메뉴 건너뛰기




Volumn 22, Issue 10, 2011, Pages 971-978

Lycopene regulation of cholesterol synthesis and efflux in human macrophages

Author keywords

ABCA1; Caveolin 1; Cholesterol; HMG CoA reductase; Lycopene; THP 1 cells

Indexed keywords

2 CHLORO 5 NITROBENZANILIDE; ABC TRANSPORTER A1; CAROTENOID; CAVEOLIN 1; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LIVER X RECEPTOR ALPHA; LYCOPENE; MEVALONIC ACID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

EID: 79956283666     PISSN: 09552863     EISSN: 18734847     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2010.08.010     Document Type: Article
Times cited : (78)

References (44)
  • 1
    • 0033552883 scopus 로고    scopus 로고
    • Atherosclerosis - an inflammatory disease
    • Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999, 340:115-126.
    • (1999) N Engl J Med , vol.340 , pp. 115-126
    • Ross, R.1
  • 2
    • 0036852744 scopus 로고    scopus 로고
    • The macrophage foam cell as a target for therapeutic intervention
    • Li A.C., Glass C.K. The macrophage foam cell as a target for therapeutic intervention. Nat Med 2002, 8:1235-1242.
    • (2002) Nat Med , vol.8 , pp. 1235-1242
    • Li, A.C.1    Glass, C.K.2
  • 3
    • 0022549920 scopus 로고
    • A receptor-mediated pathway for cholesterol homeostasis
    • Brown M.S., Goldstein J.L. A receptor-mediated pathway for cholesterol homeostasis. Science 1986, 232:34-47.
    • (1986) Science , vol.232 , pp. 34-47
    • Brown, M.S.1    Goldstein, J.L.2
  • 4
    • 0035170229 scopus 로고    scopus 로고
    • High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport
    • von Eckardstein A., Nofer J.R., Assmann G. High density lipoproteins and arteriosclerosis. Role of cholesterol efflux and reverse cholesterol transport. Arterioscl Thromb Vasc Biol 2001, 21:13-27.
    • (2001) Arterioscl Thromb Vasc Biol , vol.21 , pp. 13-27
    • von Eckardstein, A.1    Nofer, J.R.2    Assmann, G.3
  • 5
    • 0032851111 scopus 로고    scopus 로고
    • Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway
    • Edwards P.A., Ericsson J. Sterols and isoprenoids: signaling molecules derived from the cholesterol biosynthetic pathway. Annu Rev Biochem 1999, 68:157-185.
    • (1999) Annu Rev Biochem , vol.68 , pp. 157-185
    • Edwards, P.A.1    Ericsson, J.2
  • 6
    • 0035843962 scopus 로고    scopus 로고
    • Structural mechanism for statin inhibition of HMG-CoA reductase
    • Istvan E.S., Deisenhofer J. Structural mechanism for statin inhibition of HMG-CoA reductase. Science 2001, 292:1160-1164.
    • (2001) Science , vol.292 , pp. 1160-1164
    • Istvan, E.S.1    Deisenhofer, J.2
  • 7
    • 0019135838 scopus 로고
    • Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth
    • Brown M.S., Goldstein J.L. Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth. J Lipid Res 1980, 21:505-517.
    • (1980) J Lipid Res , vol.21 , pp. 505-517
    • Brown, M.S.1    Goldstein, J.L.2
  • 8
    • 4244005749 scopus 로고
    • Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygote
    • Bilheimer D.W., Grundy S.M., Brown M.S., Goldstein J.L. Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygote. Proc Natl Acad Sci U S A 1989, 80:4142-4228.
    • (1989) Proc Natl Acad Sci U S A , vol.80 , pp. 4142-4228
    • Bilheimer, D.W.1    Grundy, S.M.2    Brown, M.S.3    Goldstein, J.L.4
  • 9
    • 0034644537 scopus 로고    scopus 로고
    • Ras and Rho GTPases: a family reunion
    • Bar-Sagi D., Hall A. Ras and Rho GTPases: a family reunion. Cell 2000, 103:227-238.
    • (2000) Cell , vol.103 , pp. 227-238
    • Bar-Sagi, D.1    Hall, A.2
  • 10
    • 0034672686 scopus 로고    scopus 로고
    • Functional aspects of polyisoprenoid protein substituents: roles in protein-protein interaction and trafficking
    • Sinensky M. Functional aspects of polyisoprenoid protein substituents: roles in protein-protein interaction and trafficking. Biochem Biophys Acta 2000, 1529:203-209.
