Repurposing a Prokaryotic Toxin-Antitoxin System for the Selective Killing of Oncogenically Stressed Human Cells

ACS Synthetic Biology

Volumn 5, Issue 7, 2016, Pages 540-546

  Preston, Mark A ^a   Pimentel, Belén ^a   Bermejo Rodríguez, Camino ^a   Dionne, Isabelle ^a   Turnbull, Alice ^a   De La Cueva Méndez, Guillermo ^a,b  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Institute of Biomedical Research in Malaga and BIONAND Nanomedicine Platform   (Spain)

Author keywords

cancer cell killing; gene therapy; HPV; Kid Kis; protein therapy; smart therapeutic system; toxin antitoxin system

Indexed keywords

ANTITOXIN; ANTITOXIN KIS; PROTEIN E6; TOXIN; TOXIN KID; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; BACTERIAL TOXIN; DNA BINDING PROTEIN; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 16; E6 PROTEIN, HUMAN PAPILLOMAVIRUS TYPE 18; KID PROTEIN, BACTERIA; KIS PROTEIN, BACTERIA; ONCOPROTEIN; POLYUBIQUITIN; RECOMBINANT PROTEIN; REPRESSOR PROTEIN;

ARTICLE; CANCER GENE THERAPY; CELL KILLING; CELL PROLIFERATION; CELL PROTECTION; CELL STRESS; CONTROLLED STUDY; ESCHERICHIA COLI; EXPRESSION VECTOR; FEMALE; GENETIC ENGINEERING; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR CLONING; PDZ DOMAIN; PRIORITY JOURNAL; PROKARYOTE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; TUMOR CELL DESTRUCTION; UBIQUITINATION; APOPTOSIS; GENETICS; GROWTH, DEVELOPMENT AND AGING; HEK293 CELL LINE; METABOLISM; PATHOLOGY; PROCEDURES; UTERINE CERVIX TUMOR; VIROLOGY;

ANTITOXINS; APOPTOSIS; BACTERIAL PROTEINS; BACTERIAL TOXINS; CELL PROLIFERATION; DNA-BINDING PROTEINS; ESCHERICHIA COLI; FEMALE; GENETIC ENGINEERING; HEK293 CELLS; HUMANS; ONCOGENE PROTEINS, VIRAL; POLYUBIQUITIN; RECOMBINANT PROTEINS; REPRESSOR PROTEINS; UTERINE CERVICAL NEOPLASMS;

EID: 84978476493     PISSN: None     EISSN: 21615063     Source Type: Journal    
DOI: 10.1021/acssynbio.5b00096     Document Type: Article

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