Lycopene and Its Antioxidant Role in the Prevention of Cardiovascular Diseases—A Critical Review

Critical Reviews in Food Science and Nutrition

Volumn 56, Issue 11, 2016, Pages 1868-1879

  Müller, Lars ^a   Caris Veyrat, Catherine ^b,c   Lowe, Gordon ^d   Böhm, Volker ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^b UMR A 408 INRA University of Avignon   (France)

^c UNIVERSITY OF AVIGNON   (France)

^d LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

Author keywords

Atherosclerosis; in vitro; in vivo; isomerization; LDL oxidation

Indexed keywords

ANTIOXIDANTS; BLOOD; CARDIOLOGY; CHEMICAL VAPOR DEPOSITION; ENDOTHELIAL CELLS; ISOMERIZATION; PIGMENTS; TISSUE CULTURE;

ACUTE MYOCARDIAL INFARCTION; ATHEROSCLEROSIS; CHEMICAL AND BIOLOGICALS; EPIDEMIOLOGICAL STUDIES; IN-VITRO; IN-VIVO; LDL OXIDATION; LOW DENSITY LIPOPROTEINS;

DISEASES;

ANTIOXIDANT; CAROTENOID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; LYCOPENE; REACTIVE OXYGEN METABOLITE; TRIACYLGLYCEROL;

BLOOD; CARDIOVASCULAR DISEASE; DRUG EFFECT; HUMAN; METABOLISM; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK FACTOR;

ANTIOXIDANTS; CARDIOVASCULAR DISEASES; CAROTENOIDS; CHOLESTEROL, HDL; CHOLESTEROL, LDL; HUMANS; LYCOPENE; OXIDATIVE STRESS; RANDOMIZED CONTROLLED TRIALS AS TOPIC; REACTIVE OXYGEN SPECIES; RISK FACTORS; TRIGLYCERIDES;

EID: 84976288348     PISSN: 10408398     EISSN: 15497852     Source Type: Journal    
DOI: 10.1080/10408398.2013.801827     Document Type: Article

References (120)