    • (2000) Biochem Biophys Acta , vol.1529 , pp. 203-209
    • Sinensky, M.1
  • 11
    • 0032844429 scopus 로고    scopus 로고
    • 1999. Antiatherogenic properties of naringenin, a citrus flavonoid
    • Wilcox L.J., Borradaile N.M., Huff M.W. 1999. Antiatherogenic properties of naringenin, a citrus flavonoid. Cardiovasc Drug Rev 1999, 17:160-178.
    • (1999) Cardiovasc Drug Rev , vol.17 , pp. 160-178
    • Wilcox, L.J.1    Borradaile, N.M.2    Huff, M.W.3
  • 12
    • 0038776380 scopus 로고    scopus 로고
    • Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma
    • Hu E., Kim J.B., Sarraf P., Spiegelman B.M. Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma. Science 1996, 274:2100-2103.
    • (1996) Science , vol.274 , pp. 2100-2103
    • Hu, E.1    Kim, J.B.2    Sarraf, P.3    Spiegelman, B.M.4
  • 13
    • 0030885520 scopus 로고    scopus 로고
    • The orphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism
    • Forman B.M., Ruan B., Chen J., Schroepfer G.J.J., Evans R.M. The orphan nuclear receptor LXRα is positively and negatively regulated by distinct products of mevalonate metabolism. Proc Natl Acad Sci U S A 1997, 94:10588-10593.
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 10588-10593
    • Forman, B.M.1    Ruan, B.2    Chen, J.3    Schroepfer, G.J.J.4    Evans, R.M.5
  • 14
    • 0030840424 scopus 로고    scopus 로고
    • Tissue expression studies on the mouse acyl-CoA:cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice
    • Meiner V.L., Tam C., Gunn M.D., Farese R.V. Tissue expression studies on the mouse acyl-CoA:cholesterol acyltransferase gene (Acact): findings supporting the existence of multiple cholesterol esterification enzymes in mice. J Lipid Res 1997, 38:1928-1933.
    • (1997) J Lipid Res , vol.38 , pp. 1928-1933
    • Meiner, V.L.1    Tam, C.2    Gunn, M.D.3    Farese, R.V.4
  • 15
    • 0036321948 scopus 로고    scopus 로고
    • ATP-binding cassette transporter A1 and cholesterol trafficking
    • Oram J.F. ATP-binding cassette transporter A1 and cholesterol trafficking. Curr Opin Lipidol 2002, 13:373-381.
    • (2002) Curr Opin Lipidol , vol.13 , pp. 373-381
    • Oram, J.F.1
  • 16
    • 69549129239 scopus 로고    scopus 로고
    • PPARγ1-induced caveolin-1 enhances cholesterol efflux and attenuates atherosclerosis in apolipoprotein E-deficient mice
    • Hu Q., Zhang X.J., Liu C.X., Wang X.P., Zhang Y. PPARγ1-induced caveolin-1 enhances cholesterol efflux and attenuates atherosclerosis in apolipoprotein E-deficient mice. J Vasc Res 2010, 47:69-79.
    • (2010) J Vasc Res , vol.47 , pp. 69-79
    • Hu, Q.1    Zhang, X.J.2    Liu, C.X.3    Wang, X.P.4    Zhang, Y.5
  • 17
    • 0035138625 scopus 로고    scopus 로고
    • PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway
    • Chinetti G., Lestavel S., Bocher V., Remaley A.T., Neve B., Torra I.P., et al. PPAR-alpha and PPAR-gamma activators induce cholesterol removal from human macrophage foam cells through stimulation of the ABCA1 pathway. Nat Med 2001, 7:53-58.
    • (2001) Nat Med , vol.7 , pp. 53-58
    • Chinetti, G.1    Lestavel, S.2    Bocher, V.3    Remaley, A.T.4    Neve, B.5    Torra, I.P.6
  • 18
    • 17744376173 scopus 로고    scopus 로고
    • A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
    • Chawla A., Boisvert W.A., Lee C.H., Laffitte B.A., Barak Y., Joseph S.B., et al. A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis. Mol Cell 2001, 7:161-171.
