Optimal model-based design of the twin-column CaptureSMB process improves capacity utilization and productivity in protein A affinity capture

Biotechnology Journal

Volumn 11, Issue 1, 2016, Pages 135-145

  Baur, Daniel ^a   Angarita, Monica ^a   Müller Späth, Thomas ^a,b   Morbidelli, Massimo ^a  

^a ETH ZURICH   (Switzerland)

^b CHROMACON AG   (Switzerland)

Author keywords

Model based optimization; Monoclonal antibody; Periodic counter current chromatography; Protein A affinity chromatography; Sequential capture

Indexed keywords

AFFINITY CHROMATOGRAPHY; CELL CULTURE; CHROMATOGRAPHY; COLUMN CHROMATOGRAPHY; ECONOMIC AND SOCIAL EFFECTS; LIQUID CHROMATOGRAPHY; MONOCLONAL ANTIBODIES; PRODUCTIVITY; PROTEINS;

CAPACITY UTILIZATION; CHROMATOGRAPHIC PROCESS; CULTURE SUPERNATANT; MODEL BASED OPTIMIZATION; OPERATING CONDITION; PERIODIC COUNTER-CURRENT CHROMATOGRAPHIES; PROTEIN A; SEQUENTIAL CAPTURE;

ANTIBODIES;

MONOCLONAL ANTIBODY; PROTEIN A; RESIN; STAPHYLOCOCCUS PROTEIN A;

AFFINITY CHROMATOGRAPHY; ARTICLE; COUNTER CURRENT CHROMATOGRAPHY; FLOW RATE; PRIORITY JOURNAL; PROCESS DESIGN; PROCESS MODEL; PROCESS OPTIMIZATION; PROTEIN ANALYSIS; ALGORITHM; BATCH CELL CULTURE; CHEMICAL MODEL; CHEMISTRY; COMPARATIVE STUDY; DEVICES; IMMUNOLOGY; ISOLATION AND PURIFICATION; PROCEDURES;

ALGORITHMS; ANTIBODIES, MONOCLONAL; BATCH CELL CULTURE TECHNIQUES; CHROMATOGRAPHY, AFFINITY; MODELS, CHEMICAL; STAPHYLOCOCCAL PROTEIN A;

EID: 84955198136     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.201500223     Document Type: Article

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