1. I.Abete,, A.Perez-Cornago, S.Navas-Carretero, I.Bondia-Pons,, M.A.Zulet, and J.A.Martinez, (2013). A regular lycopene enriched tomato sauce consumption influences antioxidant status of healthy young-subjects: A crossover study. J. Funct. Foods 5:28–35.
2. K.D.Ahuja,, J.K.Pittaway, and M.J.Ball, (2006). Effects of olive oil and tomato lycopene combination on serum lycopene, lipid profile, and lipid oxidation. Nutrition 22:259–265.
3. W.K.Al-Delaimy,, P.Ferrari,, N.Slimani,, V.Pala,, I.Johansson,, S.Nilsson,, I.Mattisson,, E.Wirfalt,, R.Galasso,, D.Palli,, P.Vineis,, R.Tumino,, M.Dorronsoro,, G.Pera,, M.C.Ocke,, H.B.Bueno-de-Mesquita,, K.Overvad,, M.Chirlaque,, A.Trichopoulou,, A.Naska,, A.Tjonneland,, A.Olsen,, E.Lund,, E.H.Alsaker,, A.Barricarte,, E.Kesse,, M.C.Boutron-Ruault,, F.Clavel-Chapelon,, T.J.Key,, E.Spencer,, S.Bingham,, A.A.Welch,, M.J.Sanchez-Perez,, G.Nagel,, J.Linseisen,, J.R.Quiros,, P.H.Peeters,, C.H.van Gils,, H.Boeing,, A.L.van Kappel,, J.P.Steghens, and E.Riboli, (2005). Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC). Eur. J. Clin. Nutr. 59:1387–1396.
4. R.Armstrong, (2001). The physiological role and pharmacological potential of nitric oxide in neutrophil activation. Int. Immunopharmacol. 1:1501–1512.
5. A.G.Basnakian,, S.V.Shah,, E.Ok,, E.Altunel, and E.O.Apostolov, (2010). Carbamylated LDL. Adv. Clin. Chem. 51:25–52.
6. I.F.Benzie, and J.J.Strain, (1996). The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay. Anal. Biochem. 239:70–76.
7. F.Böhm,, R.Edge,, M.Burke, and T.G.Truscott, (2001). Dietary uptake of lycopene protects human cells from singlet oxygen and nitrogen dioxide—ROS components from cigarette smoke. J. Photochem. Photobiol. B64:176–178.
8. C.S.Boon,, D.J.McClements,, J.Weiss, and E.A.Decker, (2009). Role of iron and hydroperoxides in the degradation of lycopene in oil-in-water emulsions. J. Agric. Food Chem. 57:2993–2998.
9. G.Britton,, S.Liaaen-Jensen, and H.Pfander, (2004). Carotenoids Handbook. Birkhäuser Verlag, Basel.
10. B.Burton-Freeman,, J.Talbot,, E.Park,, S.Krishnankutty, and I.Edirisinghe, (2012). Protective activity of processed tomato products on postprandial oxidation and inflammation: A clinical trial in healthy weight men and women. Mol. Nutr. Food Res. 56:622–631.
11. L.P.Candeias,, K.B.Patel,, M.R.Stratford, and P.Wardman, (1993). Free hydroxyl radicals are formed on reaction between the neutrophil-derived species superoxide anion and hypochlorous acid. FEBS Lett. 333:151–153.
12. A.Cantrell,, D.J.McGarvey,, T.G.Truscott,, F.Rancan, and F.Bohm, (2003). Singlet oxygen quenching by dietary carotenoids in a model membrane environment. Arch. Biochem. Biophys. 412:47–54.
13. M.Carail, and C.Caris-Veyrat, (2006). Carotenoid oxidation products: from villain to saviour? Pure Appl. Chem. 78:1493–1503.
14. C.Caris-Veyrat,, A.Schmid,, M.Carail, and V.Böhm, (2003). Cleavage products of lycopene produced by in vitro oxidations: characterization and mechanisms of formation. J Agric. Food Chem. 51:7318–7325.
15. A.C.Carr,, M.R.McCall, and B.Frei, (2000). Oxidation of LDL by myeloperoxidase and reactive nitrogen species: reaction pathways and antioxidant protection. Arterioscler. Thromb. Vasc. Biol. 20:1716–1723.
16. C.Chanforan,, M.Loonis,, N.More,, C.Caris-Veyrat, and C.Dufour, (2012). The impact of industrial processing on health-beneficial tomato microconstituents. Food Chem. 134:1786–1795.
17. P.Y.Chew,, L.Riley,, D.L.Graham,, K.Rahman, and G.M.Lowe, (2012). Does lycopene offer human LDL any protection against myeloperoxidase activity? Mol. Cell. Biochem. 361:181–187.
