen, W.A.1
Cicek, A.2
Pratto, F.3
Alonso, J.C.4
Saenger, W.5
-
183
-
-
84922709449
-
The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence
-
Wen, Y., Behiels, E., Felix, J., Elegheert, J., Vergauwen, B., Devreese, B., et al. (2014). The bacterial antitoxin HipB establishes a ternary complex with operator DNA and phosphorylated toxin HipA to regulate bacterial persistence. Nucleic Acids Res. 42, 10134-10147. doi: 10.1093/nar/gku665
-
(2014)
Nucleic Acids Res
, vol.42
, pp. 10134-10147
-
-
Wen, Y.1
Behiels, E.2
Felix, J.3
Elegheert, J.4
Vergauwen, B.5
Devreese, B.6
-
184
-
-
84922694514
-
Toxins vapC and pasB from prokaryotic TA modules remain active in mammalian cancer cells
-
Wieteska, L., Skulimowski, A., Cybula, M., and Szemraj, J. (2014). Toxins vapC and pasB from prokaryotic TA modules remain active in mammalian cancer cells. Toxins (Basel). 6, 2948-2961. doi: 10.3390/toxins6102948
-
(2014)
Toxins (Basel)
, vol.6
, pp. 2948-2961
-
-
Wieteska, L.1
Skulimowski, A.2
Cybula, M.3
Szemraj, J.4
-
185
-
-
84862783125
-
Artificial activation of toxin-antitoxin systems as an antibacterial strategy
-
Williams, J. J., and Hergenrother, P. J. (2012). Artificial activation of toxin-antitoxin systems as an antibacterial strategy. Trends Microbiol. 20, 291-298. doi: 10.1016/j.tim.2012.02.005
-
(2012)
Trends Microbiol
, vol.20
, pp. 291-298
-
-
Williams, J.J.1
Hergenrother, P.J.2
-
186
-
-
79956328889
-
Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA
-
Winther, K. S., and Gerdes, K. (2011). Enteric virulence associated protein VapC inhibits translation by cleavage of initiator tRNA. Proc. Natl. Acad. Sci. U.S.A. 108, 7403-7407. doi: 10.1073/pnas.1019587108
-
(2011)
Proc. Natl. Acad. Sci. U.S.A
, vol.108
, pp. 7403-7407
-
-
Winther, K.S.1
Gerdes, K.2
-
187
-
-
84861550633
-
Regulation of enteric vapBC transcription: Induction by VapC toxin dimer-breaking
-
Winther, K. S., and Gerdes, K. (2012). Regulation of enteric vapBC transcription: Induction by VapC toxin dimer-breaking. Nucleic Acids Res. 40, 4347-4357. doi: 10.1093/nar/gks029
-
(2012)
Nucleic Acids Res
, vol.40
, pp. 4347-4357
-
-
Winther, K.S.1
Gerdes, K.2
-
188
-
-
64049098151
-
mRNA interferases, sequence-specific endoribonucleases from the toxin-antitoxin systems
-
Yamaguchi, Y., and Inouye, M. (2009). mRNA interferases, sequence-specific endoribonucleases from the toxin-antitoxin systems. Prog. Mol. Biol. Transl. Sci. 85, 467-500. doi: 10.1016/S0079-6603(08)00812-X
-
(2009)
Prog. Mol. Biol. Transl. Sci
, vol.85
, pp. 467-500
-
-
Yamaguchi, Y.1
Inouye, M.2
-
189
-
-
70350399514
-
MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli
-
Yamaguchi, Y., Park, J.-H., and Inouye, M. (2009). MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli. J. Biol. Chem. 284, 28746-28753. doi: 10.1074/jbc. M109.032904
-
(2009)
J. Biol. Chem
, vol.284
, pp. 28746-28753
-
-
Yamaguchi, Y.1
Park, J.-H.2
Inouye, M.3
-
190
-
-
80755144025
-
Toxin-antitoxin systems in bacteria and archaea
-
