Controlling the time evolution of mAb N-linked glycosylation - Part II: Model-based predictions

Biotechnology Progress

Volumn 32, Issue 5, 2016, Pages 1135-1148

  Villiger, Thomas K ^a   Scibona, Ernesto ^a   Stettler, Matthieu ^b   Broly, Hervé ^b   Morbidelli, Massimo ^a   Soos, Miroslav ^c  

^a ETH ZURICH   (Switzerland)

^b MERCK SERONO S A   (Switzerland)

^c INSTITUTE OF CHEMICAL TECHNOLOGY   (Czech Republic)

Author keywords

media design; microbioreactors; model based optimization; N linked glycosylation; process parameters

Indexed keywords

ANTIBODIES; BATCH DATA PROCESSING; BIOREACTORS; CELL CULTURE; CELLS; CYTOLOGY; ENZYME ACTIVITY; GLYCOSYLATION; MONOCLONAL ANTIBODIES; SAFETY FACTOR; THROUGHPUT;

DYNAMIC MATHEMATICAL MODEL; INTRA-CELLULAR MEASUREMENTS; MICRO BIOREACTOR; MODEL BASED OPTIMIZATION; MONOCLONAL ANTIBODIES (MABS); N-LINKED GLYCOSYLATION; PREDICTIVE CAPABILITIES; PROCESS PARAMETERS;

PROCESS CONTROL;

MONOCLONAL ANTIBODY;

ANIMAL; BIOLOGICAL MODEL; BIOREACTOR; CELL CULTURE; CHEMISTRY; CHO CELL LINE; CRICETULUS; GLYCOSYLATION; METABOLISM; PH; TIME FACTOR;

ANIMALS; ANTIBODIES, MONOCLONAL; BIOREACTORS; CELLS, CULTURED; CHO CELLS; CRICETULUS; GLYCOSYLATION; HYDROGEN-ION CONCENTRATION; MODELS, BIOLOGICAL; TIME FACTORS;

EID: 84978120414     PISSN: 87567938     EISSN: 15206033     Source Type: Journal    
DOI: 10.1002/btpr.2315     Document Type: Article

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