18. P.F.Conn,, C.Lambert,, E.J.Land,, W.Schalch, and T.G.Truscott, (1992). Carotene-oxygen radical interactions. Free Radical Res. Commun. 16:401–408.
19. P.Di Mascio,, S.Kaiser, and H.Sies, (1989). Lycopene as the most efficient biological carotenoid singlet oxygen quencher. Arch. Biochem. Biophys. 274:532–538.
20. G.Englert,, B.O.Brown,, G.P.Moss,, B.C.L.Weedon,, G.Britton,, T.W.Goodwin,, K.L.Simpson, and R.J.H.Williams, (1979). J. Chem. Soc., Chem. Commun. 12:545–547.
21. J.W.Erdman,, Jr.,, N.A.Ford, and B.L.Lindshield, (2009). Are the health attributes of lycopene related to its antioxidant function? Arch. Biochem. Biophys. 483:229–235.
22. H.Esterbauer,, J.Gebicki,, H.Puhl, and G.Jürgens, (1992). The role of lipid peroxidation and antioxidants in oxidative modification of LDL. Free Radic. Biol. Med. 13:341–390.
23. N.A.Ford,, A.C.Elsen,, K.Zuniga,, B.L.Lindshield, and J.W.Erdman,, Jr. (2011). Lycopene and apo-12′-lycopenal reduce cell proliferation and alter cell cycle progression in human prostate cancer cells. Nutr. Cancer 63:256–263.
24. B.Frei, and J.M.Gaziano, (1993). Content of antioxidants, preformed lipid hydroperoxides, and cholesterol as predictors of the susceptibility of human LDL to metal ion-dependent and independent oxidation. J. Lipid. Res. 34:2135–2145.
25. K.Fröhlich,, K.Kaufmann,, R.Bitsch, and V.Böhm, (2006). Effects of ingestion of tomatoes, tomato juice and tomato puree on contents of lycopene isomers, tocopherols and ascorbic acid in human plasma as well as on lycopene isomer pattern. Br. J. Nutr. 95:734–741.
26. H.E.Gabriel,, Z.Liu,, J.W.Crott,, S.W.Choi,, B.C.Song,, J.B.Mason, and E.J.Johnson, (2006). A comparison of carotenoids, retinoids, and tocopherols in the serum and buccal mucosa of chronic cigarette smokers versus nonsmokers. Cancer Epidemiol. Biomarkers Prev. 15:993–999.
27. A.Galano,, R.Vargas, and A.Martinez, (2010). Carotenoids can act as antioxidants by oxidizing the superoxide radical anion. Phys. Chem. Chem. Phys. 12:193–200.
28. P.Goupy,, E.Reynaud,, O.Dangles, and C.Caris-Veyrat, (2011). Antioxidant activity of (all-E)-lycopene and synthetic apo-lycopenoids in an chemical model of oxidative stress in the gastro-intestinal tract. New J. Chem. 36:575–587.
29. E.Gouranton,, G.Aydemir,, E.Reynaud,, J.Marcotorchino,, C.Malezet,, C.Caris-Veyrat,, R.Blomhoff,, J.F.Landrier, and R.Rühl, (2011). Apo-10′-lycopenoic acid impacts adipose tissue biology via the retinoic acid receptors. Biochim. Biophys. Acta 1811:1105–1114.
30. D.L.Graham,, M.Carail,, C.Caris-Veyrat, and G.M.Lowe, (2010). Cigarette smoke and human plasma lycopene depletion. Food Chem. Toxicol. 48:2413–2420.
31. J.J.Guo, and C.H.Hu, (2010). Mechanism of chain termination in lipid peroxidation by carotenes: a theoretical study. J. Phys. Chem. B 114:16948–16958.
32. B.Halliwell,, K.Zhao, and M.Whiteman, (2000). The gastrointestinal tract: a major site of antioxidant action? Free Radical Res. 33:819–830.
33. S.L.Hazen, and J.W.Heinecke, (1997). 3-Chlorotyrosine, a specific marker of myeloperoxidase-catalyzed oxidation, is markedly elevated in low density lipoprotein isolated from human atherosclerotic intima. J. Clin. Invest. 99:2075–2081.
34. L.K.Henry,, G.L.Catignani, and S.J.Schwartz, (1998). Oxidative degradation kinetics of lycopene, lutein, and 9-cis and all-trans β-carotene. J. Am. Oil Chem. Soc. 75:823–829.
