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Volumn 20, Issue 5, 2012, Pages 339-349

Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs

Author keywords

Cartilage; Chromatin; DNA methylation; Epigenetics; MicroRNAs

Indexed keywords

AGGRECANASE 1; COLLAGENASE 3; DICER; DNA METHYLTRANSFERASE 1; DNA METHYLTRANSFERASE 3A; DNA METHYLTRANSFERASE 3B; GELATINASE B; GROWTH DIFFERENTIATION FACTOR 5; HISTONE ACETYLTRANSFERASE; HISTONE DEACETYLASE 1; HISTONE DEACETYLASE 2; HISTONE DEACETYLASE 7; HISTONE DEACETYLASE INHIBITOR; MICRORNA; MICRORNA 140; PROTEIN ARGININE METHYLTRANSFERASE; RESVERATROL; SIRTUIN 1; SOMATOMEDIN; STROMELYSIN; UNCLASSIFIED DRUG;

EID: 84859433312     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2011.12.012     Document Type: Review
Times cited : (151)

References (111)
  • 1
    • 33846213905 scopus 로고    scopus 로고
    • Clinical aspects, pathology and pathophysiology of osteoarthritis
    • Goldring S.R., Goldring M.B. Clinical aspects, pathology and pathophysiology of osteoarthritis. J Musculoskelet Neuronal Interact 2006 Oct-Dec, 6(4):376-378.
    • (2006) J Musculoskelet Neuronal Interact , vol.6 , Issue.4 , pp. 376-378
    • Goldring, S.R.1    Goldring, M.B.2
  • 2
    • 0036976214 scopus 로고    scopus 로고
    • Molecular regulation of the chondrocyte phenotype
    • Goldring M.B. Molecular regulation of the chondrocyte phenotype. J Musculoskelet Neuronal Interact 2002 Dec, 2(6):517-520.
    • (2002) J Musculoskelet Neuronal Interact , vol.2 , Issue.6 , pp. 517-520
    • Goldring, M.B.1
  • 3
    • 79952814836 scopus 로고    scopus 로고
    • Osteoarthritis year 2010 in review: pathomechanisms
    • van den Berg W.B. Osteoarthritis year 2010 in review: pathomechanisms. Osteoarthritis Cartilage 2011 Apr, 19(4):338-341.
    • (2011) Osteoarthritis Cartilage , vol.19 , Issue.4 , pp. 338-341
    • van den Berg, W.B.1
  • 4
    • 40349087284 scopus 로고    scopus 로고
    • Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?
    • Murphy G., Nagase H. Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?. Nat Clin Pract 2008 Mar, 4(3):128-135.
    • (2008) Nat Clin Pract , vol.4 , Issue.3 , pp. 128-135
    • Murphy, G.1    Nagase, H.2
  • 5
    • 25144522176 scopus 로고    scopus 로고
    • The genetic epidemiology of human primary osteoarthritis: current status
    • Loughlin J. The genetic epidemiology of human primary osteoarthritis: current status. Expert Rev Mol Med 2005 May 24, 7(9):1-12.
    • (2005) Expert Rev Mol Med , vol.7 , Issue.9 , pp. 1-12
    • Loughlin, J.1
  • 6
    • 78049414227 scopus 로고    scopus 로고
    • Epigenetic reprogramming in plant and animal development
    • Feng S., Jacobsen S.E., Reik W. Epigenetic reprogramming in plant and animal development. Science 2010 Oct 29, 330(6004):622-627.
    • (2010) Science , vol.330 , Issue.6004 , pp. 622-627
    • Feng, S.1    Jacobsen, S.E.2    Reik, W.3
  • 7
    • 34249337761 scopus 로고    scopus 로고
    • Perceptions of epigenetics
    • Bird A. Perceptions of epigenetics. Nature 2007 May 24, 447(7143):396-398.
    • (2007) Nature , vol.447 , Issue.7143 , pp. 396-398
    • Bird, A.1
  • 8
    • 34447625911 scopus 로고    scopus 로고
    • Epigenetics and aging: the targets and the marks
    • Fraga M.F., Esteller M. Epigenetics and aging: the targets and the marks. Trends Genet 2007 Aug, 23(8):413-418.
