메뉴 건너뛰기




Volumn 39, Issue 13, 2011, Pages 5513-5525

Diversity of bacterial type II toxin-antitoxin systems: A comprehensive search and functional analysis of novel families

Author keywords

[No Author keywords available]

Indexed keywords

ANTITOXIN; BACTERIAL TOXIN;

EID: 80052196405     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkr131     Document Type: Article
Times cited : (333)

References (46)
  • 1
    • 23044469885 scopus 로고    scopus 로고
    • The PIN-domain toxin-antitoxin array in mycobacteria
    • DOI 10.1016/j.tim.2005.06.008, PII S0966842X05001666
    • Arcus, V.L., Rainey, P.B. and Turner, S.J. (2005) The PIN-domain toxin-antitoxin array in mycobacteria. Trends Microbiol., 13, 360-365. (Pubitemid 41073806)
    • (2005) Trends in Microbiology , vol.13 , Issue.8 , pp. 360-365
    • Arcus, V.L.1    Rainey, P.B.2    Turner, S.J.3
  • 2
    • 57349189421 scopus 로고    scopus 로고
    • Small toxic proteins and the antisense RNAs that repress them
    • Fozo, E.M., Hemm, M.R. and Storz, G. (2008) Small toxic proteins and the antisense RNAs that repress them. Microbiol. Mol. Biol. Rev., 72, 579-589.
    • (2008) Microbiol. Mol. Biol. Rev. , vol.72 , pp. 579-589
    • Fozo, E.M.1    Hemm, M.R.2    Storz, G.3
  • 4
    • 17844370503 scopus 로고    scopus 로고
    • Prokaryotic toxin-antitoxin stress response loci
    • DOI 10.1038/nrmicro1147
    • Gerdes, K., Christensen, S.K. and Lobner-Olesen, A. (2005) Prokaryotic toxin-antitoxin stress response loci. Nat. Rev. Microbiol., 3, 371-382. (Pubitemid 40590380)
    • (2005) Nature Reviews Microbiology , vol.3 , Issue.5 , pp. 371-382
    • Gerdes, K.1    Christensen, S.K.2    Lobner-Olesen, A.3
  • 5
    • 0028963606 scopus 로고
    • Programmed cell death in bacterial populations
    • Yarmolinsky, M.B. (1995) Programmed cell death in bacterial populations. Science, 267, 836-837.
    • (1995) Science , vol.267 , pp. 836-837
    • Yarmolinsky, M.B.1
  • 7
    • 0033740341 scopus 로고    scopus 로고
    • Postsegregational killing does not increase plasmid stability but acts to mediate the exclusion of competing plasmids
    • Cooper, T.F. and Heinemann, J.A. (2000) Postsegregational killing does not increase plasmid stability but acts to mediate the exclusion of competing plasmids. Proc. Natl Acad. Sci. USA, 97, 12643-12648.
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 12643-12648
    • Cooper, T.F.1    Heinemann, J.A.2
  • 8
    • 60849121408 scopus 로고    scopus 로고
    • HicA of Escherichia coli defines a novel family of translation- independent mRNA interferases in bacteria and archaea
    • Jorgensen, M.G., Pandey, D.P., Jaskolska, M. and Gerdes, K. (2009) HicA of Escherichia coli defines a novel family of translation-independent mRNA interferases in bacteria and archaea. J. Bacteriol., 191, 1191-1199.
    • (2009) J. Bacteriol. , vol.191 , pp. 1191-1199
    • Jorgensen, M.G.1    Pandey, D.P.2    Jaskolska, M.3    Gerdes, K.4
  • 9
    • 14244266086 scopus 로고    scopus 로고
    • Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes
    • DOI 10.1093/nar/gki201
    • Pandey, D.P. and Gerdes, K. (2005) Toxin-antitoxin loci are highly abundant in free-living but lost from host-associated prokaryotes. Nucleic Acids Res., 33, 966-976. (Pubitemid 41430517)
    • (2005) Nucleic Acids Research , vol.33 , Issue.3 , pp. 966-976
    • Pandey, D.P.1    Gerdes, K.2
  • 10
    • 46749132719 scopus 로고    scopus 로고
    • Automated discovery and phylogenetic analysis of new toxin-antitoxin systems