    • (2001) Mol Cell , vol.7 , pp. 161-171
    • Chawla, A.1    Boisvert, W.A.2    Lee, C.H.3    Laffitte, B.A.4    Barak, Y.5    Joseph, S.B.6
  • 19
    • 0037343227 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor gamma and retinoid X receptor results in net depletion of cellular cholesteryl esters in macrophages exposed to oxidized lipoproteins
    • Argmann C.A., Sawyez C.G., McNeil C.J., Hegele R.A., Huff M.W. Activation of peroxisome proliferator-activated receptor gamma and retinoid X receptor results in net depletion of cellular cholesteryl esters in macrophages exposed to oxidized lipoproteins. Arterioscler Thromb Vasc Biol 2003, 23:475-482.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 475-482
    • Argmann, C.A.1    Sawyez, C.G.2    McNeil, C.J.3    Hegele, R.A.4    Huff, M.W.5
  • 20
    • 0036845525 scopus 로고    scopus 로고
    • Lycopene tomatoes and the prevention of coronary heart disease
    • Rao A.V. Lycopene tomatoes and the prevention of coronary heart disease. Exp Biol Med 2002, 227:908-913.
    • (2002) Exp Biol Med , vol.227 , pp. 908-913
    • Rao, A.V.1
  • 21
    • 0036846616 scopus 로고    scopus 로고
    • Overview of mechanism of action of lycopene
    • Heber D., Lu Q.Y. Overview of mechanism of action of lycopene. Exp Biol Med 2002, 227:920-923.
    • (2002) Exp Biol Med , vol.227 , pp. 920-923
    • Heber, D.1    Lu, Q.Y.2
  • 22
    • 0028980890 scopus 로고
    • Effect of β-carotene on the expression of 3-hydroxy-3-methylglutariyl coenzyme A reductase in rat liver
    • Moreno F.S., Rossiello M.R., Manjeshwar S., Nath R., Rao P.M., Rajalakshmi S., et al. Effect of β-carotene on the expression of 3-hydroxy-3-methylglutariyl coenzyme A reductase in rat liver. Cancer Letters 1995, 96:201-208.
    • (1995) Cancer Letters , vol.96 , pp. 201-208
    • Moreno, F.S.1    Rossiello, M.R.2    Manjeshwar, S.3    Nath, R.4    Rao, P.M.5    Rajalakshmi, S.6
  • 23
    • 0031589211 scopus 로고    scopus 로고
    • Hypocholesterolemic effect of lycopene and β-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophage
    • Fuhrman B., Elis A., Aviram M. Hypocholesterolemic effect of lycopene and β-carotene is related to suppression of cholesterol synthesis and augmentation of LDL receptor activity in macrophage. Biochem Biophys Res Com 1997, 223:658-662.
    • (1997) Biochem Biophys Res Com , vol.223 , pp. 658-662
    • Fuhrman, B.1    Elis, A.2    Aviram, M.3
  • 24
    • 0032868926 scopus 로고    scopus 로고
    • Isoprenoid-mediated inhibition of mevalonate synthesis: potential application to cancer
    • Elson C.E., Peffley D.M., Hentosh P., Mo H. Isoprenoid-mediated inhibition of mevalonate synthesis: potential application to cancer. Proc Soc Exp Biol Med 1999, 22:294-310.
    • (1999) Proc Soc Exp Biol Med , vol.22 , pp. 294-310
    • Elson, C.E.1    Peffley, D.M.2    Hentosh, P.3    Mo, H.4
  • 25
    • 54149115153 scopus 로고    scopus 로고
    • Activation of the adenosine-A3 receptor stimulates matrix metalloproteinase-9 secretion by macrophages
    • Velot E., Haas B., Léonard F., Ernens I., Rolland-Turner M., Schwartz C., et al. Activation of the adenosine-A3 receptor stimulates matrix metalloproteinase-9 secretion by macrophages. Cardiovasc Res Issue 2008, 80:246-254.
    • (2008) Cardiovasc Res Issue , vol.80 , pp. 246-254
    • Velot, E.1    Haas, B.2    Léonard, F.3    Ernens, I.4    Rolland-Turner, M.5    Schwartz, C.6
  • 26
    • 0027958282 scopus 로고
    • Evaluation of the analysis of cholesterol oxides by liquid chromatography
    • Chen B.H., Chen Y.C. Evaluation of the analysis of cholesterol oxides by liquid chromatography. J Chromatography A 1994, 661:127-136.
    • (1994) J Chromatography A , vol.661 , pp. 127-136
    • Chen, B.H.1    Chen, Y.C.2
  • 27
    • 80053124592 scopus 로고
    • Hydroxymethylglutaryl-CoA reductase in plants
    • CRC Press, Boca Raton (Fla), J.R. Sabine (Ed.)
