Antitoxin MqsA helps mediate the bacterial general stress response

Nature Chemical Biology

Volumn 7, Issue 6, 2011, Pages 359-366

  Wang, Xiaoxue ^a   Kim, Younghoon ^a   Hong, Seok Hoon ^a   Ma, Qun ^a   Brown, Breann L ^b   Pu, Mingming ^a   Tarone, Aaron M ^c   Benedik, Michael J ^c   Peti, Wolfgang ^b   Page, Rebecca ^d   Wood, Thomas K ^a,c  

^a Texas AandM University   (United States)

^b BROWN UNIVERSITY   (United States)

^c TEXAS A AND M UNIVERSITY   (United States)

^d BROWN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITOXIN; CATALASE; ENDOPEPTIDASE LA; GUANOSINE PHOSPHATE; MQSA ANTITOXIN; MQSRA ANTITOXIN; REGULATOR PROTEIN; RNA POLYMERASE; UNCLASSIFIED DRUG;

BACTERIAL GROWTH; BACTERIAL PHENOMENA AND FUNCTIONS; BACTERIAL STRAIN; BIOFILM; CELL MOTILITY; CELLULAR STRESS RESPONSE; DNA BINDING; ENZYME ACTIVITY; GENE CONTROL; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN INDUCTION; REVIEW; RNA TRANSCRIPTION; SEQUENCE ANALYSIS; TOXIN ANTITOXIN SYSTEM;

BACTERIA (MICROORGANISMS);

EID: 79956074557     PISSN: 15524450     EISSN: 15524469     Source Type: Journal    
DOI: 10.1038/nchembio.560     Document Type: Review

References (50)

