-
2
-
-
84897430821
-
All-cause mortality and serious cardiovascular events in people with hip and knee osteoarthritis: a population based cohort study
-
Hawker GA, Croxford R, Bierman AS, Harvey PJ, Ravi B, Stanaitis I, Lipscombe LL., All-cause mortality and serious cardiovascular events in people with hip and knee osteoarthritis:a population based cohort study. PLoS One 2014;9:e91286.
-
(2014)
PLoS One
, vol.9
, pp. e91286
-
-
Hawker, G.A.1
Croxford, R.2
Bierman, A.S.3
Harvey, P.J.4
Ravi, B.5
Stanaitis, I.6
Lipscombe, L.L.7
-
3
-
-
84903701434
-
The individual and socioeconomic impact of osteoarthritis
-
Hunter DJ, Schofield D, Callander E., The individual and socioeconomic impact of osteoarthritis. Nat Rev Rheumatol 2014;10:437–41.
-
(2014)
Nat Rev Rheumatol
, vol.10
, pp. 437-441
-
-
Hunter, D.J.1
Schofield, D.2
Callander, E.3
-
4
-
-
84861827675
-
Osteoarthritis: a disease of the joint as an organ
-
Loeser RF, Goldring SR, Scanzello CR, Goldring MB., Osteoarthritis:a disease of the joint as an organ. Arthritis Rheumatol 2012;64:1697–1707.
-
(2012)
Arthritis Rheumatol
, vol.64
, pp. 1697-1707
-
-
Loeser, R.F.1
Goldring, S.R.2
Scanzello, C.R.3
Goldring, M.B.4
-
5
-
-
84855994698
-
Emerging frontiers in cartilage and chondrocyte biology
-
Fosang AJ, Beier F., Emerging frontiers in cartilage and chondrocyte biology. Best Pract Res Clin Rheumatol 2011;25:751–66.
-
(2011)
Best Pract Res Clin Rheumatol
, vol.25
, pp. 751-766
-
-
Fosang, A.J.1
Beier, F.2
-
6
-
-
84885308609
-
Insights from human genetic studies into the pathways involved in osteoarthritis
-
Reynard LN, Loughlin J., Insights from human genetic studies into the pathways involved in osteoarthritis. Nat Rev Rheumatol 2013;9:573–83.
-
(2013)
Nat Rev Rheumatol
, vol.9
, pp. 573-583
-
-
Reynard, L.N.1
Loughlin, J.2
-
7
-
-
84995580437
-
van der Kraan PM. Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis
-
in press
-
van den Bosch MH, Gleissl TA, Blom AB, van den Berg WB, van Lent PL, van der Kraan PM. Wnts talking with the TGF-β superfamily:WISPers about modulation of osteoarthritis. Rheumatology (Oxford) 2016 (in press).
-
(2016)
Rheumatology (Oxford)
-
-
van den Bosch, M.H.1
Gleissl, T.A.2
Blom, A.B.3
van den Berg, W.B.4
van Lent, P.L.5
-
8
-
-
84969375518
-
The genetic epidemiological landscape of hip and knee osteoarthritis: where are we now and where are we going?
-
Zengini E, Finan C, Wilkinson JM., The genetic epidemiological landscape of hip and knee osteoarthritis:where are we now and where are we going? J Rheumatol 2016;43:260–6.
-
(2016)
J Rheumatol
, vol.43
, pp. 260-266
-
-
Zengini, E.1
Finan, C.2
Wilkinson, J.M.3
-
9
-
-
34047103363
-
A functional polymorphism in the 5’ UTR of GDF5 is associated with susceptibility to osteoarthritis
-
Miyamoto Y, Mabuchi A, Shi D, Kubo T, Takatori Y, Saito S, Fujioka M, Sudo A, Uchida A, Yamamoto S, Ozaki K, Takigawa M, Tanaka T, Nakamura Y, Jiang Q, Ikegawa S., A functional polymorphism in the 5’ UTR of GDF5 is associated with susceptibility to osteoarthritis. Nat Genet 2007;39:529–33.
-
(2007)
Nat Genet
, vol.39
, pp. 529-533
-
-
Miyamoto, Y.1
Mabuchi, A.2
Shi, D.3
Kubo, T.4
Takatori, Y.5
Saito, S.6
Fujioka, M.7
Sudo, A.8
Uchida, A.9
Yamamoto, S.10
Ozaki, K.11
Takigawa, M.12
Tanaka, T.13
Nakamura, Y.14
Jiang, Q.15
Ikegawa, S.16
-
10
-
-
67650074525
-
Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism
-
Egli R, Southam L, Wilkins JM, Lorenzen I, Pombo-Suarez M, Gonzalez A, Carr A, Chapman K, Loughlin J., Functional analysis of the osteoarthritis susceptibility-associated GDF5 regulatory polymorphism. Arthritis Rheumatol 2009;60:2055–64.
-
(2009)
Arthritis Rheumatol
, vol.60
, pp. 2055-2064
-
-
Egli, R.1
Southam, L.2
Wilkins, J.M.3
Lorenzen, I.4
Pombo-Suarez, M.5
Gonzalez, A.6
Carr, A.7
Chapman, K.8
Loughlin, J.9
-
11
-
-
84862565364
-
Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues
-
Bos SD, Bovée JV, Duijnisveld BJ, Raine EV, van Dalen WJ, Ramos YF, van der Breggen R, Nelissen RG, Slagboom PE, Loughlin J, Meulenbelt I., Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues. Ann Rheum Dis 2012;71:1254–8.
-
(2012)
Ann Rheum Dis
, vol.71
, pp. 1254-1258
-
-
Bos, S.D.1
Bovée, J.V.2
Duijnisveld, B.J.3
Raine, E.V.4
van Dalen, W.J.5
Ramos, Y.F.6
van der Breggen, R.7
Nelissen, R.G.8
Slagboom, P.E.9
Loughlin, J.10
Meulenbelt, I.11
-
12
-
-
84899638695
-
arcOGEN Consortium
-
Styrkarsdottir U, Thorleifsson G, Helgadottir HT, Bomer N, Metrustry S, Bierma-Zeinstra S, Strijbosch AM, Evangelou E, Hart D, Beekman M, Jonasdottir A, Sigurdsson A, Eiriksson FF, Thorsteinsdottir M, Frigge ML, Kong A, Gudjonsson SA, Magnusson OT, Masson G,; TREAT-OA, Consortium; arcOGEN Consortium, Hofman A, Arden NK, Ingvarsson T, Lohmander S, Kloppenburg M, Rivadeneira F, Nelissen RG, Spector T, Uitterlinden A, Slagboom PE, Thorsteinsdottir U, Jonsdottir I, Valdes AM, Meulenbelt I, van Meurs J, Jonsson H, Stefansson K. Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31. Nat Genet 2014;46:498–502.
-
(2014)
Hofman A, Arden NK, Ingvarsson T, Lohmander S, Kloppenburg M, Rivadeneira F, Nelissen RG, Spector T, Uitterlinden A, Slagboom PE, Thorsteinsdottir U, Jonsdottir I, Valdes AM, Meulenbelt I, van Meurs J, Jonsson H, Stefansson K. Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31. Nat Genet
, vol.46
, pp. 498-502
-
-
Styrkarsdottir, U.1
Thorleifsson, G.2
Helgadottir, H.T.3
Bomer, N.4
Metrustry, S.5
Bierma-Zeinstra, S.6
Strijbosch, A.M.7
Evangelou, E.8
Hart, D.9
Beekman, M.10
Jonasdottir, A.11
Sigurdsson, A.12
Eiriksson, F.F.13
Thorsteinsdottir, M.14
Frigge, M.L.15
Kong, A.16
Gudjonsson, S.A.17
Magnusson, O.T.18
Masson, G.19
Consortium, T.R.E.A.T.-O.A.20
more..
