The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family

Molecular Microbiology

Volumn 29, Issue 4, 1998, Pages 1065-1076

  Gotfredsen, Marie ^a   Gerdes, Kenn ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BACTERIAL GENE; ESCHERICHIA COLI K 12; GENE CONTROL; HAEMOPHILUS INFLUENZAE; MULTIGENE FAMILY; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; PRIORITY JOURNAL; REPLICON; SEQUENCE HOMOLOGY; VIBRIO CHOLERAE;

AMINO ACID SEQUENCE; ANTITOXINS; BACTERIAL TOXINS; BASE SEQUENCE; CYTOTOXINS; DNA PRIMERS; ESCHERICHIA COLI; GENES, BACTERIAL; HAEMOPHILUS INFLUENZAE; MOLECULAR SEQUENCE DATA; MOLECULAR WEIGHT; MULTIGENE FAMILY; OPERON; PLASMIDS; PROTO-ONCOGENE PROTEINS; REPLICON; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; TRANSCRIPTION FACTOR RELB; TRANSCRIPTION FACTORS; VIBRIO CHOLERAE;

BACTERIA (MICROORGANISMS); ESCHERICHIA; ESCHERICHIA COLI; ESCHERICHIA COLI K12; HAEMOPHILUS INFLUENZAE; NEGIBACTERIA; VIBRIO CHOLERAE;

EID: 0031816179     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1998.00993.x     Document Type: Article

References (50)

