High-throughput profiling of nucleotides and nucleotide sugars to evaluate their impact on antibody N-glycosylation

Journal of Biotechnology

Volumn 229, Issue , 2016, Pages 3-12

  Villiger, Thomas K ^a   Steinhoff, Robert F ^a   Ivarsson, Marija ^a   Solacroup, Thomas ^b   Stettler, Matthieu ^b   Broly, Hervé ^b   Krismer, Jasmin ^a   Pabst, Martin ^a   Zenobi, Renato ^a   Morbidelli, Massimo ^a   Soos, Miroslav ^a,c  

^a ETH ZURICH   (Switzerland)

^b MERCK SERONO S A   (Switzerland)

^c INSTITUTE OF CHEMICAL TECHNOLOGY   (Czech Republic)

Author keywords

High throughput; MALDI TOF MS; Media optimization; Micro scale bioreactors; N linked glycosylation; Nucleotide sugars

Indexed keywords

AMINO ACIDS; ANIMAL CELL CULTURE; BATCH DATA PROCESSING; BIOREACTORS; CELL CULTURE; CELLS; CYTOLOGY; DESORPTION; GLYCOSYLATION; INDUCTIVELY COUPLED PLASMA; MAMMALS; MASS SPECTROMETRY; NUCLEOTIDES; SUGARS;

HIGH THROUGHPUT; MALDI TOF MS; MEDIA OPTIMIZATION; N-LINKED GLYCOSYLATION; NUCLEOTIDE SUGAR;

THROUGHPUT;

ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ANTIBODY; ASPARAGINE; CYTIDINE DIPHOSPHATE; CYTIDINE PHOSPHATE; CYTIDINE TRIPHOSPHATE; FUCOSE; GALACTOSE; GUANOSINE DIPHOSPHATE; GUANOSINE PHOSPHATE; GUANOSINE TRIPHOSPHATE; IMMUNOGLOBULIN G ANTIBODY; MANGANESE; MANNOSE; MONOSACCHARIDE; N ACETYLGLUCOSAMINE; NUCLEOTIDE; URIDINE; URIDINE DIPHOSPHATE; URIDINE PHOSPHATE; URIDINE TRIPHOSPHATE;

ANIMAL CELL; ARTICLE; BATCH PROCESS; BIOREACTOR; CELL CULTURE; CELL VIABILITY; GLYCOSYLATION; HIGH THROUGHPUT SCREENING; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN QUALITY; SYNTHESIS; ANIMAL; CHEMISTRY; CHO CELL LINE; CRICETULUS; HAMSTER; HIGH THROUGHPUT SEQUENCING; PROCEDURES;

ANIMALS; ANTIBODIES; CHO CELLS; CRICETINAE; CRICETULUS; GLYCOSYLATION; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; NUCLEOTIDES;

EID: 84964852946     PISSN: 01681656     EISSN: 18734863     Source Type: Journal    
DOI: 10.1016/j.jbiotec.2016.04.039     Document Type: Article

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