35. G.Hsiao,, Y.Wang,, N.H.Tzu,, T.H.Fong,, M.Y.Shen,, K.H.Lin,, D.S.Chou, and J.R.Sheu, (2005). Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J. Labatory Clin. Med. 146:216–226.
36. C.F.Hung,, T.F.Huang,, B.H.Chen,, J.M.Shieh,, P.H.Wu, and W.B.Wu, (2008). Lycopene inhibits TNF-alpha-induced endothelial ICAM-1 expression and monocyte-endothelial adhesion. Eur. J. Pharmacol. 586:275–282.
37. J.S.Hurst,, J.E.Contreras,, W.G.Siems, and F.J.G.M.van Kuijk, (2004). Oxidation of carotenoids by heat and tobacco smoke. BioFactors 20:23–35.
38. IUPAC. (1971). IUPAC Commission on the Nomenclature of Organic Chemistry and IUPAC-IUB Commission on Biochemical Nomenclature. Carotenoids, pp. 851–864. O. Isler. Birkhäuser Verlag, Basel.
39. IUPAC. (1975). IUPAC Commission on the Nomenclature of Organic Chemistry (CNOC) and IUPAC-IUB Commission on Biochemical Nomenclature (CBN), Nomenclature of carotenoids (Rules approved 1974). Pure Appl. Chem. 41:107–131.
40. M.Jenab,, P.Ferrari,, M.Mazuir,, A.Tjonneland,, F.Clavel-Chapelon,, J.Linseisen,, A.Trichopoulou,, R.Tumino,, H.B.Bueno-de-Mesquita,, E.Lund,, C.A.Gonz lez,, G.Johansson,, T.J.Key, and E.Riboli, (2005). Variations in lycopene blood levels and tomato consumption across European countries based on the European Prospective Investigation into Cancer and Nutrition (EPIC) study. J. Nutr. 135:2032S–2036S.
41. W.Jessup,, L.Kritharides, and R.Stocker, (2004). Lipid oxidation in atherogenesis: an overview. Biochem. Soc. Trans. 32:134–138.
42. J.Karppi,, S.Kurl,, J.A.Laukkanen,, T.H.Rissanen, and J.Kauhanen, (2011). Plasma carotenoids are related to intima-media thickness of the carotid artery wall in men from eastern Finland. J. Int. Med. 270:478–485.
43. J.Karppi,, J.A.Laukkanen,, T.H.Mäkikallio,, K.Ronkainen, and S.Kurl, (2012a). Low β-carotene concentrations increase the risk of cardiovascular disease mortality among Finnish men with risk factors. Nutr. Metab. Card. Dis. 22:921–928.
44. J.Karppi,, J.A.Laukkanen,, J.Sivenius,, K.Ronkainen, and S.Kurl, (2012b). Serum lycopene decreases the risk of stroke in men. Neurology 79:1540–1547.
45. J.Karppi,, J.A.Laukkanen,, T.H.Mäkikallio,, K.Ronkainen, and S.Kurl, (2013). Serum β-carotene and the risk of sudden cardiac death in men: A population-based follow-up study. Atherosclerosis 226:172–177.
46. E.Kassi,, M.Dalamaga,, E.Faviou,, G.Hroussalas,, K.Kazanis,, C.Nounopoulos, and A.Dionyssiou-Asteriou, (2009). Circulating oxidized LDL levels, current smoking and obesity in postmenopausal women. Atherosclerosis 205:279–283.
47. F.Khachik,, G.R.Beecher, and J.C.Smith,, Jr. (1995). Lutein, lycopene, and their oxidative metabolites in chemoprevention of cancer. J. Cell. Biochem. 22:236–246.
48. F.Khachik,, C.J.Spangler,, J.C.Smith,, Jr. and L.M.Canfield, (1997). Identification, quantification, and relative concentrations of carotenoids and their metabolites in human milk and serum. Anal. Chem. 69:1873–1881.
49. O.Y.Kim,, H.Y.Yoe,, H.J.Kim,, J.Y.Park,, J.Y.Kim,, S.H.Lee,, J.H.Lee,, K.P.Lee and Y.Jang, (2010). Independent inverse relationship between serum lycopene concentration and arterial stiffness. Atherosclerosis 208:581–586.
50. K.-W.Kong,, H.-E.Khoo,, K.N.Prasad,, A.Ismail,, C.-P.Tan and N.F.Rajab, (2010). Revealing the power of the natural red pigment lycopene. Molecules 15:959–987.
51. R.E.Kopec,, K.M.Riedl,, E.H.Harrison,, R.W.Curley,, Jr., D.P.Hruszkewycz,, S.K.Clinton, and S.J.Schwartz, (2010). Identification and quantification of apo-lycopenals in fruits, vegetables, and human plasma. J. Agric. Food Chem. 58:3290–3296.