-
13
-
-
84859433312
-
Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs
-
Barter MJ, Bui C, Young DA., Epigenetic mechanisms in cartilage and osteoarthritis:DNA methylation, histone modifications and microRNAs. Osteoarthritis Cartilage 2012;20:339–49.
-
(2012)
Osteoarthritis Cartilage
, vol.20
, pp. 339-349
-
-
Barter, M.J.1
Bui, C.2
Young, D.A.3
-
14
-
-
84875999020
-
Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites
-
Hashimoto K, Otero M, Imagawa K, de Andrés MC, Coico JM, Roach HI, Oreffo RO, Marcu KB, Goldring MB., Regulated transcription of human matrix metalloproteinase 13 (MMP13) and interleukin-1β (IL1B) genes in chondrocytes depends on methylation of specific proximal promoter CpG sites. J Biol Chem 2013;288:10061–72.
-
(2013)
J Biol Chem
, vol.288
, pp. 10061-10072
-
-
Hashimoto, K.1
Otero, M.2
Imagawa, K.3
de Andrés, M.C.4
Coico, J.M.5
Roach, H.I.6
Oreffo, R.O.7
Marcu, K.B.8
Goldring, M.B.9
-
15
-
-
84881343888
-
The role of microRNAs in osteoarthritis and chondrogenesis
-
Le LT, Swingler TE, Clark IM., The role of microRNAs in osteoarthritis and chondrogenesis. Arthritis Rheumatol 2013;65:1963–74.
-
(2013)
Arthritis Rheumatol
, vol.65
, pp. 1963-1974
-
-
Le, L.T.1
Swingler, T.E.2
Clark, I.M.3
-
16
-
-
84958171760
-
Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA
-
Crowe N, Swingler TE, Le LT, Barter MJ, Wheeler G, Pais H, Donell ST, Young DA, Dalmay T, Clark IM., Detecting new microRNAs in human osteoarthritic chondrocytes identifies miR-3085 as a human, chondrocyte-selective, microRNA. Osteoarthritis Cartilage 2016;24:534–43.
-
(2016)
Osteoarthritis Cartilage
, vol.24
, pp. 534-543
-
-
Crowe, N.1
Swingler, T.E.2
Le, L.T.3
Barter, M.J.4
Wheeler, G.5
Pais, H.6
Donell, S.T.7
Young, D.A.8
Dalmay, T.9
Clark, I.M.10
-
17
-
-
84871770976
-
Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis
-
Delgado-Calle J, Fernández AF, Sainz J, Zarrabeitia MT, Sañudo C, García-Renedo R, Pérez-Núñez MI, García-Ibarbia C, Fraga MF, Riancho JA., Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis. Arthritis Rheumatol 2013;65:197–205.
-
(2013)
Arthritis Rheumatol
, vol.65
, pp. 197-205
-
-
Delgado-Calle, J.1
Fernández, A.F.2
Sainz, J.3
Zarrabeitia, M.T.4
Sañudo, C.5
García-Renedo, R.6
Pérez-Núñez, M.I.7
García-Ibarbia, C.8
Fraga, M.F.9
Riancho, J.A.10
-
18
-
-
84895419805
-
Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients
-
Fernández-Tajes J, Soto-Hermida A, Vázquez-Mosquera ME, Cortés-Pereira E, Mosquera A, Fernández-Moreno M, Oreiro N, Fernández-López C, Fernández JL, Rego-Pérez I, Blanco FJ., Genome-wide DNA methylation analysis of articular chondrocytes reveals a cluster of osteoarthritic patients. Ann Rheum Dis 2014;73:668–77.
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 668-677
-
-
Fernández-Tajes, J.1
Soto-Hermida, A.2
Vázquez-Mosquera, M.E.3
Cortés-Pereira, E.4
Mosquera, A.5
Fernández-Moreno, M.6
Oreiro, N.7
Fernández-López, C.8
Fernández, J.L.9
Rego-Pérez, I.10
Blanco, F.J.11
-
19
-
-
84922240639
-
Knee and hip articular cartilage have distinct epigenomic landscapes: implications for future cartilage regeneration approaches
-
den Hollander W, Ramos YF, Bos SD, Bomer N, van der Breggen R, Lakenberg N, de Dijcker WJ, Duijnisveld BJ, Slagboom PE, Nelissen RG, Meulenbelt I., Knee and hip articular cartilage have distinct epigenomic landscapes:implications for future cartilage regeneration approaches. Ann Rheum Dis 2014;73:2208–12.
-
(2014)
Ann Rheum Dis
, vol.73
, pp. 2208-2212
-
-
den Hollander, W.1
Ramos, Y.F.2
Bos, S.D.3
Bomer, N.4
van der Breggen, R.5
Lakenberg, N.6
de Dijcker, W.J.7
Duijnisveld, B.J.8
Slagboom, P.E.9
Nelissen, R.G.10
Meulenbelt, I.11
-
20
-
-
84904667534
-
Characterization of the cartilage DNA methylome in knee and hip osteoarthritis
-
Rushton MD, Reynard LN, Barter MJ, Refaie R, Rankin KS, Young DA, Loughlin J., Characterization of the cartilage DNA methylome in knee and hip osteoarthritis. Arthritis Rheumatol 2014;66:2450–60.
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 2450-2460
-
-
Rushton, M.D.1
Reynard, L.N.2
Barter, M.J.3
Refaie, R.4
Rankin, K.S.5
Young, D.A.6
Loughlin, J.7
-
21
-
-
84908381697
-
Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage
-
Jeffries MA, Donica M, Baker LW, Stevenson ME, Annan AC, Humphrey MB, James JA, Sawalha AH., Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage. Arthritis Rheumatol 2014;66:2804–15.
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 2804-2815
-
-
Jeffries, M.A.1
Donica, M.2
Baker, L.W.3
Stevenson, M.E.4
Annan, A.C.5
Humphrey, M.B.6
James, J.A.7
Sawalha, A.H.8
-
22
-
-
84911447416
-
Epigenetic differences in human cartilage between mild and severe OA
-
Moazedi-Fuerst FC, Hofner M, Gruber G, Weinhaeusel A, Stradner MH, Angerer H, Peischler D, Lohberger B, Glehr M, Leithner A, Sonntagbauer M, Graninger WB., Epigenetic differences in human cartilage between mild and severe OA. J Orthop Res 2014;32:1636–45.
-
(2014)
J Orthop Res
, vol.32
, pp. 1636-1645
-
-
Moazedi-Fuerst, F.C.1
Hofner, M.2
Gruber, G.3
Weinhaeusel, A.4
Stradner, M.H.5
Angerer, H.6
Peischler, D.7
Lohberger, B.8
Glehr, M.9
Leithner, A.10
Sonntagbauer, M.11
Graninger, W.B.12
-
23
-
-
84959213184
-
Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk
-
Rushton MD, Reynard LN, Young DA, Shepherd C, Aubourg G, Gee F, Darlay R, Deehan D, Cordell HJ, Loughlin J., Methylation quantitative trait locus analysis of osteoarthritis links epigenetics with genetic risk. Hum Mol Genet 2015;24:7432–44.
-
(2015)
Hum Mol Genet
, vol.24
, pp. 7432-7444
-
-
Rushton, M.D.1
Reynard, L.N.2
Young, D.A.3
Shepherd, C.4
Aubourg, G.5
Gee, F.6
Darlay, R.7
Deehan, D.8
Cordell, H.J.9
Loughlin, J.10
-
24
-
-
84938150955
-
Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage
-
den Hollander W, Ramos YF, Bomer N, Elzinga S, van der Breggen R, Lakenberg N, de Dijcker WJ, Suchiman HE, Duijnisveld BJ, Houwing-Duistermaat JJ, Slagboom PE, Bos SD, Nelissen RG, Meulenbelt I., Transcriptional associations of osteoarthritis-mediated loss of epigenetic control in articular cartilage. Arthritis Rheumatol. 2015;67:2108–16.