    • Guglielmini, J., Szpirer, C. and Milinkovitch, M.C. (2008) Automated discovery and phylogenetic analysis of new toxin-antitoxin systems. BMC Microbiol., 8, 104.
    • (2008) BMC Microbiol. , vol.8 , pp. 104
    • Guglielmini, J.1    Szpirer, C.2    Milinkovitch, M.C.3
  • 11
    • 74249084586 scopus 로고    scopus 로고
    • Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: Implications for pathogenesis, stress responses, and evolution
    • Ramage, H.R., Connolly, L.E. and Cox, J.S. (2009) Comprehensive functional analysis of Mycobacterium tuberculosis toxin-antitoxin systems: implications for pathogenesis, stress responses, and evolution. PLoS Genet., 5, e1000767.
    • (2009) PLoS Genet. , vol.5
    • Ramage, H.R.1    Connolly, L.E.2    Cox, J.S.3
  • 12
    • 1542472730 scopus 로고    scopus 로고
    • New connections in the prokaryotic toxin-antitoxin network: Relationship with the eukaryotic nonsense-mediated RNA decay system
    • Anantharaman, V. and Aravind, L. (2003) New connections in the prokaryotic toxin-antitoxin network: relationship with the eukaryotic nonsense-mediated RNA decay system. Genome Biol., 4, R81.
    • (2003) Genome Biol , vol.4
    • Anantharaman, V.1    Aravind, L.2
  • 13
    • 77951619556 scopus 로고    scopus 로고
    • Abundance of type i toxin-antitoxin systems in bacteria: Searches for new candidates and discovery of novel families
    • Fozo, E.M., Makarova, K.S., Shabalina, S.A., Yutin, N., Koonin, E.V. and Storz, G. (2010) Abundance of type I toxin-antitoxin systems in bacteria: searches for new candidates and discovery of novel families. Nucleic Acids Res., 38, 3743-3759.
    • (2010) Nucleic Acids Res. , vol.38 , pp. 3743-3759
    • Fozo, E.M.1    Makarova, K.S.2    Shabalina, S.A.3    Yutin, N.4    Koonin, E.V.5    Storz, G.6
  • 14
    • 57149085868 scopus 로고    scopus 로고
    • Genomics of bacteria and archaea: The emerging dynamic view of the prokaryotic world
    • Koonin, E.V. and Wolf, Y.I. (2008) Genomics of bacteria and archaea: the emerging dynamic view of the prokaryotic world. Nucleic Acids Res., 36, 6688-6719.
    • (2008) Nucleic Acids Res. , vol.36 , pp. 6688-6719
    • Koonin, E.V.1    Wolf, Y.I.2
  • 15
    • 67650299651 scopus 로고    scopus 로고
    • The decay of the chromosomally encoded ccdO157 toxin-antitoxin system in the Escherichia coli species
    • Mine, N., Guglielmini, J., Wilbaux, M. and Van Melderen, L. (2009) The decay of the chromosomally encoded ccdO157 toxin-antitoxin system in the Escherichia coli species. Genetics, 181, 1557-1566.
    • (2009) Genetics , vol.181 , pp. 1557-1566
    • Mine, N.1    Guglielmini, J.2    Wilbaux, M.3    Van Melderen, L.4
  • 16
    • 34548488930 scopus 로고    scopus 로고
    • Hypothetical functions of toxin-antitoxin systems
    • DOI 10.1128/JB.00958-07
    • Magnuson, R.D. (2007) Hypothetical functions of toxin-antitoxin systems. J. Bacteriol., 189, 6089-6092. (Pubitemid 47378614)
    • (2007) Journal of Bacteriology , vol.189 , Issue.17 , pp. 6089-6092
    • Magnuson, R.D.1
  • 17
    • 63449102873 scopus 로고    scopus 로고
    • Bacterial toxin-antitoxin systems: More than selfish entities?
    • Van Melderen, L. and Saavedra De Bast, M. (2009) Bacterial toxin-antitoxin systems: more than selfish entities? PLoS Genet., 5, e1000437.
    • (2009) PLoS Genet. , vol.5
    • Van Melderen, L.1    Saavedra De Bast, M.2
  • 18
    • 78649649439 scopus 로고    scopus 로고
    • Toxin-antitoxin systems: Why so many, what for?
    • Van Melderen, L. (2011) Toxin-antitoxin systems: why so many, what for? Curr. Opin. Microbiol., 13, 781-785.
    • (2011) Curr. Opin. Microbiol. , vol.13 , pp. 781-785
