Crystal structure of the VapBc-15 complex from mycobacterium tuberculosis reveals a two-metal ion dependent pin-domain ribonuclease and a variable mode of toxin-antitoxin assembly

Journal of Structural Biology

Volumn 188, Issue 3, 2014, Pages 249-258

  Das, Uddipan ^a   Pogenberg, Vivian ^b   Subhramanyam, Udaya Kumar Tiruttani ^c   Wilmanns, Matthias ^b   Gourinath, Samudrala ^d   Srinivasan, Alagiri ^a  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^c FORSCHUNGSZENTRUM JÜLICH   (Germany)

^d JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

Mycobacterium tuberculosis; Toxin; Toxin antitoxin; VapB 15; VapBC 15; VapC 15; X ray crystallography

Indexed keywords

AMINO ACID; ANTITOXIN; METAL ION; RIBONUCLEASE; RIBONUCLEASE H; TOXIN; UNCLASSIFIED DRUG; VAPBC 15 PROTEIN COMPLEX; BACTERIAL PROTEIN; BACTERIAL TOXIN; DNA BINDING PROTEIN; MEMBRANE PROTEIN; VAPB PROTEIN, BACTERIA;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; METHANOCALDOCOCCUS JANNASCHII; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PROTEIN DOMAIN; PROTEIN SECONDARY STRUCTURE; CHEMICAL STRUCTURE; METABOLISM; PROTEIN TERTIARY STRUCTURE; X RAY DIFFRACTION;

METHANOCALDOCOCCUS JANNASCHII; MYCOBACTERIUM TUBERCULOSIS;

ANTITOXINS; BACTERIAL PROTEINS; BACTERIAL TOXINS; DNA-BINDING PROTEINS; MEMBRANE GLYCOPROTEINS; MODELS, MOLECULAR; MYCOBACTERIUM TUBERCULOSIS; PROTEIN STRUCTURE, TERTIARY; RIBONUCLEASES; X-RAY DIFFRACTION;

EID: 84918574813     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2014.10.002     Document Type: Article

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