-
(2015)
Arthritis Rheumatol
, vol.67
, pp. 2108-2116
-
-
den Hollander, W.1
Ramos, Y.F.2
Bomer, N.3
Elzinga, S.4
van der Breggen, R.5
Lakenberg, N.6
de Dijcker, W.J.7
Suchiman, H.E.8
Duijnisveld, B.J.9
Houwing-Duistermaat, J.J.10
Slagboom, P.E.11
Bos, S.D.12
Nelissen, R.G.13
Meulenbelt, I.14
-
25
-
-
0037372003
-
Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals
-
Jaenisch R, Bird A., Epigenetic regulation of gene expression:how the genome integrates intrinsic and environmental signals. Nat Genet 2003;33 Suppl:245–54.
-
(2003)
Nat Genet
-
-
Jaenisch, R.1
Bird, A.2
-
27
-
-
66149146320
-
Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1
-
Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y, Agarwal S, Iyer LM, Liu DR, Aravind L, Rao A., Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 2009;324:930–5.
-
(2009)
Science
, vol.324
, pp. 930-935
-
-
Tahiliani, M.1
Koh, K.P.2
Shen, Y.3
Pastor, W.A.4
Bandukwala, H.5
Brudno, Y.6
Agarwal, S.7
Iyer, L.M.8
Liu, D.R.9
Aravind, L.10
Rao, A.11
-
28
-
-
77956189495
-
Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
-
Ito S, D’Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y., Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 2010;466:1129–33.
-
(2010)
Nature
, vol.466
, pp. 1129-1133
-
-
Ito, S.1
D’Alessio, A.C.2
Taranova, O.V.3
Hong, K.4
Sowers, L.C.5
Zhang, Y.6
-
29
-
-
80052461558
-
L
-
Ito, S., Shen L, Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science 2011;333:1300–3.
-
(2011)
Dai Q, Wu SC, Collins LB, Swenberg JA, He C, Zhang Y. Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine. Science
, vol.333
, pp. 1300-1303
-
-
Shen, I.S.1
-
30
-
-
79959937861
-
Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair
-
Cortellino S, Xu J, Sannai M, Moore R, Caretti E, Cigliano A, Le Coz M, Devarajan K, Wessels A, Soprano D, Abramowitz LK, Bartolomei MS, Rambow F, Bassi MR, Bruno T, Fanciulli M, Renner C, Klein-Szanto AJ, Matsumoto Y, Kobi D, Davidson I, Alberti C, Larue L, Bellacosa A., Thymine DNA glycosylase is essential for active DNA demethylation by linked deamination-base excision repair. Cell 2011;146:67–79.
-
(2011)
Cell
, vol.146
, pp. 67-79
-
-
Cortellino, S.1
Xu, J.2
Sannai, M.3
Moore, R.4
Caretti, E.5
Cigliano, A.6
Le Coz, M.7
Devarajan, K.8
Wessels, A.9
Soprano, D.10
Abramowitz, L.K.11
Bartolomei, M.S.12
Rambow, F.13
Bassi, M.R.14
Bruno, T.15
Fanciulli, M.16
Renner, C.17
Klein-Szanto, A.J.18
Matsumoto, Y.19
Kobi, D.20
Davidson, I.21
Alberti, C.22
Larue, L.23
Bellacosa, A.24
more..
-
31
-
-
80052495940
-
Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA
-
He YF, Li BZ, Li Z, Liu P, Wang Y, Tang Q, Ding J, Jia Y, Chen Z, Li L, Sun Y, Li X, Dai Q, Song CX, Zhang K, He C, Xu GL. Tet-mediated formation of 5-carboxylcytosine and its excision by TDG in mammalian DNA. Science 2011;333:1303–7.
-
(2011)
Science
, vol.333
, pp. 1303-1307
-
-
-
32
-
-
84874408168
-
Editorial: more evidence for a role of CpG methylation in the pathogenesis of osteoarthritis
-
Young DA., Editorial:more evidence for a role of CpG methylation in the pathogenesis of osteoarthritis. Arthritis Rheumatol 2013;65,555–8.
-
(2013)
Arthritis Rheumatol
, vol.65
, pp. 555-558
-
-
Young, D.A.1
-
33
-
-
61449135868
-
Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation
-
Cheung KS, Hashimoto K, Yamada N, Roach HI., Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation. Rheumatol Int 2009;29:525–34.
-
(2009)
Rheumatol Int
, vol.29
, pp. 525-534
-
-
Cheung, K.S.1
Hashimoto, K.2
Yamada, N.3
Roach, H.I.4
-
34
-
-
84863189550
-
MJ
-
Bui, C., Barter MJ, Scott JL, Xu Y, Galler M, Reynard LN, Rowan AD, Young DA. cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis. FASEB J 2012;26:3000–11.
-
(2012)
Scott JL, Xu Y, Galler M, Reynard LN, Rowan AD, Young DA. cAMP response element-binding (CREB) recruitment following a specific CpG demethylation leads to the elevated expression of the matrix metalloproteinase 13 in human articular chondrocytes and osteoarthritis. FASEB J
, vol.26
, pp. 3000-3011
-
-
Barter, B.C.1
-
35
-
-
84897020095
-
A global increase in 5-hydroxymethylcytosine levels marks osteoarthritic chondrocytes
-
Taylor SE, Smeriglio P, Dhulipala L, Rath M, Bhutani N., A global increase in 5-hydroxymethylcytosine levels marks osteoarthritic chondrocytes. Arthritis Rheumatol 2014;66:90–100.
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 90-100
-
-
Taylor, S.E.1
Smeriglio, P.2
Dhulipala, L.3
Rath, M.4
Bhutani, N.5
-
36
-
-
84938099956
-
Genome-wide mapping of DNA hydroxymethylation in osteoarthritic chondrocytes
-
Taylor SE, Li YH, Wong WH, Bhutani N., Genome-wide mapping of DNA hydroxymethylation in osteoarthritic chondrocytes. Arthritis Rheumatol 2015;67:2129–40.
-
(2015)
Arthritis Rheumatol
, vol.67
, pp. 2129-2140
-
-
Taylor, S.E.1
Li, Y.H.2
Wong, W.H.3
Bhutani, N.4
-
37
-
-
77749277177
-
The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing
-
Huang Y, Pastor WA, Shen Y, Tahiliani M, Liu DR, Rao A., The behaviour of 5-hydroxymethylcytosine in bisulfite sequencing. PLoS One 2010;5:e8888.
-
(2010)
PLoS One
, vol.5
, pp. e8888
-
-
Huang, Y.1
Pastor, W.A.2
Shen, Y.3
Tahiliani, M.4
Liu, D.R.5
Rao, A.6
-
38
-
-
84902182150
-
Mechanism and function of oxidative reversal of DNA and RNA methylation
-
Shen L, Song CX, He C, Zhang Y., Mechanism and function of oxidative reversal of DNA and RNA methylation. Annu Rev Biochem 2014;83:585–614.
-
(2014)
Annu Rev Biochem
, vol.83
, pp. 585-614
-
-
Shen, L.1
Song, C.X.2
He, C.3
Zhang, Y.4
-
39
-
-
80055088609
-
TET2: epigenetic safeguard for HSC
-
Ko M, Rao A., TET2:epigenetic safeguard for HSC. Blood 2011;118,4501–3.
-
(2011)
Blood
, vol.118
, pp. 4501-4503
-
-
Ko, M.1
Rao, A.2
-
40
-
-
84875949201
-
Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells
-
Vincent JJ, Huang Y, Chen PY, Feng S, Calvopiña JH, Nee K, Lee SA, Le T, Yoon AJ, Faull K, Fan G, Rao A, Jacobsen SE, Pellegrini M, Clark AT., Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells. Cell Stem Cell 2013;12:470–8.