1. Gerdes, K., Christensen, S.K. & Løbner-Olesen, A. Prokaryotic toxin-antitoxin stress response loci. Nat. Rev. Microbiol. 3, 371-382 (2005). (Pubitemid 40590380)
2. Tsilibaris, V., Maenhaut-Michel, G., Mine, N. & Van Melderen, L. What is the benefit to Escherichia coli of having multiple toxin-antitoxin systems in its genome? J. Bacteriol. 189, 6101-6108 (2007). (Pubitemid 47378616)
3. Magnuson, R.D. Hypothetical functions of toxin-antitoxin systems. J. Bacteriol. 189, 6089-6092 (2007). (Pubitemid 47378614)
4. Shah, D. et al. Persisters: A distinct physiological state of E. coli. BMC Microbiol. 6, 53 (2006).
5. Pecota, D.C. & Wood, T.K. Exclusion of T4 phage by the hok/sok killer locus from plasmid R1. J. Bacteriol. 178, 2044-2050 (1996). (Pubitemid 26110551)
6. Kim, Y., Wang, X., Ma, Q., Zhang, X.-S. & Wood, T.K. Toxin-antitoxin systems in Escherichia coli influence biofilm formation through YjgK (TabA) and fimbriae. J. Bacteriol. 191, 1258-1267 (2009).
7. Yamaguchi, Y., Park, J.-H. & Inouye, M. MqsR, a crucial regulator for quorum sensing and biofilm formation, is a GCU-specific mRNA interferase in Escherichia coli. J. Biol. Chem. 284, 28746-28753 (2009).
8. Brown, B.L. et al. Three dimensional structure of the MqsR:MqsA complex: A novel TA pair comprised of a toxin homologous to RelE and an antitoxin with unique properties. PLoS Pathog. 5, e1000706 (2009).
9. Aizenman, E., Engelberg-Kulka, H. & Glaser, G. An Escherichia coli chromosomal "addiction module" regulated by 3',5'-bispyrophosphate: A model for programmed bacterial cell death. Proc. Natl. Acad. Sci. USA 93, 6059-6063 (1996).
10. Gotfredsen, M. & Gerdes, K. The Escherichia coli relBE genes belong to a new toxin-antitoxin gene family. Mol. Microbiol. 29, 1065-1076 (1998). (Pubitemid 28389446)
11. Masuda, Y., Miyakawa, K., Nishimura, Y. & Ohtsubo, E. chpA and chpB, Escherichia coli chromosomal homologs of the pem locus responsible for stable maintenance of plasmid R100. J. Bacteriol. 175, 6850-6856 (1993). (Pubitemid 23322434)
12. Cherny, I. & Gazit, E. The YefM antitoxin defines a family of natively unfolded proteins: Implications as a novel antibacterial target. J. Biol. Chem. 279, 8252-8261 (2004). (Pubitemid 38294717)
13. Motiejunaite, R., Armalyte, J., Markuckas, A. & Sužiedeliene, E. Escherichia coli dinJ-yafQ genes act as a toxin-antitoxin module. FEMS Microbiol. Lett. 268, 112-119 (2007). (Pubitemid 46192843)
14. Schmidt, O. et al. prlF and yhaV encode a new toxin-antitoxin system in Escherichia coli. J. Mol. Biol. 372, 894-905 (2007). (Pubitemid 47368350)
15. González Barrios, A.F. et al. Autoinducer 2 controls biofilm formation in Escherichia coli through a novel motility quorum-sensing regulator (MqsR, B3022). J. Bacteriol. 188, 305-316 (2006).
16. Ren, D., Bedzyk, L.A., Thomas, S.M., Ye, R.W. & Wood, T.K. Gene expression in Escherichia coli biofilms. Appl. Microbiol. Biotechnol. 64, 515-524 (2004). (Pubitemid 38686161)
17. Kim, Y. & Wood, T.K. Toxins Hha and CspD and small RNA regulator Hfq are involved in persister cell formation through MqsR in Escherichia coli. Biochem. Biophys. Res. Commun. 391, 209-213 (2010).
18. Kim, Y. et al. Escherichia coli toxin/antitoxin pair MqsR/MqsA regulate toxin CspD. Environ. Microbiol. 12, 1105-1121 (2010).
19. Pesavento, C. et al. Inverse regulatory coordination of motility and curli-mediated adhesion in Escherichia coli. Genes Dev. 22, 2434-2446 (2008).
20. Hengge, R. The two-component network and the general stress sigma factor RpoS (sS) in Escherichia coli. in Bacterial Signal Transduction: Networks and Drug Targets 40-53 (Springer, New York, 2008).
21. Boehm, A. et al. Second messenger-mediated adjustment of bacterial swimming velocity. Cell 141, 107-116 (2010).
22. Pesavento, C. & Hengge, R. Bacterial nucleotide-based second messengers. Curr. Opin. Microbiol. 12, 170-176 (2009).
23. 2 and broad-spectrum near-UV radiation by the Escherichia coli katF locus. J. Bacteriol. 168, 13-21 (1986). (Pubitemid 16001578)
24. Storz, G. & Imlay, J.A. Oxidative stress. Curr. Opin. Microbiol. 2, 188-194 (1999). (Pubitemid 29176944)
25. Lacour, S. & Landini, P. sS-dependent gene expression at the onset of stationary phase in Escherichia coli: Function of sS-dependent genes and identification of their promoter sequences. J. Bacteriol. 186, 7186-7195 (2004). (Pubitemid 39383102)
26. Baba, T. et al. Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: The Keio collection. Mol. Syst. Biol. 2, 2006.0008 (2006).