1. Aizenman, E., Engelberg-Kulka, H., and Glaser, G. (1996) An Escherichia coli chromosomal 'addiction module' regulated by 3′,5′-bispyrophosphate: a model for programmed bacterial cell death. Proc Natl Acad Sci USA 93: 6059-6063.
2. Altschul, S.F., Gish, W., Miller, W., Myers, E.W., and Lipman, D.J. (1990) Basic local alignment search tool. J Mol Biol 215: 403-410.
3. Bech, F.W., Jørgensen, S.T., Diderichsen, B., and Karlström, O.H. (1985) Sequence of the relB transcription unit from Escherichia coli and identification of the relB gene. EMBO J 4: 1059-1066.
4. Bernard, P., and Couturier, M. (1992) Cell killing by the F plasmid CcdB protein involves poisoning of DNA-topoisomerase II complexes. J Mol Biol 226: 735-745.
5. Bernard, P., Kezdy, K.E., Van Melderen, L., Steyaert, J., Wyns, L., Pato, M.L., et al. (1993) The F plasmid CcdB protein induces efficient ATP-dependent DNA cleavage by gyrase. J Mol Biol 234: 534-541.
6. Bertani, G. (1951) The mode of phage liberation by lysogenic Escherichia coli. J Bacteriol 62: 293-300.
7. Blattner, F.R., Plunkett, III, G., Bloch, C.A., Perna, N.T., Burland, V., Riley, M., et al. (1997) The complete genome sequence of Escherichia coli K-12. Science 277: 1453-1474.
8. Bolivar, F. (1978) Construction and characterization of new cloning vehicles. III. Derivatives of plasmid pBR322 carrying unique EcoRI sites for selection of EcoRI generated recombinant DNA molecules. Gene 4: 121-136.
9. Bravo, A., de Torrontegui, G., and Diaz, R. (1987) Identification of components of a new stability system of plasmid R1, ParD, that is close to the origin of replication of this plasmid. Mol Gen Genet 210: 101-110.
10. Casadaban, M.J., and Cohen, S.N. (1980) Analysis of gene control signals by DNA fusion and cloning in Escherichia coli. J Mol Biol 138: 179-207.
11. Cashel, M., Gentry, D.R., Hernandez, V.J., and Vinella, D. (1996) The stringent response. In Escherichia coli and Salmonella. Neidhardt, F.C. (ed.). Washington, DC: American Society for Microbiology Press, pp. 1458-1496.
12. Clark, D., and Maalø, O. (1967) DNA replication and the division cycle in Escherichia coli. J Mol Biol 23: 99-112.
13. Dam, M., and Gerdes, K. (1994) Partitioning of plasmid R1. Ten direct repeats flanking the parA promoter constitute a centromere-like partition site parC, that expresses incompatibility. J Mol Biol 236: 1289-1298.
14. Diderichsen, B., Fiil, N.P., and Lavalle, R. (1977) Genetics of the relB locus in Escherichia coli. J Bacteriol 131: 30-33.
15. Fleischmann, R.D., Adams, M.D., White, O., Clayton, R.A., Kirkness, E.F., Kerlavage, A.R., et al. (1995) Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science 269: 496-512.
16. Franzon, V.L., Barker, A., and Manning, P.A. (1993) Nucleotide sequence of the mannose-fucose-resistant hemagglutinin of Vibrio cholera O1 and construction of a mutant. Infect Immun 61: 3032-3037.
17. Gerdes, K., and Molin, S. (1986) Partitioning of plasmid R1. Structural and functional analysis of the parA locus. J Mol Biol 190: 269-279.
18. Gerdes, K., Larsen, J.E.L., and Molin, S. (1985) Stable inheritance of plasmid R1 requires two different loci. J Bacteriol 161: 292-298.
19. Gerdes, K., Rasmussen, P.B., and Molin, S. (1986a) Unique type of plasmid maintenance: postsegregational killing of plasmid-free cells. Proc Natl Acad Sci USA 83: 3116-3120.
20. Gerdes, K., Bech, F.W., Jørgensen, S.T., Løbner-Olesen, A., Rasmussen, P.B., Atlung, T., et al. (1986b) Mechanism of postsegregational killing by the hok gene product of the parB system of plasmid R1 and its homology with the relF gene product of the E coli relB operon. EMBO J 5: 2023-2029.
21. Gerdes, K., Poulsen, L.K., Thisted, T., Nielsen, A.K., Martinussen, J., and Andreasen, P.H. (1990) The hok killer gene family in Gram-negative bacteria. New Biol 2: 946-956.
22. Gerdes, K., Gultyaev, A.P., Franch, T., Pedersen, K., and Mikkelsen, N.D. (1997) Antisense RNA-regulated programmed cell death. Annu Rev Genet 31: 1-31.
23. Harlow, G.R., Gregg-Jolly, L.A., and Mount, D.W. (1994) Identification of high affinity binding sites for LexA which define new DNA damage-inducible genes in Escherichia coli. J Mol Biol 241: 507-523.
24. Jensen, R.B., and Gerdes, K. (1995) Programmed cell death in bacteria: proteic plasmid stabilization systems. Mol Microbiol 17: 205-210.
25. Johnson, E.P., Ström, A.R., and Helinski, D.R. (1996) Plasmid RK2 toxin protein ParE: purification and interaction with the ParD antitoxin protein. J Bacteriol 176: 1420-1429.