52. N.I.Krinsky, and K.-J.Yeum, (2003). Carotenoid-radical interactions. Biochem. Biophys. Res. Commun. 305:754–760.
53. H.S.Kruth,, W.Huang,, I.Ishii, and W.Y.Zhang, (2002). Macrophage foam cell formation with native low density lipoprotein. J. Biol. Chem. 277:34573–34580.
54. P.Libby,, P.M.Ridker, and A.Maseri, (2002). Inflammation and atherosclerosis. Circulation 105:1135–1143.
55. K.Linnewiel,, H.Ernst,, C.Caris-Veyrat,, A.Ben-Dor,, A.Kampf,, H.Salman,, M.Danilenko,, J.Levy, and Y.Sharoni, (2009). Structure activity relationship of carotenoid derivatives in activation of the electrophile/antioxidant response element transcription system. Free Radical Biol. Med. 47:659–667.
56. D.Liu,, J.Shi,, A.Colina Ibarra,, Y.Kakuda, and S.J.Xue, (2008). The scavenging capacity and synergistic effects of lycopene, vitamin E, vitamin C, and β-carotene mixtures on the DPPH free radical. LWT-Food Sci. Technol. 41:1344–4139.
57. G.M.Lowe,, R.F.Bilton,, I.G.Davies,, T.C.Ford,, D.Billington, and A.J.Young, (1999). Carotenoid composition and antioxidant potential in subfractions of human low-density lipoprotein. Ann. Clin. Biochem. 36(Pt 3):323–332.
58. G.M.Lowe,, K.Vlismas,, D.L.Graham,, M.Carail,, C.Caris-Veyrat, and A.J.Young, (2009). The degradation of (all-E)-beta-carotene by cigarette smoke. Free Radic. Res. 43:280–286.
59. Y.Lu,, H.Etoh,, N.Watanabe,, K.Ina,, N.Ukai,, S.Oshima,, F.Ojima,, H.Sakamoto, and Y.Ishiguro, (1995). A new carotenoid, hydrogen peroxide oxidation products from lycopene. Biosci. Biotechnol. Biochem. 59:2153–2155.
60. E.Malle,, G.Marsche,, J.Arnhold, and M.J.Davies, (2006). Modification of low-density lipoprotein by myeloperoxidase-derived oxidants and reagent hypochlorous acid. Biochim. Biophys. Acta 1761:392–415.
61. R.Martínez-Tómas,, F.Pérez-Llamas,, M.Sánchez-Campillo,, D.Gonzaléz-Silvera,, A.I.Cascales,, M.García-Fernández,, J.A.López-Jiménez,, S.Zamora Navarro,, M.I.Burgos,, F.López-Azorín,, A.Wellner,, F.Avilés Plaza,, L.Bialek,, M.Aminger, and E.Larqué, (2012). Daily intake of fruit and vegetable soups processed in different ways increases human serum β-carotene and lycopene concentrations and reduces levels of several oxidative stress markers in healthy subjects. Food Chem. 134:127–133.
62. J.McEneny,, L.Wade,, I.S.Young,, L.Masson,, G.Duthie,, A.McGinty,, C.McMaster, and F.Thies, (2013). Lycopene intervention reduces inflammation and improves HDL functionality in moderately overweight middle-aged individuals. J. Nutr. Biochem. 24:163–168.
63. J.R.McNamara,, D.M.Small,, Z.Li, and E.J.Schaefer, (1996). Differences in LDL subspecies involve alterations in lipid composition and conformational changes in apolipoprotein Brit. J. Lipid Res. 37:1924–1935.
64. H.McNulty,, R.F.Jacob, and R.P.Mason, (2008). Biologic activity of carotenoids related to distinct membrane physicochemical interactions. Am. J. Cardiol. 101:20D–29D.
65. D.S.Michaud,, E.L.Giovannucci,, A.Ascherio,, E.B.Rimm,, M.R.Forman,, L.Sampson, and W.C.Willett, (1998). Associations of plasma carotenoid concentrations and dietary intake of specific carotenoids in samples of two prospective cohort studies using a new carotenoid database. Cancer Epidemiol., Biomarkers Prev. 7:283–290.
66. J.Milde,, E.F.Elstner, and J.Grassmann, (2007). Synergistic effects of phenolics and carotenoids on human low-density lipoprotein oxidation. Mol. Nutr. Food Res. 51:956–961.
67. N.J.Miller,, J.Sampson,, L.P.Candeias,, P.M.Bramley, and C.A.Rice-Evans, (1996). Antioxidant activities of carotenes and xanthophylls. FEBS Lett. 384:240–242.