    • (2007) Trends Genet , vol.23 , Issue.8 , pp. 413-418
    • Fraga, M.F.1    Esteller, M.2
  • 9
    • 77950625195 scopus 로고    scopus 로고
    • Epigenetic transgenerational actions of environmental factors in disease etiology
    • Skinner M.K., Manikkam M., Guerrero-Bosagna C. Epigenetic transgenerational actions of environmental factors in disease etiology. Trends Endocrinol Metab 2010 Apr, 21(4):214-222.
    • (2010) Trends Endocrinol Metab , vol.21 , Issue.4 , pp. 214-222
    • Skinner, M.K.1    Manikkam, M.2    Guerrero-Bosagna, C.3
  • 10
    • 34848911647 scopus 로고    scopus 로고
    • DNA methylation: the nuts and bolts of repression
    • Miranda T.B., Jones P.A. DNA methylation: the nuts and bolts of repression. J Cell Physiol 2007 Nov, 213(2):384-390.
    • (2007) J Cell Physiol , vol.213 , Issue.2 , pp. 384-390
    • Miranda, T.B.1    Jones, P.A.2
  • 11
    • 77957970301 scopus 로고    scopus 로고
    • Epigenetic modifications and human disease
    • Portela A., Esteller M. Epigenetic modifications and human disease. Nat Biotechnol 2010 Oct, 28(10):1057-1068.
    • (2010) Nat Biotechnol , vol.28 , Issue.10 , pp. 1057-1068
    • Portela, A.1    Esteller, M.2
  • 12
    • 59149084538 scopus 로고    scopus 로고
    • The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores
    • Irizarry R.A., Ladd-Acosta C., Wen B., Wu Z., Montano C., Onyango P., et al. The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores. Nat Genet 2009 Feb, 41(2):178-186.
    • (2009) Nat Genet , vol.41 , Issue.2 , pp. 178-186
    • Irizarry, R.A.1    Ladd-Acosta, C.2    Wen, B.3    Wu, Z.4    Montano, C.5    Onyango, P.6
  • 13
    • 33847304609 scopus 로고    scopus 로고
    • Gene body-specific methylation on the active X chromosome
    • Hellman A., Chess A. Gene body-specific methylation on the active X chromosome. Science 2007 Feb 23, 315(5815):1141-1143.
    • (2007) Science , vol.315 , Issue.5815 , pp. 1141-1143
    • Hellman, A.1    Chess, A.2
  • 14
    • 0026708177 scopus 로고
    • Targeted mutation of the DNA methyltransferase gene results in embryonic lethality
    • Li E., Bestor T.H., Jaenisch R. Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 1992 Jun 12, 69(6):915-926.
    • (1992) Cell , vol.69 , Issue.6 , pp. 915-926
    • Li, E.1    Bestor, T.H.2    Jaenisch, R.3
  • 15
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • Okano M., Bell D.W., Haber D.A., Li E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 1999 Oct 29, 99(3):247-257.
    • (1999) Cell , vol.99 , Issue.3 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 16
    • 15744401773 scopus 로고    scopus 로고
    • Eukaryotic cytosine methyltransferases
    • Goll M.G., Bestor T.H. Eukaryotic cytosine methyltransferases. Annu Rev Biochem 2005, 74:481-514.
    • (2005) Annu Rev Biochem , vol.74 , pp. 481-514
    • Goll, M.G.1    Bestor, T.H.2
  • 17
    • 61549140408 scopus 로고    scopus 로고
    • DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes
    • Sesselmann S., Soder S., Voigt R., Haag J., Grogan S.P., Aigner T. DNA methylation is not responsible for p21WAF1/CIP1 down-regulation in osteoarthritic chondrocytes. Osteoarthritis Cartilage 2009 Apr, 17(4):507-512.