    • Van Melderen, L.1
  • 19
    • 33947330447 scopus 로고    scopus 로고
    • Chromosomal toxin-antitoxin loci can diminish large-scale genome reductions in the absence of selection
    • DOI 10.1111/j.1365-2958.2007.05613.x
    • Szekeres, S., Dauti, M., Wilde, C., Mazel, D. and Rowe-Magnus, D.A. (2007) Chromosomal toxin-antitoxin loci can diminish large-scale genome reductions in the absence of selection. Mol. Microbiol., 63, 1588-1605. (Pubitemid 46437131)
    • (2007) Molecular Microbiology , vol.63 , Issue.6 , pp. 1588-1605
    • Szekeres, S.1    Dauti, M.2    Wilde, C.3    Mazel, D.4    Rowe-Magnus, D.A.5
  • 20
    • 63449105641 scopus 로고    scopus 로고
    • A toxin-antitoxin system promotes the maintenance of an integrative conjugative element
    • Wozniak, R.A. and Waldor, M.K. (2009) A toxin-antitoxin system promotes the maintenance of an integrative conjugative element. PLoS Genet., 5, e1000439.
    • (2009) PLoS Genet. , vol.5
    • Wozniak, R.A.1    Waldor, M.K.2
  • 21
    • 0037338682 scopus 로고    scopus 로고
    • Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by a multidrug-resistant, clinical isolate of Enterococcus faecium
    • DOI 10.1046/j.1365-2958.2003.03387.x
    • Grady, R. and Hayes, F. (2003) Axe-Txe, a broad-spectrum proteic toxin-antitoxin system specified by a multidrug-resistant, clinical isolate of Enterococcus faecium. Mol. Microbiol., 47, 1419-1432. (Pubitemid 36307861)
    • (2003) Molecular Microbiology , vol.47 , Issue.5 , pp. 1419-1432
    • Grady, R.1    Hayes, F.2
  • 23
    • 33750420023 scopus 로고    scopus 로고
    • The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system in archaea and bacteria
    • DOI 10.1093/bioinformatics/btl418
    • Makarova, K.S., Grishin, N.V. and Koonin, E.V. (2006) The HicAB cassette, a putative novel, RNA-targeting toxin-antitoxin system in archaea and bacteria. Bioinformatics, 22, 2581-2584. (Pubitemid 44642594)
    • (2006) Bioinformatics , vol.22 , Issue.21 , pp. 2581-2584
    • Makarova, K.S.1    Grishin, N.V.2    Koonin, E.V.3
  • 24
    • 67649933665 scopus 로고    scopus 로고
    • Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes
    • Makarova, K.S., Wolf, Y.I. and Koonin, E.V. (2009) Comprehensive comparative-genomic analysis of type 2 toxin-antitoxin systems and related mobile stress response systems in prokaryotes. Biol. Direct, 4, 19.
    • (2009) Biol. Direct , vol.4 , pp. 19
    • Makarova, K.S.1    Wolf, Y.I.2    Koonin, E.V.3
  • 25
    • 0018956590 scopus 로고
    • Analysis of gene control signals by DNA fusion and cloning in Escherichia coli
    • DOI 10.1016/0022-2836(80)90283-1
    • Casadaban, M.J. and Cohen, S.N. (1980) Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. J. Mol. Biol., 138, 179-207. (Pubitemid 10044378)
    • (1980) Journal of Molecular Biology , vol.138 , Issue.2 , pp. 179-207
    • Casadaban, M.J.1    Cohen, S.N.2
  • 26
    • 0025992789 scopus 로고
    • Residual guanosine 3′,5′-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations
    • Xiao, H., Kalman, M., Ikehara, K., Zemel, S., Glaser, G. and Cashel, M. (1991) Residual guanosine 30, 50-bispyrophosphate synthetic activity of relA null mutants can be eliminated by spoT null mutations. J. Biol. Chem., 266, 5980-5990. (Pubitemid 21909592)
    • (1991) Journal of Biological Chemistry , vol.266 , Issue.9 , pp. 5980-5990
    • Xiao, H.1    Kalman, M.2    Ikehara, K.3    Zemel, S.4    Glaser, G.5    Cashel, M.6
  • 27
    • 33947139094 scopus 로고    scopus 로고