68. A.Mortensen,, L.H.Skibsted,, J.Sampson,, C.Rice-Evans, and S.A.Everett, (1997). Comparative mechanisms and rates of free radical scavenging by carotenoid antioxidants. FEBS Lett. 418:91–97.
69. A.Mortensen,, L.H.Skibstedt, and T.G.Truscott, (2001). The interaction of dietary carotenoids with radical species. Arch. Biochem. Biophys. 385:13–19.
70. L.W.Morton,, N.C.Ward,, K.D.Croft, and I.B.Puddey, (2002). Evidence for the nitration of gamma-tocopherol in vivo: 5-nitro-gamma-tocopherol is elevated in the plasma of subjects with coronary heart disease. Biochem. J. 364:625–628.
71. L.Müller, and V.Böhm, (2011a). Antioxidant activity of β-carotene compounds in different in vitro assays. Molecules 16:1055–1069.
72. L.Müller,, K.Fröhlich, and V.Böhm, (2011b). Comparative antioxidant activities of carotenoids measured by ferric reducing antioxidant power (FRAP), ABTS bleaching assay (aTEAC), DPPH assay and peroxyl radical scavenging assay. Food Chem. 129:139–148.
73. L.Müller,, P.Goupy,, K.Fröhlich,, O.Dangles,, C.Caris-Veyrat, and V.Böhm, (2011c). Comparative study on antioxidant activity of lycopene (Z)-isomers in different assays. J. Agric. Food Chem. 59:4504–4511.
74. L.Müller,, E.Reynaud,, P.Goupy,, C.Caris-Veyrat, and V.Böhm, (2012). Do apo-lycopenoids have antioxidant activity in vitro? J. Am. Oil Chem. Soc. 88:849–858.
75. K.Muzandu,, M.Ishizuka,, K.Q.Sakamoto,, Z.Shaban,, El K.Bohi,, A.Kazusaka, and S.Fujita, (2006). Effect of lycopene and beta-carotene on peroxynitrite-mediated cellular modifications. Toxicol. Appl. Pharmacol. 215:330–340.
76. M.Napolitano,, C.De Pascale,, C.Wheeler-Jones,, K.M.Botham, and E.Bravo, (2007). Effects of lycopene on the induction of foam cell formation by modified LDL. Am. J. Physiol. Endocrinol. Metab. 293:E1820–1827.
77. J.R.Nofer,, M.F.Brodde, and B.E.Kehrel, (2010). High-density lipoproteins, platelets and the pathogenesis of atherosclerosis. Clin. Exp. Pharmacol. Physiol. 37:726–735.
78. A.O.Omoni, and R.E.Aluko, (2005). The anti-carcinogenic and anti-atherogenic effects of lycopene: a review. Trends Food Sci. Technol. 16:344–350.
79. M.E.O'Neill,, Y.Carroll,, B.Corridan,, B.Olmedilla,, F.Granado,, I.Blanco,, H.van den Berg,, I.Hininger,, A.-M.Rousell,, M.Chopra,, S.Southon,, D.I.Thurnham, (2001). A European carotenoid database to assess carotenoid intakes and its use in a five-country comparative study. Br. J. Nutr. 85:499–507.
80. M.Özyürek,, B.Bektasoglu,, K.Güclü,, N.Güngör, and R.Apak, (2008). Simultaneous total antioxidant capacity assay of lipophilic and hydrophilic antioxidants in the same acetone-water solution containing 2% methyl-beta-cyclodextrin using the cupric reducing antioxidant capacity (CUPRAC) method. Anal. Chim. Acta 630:28–39.
81. P.Palozza,, N.Parrone,, R.E.Simone, and A.Catalano, (2010). Lycopene in atherosclerosis prevention: an integrated scheme of the potential mechanisms of action from cell culture studies. Arch. Biochem. Biophys. 504:26–33.
82. P.Palozza,, R.Simone,, A.Catalano,, A.Boninsegna,, V.Böhm,, K.Fröhlich,, M.C.Mele,, G.Monego, and F.O.Ranelletti, (2010). Lycopene prevents 7-ketocholesterol-induced oxidative stress, cell cycle arrest and apoptosis in human macrophages. J. Nutr. Biochem. 21:34–46.
83. P.Palozza,, R.Simone,, A.Catalano,, N.Parrone,, G.Monego, and F.O.Ranelletti, (2011). Lycopene regulation of cholesterol synthesis and efflux in human macrophages. J. Nutr. Biochem. 22:971–978.