    • (2009) Osteoarthritis Cartilage , vol.17 , Issue.4 , pp. 507-512
    • Sesselmann, S.1    Soder, S.2    Voigt, R.3    Haag, J.4    Grogan, S.P.5    Aigner, T.6
  • 18
    • 0023613967 scopus 로고
    • Effect of S-adenosylmethionine on experimental osteoarthritis in rabbits
    • Barcelo H.A., Wiemeyer J.C., Sagasta C.L., Macias M., Barreira J.C. Effect of S-adenosylmethionine on experimental osteoarthritis in rabbits. Am J Med 1987 Nov 20, 83(5A):55-59.
    • (1987) Am J Med , vol.83 , Issue.5 A , pp. 55-59
    • Barcelo, H.A.1    Wiemeyer, J.C.2    Sagasta, C.L.3    Macias, M.4    Barreira, J.C.5
  • 19
    • 74549116052 scopus 로고    scopus 로고
    • Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients
    • Kim J., Lee E.Y., Koh E.M., Cha H.S., Yoo B., Lee C.K., et al. Comparative clinical trial of S-adenosylmethionine versus nabumetone for the treatment of knee osteoarthritis: an 8-week, multicenter, randomized, double-blind, double-dummy, Phase IV study in Korean patients. Clin Ther 2009 Dec, 31(12):2860-2872.
    • (2009) Clin Ther , vol.31 , Issue.12 , pp. 2860-2872
    • Kim, J.1    Lee, E.Y.2    Koh, E.M.3    Cha, H.S.4    Yoo, B.5    Lee, C.K.6
  • 20
    • 0036256468 scopus 로고    scopus 로고
    • Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis
    • Soeken K.L., Lee W.L., Bausell R.B., Agelli M., Berman B.M. Safety and efficacy of S-adenosylmethionine (SAMe) for osteoarthritis. J Fam Pract 2002 May, 51(5):425-430.
    • (2002) J Fam Pract , vol.51 , Issue.5 , pp. 425-430
    • Soeken, K.L.1    Lee, W.L.2    Bausell, R.B.3    Agelli, M.4    Berman, B.M.5
  • 22
    • 77954345408 scopus 로고    scopus 로고
    • Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway
    • Hajkova P., Jeffries S.J., Lee C., Miller N., Jackson S.P., Surani M.A. Genome-wide reprogramming in the mouse germ line entails the base excision repair pathway. Science 2010 Jul 2, 329(5987):78-82.
    • (2010) Science , vol.329 , Issue.5987 , pp. 78-82
    • Hajkova, P.1    Jeffries, S.J.2    Lee, C.3    Miller, N.4    Jackson, S.P.5    Surani, M.A.6
  • 23
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain
    • Kriaucionis S., Heintz N. The nuclear DNA base 5-hydroxymethylcytosine is present in Purkinje neurons and the brain. Science 2009 May 15, 324(5929):929-930.
    • (2009) Science , vol.324 , Issue.5929 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 24
    • 79955538247 scopus 로고    scopus 로고
    • Hydroxylation of 5-Methylcytosine by TET1 promotes active DNA demethylation in the adult brain
    • Guo J.U., Su Y., Zhong C., Ming G.L., Song H. Hydroxylation of 5-Methylcytosine by TET1 promotes active DNA demethylation in the adult brain. Cell 2011 Apr 29, 145(3):423-434.
    • (2011) Cell , vol.145 , Issue.3 , pp. 423-434
    • Guo, J.U.1    Su, Y.2    Zhong, C.3    Ming, G.L.4    Song, H.5
  • 25
    • 77951116072 scopus 로고    scopus 로고
    • CpG islands influence chromatin structure via the CpG-binding protein Cfp1
    • Thomson J.P., Skene P.J., Selfridge J., Clouaire T., Guy J., Webb S., et al. CpG islands influence chromatin structure via the CpG-binding protein Cfp1. Nature 2010 Apr 15, 464(7291):1082-1086.
    • (2010) Nature , vol.464 , Issue.7291 , pp. 1082-1086
    • Thomson, J.P.1    Skene, P.J.2    Selfridge, J.3    Clouaire, T.4    Guy, J.5    Webb, S.6
  • 26
    • 0022001708 scopus 로고
    • Methylation of type II and type I collagen genes in differentiated and dedifferentiated chondrocytes
    • Fernandez M.P., Young M.F., Sobel M.E. Methylation of type II and type I collagen genes in differentiated and dedifferentiated chondrocytes. J Biol Chem 1985 Feb 25, 260(4):2374-2378.