    • Garg V.K., Douglas T.J. Hydroxymethylglutaryl-CoA reductase in plants. Hydroxymethylglutaryl coenzyme A reductase 1983, 29-37. CRC Press, Boca Raton (Fla). J.R. Sabine (Ed.).
    • (1983) Hydroxymethylglutaryl coenzyme A reductase , pp. 29-37
    • Garg, V.K.1    Douglas, T.J.2
  • 28
    • 0037229435 scopus 로고    scopus 로고
    • Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at the post-transcriptional level
    • Peffley D.M., Gayen A.K. Plant-derived monoterpenes suppress hamster kidney cell 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis at the post-transcriptional level. J Nutr 2003, 133:38-44.
    • (2003) J Nutr , vol.133 , pp. 38-44
    • Peffley, D.M.1    Gayen, A.K.2
  • 29
    • 33645509662 scopus 로고    scopus 로고
    • Dietary lycopene downregulates carotenoid 15,15'-monooxygenase and PPAR-gamma in selected rat tissues
    • Zaripheh S., Nara T.Y., Nakamura M.T., Erdman J.W. Dietary lycopene downregulates carotenoid 15,15'-monooxygenase and PPAR-gamma in selected rat tissues. J Nutr 2006, 136:932-938.
    • (2006) J Nutr , vol.136 , pp. 932-938
    • Zaripheh, S.1    Nara, T.Y.2    Nakamura, M.T.3    Erdman, J.W.4
  • 30
    • 24144467460 scopus 로고    scopus 로고
    • Upregulation of connexin 43 by retinoids but not by non-provitamin A carotenoids requires RARs
    • Vine A.L., Bertram J.S. Upregulation of connexin 43 by retinoids but not by non-provitamin A carotenoids requires RARs. Nutr Cancer 2005, 52:105-113.
    • (2005) Nutr Cancer , vol.52 , pp. 105-113
    • Vine, A.L.1    Bertram, J.S.2
  • 32
    • 36049032810 scopus 로고    scopus 로고
    • β-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor γ expression and reactive oxygen species production in MCF-7 cancer cells
    • Cui Y., Lu Z., Baia L., Shi Z., Zhao W.E., Zhao B. β-Carotene induces apoptosis and up-regulates peroxisome proliferator-activated receptor γ expression and reactive oxygen species production in MCF-7 cancer cells. Eur J Cancer 2007, 43:2590-2601.
    • (2007) Eur J Cancer , vol.43 , pp. 2590-2601
    • Cui, Y.1    Lu, Z.2    Baia, L.3    Shi, Z.4    Zhao, W.E.5    Zhao, B.6
  • 33
    • 1842424448 scopus 로고    scopus 로고
    • Liver X receptors as potential therapeutic targets for multiple diseases
    • Cao G., Liang Y., Jiang X.C., Eacho P.I. Liver X receptors as potential therapeutic targets for multiple diseases. Drug News Perspect 2004, 17:35-41.
    • (2004) Drug News Perspect , vol.17 , pp. 35-41
    • Cao, G.1    Liang, Y.2    Jiang, X.C.3    Eacho, P.I.4
  • 34
    • 0037243138 scopus 로고    scopus 로고
    • Caveolins and macrophage lipid metabolism
    • Gargalovic P., Ladislav D. Caveolins and macrophage lipid metabolism. Lipid Res 2003, 44:11-21.
    • (2003) Lipid Res , vol.44 , pp. 11-21
    • Gargalovic, P.1    Ladislav, D.2
  • 35
    • 0035963902 scopus 로고    scopus 로고
    • Caveolae and intracellular trafficking of cholesterol
    • Fielding C.J., Fielding P.E. Caveolae and intracellular trafficking of cholesterol. Adv Drug Deliv Rev 2001, 49:251-264.
    • (2001) Adv Drug Deliv Rev , vol.49 , pp. 251-264
    • Fielding, C.J.1    Fielding, P.E.2
  • 36
    • 26444537961 scopus 로고    scopus 로고
    • Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 Cells treated with ezetimibe
    • During A., Dawson H.D., Harrison E.H. Carotenoid transport is decreased and expression of the lipid transporters SR-BI, NPC1L1, and ABCA1 is downregulated in Caco-2 Cells treated with ezetimibe. J Nutr 2005, 135:2305-2312.