    • The novel transcription factor SgrR coordinates the response to glucose-phosphate stress
    • DOI 10.1128/JB.01689-06
    • Vanderpool, C.K. and Gottesman, S. (2007) The novel transcription factor SgrR coordinates the response to glucose-phosphate stress. J. Bacteriol., 189, 2238-2248. (Pubitemid 46411338)
    • (2007) Journal of Bacteriology , vol.189 , Issue.6 , pp. 2238-2248
    • Vanderpool, C.K.1    Gottesman, S.2
  • 28
    • 0029018327 scopus 로고
    • Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter
    • Guzman, L.M., Belin, D., Carson, M.J. and Beckwith, J. (1995) Tight regulation, modulation, and high-level expression by vectors containing the arabinose PBAD promoter. J. Bacteriol., 177, 4121-4130.
    • (1995) J. Bacteriol. , vol.177 , pp. 4121-4130
    • Guzman, L.M.1    Belin, D.2    Carson, M.J.3    Beckwith, J.4
  • 29
    • 1642483754 scopus 로고    scopus 로고
    • Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: Involvement of the yefM-yoeB toxin-antitoxin system
    • DOI 10.1046/j.1365-2958.2003.03941.x
    • Christensen, S.K., Maenhaut-Michel, G., Mine, N., Gottesman, S., Gerdes, K. and Van Melderen, L. (2004) Overproduction of the Lon protease triggers inhibition of translation in Escherichia coli: involvement of the yefM-yoeB toxin-antitoxin system. Mol. Microbiol., 51, 1705-1717. (Pubitemid 38406543)
    • (2004) Molecular Microbiology , vol.51 , Issue.6 , pp. 1705-1717
    • Christensen, S.K.1    Maenhaut-Michel, G.2    Mine, N.3    Gottesman, S.4    Gerdes, K.5    Van Melderen, L.6
  • 31
    • 34147093024 scopus 로고    scopus 로고
    • Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7
    • DOI 10.1128/JB.01679-06
    • Wilbaux, M., Mine, N., Guerout, A.M., Mazel, D. and Van Melderen, L. (2007) Functional interactions between coexisting toxin-antitoxin systems of the ccd family in Escherichia coli O157:H7. J. Bacteriol., 189, 2712-2719. (Pubitemid 46556053)
    • (2007) Journal of Bacteriology , vol.189 , Issue.7 , pp. 2712-2719
    • Wilbaux, M.1    Mine, N.2    Guerout, A.-M.3    Mazel, D.4    Van Melderen, L.5
  • 32
    • 4844230876 scopus 로고    scopus 로고
    • Identification and characterization of a nontypeable Haemophilus influenzae putative toxin-antitoxin locus
    • Daines, D.A., Jarisch, J. and Smith, A.L. (2004) Identification and characterization of a nontypeable Haemophilus influenzae putative toxin-antitoxin locus. BMC Microbiol., 4, 30.
    • (2004) BMC Microbiol , vol.4 , pp. 30
    • Daines, D.A.1    Jarisch, J.2    Smith, A.L.3
  • 33
    • 77951555583 scopus 로고    scopus 로고
    • New toxins homologous to ParE belonging to three-component toxin-antitoxin systems in Escherichia coli O157:H7
    • Hallez, R., Geeraerts, D., Sterckx, Y., Mine, N., Loris, R. and Van Melderen, L. (2010) New toxins homologous to ParE belonging to three-component toxin-antitoxin systems in Escherichia coli O157:H7. Mol. Microbiol., 76, 719-732.
    • (2010) Mol. Microbiol. , vol.76 , pp. 719-732
    • Hallez, R.1    Geeraerts, D.2    Sterckx, Y.3    Mine, N.4    Loris, R.5    Van Melderen, L.6
  • 35
    • 33645072739 scopus 로고    scopus 로고
    • The chromosomal relBE2 toxin-antitoxin locus of Streptococcus pneumoniae: Characterization and use of a bioluminescence resonance energy transfer assay to detect toxin-antitoxin interaction
    • Nieto, C., Pellicer, T., Balsa, D., Christensen, S.K., Gerdes, K. and Espinosa, M. (2006) The chromosomal relBE2 toxin-antitoxin locus of Streptococcus pneumoniae: characterization and use of a bioluminescence resonance energy transfer assay to detect toxin-antitoxin interaction. Mol. Microbiol., 59, 1280-1296.