-
(2013)
Cell Stem Cell
, vol.12
, pp. 470-478
-
-
Vincent, J.J.1
Huang, Y.2
Chen, P.Y.3
Feng, S.4
Calvopiña, J.H.5
Nee, K.6
Lee, S.A.7
Le, T.8
Yoon, A.J.9
Faull, K.10
Fan, G.11
Rao, A.12
Jacobsen, S.E.13
Pellegrini, M.14
Clark, A.T.15
-
41
-
-
84876907152
-
Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming
-
Song CX, Szulwach KE, Dai Q, Fu Y, Mao SQ, Lin L, Street C, Li Y, Poidevin M, Wu H, Gao J, Liu P, Li L, Xu GL, Jin P, He C., Genome-wide profiling of 5-formylcytosine reveals its roles in epigenetic priming. Cell 2013;153:678–91.
-
(2013)
Cell
, vol.153
, pp. 678-691
-
-
Song, C.X.1
Szulwach, K.E.2
Dai, Q.3
Fu, Y.4
Mao, S.Q.5
Lin, L.6
Street, C.7
Li, Y.8
Poidevin, M.9
Wu, H.10
Gao, J.11
Liu, P.12
Li, L.13
Xu, G.L.14
Jin, P.15
He, C.16
-
42
-
-
84879547408
-
Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA
-
Lu X, Song CX, Szulwach K, Wang Z, Weidenbacher P, Jin P, He C., Chemical modification-assisted bisulfite sequencing (CAB-Seq) for 5-carboxylcytosine detection in DNA. J Am Chem Soc 2013;135,9315–7.
-
(2013)
J Am Chem Soc
, vol.135
, pp. 9315-9317
-
-
Lu, X.1
Song, C.X.2
Szulwach, K.3
Wang, Z.4
Weidenbacher, P.5
Jin, P.6
He, C.7
-
43
-
-
84926336317
-
Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis
-
Bomer N, den HW, Ramos YF, Bos SD, van der Breggen R, Lakenberg N, Pepers BA, van Eeden AE, Darvishan A, Tobi EW, Duijnisveld BJ, van den Akker EB, Heijmans BT, van Roon-Mom WM, Verbeek FJ, van Osch GJ, Nelissen RG, Slagboom PE, Meulenbelt I., Underlying molecular mechanisms of DIO2 susceptibility in symptomatic osteoarthritis. Ann Rheum Dis 2015;74:1571–9.
-
(2015)
Ann Rheum Dis
, vol.74
, pp. 1571-1579
-
-
Bomer, N.1
den, R.Y.F.2
Bos, S.D.3
van der Breggen, R.4
Lakenberg, N.5
Pepers, B.A.6
van Eeden, A.E.7
Darvishan, A.8
Tobi, E.W.9
Duijnisveld, B.J.10
van den Akker, E.B.11
Heijmans, B.T.12
van Roon-Mom, W.M.13
Verbeek, F.J.14
van Osch, G.J.15
Nelissen, R.G.16
Slagboom, P.E.17
Meulenbelt, I.18
-
44
-
-
80051693596
-
Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation
-
Reynard LN, Bui C, Canty-Laird EG, Young DA, Loughlin J., Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation. Hum Mol Genet 2011;20:3450–60.
-
(2011)
Hum Mol Genet
, vol.20
, pp. 3450-3460
-
-
Reynard, L.N.1
Bui, C.2
Canty-Laird, E.G.3
Young, D.A.4
Loughlin, J.5
-
45
-
-
27644548948
-
van den Boom D. Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry
-
Ehrich M, Nelson MR, Stanssens P, Zabeau M, Liloglou T, Xinarianos G, Cantor CR, Field JK, van den Boom D. Quantitative high-throughput analysis of DNA methylation patterns by base-specific cleavage and mass spectrometry. Proc Natl Acad Sci USA 2005;102:15785–90.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 15785-15790
-
-
Ehrich, M.1
Nelson, M.R.2
Stanssens, P.3
Zabeau, M.4
Liloglou, T.5
Xinarianos, G.6
Cantor, C.R.7
Field, J.K.8
-
47
-
-
78649475003
-
Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis
-
Du P, Zhang X, Huang CC, Jafari N, Kibbe WA, Hou L, Lin SM., Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis. BMC Bioinf 2010;11:587.
-
(2010)
BMC Bioinf
, vol.11
, pp. 587
-
-
Du, P.1
Zhang, X.2
Huang, C.C.3
Jafari, N.4
Kibbe, W.A.5
Hou, L.6
Lin, S.M.7
-
48
-
-
84865790047
-
An integrated encyclopedia of DNA elements in the human genome
-
Bernstein BE, Birney E, Dunham I, Green ED, Gunter C, Snyder M., An integrated encyclopedia of DNA elements in the human genome. Nature 2012;489:57–74.
-
(2012)
Nature
, vol.489
, pp. 57-74
-
-
Bernstein, B.E.1
Birney, E.2
Dunham, I.3
Green, E.D.4
Gunter, C.5
Snyder, M.6
-
49
-
-
0035839136
-
Translating the histone code
-
Jenuwein T, Allis CD., Translating the histone code. Science 2001;293:1074–80.
-
(2001)
Science
, vol.293
, pp. 1074-1080
-
-
Jenuwein, T.1
Allis, C.D.2
-
50
-
-
47849083984
-
Epigenetic interplay between histone modifications and DNA methylation in gene silencing
-
Vaissiere T, Sawan C, Herceg Z., Epigenetic interplay between histone modifications and DNA methylation in gene silencing. Mutat Res 2008:659:40–8.
-
(2008)
Mutat Res
, vol.659
, pp. 40-48
-
-
Vaissiere, T.1
Sawan, C.2
Herceg, Z.3
-
51
-
-
84863621527
-
Cancer epigenetics: from mechanism to therapy
-
Dawson MA, Kouzarides T., Cancer epigenetics:from mechanism to therapy. Cell 2012;150:12–27.
-
(2012)
Cell
, vol.150
, pp. 12-27
-
-
Dawson, M.A.1
Kouzarides, T.2
-
52
-
-
84859893371
-
Histone methylation: a dynamic mark in health, disease and inheritance
-
Greer EL, Shi Y., Histone methylation:a dynamic mark in health, disease and inheritance. Nat Rev Genet 2012;13:343–57.
-
(2012)
Nat Rev Genet
, vol.13
, pp. 343-357
-
-
Greer, E.L.1
Shi, Y.2
-
53
-
-
59349100985
-
Dynamic protein methylation in chromatin biology
-
Ng SS, Yue WW, Oppermann U, Klose RJ., Dynamic protein methylation in chromatin biology. Cell Mol Life Sci 2009;66:407–22.
-
(2009)
Cell Mol Life Sci
, vol.66
, pp. 407-422
-
-
Ng, S.S.1
Yue, W.W.2
Oppermann, U.3
Klose, R.J.4
-
54
-
-
84876100588
-
Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases?
-
Oppermann U., Why is epigenetics important in understanding the pathogenesis of inflammatory musculoskeletal diseases? Arthritis Res Ther 2013;15:209.
-
(2013)
Arthritis Res Ther
, vol.15
, pp. 209
-
-
Oppermann, U.1
-
55
-
-
84937416706
-
The promise and peril of chemical probes
-
Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O’Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ., The promise and peril of chemical probes. Nat Chem Biol 2015;11:536–41.
-
(2015)
Nat Chem Biol
, vol.11
, pp. 536-541
-
-
Arrowsmith, C.H.1
Audia, J.E.2
Austin, C.3
Baell, J.4
Bennett, J.5
Blagg, J.6
Bountra, C.7
Brennan, P.E.8
Brown, P.J.9
Bunnage, M.E.10
Buser-Doepner, C.11
Campbell, R.M.12
Carter, A.J.13
Cohen, P.14
Copeland, R.A.15
Cravatt, B.16
Dahlin, J.L.17
Dhanak, D.18
Edwards, A.M.19
Frederiksen, M.20
Frye, S.V.21
Gray, N.22
Grimshaw, C.E.23
Hepworth, D.24
Howe, T.25
Huber, K.V.26
Jin, J.27
Knapp, S.28
Kotz, J.D.29
Kruger, R.G.30
Lowe, D.31
Mader, M.M.32
Marsden, B.33
Mueller-Fahrnow, A.34
Müller, S.35
O’Hagan, R.C.36
Overington, J.P.37
Owen, D.R.38
Rosenberg, S.H.39
Roth, B.40
Ross, R.41
Schapira, M.42
Schreiber, S.L.43
Shoichet, B.44
Sundström, M.45
Superti-Furga, G.46
Taunton, J.47
Toledo-Sherman, L.48
Walpole, C.49
Walters, M.A.50
Willson, T.M.51
Workman, P.52
Young, R.N.53
Zuercher, W.J.54
more..