    • (1985) J Biol Chem , vol.260 , Issue.4 , pp. 2374-2378
    • Fernandez, M.P.1    Young, M.F.2    Sobel, M.E.3
  • 27
    • 14144251836 scopus 로고    scopus 로고
    • DNA methylation is not likely to be responsible for aggrecan down regulation in aged or osteoarthritic cartilage
    • Poschl E., Fidler A., Schmidt B., Kallipolitou A., Schmid E., Aigner T. DNA methylation is not likely to be responsible for aggrecan down regulation in aged or osteoarthritic cartilage. Ann Rheum Dis 2005 Mar, 64(3):477-480.
    • (2005) Ann Rheum Dis , vol.64 , Issue.3 , pp. 477-480
    • Poschl, E.1    Fidler, A.2    Schmidt, B.3    Kallipolitou, A.4    Schmid, E.5    Aigner, T.6
  • 28
    • 51849083414 scopus 로고    scopus 로고
    • Correlation of COL10A1 induction during chondrogenesis of mesenchymal stem cells with demethylation of two CpG sites in the COL10A1 promoter
    • Zimmermann P., Boeuf S., Dickhut A., Boehmer S., Olek S., Richter W. Correlation of COL10A1 induction during chondrogenesis of mesenchymal stem cells with demethylation of two CpG sites in the COL10A1 promoter. Arthritis Rheum 2008 Sep, 58(9):2743-2753.
    • (2008) Arthritis Rheum , vol.58 , Issue.9 , pp. 2743-2753
    • Zimmermann, P.1    Boeuf, S.2    Dickhut, A.3    Boehmer, S.4    Olek, S.5    Richter, W.6
  • 29
    • 66049119725 scopus 로고    scopus 로고
    • Methylation status of CpG islands in the promoter regions of signature genes during chondrogenesis of human synovium-derived mesenchymal stem cells
    • Ezura Y., Sekiya I., Koga H., Muneta T., Noda M. Methylation status of CpG islands in the promoter regions of signature genes during chondrogenesis of human synovium-derived mesenchymal stem cells. Arthritis Rheum 2009 May, 60(5):1416-1426.
    • (2009) Arthritis Rheum , vol.60 , Issue.5 , pp. 1416-1426
    • Ezura, Y.1    Sekiya, I.2    Koga, H.3    Muneta, T.4    Noda, M.5
  • 30
    • 43049122786 scopus 로고    scopus 로고
    • A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility
    • Chapman K., Takahashi A., Meulenbelt I., Watson C., Rodriguez-Lopez J., Egli R., et al. A meta-analysis of European and Asian cohorts reveals a global role of a functional SNP in the 5' UTR of GDF5 with osteoarthritis susceptibility. Hum Mol Genet 2008 May 15, 17(10):1497-1504.
    • (2008) Hum Mol Genet , vol.17 , Issue.10 , pp. 1497-1504
    • Chapman, K.1    Takahashi, A.2    Meulenbelt, I.3    Watson, C.4    Rodriguez-Lopez, J.5    Egli, R.6
  • 31
    • 80051693596 scopus 로고    scopus 로고
    • Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation
    • Reynard L.N., Bui C., Canty-Laird E.G., Young D.A., Loughlin J. Expression of the osteoarthritis-associated gene GDF5 is modulated epigenetically by DNA methylation. Hum Mol Genet 2011 Sep 1, 20(17):3450-3460.
    • (2011) Hum Mol Genet , vol.20 , Issue.17 , pp. 3450-3460
    • Reynard, L.N.1    Bui, C.2    Canty-Laird, E.G.3    Young, D.A.4    Loughlin, J.5
  • 32
  • 33
    • 26844518429 scopus 로고    scopus 로고
    • Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions
    • Roach H.I., Yamada N., Cheung K.S., Tilley S., Clarke N.M., Oreffo R.O., et al. Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis Rheum 2005 Oct, 52(10):3110-3124.