84. R.Paoletti,, A.M.Gotto,, Jr. and D.P.Hajjar, (2004). Inflammation in atherosclerosis and implications for therapy. Circulation 109:III-20–III-26.
85. S.Pennathur,, D.Maitra,, J.Byun,, I.Sliskovic,, I.Abdulhamid,, G.M.Saed,, M.P.Diamond, and H.M.Abu-Soud, (2010). Potent antioxidative activity of lycopene: A potential role in scavenging hypochlorous acid. Free Radical Biol. Med. 49:205–213.
86. R.Pulido,, L.Bravo, and F.Saura-Calixto, (2000). Antioxidant activity of dietary polyphenols as determined by a modified ferric reducing/antioxidant power assay. J. Agric. Food Chem. 48:3396–3402.
87. A.V.Rao,, M.R.Ray, and L.G.Rao, (2006). Lycopene. Adv. Food Nutr. Res. 51:99–164.
88. E.Reynaud,, G.Aydemir,, R.Rühl,, O.Dangles, and C.Caris-Veyrat, (2011). Organic synthesis of new putative lycopene metabolites and preliminary investigation of their cell-signalling effects. J. Agric. Food Chem. 59:1457–1463.
89. M.Rizzo, and K.Berneis, (2007). Who needs to care about small, dense low-density lipoproteins? Int. J. Clin. Pract. 61:1949–1956.
90. D.B.Rodriguez-Amaya, (2001). A guide to carotenoid analysis in food, ILSI Press, Washington.
91. J.E.Romanchik,, D.W.Morel, and E.H.Harrison, (1995). Distributions of carotenoids and alpha-tocopherol among lipoproteins do not change when human plasma is incubated in vitro. J. Nutr. 125:2610–2617.
92. C.H.S.Ruxton,, E.J.Gardner, and D.Walker, (2006). Can pure fruit and vegetable juices protect against cancer and cardiovascular disease too? A review of the evidence. Int. J. Food Sci. Nutr. 57:249–272.
93. J.Schierle,, W.Bretzel,, I.Bühler,, N.Faccin,, D.Hess,, K.Steiner, and W.Schüep, (1997). Content and isomeric ratio of lycopene in food and human blood plasma. Food Chem. 59:459–465.
94. J.P.Segrest,, M.K.Jones,, H.De Loof, and N.Dashti, (2001). Structure of apolipoprotein B-100 in low density lipoproteins. J. Lipid. Res. 42:1346–1367.
95. H.D.Sesso,, J.E.Buring,, E.P.Norkus, and J.M.Gaziano, (2005) Plasma lycopene, other carotenoids, and retinol, and the risk of cardiovascular disease in men. Am. J. Clin. Nutr. 81:990–997.
96. P.K.Shah, (1999). Plaque disruption and thrombosis. Potential role of inflammation and infection. Cardiol. Clin. 17:271–281.
97. J.Shi, and M.Le Maguer, (2000). Lycopene in tomatoes: chemical and physical properties affected by food processing. Crit. Rev. Biotechnol. 20:293–334.
98. M.L.Silaste,, G.Alfthan,, A.Aro,, Y.A.Kesaniemi, and S.Horkko, (2007). Tomato juice decreases LDL cholesterol levels and increases LDL resistance to oxidation. Br. J. Nutr. 98:1251–1258.
99. W.Stahl,, A.Junghans,, B.de Boer,, E.S.Driomina,, K.Briviba, and H.Sies, (1998). Carotenoid mixtures protect multilamellar liposomes against oxidative damage: synergistic effects of lycopene and lutein. FEBS Lett. 427:305–308.
100. W.Stahl,, H.Sies, (2003). Antioxidant activity of carotenoids. Mol. Aspects Med. 24:345–351.
101. A.R.Sundquist,, K.Briviba, and H.Sies, (1994). Singlet oxygen quenching by carotenoids. Methods Enzymol. 234:384–388.
102. J.Swain, and J.M.Gutteridge, (1995). Prooxidant iron and copper, with ferroxidase and xanthine oxidase activities in human atherosclerotic material. FEBS Lett. 368:513–515.
103. X.Tang,, X.Yang,, Y.Peng, and J.Lin, (2009). Protective effects of lycopene against H2O2-induced oxidative injury and apoptosis in human endothelial cells. Cardiovasc. Drugs Ther. 23:439–448.
104. F.Thies,, L.F.Masson,, A.Rudd,, N.Vaughan,, C.Tsang,, J.Brittenden,, W.G.Simpson,, S.Duthie,, G.W.Horgan, and G.Duthie, (2012). Effect of a tomato-rich diet on markers of cardiovascular disease risk in moderately overweight, disease-free, middle-aged adults: a randomized controlled trial. Am. J. Clin. Nutr. 95:1013–1022.
