Characterization of glycosylation sites for a recombinant IgG1 monoclonal antibody and a CTLA4-Ig fusion protein by liquid chromatography-mass spectrometry peptide mapping

Journal of Chromatography A

Volumn 1218, Issue 45, 2011, Pages 8140-8149

  Bongers, Jacob ^a   Devincentis, John ^a   Fu, Jinmei ^a   Huang, Peiqing ^b   Kirkley, David H ^a   Leister, Kirk ^a   Liu, Peiran ^b   Ludwig, Richard ^b   Rumney, Kathleen ^a   Tao, Li ^b   Wu, Wei ^b   Russell, Reb J ^b  

^a BRISTOL MYERS SQUIBB COMPANY   (United States)

^b NONE   (United States)

Author keywords

Antibody; CTLA 4; Fc fusion; Glycosylation; LC MS; Peptide map

Indexed keywords

ANTIBODIES; GLYCOSYLATION; IONS; LIQUID CHROMATOGRAPHY; MAPPING; MASS SPECTROMETERS; MASS SPECTROMETRY; MONOCLONAL ANTIBODIES; OLIGOSACCHARIDES; RECOMBINANT PROTEINS;

CTLA-4; CTLA4-IG FUSION PROTEINS; IN-SOURCE COLLISION-INDUCED DISSOCIATIONS; LC-MS; LIQUID CHROMATOGRAPHY - MASS SPECTROMETRIES; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; PROTEIN GLYCOSYLATION; SELECTED ION MONITORING;

PEPTIDES;

ABATACEPT; ASPARTIC ACID; CARBOHYDRATE; ENDOPROTEINASE; GLYCAN; GLYCOPEPTIDE; MONOCLONAL ANTIBODY; OLIGOSACCHARIDE; PROTEINASE; RECOMBINANT IMMUNOGLOBULIN G1 MONOCLONAL ANTIBODY; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; COLLISIONALLY ACTIVATED DISSOCIATION; CONTROLLED STUDY; ION CURRENT; LINEAR ION TRAP MASS SPECTROMETER; LIQUID CHROMATOGRAPHY; MASS SPECTROMETER; MASS SPECTROMETRY; MOLECULAR WEIGHT; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN GLYCOSYLATION; QUANTITATIVE ANALYSIS;

EID: 80054688998     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2011.08.089     Document Type: Article

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