    • (2005) Arthritis Rheum , vol.52 , Issue.10 , pp. 3110-3124
    • Roach, H.I.1    Yamada, N.2    Cheung, K.S.3    Tilley, S.4    Clarke, N.M.5    Oreffo, R.O.6
  • 34
    • 0027535235 scopus 로고
    • Effects of DNA methylation on DNA-binding proteins and gene expression
    • Tate P.H., Bird A.P. Effects of DNA methylation on DNA-binding proteins and gene expression. Curr Opin Genet Dev 1993 Apr, 3(2):226-231.
    • (1993) Curr Opin Genet Dev , vol.3 , Issue.2 , pp. 226-231
    • Tate, P.H.1    Bird, A.P.2
  • 35
    • 33644854871 scopus 로고    scopus 로고
    • A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory
    • Murayama A., Sakura K., Nakama M., Yasuzawa-Tanaka K., Fujita E., Tateishi Y., et al. A specific CpG site demethylation in the human interleukin 2 gene promoter is an epigenetic memory. Embo J 2006 Mar 8, 25(5):1081-1092.
    • (2006) Embo J , vol.25 , Issue.5 , pp. 1081-1092
    • Murayama, A.1    Sakura, K.2    Nakama, M.3    Yasuzawa-Tanaka, K.4    Fujita, E.5    Tateishi, Y.6
  • 36
    • 70350561846 scopus 로고    scopus 로고
    • DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes
    • Hashimoto K., Oreffo R.O., Gibson M.B., Goldring M.B., Roach H.I. DNA demethylation at specific CpG sites in the IL1B promoter in response to inflammatory cytokines in human articular chondrocytes. Arthritis Rheum 2009 Nov, 60(11):3303-3313.
    • (2009) Arthritis Rheum , vol.60 , Issue.11 , pp. 3303-3313
    • Hashimoto, K.1    Oreffo, R.O.2    Gibson, M.B.3    Goldring, M.B.4    Roach, H.I.5
  • 37
    • 36549024994 scopus 로고    scopus 로고
    • Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention
    • Iliopoulos D., Malizos K.N., Tsezou A. Epigenetic regulation of leptin affects MMP-13 expression in osteoarthritic chondrocytes: possible molecular target for osteoarthritis therapeutic intervention. Ann Rheum Dis 2007 Dec, 66(12):1616-1621.
    • (2007) Ann Rheum Dis , vol.66 , Issue.12 , pp. 1616-1621
    • Iliopoulos, D.1    Malizos, K.N.2    Tsezou, A.3
  • 38
    • 33847076849 scopus 로고    scopus 로고
    • Chromatin modifications and their function
    • Kouzarides T. Chromatin modifications and their function. Cell 2007 Feb 23, 128(4):693-705.
    • (2007) Cell , vol.128 , Issue.4 , pp. 693-705
    • Kouzarides, T.1
  • 39
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • Jenuwein T., Allis C.D. Translating the histone code. Science 2001 Aug 10, 293(5532):1074-1080.
    • (2001) Science , vol.293 , Issue.5532 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 40
    • 33746457753 scopus 로고    scopus 로고
    • Enhanced histone acetylation and transcription: a dynamic perspective
    • Clayton A.L., Hazzalin C.A., Mahadevan L.C. Enhanced histone acetylation and transcription: a dynamic perspective. Mol Cell 2006 Aug 4, 23(3):289-296.
    • (2006) Mol Cell , vol.23 , Issue.3 , pp. 289-296
    • Clayton, A.L.1    Hazzalin, C.A.2    Mahadevan, L.C.3
  • 41
    • 1842578986 scopus 로고    scopus 로고
    • Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis
    • Gregoretti I.V., Lee Y.M., Goodson H.V. Molecular evolution of the histone deacetylase family: functional implications of phylogenetic analysis. J Mol Biol 2004 Apr 16, 338(1):17-31.
    • (2004) J Mol Biol , vol.338 , Issue.1 , pp. 17-31
    • Gregoretti, I.V.1    Lee, Y.M.2    Goodson, H.V.3
  • 42
    • 34248151365 scopus 로고    scopus 로고
    • The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation
    • Inoue T., Hiratsuka M., Osaki M., Oshimura M. The molecular biology of mammalian SIRT proteins: SIRT2 in cell cycle regulation. Cell Cycle 2007 May 2, 6(9):1011-1018.