-
56
-
-
84926189204
-
Three-dimensional genome architecture: players and mechanisms
-
Pombo A, Dillon N., Three-dimensional genome architecture:players and mechanisms. Nat Rev Mol Cell Biol 2015;16:245–57.
-
(2015)
Nat Rev Mol Cell Biol
, vol.16
, pp. 245-257
-
-
Pombo, A.1
Dillon, N.2
-
57
-
-
84943348625
-
Architectural proteins, transcription, and the three-dimensional organization of the genome
-
Cubeñas-Potts C, Corces VG., Architectural proteins, transcription, and the three-dimensional organization of the genome. FEBS Lett 2015;589:2923–30.
-
(2015)
FEBS Lett
, vol.589
, pp. 2923-2930
-
-
Cubeñas-Potts, C.1
Corces, V.G.2
-
58
-
-
85018233668
-
CTCF as a multifunctional protein in genome regulation and gene expression
-
Kim S, Yu NK, Kaang BK., CTCF as a multifunctional protein in genome regulation and gene expression. Exp Mol Med 2015;47:e166.
-
(2015)
Exp Mol Med
, vol.47
, pp. e166
-
-
Kim, S.1
Yu, N.K.2
Kaang, B.K.3
-
59
-
-
78649921825
-
Functional analysis of CTCF during mammalian limb development
-
Soshnikova N, Montavon T, Leleu M, Galjart N, Duboule D., Functional analysis of CTCF during mammalian limb development. Dev Cell 2010;19:819–30.
-
(2010)
Dev Cell
, vol.19
, pp. 819-830
-
-
Soshnikova, N.1
Montavon, T.2
Leleu, M.3
Galjart, N.4
Duboule, D.5
-
60
-
-
84930091577
-
Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions
-
Lupiáñez DG, Kraft K, Heinrich V, Krawitz P, Brancati F, Klopocki E, Horn D, Kayserili H, Opitz JM, Laxova R, Santos-Simarro F, Gilbert-Dussardier B, Wittler L, Borschiwer M, Haas SA, Osterwalder M, Franke M, Timmermann B, Hecht J, Spielmann M, Visel A, Mundlos S., Disruptions of topological chromatin domains cause pathogenic rewiring of gene-enhancer interactions. Cell 2015;161:1012–25.
-
(2015)
Cell
, vol.161
, pp. 1012-1025
-
-
Lupiáñez, D.G.1
Kraft, K.2
Heinrich, V.3
Krawitz, P.4
Brancati, F.5
Klopocki, E.6
Horn, D.7
Kayserili, H.8
Opitz, J.M.9
Laxova, R.10
Santos-Simarro, F.11
Gilbert-Dussardier, B.12
Wittler, L.13
Borschiwer, M.14
Haas, S.A.15
Osterwalder, M.16
Franke, M.17
Timmermann, B.18
Hecht, J.19
Spielmann, M.20
Visel, A.21
Mundlos, S.22
more..
-
61
-
-
84955486608
-
Gene regulation and chromatin organization: relevance of cohesin mutations to human disease
-
Watrin E, Kaiser FJ, Wendt KS., Gene regulation and chromatin organization:relevance of cohesin mutations to human disease. Curr Opin Genet Dev 2016;37:59–66.
-
(2016)
Curr Opin Genet Dev
, vol.37
, pp. 59-66
-
-
Watrin, E.1
Kaiser, F.J.2
Wendt, K.S.3
-
62
-
-
80455143730
-
Cartilage biology in osteoarthritis-lessons from developmental biology
-
Pitsillides AA, Beier F., Cartilage biology in osteoarthritis-lessons from developmental biology. Nat Rev Rheumatol 2011;7:654–63.
-
(2011)
Nat Rev Rheumatol
, vol.7
, pp. 654-663
-
-
Pitsillides, A.A.1
Beier, F.2
-
63
-
-
84855297335
-
A decade of 3C technologies: insights into nuclear organization
-
de Wit E, de Laat W., A decade of 3C technologies:insights into nuclear organization. Genes Dev 2012;26:11–24.
-
(2012)
Genes Dev
, vol.26
, pp. 11-24
-
-
de Wit, E.1
de Laat, W.2
-
64
-
-
84865727393
-
The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression
-
Derrien T, Johnson R, Bussotti G, Tanzer A, Djebali S, Tilgner H, Guernec G, Martin D, Merkel A, Knowles DG, Lagarde J, Veeravalli L, Ruan X, Ruan Y, Lassmann T, Carninci P, Brown JB, Lipovich L, Gonzalez JM, Thomas M, Davis CA, Shiekhattar R, Gingeras TR, Hubbard TJ, Notredame C, Harrow J, Guigó R., The GENCODE v7 catalog of human long noncoding RNAs:analysis of their gene structure, evolution, and expression. Genome Res 2012;22:1775–89.
-
(2012)
Genome Res
, vol.22
, pp. 1775-1789
-
-
Derrien, T.1
Johnson, R.2
Bussotti, G.3
Tanzer, A.4
Djebali, S.5
Tilgner, H.6
Guernec, G.7
Martin, D.8
Merkel, A.9
Knowles, D.G.10
Lagarde, J.11
Veeravalli, L.12
Ruan, X.13
Ruan, Y.14
Lassmann, T.15
Carninci, P.16
Brown, J.B.17
Lipovich, L.18
Gonzalez, J.M.19
Thomas, M.20
Davis, C.A.21
Shiekhattar, R.22
Gingeras, T.R.23
Hubbard, T.J.24
Notredame, C.25
Harrow, J.26
Guigó, R.27
more..
-
65
-
-
77953067173
-
MicroRNA-140 plays dual roles in both cartilage development and homeostasis
-
Miyaki S, Sato T, Inoue A, Otsuki S, Ito Y, Yokoyama S, Kato Y, Takemoto F, Nakasa T, Yamashita S, Takada S, Lotz MK, Ueno-Kudo H, Asahara H., MicroRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev 2010;24:1173–85.
-
(2010)
Genes Dev
, vol.24
, pp. 1173-1185
-
-
Miyaki, S.1
Sato, T.2
Inoue, A.3
Otsuki, S.4
Ito, Y.5
Yokoyama, S.6
Kato, Y.7
Takemoto, F.8
Nakasa, T.9
Yamashita, S.10
Takada, S.11
Lotz, M.K.12
Ueno-Kudo, H.13
Asahara, H.14
-
66
-
-
84945444117
-
Genome-wide microRNA and gene analysis of mesenchymal stem cell chondrogenesis identifies an essential role and multiple targets for miR 140-5p
-
Barter MJ, Tselepi M, Gómez R, Woods S, Hui W, Smith GR, Shanley DP, Clark IM, Young DA., Genome-wide microRNA and gene analysis of mesenchymal stem cell chondrogenesis identifies an essential role and multiple targets for miR 140-5p. Stem Cells 2015;33:3266–80.
-
(2015)
Stem Cells
, vol.33
, pp. 3266-3280
-
-
Barter, M.J.1
Tselepi, M.2
Gómez, R.3
Woods, S.4
Hui, W.5
Smith, G.R.6
Shanley, D.P.7
Clark, I.M.8
Young, D.A.9
-
67
-
-
84861904178
-
Genome regulation by long noncoding RNAs
-
Rinn JL, Chang HY., Genome regulation by long noncoding RNAs. Annu Rev Biochem 2012;81:145–66.