27. Landini, P. Cross-talk mechanisms in biofilm formation and responses to environmental and physiological stress in Escherichia coli. Res. Microbiol. 160, 259-266 (2009).
28. Brown, B.L., Wood, T.K., Peti, W. & Page, R. Structure of the Escherichia coli antitoxin MqsA (YgiT/b3021) bound to its gene promoter reveals extensive domain rearrangements and the specificity of transcriptional regulation. J. Biol. Chem. 286, 2285-2296 (2011).
29. Alexeyev, M.F. The pKNOCK series of broad-host-range mobilizable suicide vectors for gene knockout and targeted DNA insertion into the chromosome of gram-negative bacteria. Biotechniques 26, 824-828 (1999).
30. Ma, Q. & Wood, T.K. OmpA influences Escherichia coli biofilm formation by repressing cellulose production through the CpxAR two-component system. Environ. Microbiol. 11, 2735-2746 (2009).
31. Donegan, N.P., Thompson, E.T., Fu, Z. & Cheung, A.L. Proteolytic regulation of toxin-antitoxin systems by ClpPC in Staphylococcus aureus. J. Bacteriol. 192, 1416-1422 (2010).
32. Altuvia, S., Weinstein-Fischer, D., Zhang, A., Postow, L. & Storz, G. A small, stable RNA induced by oxidative stress: Role as a pleiotropic regulator and antimutator. Cell 90, 43-53 (1997). (Pubitemid 28009417)
33. Van Melderen, L., Bernard, P. & Couturier, M. Lon-dependent proteolysis of CcdA is the key control for activation of CcdB in plasmid-free segregant bacteria. Mol. Microbiol. 11, 1151-1157 (1994). (Pubitemid 24201630)
34. Christensen, S.K., Mikkelsen, M., Pedersen, K. & Gerdes, K. RelE, a global inhibitor of translation, is activated during nutritional stress. Proc. Natl. Acad. Sci. USA 98, 14328-14333 (2001). (Pubitemid 33121391)
35. Kasari, V., Kurg, K., Margus, T., Tenson, T. & Kaldalu, N. The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair. J. Bacteriol. 192, 2908-2919 (2010).
36. Kolodkin-Gal, I., Verdiger, R., Shlosberg-Fedida, A. & Engelberg-Kulka, H. A differential effect of E. coli toxin-antitoxin systems on cell death in liquid media and biofilm formation. PLoS ONE 4, e6785 (2009).
37. Zhang, X.-S., García-Contreras, R. & Wood, T.K. YcfR (BhsA) influences Escherichia coli biofilm formation through stress response and surface hydrophobicity. J. Bacteriol. 189, 3051-3062 (2007). (Pubitemid 46697394)
38. Ito, A., May, T., Kawata, K. & Okabe, S. Significance of rpoS during maturation of Escherichia coli biofilms. Biotechnol. Bioeng. 99, 1462-1471 (2008). (Pubitemid 351548686)
39. Domka, J., Lee, J., Bansal, T. & Wood, T.K. Temporal gene-expression in Escherichia coli K-12 biofilms. Environ. Microbiol. 9, 332-346 (2007). (Pubitemid 46072122)
40. Ito, A., Taniuchi, A., May, T., Kawata, K. & Okabe, S. Increased antibiotic resistance of Escherichia coli in mature biofilms. Appl. Environ. Microbiol. 75, 4093-4100 (2009).
41. Ito, A., May, T., Taniuchi, A., Kawata, K. & Okabe, S. Localized expression profiles of rpoS in Escherichia coli biofilms. Biotechnol. Bioeng. 103, 975-983 (2009).
42. Zheng, M. et al. DNA microarray-mediated transcriptional profiling of the Escherichia coli response to hydrogen peroxide. J. Bacteriol. 183, 4562-4570 (2001). (Pubitemid 32646006)
43. Zhang, A. et al. The OxyS regulatory RNA represses rpoS translation and binds the Hfq (HF-I) protein. EMBO J. 17, 6061-6068 (1998). (Pubitemid 28474799)
44. Gruber, T.M. & Gross, C.A. Multiple sigma subunits and the partitioning of bacterial transcription space. Annu. Rev. Microbiol. 57, 441-466 (2003). (Pubitemid 37392951)
45. Pennington, J.M. & Rosenberg, S.M. Spontaneous DNA breakage in single living Escherichia coli cells. Nat. Genet. 39, 797-802 (2007). (Pubitemid 46848597)
46. Dörr, T., Lewis, K. & Vulic, M. SOS response induces persistence to fluoroquinolones in Escherichia coli. PLoS Genet. 5, e1000760 (2009).
47. Datsenko, K.A. & Wanner, B.L. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. USA 97, 6640-6645 (2000). (Pubitemid 30412767)
48. Ueda, A. & Wood, T.K. Connecting quorum sensing, c-di-GMP, Pel polysaccharide, and biofilm formation in Pseudomonas aeruginosa through tyrosine phosphatase TpbA (PA3885). PLoS Pathog. 5, e1000483 (2009).
49. Macvanin, M. & Hughes, D. Assays of sensitivity of antibiotic-resistant bacteria to hydrogen peroxide and measurement of catalase activity. in Antibiotic Resistance Protocols: Second Edition, Methods in Molecular Biology Vol. 642 (Gillespie, S.H. & McHugh, T.D., eds), 95-103 (Humana Press, 2010).
50. Rice, P., Longden, I. & Bleasby, A. EMBOSS: The European Molecular Biology Open Software Suite (2000). Trends Genet. 16, 276-277 (2000).