    • (2007) Cell Cycle , vol.6 , Issue.9 , pp. 1011-1018
    • Inoue, T.1    Hiratsuka, M.2    Osaki, M.3    Oshimura, M.4
  • 43
    • 34247880441 scopus 로고    scopus 로고
    • Development of histone deacetylase inhibitors for cancer treatment
    • Marchion D., Munster P. Development of histone deacetylase inhibitors for cancer treatment. Expert Rev Anticancer Ther 2007 Apr, 7(4):583-598.
    • (2007) Expert Rev Anticancer Ther , vol.7 , Issue.4 , pp. 583-598
    • Marchion, D.1    Munster, P.2
  • 44
    • 68949212379 scopus 로고    scopus 로고
    • Lysine acetylation targets protein complexes and co-regulates major cellular functions
    • Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., et al. Lysine acetylation targets protein complexes and co-regulates major cellular functions. Science 2009 Aug 14, 325(5942):834-840.
    • (2009) Science , vol.325 , Issue.5942 , pp. 834-840
    • Choudhary, C.1    Kumar, C.2    Gnad, F.3    Nielsen, M.L.4    Rehman, M.5    Walther, T.C.6
  • 45
    • 17044392996 scopus 로고    scopus 로고
    • Role of protein methylation in regulation of transcription
    • Lee D.Y., Teyssier C., Strahl B.D., Stallcup M.R. Role of protein methylation in regulation of transcription. Endocr Rev 2005 Apr, 26(2):147-170.
    • (2005) Endocr Rev , vol.26 , Issue.2 , pp. 147-170
    • Lee, D.Y.1    Teyssier, C.2    Strahl, B.D.3    Stallcup, M.R.4
  • 46
    • 33646486601 scopus 로고    scopus 로고
    • Histone lysine demethylases and their impact on epigenetics
    • Trojer P., Reinberg D. Histone lysine demethylases and their impact on epigenetics. Cell 2006 Apr 21, 125(2):213-217.
    • (2006) Cell , vol.125 , Issue.2 , pp. 213-217
    • Trojer, P.1    Reinberg, D.2
  • 47
    • 78049402859 scopus 로고    scopus 로고
    • Molecular signals of epigenetic states
    • Bonasio R., Tu S., Reinberg D. Molecular signals of epigenetic states. Science 2010 Oct 29, 330(6004):612-616.
    • (2010) Science , vol.330 , Issue.6004 , pp. 612-616
    • Bonasio, R.1    Tu, S.2    Reinberg, D.3
  • 48
    • 51149086596 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes
    • Chabane N., Zayed N., Afif H., Mfuna-Endam L., Benderdour M., Boileau C., et al. Histone deacetylase inhibitors suppress interleukin-1beta-induced nitric oxide and prostaglandin E2 production in human chondrocytes. Osteoarthritis Cartilage 2008 Oct, 16(10):1267-1274.
    • (2008) Osteoarthritis Cartilage , vol.16 , Issue.10 , pp. 1267-1274
    • Chabane, N.1    Zayed, N.2    Afif, H.3    Mfuna-Endam, L.4    Benderdour, M.5    Boileau, C.6
  • 49
    • 21644471962 scopus 로고    scopus 로고
    • Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption
    • Young D.A., Lakey R.L., Pennington C.J., Jones D., Kevorkian L., Edwards D.R., et al. Histone deacetylase inhibitors modulate metalloproteinase gene expression in chondrocytes and block cartilage resorption. Arthritis Res Ther 2005, 7(3):R503-R512.
    • (2005) Arthritis Res Ther , vol.7 , Issue.3
    • Young, D.A.1    Lakey, R.L.2    Pennington, C.J.3    Jones, D.4    Kevorkian, L.5    Edwards, D.R.6
  • 50
    • 58149123407 scopus 로고    scopus 로고
    • Inhibition of histone deacetylases antagonized FGF2 and IL-1beta effects on MMP expression in human articular chondrocytes
    • Wang X., Song Y., Jacobi J.L., Tuan R.S. Inhibition of histone deacetylases antagonized FGF2 and IL-1beta effects on MMP expression in human articular chondrocytes. Growth Factors 2009 Feb, 27(1):40-49.