-
(2012)
Annu Rev Biochem
, vol.81
, pp. 145-166
-
-
Rinn, J.L.1
Chang, H.Y.2
-
68
-
-
84904735424
-
Transcriptional regulatory functions of nuclear long noncoding RNAs
-
Vance KW, Ponting CP., Transcriptional regulatory functions of nuclear long noncoding RNAs. Trends Genet 2014;30:348–55.
-
(2014)
Trends Genet
, vol.30
, pp. 348-355
-
-
Vance, K.W.1
Ponting, C.P.2
-
69
-
-
84898656101
-
Long noncoding RNA related to cartilage injury promotes chondrocyte extracellular matrix degradation in osteoarthritis
-
Liu Q, Zhang X, Dai L, Hu X, Zhu J, Li L, Zhou C, Ao Y., Long noncoding RNA related to cartilage injury promotes chondrocyte extracellular matrix degradation in osteoarthritis. Arthritis Rheumatol 2014;66:969–78.
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 969-978
-
-
Liu, Q.1
Zhang, X.2
Dai, L.3
Hu, X.4
Zhu, J.5
Li, L.6
Zhou, C.7
Ao, Y.8
-
70
-
-
84904659936
-
Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study
-
Ramos YF, den Hollander W, Bovee JV, Bomer N, van der Breggen R, Lakenberg N, Keurentjes JC, Goeman JJ, Slagboom PE, Nelissen RG, Bos SD, Meulenbelt I., Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study. PLoS One 2014;9:e103056.
-
(2014)
PLoS One
, vol.9
, pp. e103056
-
-
Ramos, Y.F.1
den Hollander, W.2
Bovee, J.V.3
Bomer, N.4
van der Breggen, R.5
Lakenberg, N.6
Keurentjes, J.C.7
Goeman, J.J.8
Slagboom, P.E.9
Nelissen, R.G.10
Bos, S.D.11
Meulenbelt, I.12
-
71
-
-
33750032729
-
Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis
-
Aigner T, Fundel K, Saas J, Gebhard PM, Haag J, Weiss T, Zien A, Obermayr F, Zimmer R, Bartnik E., Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheumatol 2006;54:3533–44.
-
(2006)
Arthritis Rheumatol
, vol.54
, pp. 3533-3544
-
-
Aigner, T.1
Fundel, K.2
Saas, J.3
Gebhard, P.M.4
Haag, J.5
Weiss, T.6
Zien, A.7
Obermayr, F.8
Zimmer, R.9
Bartnik, E.10
-
72
-
-
84864383496
-
Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA
-
Xu Y, Barter MJ, Swan DC, Rankin KS, Rowan AD, Santibanez-Koref M, Loughlin J, Young DA., Identification of the pathogenic pathways in osteoarthritic hip cartilage:commonality and discord between hip and knee OA. Osteoarthritis Cartilage 2012;20:1029–38.
-
(2012)
Osteoarthritis Cartilage
, vol.20
, pp. 1029-1038
-
-
Xu, Y.1
Barter, M.J.2
Swan, D.C.3
Rankin, K.S.4
Rowan, A.D.5
Santibanez-Koref, M.6
Loughlin, J.7
Young, D.A.8
-
73
-
-
77950021301
-
Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis
-
Karlsson C, Dehne T, Lindahl A, Brittberg M, Pruss A, Sittinger M, Ringe J., Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis. Osteoarthritis Cartilage 2010;18:581–92.
-
(2010)
Osteoarthritis Cartilage
, vol.18
, pp. 581-592
-
-
Karlsson, C.1
Dehne, T.2
Lindahl, A.3
Brittberg, M.4
Pruss, A.5
Sittinger, M.6
Ringe, J.7
-
74
-
-
60249098721
-
Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology
-
Geyer M, Grassel S, Straub RH, Schett G, Dinser R, Grifka J, Gay S, Neumann E, Muller-Ladner U., Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology. Osteoarthritis Cartilage 2009;17:328–35.
-
(2009)
Osteoarthritis Cartilage
, vol.17
, pp. 328-335
-
-
Geyer, M.1
Grassel, S.2
Straub, R.H.3
Schett, G.4
Dinser, R.5
Grifka, J.6
Gay, S.7
Neumann, E.8
Muller-Ladner, U.9
-
75
-
-
84898670942
-
Gene expression pattern of cells from inflamed and normal areas of osteoarthritis synovial membrane
-
Lambert C, Dubuc JE, Montell E, Verges J, Munaut C, Noel A, Henrotin Y., Gene expression pattern of cells from inflamed and normal areas of osteoarthritis synovial membrane. Arthritis Rheumatol 2014;66:960–8.
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 960-968
-
-
Lambert, C.1
Dubuc, J.E.2
Montell, E.3
Verges, J.4
Munaut, C.5
Noel, A.6
Henrotin, Y.7
-
76
-
-
84896266325
-
van der Kraan PM. Gene expression analysis of murine and human osteoarthritis synovium reveals elevation of transforming growth factor beta-responsive genes in osteoarthritis-related fibrosis
-
Remst DF, Blom AB, Vitters EL, Bank RA, van den Berg WB, Blaney Davidson EN, van der Kraan PM. Gene expression analysis of murine and human osteoarthritis synovium reveals elevation of transforming growth factor beta-responsive genes in osteoarthritis-related fibrosis. Arthritis Rheumatol 2014;66:647–56.
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 647-656
-
-
-
77
-
-
84896996773
-
Genes relevant with osteoarthritis by comparison gene expression profiles of synovial membrane of osteoarthritis patients at different stages
-
Ma CH, Lv Q, Cao Y, Wang Q, Zhou XK, Ye BW, Yi CQ., Genes relevant with osteoarthritis by comparison gene expression profiles of synovial membrane of osteoarthritis patients at different stages. Eur Rev Med Pharmacol Sci 2014;18:431–9.
-
(2014)
Eur Rev Med Pharmacol Sci
, vol.18
, pp. 431-439
-
-
Ma, C.H.1
Lv, Q.2
Cao, Y.3
Wang, Q.4
Zhou, X.K.5
Ye, B.W.6
Yi, C.Q.7
-
78
-
-
84863262534
-
Gene expression analyses of subchondral bone in early experimental osteoarthritis by microarray
-
Zhang R, Fang H, Chen Y, Shen J, Lu H, Zeng C, Ren J, Zeng H, Li Z, Chen S, Cai D, Zhao Q., Gene expression analyses of subchondral bone in early experimental osteoarthritis by microarray. PLoS One 2012;7:e32356.
-
(2012)
PLoS One
, vol.7
, pp. e32356
-
-
Zhang, R.1
Fang, H.2
Chen, Y.3
Shen, J.4
Lu, H.5
Zeng, C.6
Ren, J.7
Zeng, H.8
Li, Z.9
Chen, S.10
Cai, D.11
Zhao, Q.12
-
79
-
-
84887550824
-
Genome-wide expression profiles of subchondral bone in osteoarthritis
-
Chou CH, Wu CC, Song IW, Chuang HP, Lu LS, Chang JH, Kuo SY, Lee CH, Wu JY, Chen YT, Kraus VB, Lee MT., Genome-wide expression profiles of subchondral bone in osteoarthritis. Arthritis Res Ther 2013;15:R190.
-
(2013)
Arthritis Res Ther
, vol.15
, pp. R190
-
-
Chou, C.H.1
Wu, C.C.2
Song, I.W.3
Chuang, H.P.4
Lu, L.S.5
Chang, J.H.6
Kuo, S.Y.7
Lee, C.H.8
Wu, J.Y.9
Chen, Y.T.10
Kraus, V.B.11
Lee, M.T.12
-
80
-
-
84926507971
-
Limma powers differential expression analyses for RNA-sequencing and microarray studies
-
Ritchie ME, Phipson B, Wu D, Hu Y, Law CW, Shi W, Smyth GK., Limma powers differential expression analyses for RNA-sequencing and microarray studies. Nucleic Acids Res 2015;43:e47.