26. Kurland, C.G., and Maalø, O. (1962) Regulation of ribosomal and transfer RNA synthesis. J Mol Biol 4: 193-210.
27. Lanzer, M., and Bujard, H. (1988) Promoters largely determine the efficiency of repressor action. Proc Natl Acad Sci USA 85: 8973-8977.
28. Lavallé, R., Desmarez, L., and De Hauwer, G. (1976) Natural messenger translation impairment in an E. coli mutant. In Control of Ribosome Synthesis. Kjeldgaard, N.O., and Maaløe, O. (eds). Copenhagen: Munksgaard, pp. 408-418.
29. Lavallé, R. (1965) Nouveaux mutants de régulation de la synthèse de l'arn. Bull Soc Chem Biol 47: 1567-1570.
30. Lehnherr, H., and Yarmolinsky, M.B. (1995) Addiction protein Phd of plasmid prophage P1 is a substrate of the ClpXP serine protease of Escherichia coli. Proc Natl Acad Sci USA 92: 3274-3277.
31. Lehnherr, H., Maguin, E., Jafri, S., Yarmolinsky, M.B. (1993) Plasmid addiction genes of bacteriophage P1:doc, which causes cell death on curing of prophage, and phd, which prevents host death when prophage is retained. J Mol Biol 233: 414-428.
32. Linn, T., and Ralling, G. (1985) A versatile multiple- and single-copy vector system for the in vitro construction of transcriptional fusions to lacZ. Plasmid 14: 134-142.
33. Masuda, Y., Miyakawa, K., Nishimura, Y., and Ohtsubo, E. (1993) chpA and chpB, Escherichia coli chromosomal homologs of the pern locus responsible for stable maintenance of plasmid R100. J Bacteriol 175: 6850-6856.
34. Metzger, S., Dror, I.B., Aizenman, E., Schreiber, G., Toone, M., Friesen, J.D., et al. (1988) The nucleotide sequence and characterization of the relA gene of Escherichia coli. J Biol Chem 263: 15699-15704.
35. Miller, J.F. (1972) Experiments in Molecular Genetics. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press.
36. Mosteller, R.D., and Kwan, S.F. (1976) Isolation of relaxed-control mutants of Escherichia coli K-12 which are sensitive to glucose starvation. Biochem Biophys Res Commun 69: 325-332.
37. Nyström, T. (1998) To be or not to be: the ultimate decision of the growth-arrested cell. FEMS Microbiol Rev 21: 283-290.
38. Ogura, T., and Hiraga, S. (1983) Mini-F plasmid genes that couple host cell division to plasmid proliferation. Proc Natl Acad Sci USA 80: 4784-4788.
39. Roberts, R.C., Ström, A.R., and Helinski, D.R. (1994) The parDE operon of the broad-host-range plasmid RK2 specifies growth inhibition associated with plasmid loss. J Mol Biol 237: 35-51.
40. Ruiz-Echevarría, M.J., Gimenez-Gallego, G., Sabariegos-Jareno, R., and Diaz-Orejas, R. (1995) Kid, a small protein of the parD stability system of plasmid R1, is an inhibitor of DNA replication acting at the initiation of DNA synthesis. J Mol Biol 247: 568-77.
41. Saul, D., Spiers, A.J., McAnulty, J., Gibbs, M.G., Bergquist, P.L., and Hill, D.F. (1989) Nucleotide sequence and replication characteristics of RepFIB, a basic replication of IncF plasmids. J Bacteriol 171: 2697-2707.
42. Schäger, H., and von Jagow, G. (1987) Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis for the separation of proteins in the range from 1 to 100 kDa. Anal Biochem 166: 368-379.
43. Stent, G.S., and Brenner, S. (1961) A genetic locus for the regulation of ribonucleic acid synthesis. Proc Natl Acad Sci USA 74: 2005-2014.
44. Tam, J.E., and Kline, B.C. (1989) The F plasmid ccd autorepressor is a complex of CcdA and CcdB proteins. Mol Gen Genet 219: 26-32.
45. Thisted, T., and Gerdes, K. (1992) Mechanism of post-segregational killing by the hok/sok system of plasmid R1:Sok antisense RNA regulates hok gene expression indirectly through the overlapping mok gene. J Mol Biol 223: 4154.
46. Tian, Q.B., Ohnishi, M., Tabuchi, A., and Terawaki, Y. (1996) A new plasmid-encoded proteic killer gene system: cloning, sequencing, and analyzing hig locus of plasmid Rts1. Biochem Biophys Res Commun 220: 280-284.
47. Tsuchimoto, S., Ohtsubo, H., and Ohtsubo, E. (1988) Two genes, pemI and pemK, responsible for stable maintenance of resistance plasmid R100. J Bacteriol 170: 1461-1466.
48. Tsuchimoto, S., Nishimura, Y., and Ohtsubo, E. (1992) The stable maintenance system pem of plasmid R100: degradation of PemI protein may allow PemK protein to inhibit cell growth. J Bacteriol 174: 4205-4211.
49. Van Melderen, L., Bernard, P., and Couturier, M. (1994) Lon-dependent proteolysis of CcdA is the key control for activation of CcdB in plasmid-free segregant bacteria. Mol Microbiol 11: 1151-1157.
50. Yanisch-Perron, C., Viera, J., and Messing, J. (1985) Improved M13 phage cloning vectors and host strains: nucleotide sequence of the M13mp18 and pUC19 vectors. Gene 33: 103-119.