    • (2006) Mol. Microbiol. , vol.59 , pp. 1280-1296
    • Nieto, C.1    Pellicer, T.2    Balsa, D.3    Christensen, S.K.4    Gerdes, K.5    Espinosa, M.6
  • 36
    • 77954022657 scopus 로고    scopus 로고
    • Interaction specificity, toxicity and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems
    • Fiebig, A., Castro Rojas, C.M., Siegal-Gaskins, D. and Crosson, S. (2010) Interaction specificity, toxicity and regulation of a paralogous set of ParE/RelE-family toxin-antitoxin systems. Mol. Microbiol., 77, 236-251.
    • (2010) Mol. Microbiol. , vol.77 , pp. 236-251
    • Fiebig, A.1    Castro Rojas, C.M.2    Siegal-Gaskins, D.3    Crosson, S.4
  • 37
    • 74349123303 scopus 로고    scopus 로고
    • Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses
    • Christensen-Dalsgaard, M., Jorgensen, M.G. and Gerdes, K. (2010) Three new RelE-homologous mRNA interferases of Escherichia coli differentially induced by environmental stresses. Mol. Microbiol., 75, 333-348.
    • (2010) Mol. Microbiol. , vol.75 , pp. 333-348
    • Christensen-Dalsgaard, M.1    Jorgensen, M.G.2    Gerdes, K.3
  • 38
    • 58449087611 scopus 로고    scopus 로고
    • Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB
    • Schumacher, M.A., Piro, K.M., Xu, W., Hansen, S., Lewis, K. and Brennan, R.G. (2009) Molecular mechanisms of HipA-mediated multidrug tolerance and its neutralization by HipB. Science, 323, 396-401.
    • (2009) Science , vol.323 , pp. 396-401
    • Schumacher, M.A.1    Piro, K.M.2    Xu, W.3    Hansen, S.4    Lewis, K.5    Brennan, R.G.6
  • 40
    • 33748309126 scopus 로고    scopus 로고
    • Shutdown decay of mRNA
    • DOI 10.1111/j.1365-2958.2006.05270.x
    • Condon, C. (2006) Shutdown decay of mRNA. Mol. Microbiol., 61, 573-583. (Pubitemid 44324085)
    • (2006) Molecular Microbiology , vol.61 , Issue.3 , pp. 573-583
    • Condon, C.1
  • 41
    • 0033976914 scopus 로고    scopus 로고
    • Toxin-antitoxin modules may regulate synthesis of macromolecules during nutritional stress
    • DOI 10.1128/JB.182.3.561-572.2000
    • Gerdes, K. (2000) Toxin-antitoxin modules may regulate synthesis of macromolecules during nutritional stress. J. Bacteriol., 182, 561-572. (Pubitemid 30053984)
    • (2000) Journal of Bacteriology , vol.182 , Issue.3 , pp. 561-572
    • Gerdes, K.1
  • 42
    • 74549170423 scopus 로고    scopus 로고
    • Three dimensional structure of the MqsR:MqsA complex: A novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties
    • Brown, B.L., Grigoriu, S., Kim, Y., Arruda, J.M., Davenport, A., Wood, T.K., Peti, W. and Page, R. (2009) Three dimensional structure of the MqsR:MqsA complex: a novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties. PLoS Pathog., 5, e1000706.
    • (2009) PLoS Pathog. , vol.5
    • Brown, B.L.1    Grigoriu, S.2    Kim, Y.3    Arruda, J.M.4    Davenport, A.5    Wood, T.K.6    Peti, W.7    Page, R.8
  • 45
    • 23944507559 scopus 로고    scopus 로고
    • The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite
    • Ogata, H., Renesto, P., Audic, S., Robert, C., Blanc, G., Fournier, P.E., Parinello, H., Claverie, J.M. and Raoult, D. (2005) The genome sequence of Rickettsia felis identifies the first putative conjugative plasmid in an obligate intracellular parasite. PLoS Biol., 3, e248.
    • (2005) PLoS Biol. , vol.3
    • Ogata, H.1    Renesto, P.2    Audic, S.3    Robert, C.4    Blanc, G.5    Fournier, P.E.6    Parinello, H.7    Claverie, J.M.8    Raoult, D.9


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.