-
(2015)
Nucleic Acids Res
, vol.43
, pp. e47
-
-
Ritchie, M.E.1
Phipson, B.2
Wu, D.3
Hu, Y.4
Law, C.W.5
Shi, W.6
Smyth, G.K.7
-
81
-
-
1342288026
-
affy–analysis of Affymetrix GeneChip data at the probe level
-
Gautier L, Cope L, Bolstad BM, Irizarry RA., affy–analysis of Affymetrix GeneChip data at the probe level. Bioinformatics 2004;20:307–15.
-
(2004)
Bioinformatics
, vol.20
, pp. 307-315
-
-
Gautier, L.1
Cope, L.2
Bolstad, B.M.3
Irizarry, R.A.4
-
82
-
-
50649089207
-
RNA-seq: an assessment of technical reproducibility and comparison with gene expression arrays
-
Marioni JC, Mason CE, Mane SM, Stephens M, Gilad Y., RNA-seq:an assessment of technical reproducibility and comparison with gene expression arrays. Genome Res 2008;18:1509–17.
-
(2008)
Genome Res
, vol.18
, pp. 1509-1517
-
-
Marioni, J.C.1
Mason, C.E.2
Mane, S.M.3
Stephens, M.4
Gilad, Y.5
-
83
-
-
84948994587
-
Advanced applications of RNA sequencing and challenges
-
Han Y, Gao S, Muegge K, Zhang W, Zhou B., Advanced applications of RNA sequencing and challenges. Bioinform Biol Insights 2015;9:29–46.
-
(2015)
Bioinform Biol Insights
, vol.9
, pp. 29-46
-
-
Han, Y.1
Gao, S.2
Muegge, K.3
Zhang, W.4
Zhou, B.5
-
84
-
-
84887791432
-
French StatOmique Consortium
-
Dillies MA, Rau A, Aubert J, Hennequet-Antier C, Jeanmougin M, Servant N, Keime C, Marot G, Castel D, Estelle J, Guernec G, Jagla B, Jouneau L, Laloë D, Le Gall C, Schaëffer B, Le Crom S, Guedj M, Jaffrézic F, French StatOmique Consortium. A comprehensive evaluation of normalization methods for Illumina high-throughput RNA sequencing data analysis. Brief Bioinform 2013;14:671–83.
-
(2013)
A comprehensive evaluation of normalization methods for Illumina high-throughput RNA sequencing data analysis. Brief Bioinform
, vol.14
, pp. 671-683
-
-
Dillies, M.A.1
Rau, A.2
Aubert, J.3
Hennequet-Antier, C.4
Jeanmougin, M.5
Servant, N.6
Keime, C.7
Marot, G.8
Castel, D.9
Estelle, J.10
Guernec, G.11
Jagla, B.12
Jouneau, L.13
Laloë, D.14
Le Gall, C.15
Schaëffer, B.16
Le Crom, S.17
Guedj, M.18
Jaffrézic, F.19
-
85
-
-
84893443187
-
An extensive evaluation of read trimming effects on Illumina NGS data analysis
-
Del FC, Scalabrin S, Morgante M, Giorgi FM., An extensive evaluation of read trimming effects on Illumina NGS data analysis. PLoS One 2013;8:e85024.
-
(2013)
PLoS One
, vol.8
, pp. e85024
-
-
Del, F.C.1
Scalabrin, S.2
Morgante, M.3
Giorgi, F.M.4
-
86
-
-
84907500627
-
RNA-Seq gene profiling–a systematic empirical comparison
-
Fonseca NA, Marioni J, Brazma A., RNA-Seq gene profiling–a systematic empirical comparison. PLoS One 2014;9:e107026.
-
(2014)
PLoS One
, vol.9
, pp. e107026
-
-
Fonseca, N.A.1
Marioni, J.2
Brazma, A.3
-
87
-
-
67649884743
-
Fast and accurate short read alignment with Burrows-Wheeler transform
-
Li H, Durbin R., Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 2009;25:1754–60.
-
(2009)
Bioinformatics
, vol.25
, pp. 1754-1760
-
-
Li, H.1
Durbin, R.2
-
88
-
-
84876996918
-
TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
-
Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R, Salzberg SL., TopHat2:accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol 2013;14:R36.
-
(2013)
Genome Biol
, vol.14
, pp. R36
-
-
Kim, D.1
Pertea, G.2
Trapnell, C.3
Pimentel, H.4
Kelley, R.5
Salzberg, S.L.6
-
89
-
-
77951820899
-
and SNP-tolerant detection of complex variants and splicing in short reads
-
Wu TD, Nacu S., Fast and SNP-tolerant detection of complex variants and splicing in short reads. Bioinformatics 2010;26:873–81.
-
(2010)
Bioinformatics
, vol.26
, pp. 873-881
-
-
Wu, T.D.1
Fast, N.S.2
-
90
-
-
84859210032
-
Fast gapped-read alignment with Bowtie 2
-
Langmead B, Salzberg SL., Fast gapped-read alignment with Bowtie 2. Nat. Methods 2012;9:357–9.
-
(2012)
Nat. Methods
, vol.9
, pp. 357-359
-
-
Langmead, B.1
Salzberg, S.L.2
-
91
-
-
84941636443
-
Tools and best practices for data processing in allelic expression analysis
-
Castel SE, Levy-Moonshine A, Mohammadi P, Banks E, Lappalainen T., Tools and best practices for data processing in allelic expression analysis. Genome Biol 2015;16:195.
-
(2015)
Genome Biol
, vol.16
, pp. 195
-
-
Castel, S.E.1
Levy-Moonshine, A.2
Mohammadi, P.3
Banks, E.4
Lappalainen, T.5
-
92
-
-
0029855587
-
Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice
-
Müller-Ladner U, Kriegsmann J, Franklin BN, Matsumoto S, Geiler T, Gay RE, Gay S., Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Path 1996;149:1607–15.
-
(1996)
Am J Path
, vol.149
, pp. 1607-1615
-
-
Müller-Ladner, U.1
Kriegsmann, J.2
Franklin, B.N.3
Matsumoto, S.4
Geiler, T.5
Gay, R.E.6
Gay, S.7
-
93
-
-
84903124488
-
The epigenome of synovial fibroblasts: an underestimated therapeutic target in rheumatoid arthritis
-
Frank-Bertoncelj M, Gay S., The epigenome of synovial fibroblasts:an underestimated therapeutic target in rheumatoid arthritis. Arthritis Res Ther 2014;16:117.
-
(2014)
Arthritis Res Ther
, vol.16
, pp. 117
-
-
Frank-Bertoncelj, M.1
Gay, S.2
-
94
-
-
0034541591
-
Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression
-
Neidhart M, Rethage J, Kuchen S, Künzler P, Crowl RM, Billingham ME, Gay RE, Gay S., Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue:association with genomic DNA hypomethylation and influence on gene expression. Arthritis Rheumatol 2000;43:2634–47.
-
(2000)
Arthritis Rheumatol
, vol.43
, pp. 2634-2647
-
-
Neidhart, M.1
Rethage, J.2
Kuchen, S.3
Künzler, P.4
Crowl, R.M.5
Billingham, M.E.6
Gay, R.E.7
Gay, S.8
-
95
-
-
84918564948
-
Epigenetics in rheumatoid arthritis
-
Klein K, Gay S., Epigenetics in rheumatoid arthritis. Curr Opin Rheumatol 2015;27:76–82.
-
(2015)
Curr Opin Rheumatol
, vol.27
, pp. 76-82
-
-
Klein, K.1
Gay, S.2
-
96
-
-
84910108317
-
Epigenome analysis reveals TBX5 as a novel transcription factor involved in the activation of rheumatoid arthritis synovial fibroblasts
-
Karouzakis E, Trenkmann M, Gay RE, Michel BA, Gay S, Neidhart M., Epigenome analysis reveals TBX5 as a novel transcription factor involved in the activation of rheumatoid arthritis synovial fibroblasts. J Immun 2014;193:4945–51.