Yamaguchi, Y., Park, J.-H., and Inouye, M. (2011). Toxin-antitoxin systems in bacteria and archaea. Annu. Rev. Genet. 45, 61-79. doi: 10.1146/annurev-genet-110410-132412
-
(2011)
Annu. Rev. Genet
, vol.45
, pp. 61-79
-
-
Yamaguchi, Y.1
Park, J.-H.2
Inouye, M.3
-
191
-
-
85006822970
-
Heterologous expression of toxins from bacterial toxin-antitoxin systems in eukaryotic cells: strategies and applications
-
Yeo, C. C., Abu Bakar, F., Chan, W. T., Espinosa, M., and Harikrishna, J. A. (2016). Heterologous expression of toxins from bacterial toxin-antitoxin systems in eukaryotic cells: strategies and applications. Toxins 8:49. doi: 10.3390/toxins8020049
-
(2016)
Toxins
, vol.8
, pp. 49
-
-
Yeo, C.C.1
Abu Bakar, F.2
Chan, W.T.3
Espinosa, M.4
Harikrishna, J.A.5
-
192
-
-
69949087541
-
Staphylococcus aureus YoeB homologues inhibit translation initiation
-
Yoshizumi, S., Zhang, Y., Yamaguchi, Y., Chen, L., Kreiswirth, B. N., and Inouye, M. (2009). Staphylococcus aureus YoeB homologues inhibit translation initiation. J. Bacteriol. 191, 5868-5872. doi: 10.1128/JB.00623-09
-
(2009)
J. Bacteriol
, vol.191
, pp. 5868-5872
-
-
Yoshizumi, S.1
Zhang, Y.2
Yamaguchi, Y.3
Chen, L.4
Kreiswirth, B.N.5
Inouye, M.6
-
193
-
-
78650066160
-
Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors
-
Yuan, J., Sterckx, Y., Mitchenall, L. A., Maxwell, A., Loris, R., and Waldor, M. K. (2010). Vibrio cholerae ParE2 poisons DNA gyrase via a mechanism distinct from other gyrase inhibitors. J. Biol. Chem. 285, 40397-40408. doi: 10.1074/jbc. M110.138776
-
(2010)
J. Biol. Chem
, vol.285
, pp. 40397-40408
-
-
Yuan, J.1
Sterckx, Y.2
Mitchenall, L.A.3
Maxwell, A.4
Loris, R.5
Waldor, M.K.6
-
194
-
-
0242361323
-
MazF Cleaves Cellular mRNAs Specifically at ACA to Block Protein Synthesis in Escherichia coli
-
Zhang, Y., Zhang, J., Hoeflich, K. P., Ikura, M., Qing, G., and Inouye, M. (2003). MazF Cleaves Cellular mRNAs Specifically at ACA to Block Protein Synthesis in Escherichia coli. Mol. Cell 12, 913-923. doi: 10.1016/S1097-2765(03)00402-7
-
(2003)
Mol. Cell
, vol.12
, pp. 913-923
-
-
Zhang, Y.1
Zhang, J.2
Hoeflich, K.P.3
Ikura, M.4
Qing, G.5
Inouye, M.6
-
195
-
-
84939553152
-
Identification and characterization of the chromosomal yefM-yoeB toxin-antitoxin system of Streptococcus suis
-
Zheng, C., Xu, J., Ren, S., Li, J., Xia, M., Chen, H., et al. (2015). Identification and characterization of the chromosomal yefM-yoeB toxin-antitoxin system of Streptococcus suis. Sci. Rep. 5:13125. doi: 10.1038/srep13125
-
(2015)
Sci. Rep
, vol.5
, pp. 13125
-
-
Zheng, C.1
Xu, J.2
Ren, S.3
Li, J.4
Xia, M.5
Chen, H.6
-
196
-
-
84945177148
-
Escherichia coli antitoxin MazE as transcription factor: insights into MazE-DNA binding
-
Zorzini, V., Buts, L., Schrank, E., Sterckx, Y. G. J., Respondek, M., Engelberg-Kulka, H., et al. (2015). Escherichia coli antitoxin MazE as transcription factor: insights into MazE-DNA binding. Nucleic Acids Res. 43, 1241-1256. doi: 10.1093/nar/gku1352
-
(2015)
Nucleic Acids Res
, vol.43
, pp. 1241-1256
-
-
Zorzini, V.1
Buts, L.2
Schrank, E.3
Sterckx, Y.G.J.4
Respondek, M.5
Engelberg-Kulka, H.6
|