    • (2005) J Nutr , vol.135 , pp. 2305-2312
    • During, A.1    Dawson, H.D.2    Harrison, E.H.3
  • 37
    • 0035136940 scopus 로고    scopus 로고
    • Progress in cardiovascular biology: PPAR for the course
    • Lazar M.A. Progress in cardiovascular biology: PPAR for the course. Nat Med 2001, 7:23-24.
    • (2001) Nat Med , vol.7 , pp. 23-24
    • Lazar, M.A.1
  • 38
    • 0037663317 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells
    • Burgermeister E., Tencer L., Liscocitch M. Peroxisome proliferator-activated receptor-gamma upregulates caveolin-1 and caveolin-2 expression in human carcinoma cells. Oncogene 2003, 22:3888-3900.
    • (2003) Oncogene , vol.22 , pp. 3888-3900
    • Burgermeister, E.1    Tencer, L.2    Liscocitch, M.3
  • 39
    • 21644434629 scopus 로고    scopus 로고
    • Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism
    • Llaverias G., Vazquez-Carrera M., Sanchez R.M., Noe V., Ciudad C.J., Laguna J.C., et al. Rosiglitazone upregulates caveolin-1 expression in THP-1 cells through a PPAR-dependent mechanism. J Lipid Res 2004, 45:2015-2024.
    • (2004) J Lipid Res , vol.45 , pp. 2015-2024
    • Llaverias, G.1    Vazquez-Carrera, M.2    Sanchez, R.M.3    Noe, V.4    Ciudad, C.J.5    Laguna, J.C.6
  • 40
    • 34250188856 scopus 로고    scopus 로고
    • β-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages
    • Matsumoto A., Mizukami H., Mizuno S., Umegaki K., Nishikawa J., Shudo K., et al. β-Cryptoxanthin, a novel natural RAR ligand, induces ATP-binding cassette transporters in macrophages. Biochem Pharmacol. 2007, 74:256-264.
    • (2007) Biochem Pharmacol. , vol.74 , pp. 256-264
    • Matsumoto, A.1    Mizukami, H.2    Mizuno, S.3    Umegaki, K.4    Nishikawa, J.5    Shudo, K.6
  • 41
    • 0032540012 scopus 로고    scopus 로고
    • PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    • Tontonoz P., Nagy L., Alvarez J.G., Thomazy V.A., Evans R.M. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 1998, 93:241-252.
    • (1998) Cell , vol.93 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.3    Thomazy, V.A.4    Evans, R.M.5
  • 42
    • 0032842826 scopus 로고    scopus 로고
    • Coexpression of scavenger receptor-BI and caveolin-1 is associated with an enhanced selective cholesteryl ester uptake in THP-1 macrophages
    • Matveev S., van der Westhuyzen D.R., Smart E.J. Coexpression of scavenger receptor-BI and caveolin-1 is associated with an enhanced selective cholesteryl ester uptake in THP-1 macrophages. J Lipid Res 1999, 40:1647-1654.
    • (1999) J Lipid Res , vol.40 , pp. 1647-1654
    • Matveev, S.1    van der Westhuyzen, D.R.2    Smart, E.J.3
  • 43
    • 0031893929 scopus 로고    scopus 로고
    • Activation of protein kinase C-zeta and phosphatidylinositol 3'-kinase and promotion of macrophage differentiation by insulin-like growth factor-I
    • Liu Q., Ning W., Dantzer R., Freund G.G., Kelly K.W. Activation of protein kinase C-zeta and phosphatidylinositol 3'-kinase and promotion of macrophage differentiation by insulin-like growth factor-I. J Immunol 1998, 160:1393-1401.
    • (1998) J Immunol , vol.160 , pp. 1393-1401
    • Liu, Q.1    Ning, W.2    Dantzer, R.3    Freund, G.G.4    Kelly, K.W.5
  • 44
    • 0033817671 scopus 로고    scopus 로고
    • Effects of lycopene and lutein supplementation on the expression of functionally associated surface molecules on blood monocytes from healthy male non-smokers
    • Hughes D.A., Wright A.J., Finglas P.M., Polley A.C., Bailey A.L., Astlev S.V., et al. Effects of lycopene and lutein supplementation on the expression of functionally associated surface molecules on blood monocytes from healthy male non-smokers. J Infect Dis 2000, 182:11-15.
    • (2000) J Infect Dis , vol.182 , pp. 11-15
    • Hughes, D.A.1    Wright, A.J.2    Finglas, P.M.3    Polley, A.C.4    Bailey, A.L.5    Astlev, S.V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.