-
(2014)
J Immun
, vol.193
, pp. 4945-4951
-
-
Karouzakis, E.1
Trenkmann, M.2
Gay, R.E.3
Michel, B.A.4
Gay, S.5
Neidhart, M.6
-
97
-
-
84903478937
-
Inhibition of spermidine/spermine N1-acetyltransferase activity: a new therapeutic concept in rheumatoid arthritis
-
Neidhart M, Karouzakis E, Jüngel A, Gay RE, Gay S., Inhibition of spermidine/spermine N1-acetyltransferase activity:a new therapeutic concept in rheumatoid arthritis. Arthritis Rheumatol 2014;66:1723–33.
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. 1723-1733
-
-
Neidhart, M.1
Karouzakis, E.2
Jüngel, A.3
Gay, R.E.4
Gay, S.5
-
98
-
-
84954338878
-
The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts
-
Klein K, Kabala PA, Grabiec AM, Gay RE, Kolling C, Lin LL, Gay S, Tak PP, Prinjha RK, Ospelt C, Reedquist KA., The bromodomain protein inhibitor I-BET151 suppresses expression of inflammatory genes and matrix degrading enzymes in rheumatoid arthritis synovial fibroblasts. Ann Rheum Dis 2016;75:422–9.
-
(2016)
Ann Rheum Dis
, vol.75
, pp. 422-429
-
-
Klein, K.1
Kabala, P.A.2
Grabiec, A.M.3
Gay, R.E.4
Kolling, C.5
Lin, L.L.6
Gay, S.7
Tak, P.P.8
Prinjha, R.K.9
Ospelt, C.10
Reedquist, K.A.11
-
99
-
-
85010066453
-
Joint specific positional differences in coding and noncoding transcriptome of synovial fibroblasts as a determinant of the susceptibility of synovial joints to rheumatoid arthritis
-
Ospelt C, Armaka M, Russo G, Bratus A, Trenkmann M, Karouzakis E, Kolling C, Gay RE, Kollias G, Gay S, Frank-Bertoncelj M., Joint specific positional differences in coding and noncoding transcriptome of synovial fibroblasts as a determinant of the susceptibility of synovial joints to rheumatoid arthritis. Arthritis Rheumatol 2014;66:S1216.
-
(2014)
Arthritis Rheumatol
, vol.66
, pp. S1216
-
-
Ospelt, C.1
Armaka, M.2
Russo, G.3
Bratus, A.4
Trenkmann, M.5
Karouzakis, E.6
Kolling, C.7
Gay, R.E.8
Kollias, G.9
Gay, S.10
Frank-Bertoncelj, M.11
-
100
-
-
42449156220
-
Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis
-
Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, Detmar M, Gay S, Kyburz D., Altered expression of microRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheumatol 2008;58:1001–9.
-
(2008)
Arthritis Rheumatol
, vol.58
, pp. 1001-1009
-
-
Stanczyk, J.1
Pedrioli, D.M.2
Brentano, F.3
Sanchez-Pernaute, O.4
Kolling, C.5
Gay, R.E.6
Detmar, M.7
Gay, S.8
Kyburz, D.9
-
101
-
-
79960595150
-
MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis
-
Kurowska-Stolarska M, Alivernini S, Ballantine LE, Asquith DL, Millar NL, Gilchrist DS, Reilly J, Ierna M, Fraser AR, Stolarski B, McSharry C, Hueber AJ, Baxter D, Hunter J, Gay S, Liew FY, McInnes IB., MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proc Natl Acad Sci USA 2011;108:11193–8.
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 11193-11198
-
-
Kurowska-Stolarska, M.1
Alivernini, S.2
Ballantine, L.E.3
Asquith, D.L.4
Millar, N.L.5
Gilchrist, D.S.6
Reilly, J.7
Ierna, M.8
Fraser, A.R.9
Stolarski, B.10
McSharry, C.11
Hueber, A.J.12
Baxter, D.13
Hunter, J.14
Gay, S.15
Liew, F.Y.16
McInnes, I.B.17
-
102
-
-
79551655444
-
Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation
-
Stanczyk J, Ospelt C, Karouzakis E, Filer A, Raza K, Kolling C, Gay R, Buckley CD, Tak PP, Gay S, Kyburz D., Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation. Arthritis Rheumatol 2011;63:373–81.
-
(2011)
Arthritis Rheumatol
, vol.63
, pp. 373-381
-
-
Stanczyk, J.1
Ospelt, C.2
Karouzakis, E.3
Filer, A.4
Raza, K.5
Kolling, C.6
Gay, R.7
Buckley, C.D.8
Tak, P.P.9
Gay, S.10
Kyburz, D.11
-
103
-
-
81155126063
-
MicroRNA-18a enhances the interleukin-6 mediated production of the acute-phase proteins fibrinogen and haptoglobin in human hepatocytes
-
Brock M, Trenkmann M, Gay RE, Gay S, Speich R, Huber LC., MicroRNA-18a enhances the interleukin-6 mediated production of the acute-phase proteins fibrinogen and haptoglobin in human hepatocytes. J Biol Chem 2011;286:40142–50.
-
(2011)
J Biol Chem
, vol.286
, pp. 40142-40150
-
-
Brock, M.1
Trenkmann, M.2
Gay, R.E.3
Gay, S.4
Speich, R.5
Huber, L.C.6
-
104
-
-
84875721809
-
Tumor necrosis factor α-induced microRNA-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling
-
Trenkmann M, Brock M, Gay RE, Michel BA, Gay S, Huber LC., Tumor necrosis factor α-induced microRNA-18a activates rheumatoid arthritis synovial fibroblasts through a feedback loop in NF-κB signaling. Arthritis Rheumatol 2013;65:916–27.
-
(2013)
Arthritis Rheumatol
, vol.65
, pp. 916-927
-
-
Trenkmann, M.1
Brock, M.2
Gay, R.E.3
Michel, B.A.4
Gay, S.5
Huber, L.C.6
-
105
-
-
84860649140
-
MicroRNAs in rheumatoid arthritis: potential role in diagnosis and therapy
-
Filkova M, Jüngel A, Gay RE, Gay S., MicroRNAs in rheumatoid arthritis:potential role in diagnosis and therapy. BioDrugs 2012;26:131–41.
-
(2012)
BioDrugs
, vol.26
, pp. 131-141
-
-
Filkova, M.1
Jüngel, A.2
Gay, R.E.3
Gay, S.4
-
106
-
-
84922347131
-
AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension
-
Brock M, Samillan VJ, Trenkmann M, Schwarzwald C, Ulrich S, Gay RE, Gassmann M, Ostergaard L, Gay S, Speich R, Huber LC., AntagomiR directed against miR-20a restores functional BMPR2 signalling and prevents vascular remodelling in hypoxia-induced pulmonary hypertension. Eur Heart J 2014;35:3203–11.
-
(2014)
Eur Heart J
, vol.35
, pp. 3203-3211
-
-
Brock, M.1
Samillan, V.J.2
Trenkmann, M.3
Schwarzwald, C.4
Ulrich, S.5
Gay, R.E.6
Gassmann, M.7
Ostergaard, L.8
Gay, S.9
Speich, R.10
Huber, L.C.11
-
107
-
-
84971300817
-
Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic subchondral bone and similarity to overlying cartilage
-
in press
-
Jeffries MA, Donica M, Baker L, Stevenson M, Annan AC, Humphrey MB, James JA, Sawalha AH., Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic subchondral bone and similarity to overlying cartilage. Arthritis Rheumatol 2016 (in press).
-
Arthritis Rheumatol
, vol.2016
-
-
Jeffries, M.A.1
Donica, M.2
Baker, L.3
Stevenson, M.4
Annan, A.C.5
Humphrey, M.B.6
James, J.A.7
Sawalha, A.H.8
|