105. J.P.Thomas,, B.Kalyanaraman, and A.W.Girotti, (1994). Involvement of preexisting lipid hydroperoxides in Cu(2+)-stimulated oxidation of low-density lipoprotein. Arch. Biochem. Biophys. 315:244–254.
106. S.Tsimikas, and Y.I.Miller, (2011). Oxidative modification of lipoproteins: mechanisms, role in inflammation and potential clinical applications in cardiovascular disease. Curr. Pharm. Design 17:27–37.
107. S.Vainio, and E.Ikonen, (2003). Macrophage cholesterol transport: a critical player in foam cell formation. Ann. Med. 35:146–155.
108. F.Visioli,, P.Riso,, S.Grande,, C.Galli, and M.Porrini, (2003). Protective activity of tomato products on in vivo markers of lipid oxidation. Eur. J. Nutr. 42:201–206.
109. K.H.Wagner, and I.Elmadfa, (2003). Biological relevance of terpenoids. Overview focusing on mono-, di- and tetraterpenes. Ann. Nutr. Metab. 47:95–106.
110. X.D.Wang, (2004), Carotenoid oxidative/degradative products and their biological activities. In: Carotenoids in Healths and Disease, pp. 313–335. N.I.Krinsky,, S.T.Mayne, and H.Sies, Eds., CRC Press, Boca Raton.
111. B.C.L.Weedon, and G.P.Moss, (1995), Structure and Nomenclature. In: Carotenoids, Volume 1A: Isolation and Analysis, pp. 27–70. G.Britton,, S.Liaaen-Jensen, and H.Pfander, Eds, Birkhäuser Verlag, Basel.
112. C.C.Winterbourn, and A.J.Kettle, (2000). Biomarkers of myeloperoxidase-derived hypochlorous acid. Free Radical Biol. Med. 29:403–409.
113. A.A.Woodall,, G.Britton, and M.J.Jackson, (1995). Antioxidant activity of carotenoids in phosphatidylcholine vesicles: chemical and structural considerations. Biochem. Soc. Trans. 23:133S.
114. A.A.Woodall,, G.Britton, and M.J.Jackson, (1997). Carotenoids and protection of phospholipids in solution or in liposomes against oxidation by peroxyl radicals: Relationship between carotenoid structure and protective ability. Biochim. Biophys. Acta 1336:575–586.
115. A.J.Wright,, S.Southon,, M.Chopra,, A.Meyer-Wenger,, U.Moser,, F.Granado,, B.Olmedilla,, B.Corridan,, I.Hinninger,, A.M.Roussel,, H.van den Berg, and D.I.Thurnham, (2002). Comparison of LDL fatty acid and carotenoid concentrations and oxidative resistance of LDL in volunteers from countries with different rates of cardiovascular disease. Br. J. Nutr. 87:21–29.
116. P.Xaplanteris,, C.Vlachopoulos,, P.Pietri,, D.Terentes-Printzios,, D.Kardara,, N.Alexopoulos,, K.Aznaouridis,, A.Miliou, and C.Stefanadis, (2012). Tomato paste supplementation improves endothelial dynamics and reduces plasma total oxidative status in healthy subjects. Nutr. Res. 32:390–394.
117. L.F.Yamaguchi,, G.R.Martinez,, L.H.Catalani,, M.H.Medeiros, and P.Di Mascio, (1999). Lycopene entrapped in human albumin protects 2′-deoxyguanosine against singlet oxygen damage. Arch. Latinam. Nutr. 49:12S–20S.
118. S.Yamashita, and Y.Matsuzawa, (2009). Where are we with probucol: a new life for an old drug? Atherosclerosis 207:16–23.
119. K.-J.Yeum,, G.Aldini,, H.-Y.Chung,, N.I.Krinsky, and R.M.Russell, (2003). The activities of antioxidant nutrients in human plasma depend on the localization of attacking radical species. J. Nutr. 133:2688–2691.
120. R.Zhang,, M.L.Brennan,, Z.Shen,, J.C.MacPherson,, D.Schmitt,, C.E.Molenda, and S.L.Hazen, (2002). Myeloperoxidase functions as a major enzymatic catalyst for initiation of lipid peroxidation at sites of inflammation. J. Biol. Chem. 277:46116–46122.