    • (2009) Growth Factors , vol.27 , Issue.1 , pp. 40-49
    • Wang, X.1    Song, Y.2    Jacobi, J.L.3    Tuan, R.S.4
  • 51
    • 33947111431 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinase gene expression by a retinoid X receptor-specific ligand
    • Burrage P.S., Huntington J.T., Sporn M.B., Brinckerhoff C.E. Regulation of matrix metalloproteinase gene expression by a retinoid X receptor-specific ligand. Arthritis Rheum 2007 Mar, 56(3):892-904.
    • (2007) Arthritis Rheum , vol.56 , Issue.3 , pp. 892-904
    • Burrage, P.S.1    Huntington, J.T.2    Sporn, M.B.3    Brinckerhoff, C.E.4
  • 52
    • 27444436736 scopus 로고    scopus 로고
    • Sox9 and p300 cooperatively regulate chromatin-mediated transcription
    • Furumatsu T., Tsuda M., Yoshida K., Taniguchi N., Ito T., Hashimoto M., et al. Sox9 and p300 cooperatively regulate chromatin-mediated transcription. J Biol Chem 2005 Oct 21, 280(42):35203-35208.
    • (2005) J Biol Chem , vol.280 , Issue.42 , pp. 35203-35208
    • Furumatsu, T.1    Tsuda, M.2    Yoshida, K.3    Taniguchi, N.4    Ito, T.5    Hashimoto, M.6
  • 53
    • 70349670585 scopus 로고    scopus 로고
    • A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes
    • Hong S., Derfoul A., Pereira-Mouries L., Hall D.J. A novel domain in histone deacetylase 1 and 2 mediates repression of cartilage-specific genes in human chondrocytes. FASEB J 2009 Oct, 23(10):3539-3552.
    • (2009) FASEB J , vol.23 , Issue.10 , pp. 3539-3552
    • Hong, S.1    Derfoul, A.2    Pereira-Mouries, L.3    Hall, D.J.4
  • 54
    • 34447131517 scopus 로고    scopus 로고
    • Regulation of type II collagen expression by histone deacetylase in articular chondrocytes
    • Huh Y.H., Ryu J.H., Chun J.S. Regulation of type II collagen expression by histone deacetylase in articular chondrocytes. J Biol Chem 2007 Jun 8, 282(23):17123-17131.
    • (2007) J Biol Chem , vol.282 , Issue.23 , pp. 17123-17131
    • Huh, Y.H.1    Ryu, J.H.2    Chun, J.S.3
  • 55
    • 79952394907 scopus 로고    scopus 로고
    • Valproic acid suppresses interleukin-1ss-induced microsomal prostaglandin E2 synthase-1 expression in chondrocytes through upregulation of NAB1
    • Zayed N., El Mansouri F.E., Chabane N., Kapoor M., Martel-Pelletier J., Benderdour M., et al. Valproic acid suppresses interleukin-1ss-induced microsomal prostaglandin E2 synthase-1 expression in chondrocytes through upregulation of NAB1. J Rheumatol 2011 Mar, 38(3):492-502.
    • (2011) J Rheumatol , vol.38 , Issue.3 , pp. 492-502
    • Zayed, N.1    El Mansouri, F.E.2    Chabane, N.3    Kapoor, M.4    Martel-Pelletier, J.5    Benderdour, M.6
  • 56
    • 78149460199 scopus 로고    scopus 로고
    • Alleviation of osteoarthritis by trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis
    • Chen W.P., Bao J.P., Hu P.F., Feng J., Wu L.D. Alleviation of osteoarthritis by trichostatin A, a histone deacetylase inhibitor, in experimental osteoarthritis. Mol Biol Rep 2010 Dec, 37(8):3967-3972.
    • (2010) Mol Biol Rep , vol.37 , Issue.8 , pp. 3967-3972
    • Chen, W.P.1    Bao, J.P.2    Hu, P.F.3    Feng, J.4    Wu, L.D.5
  • 57
    • 0346873023 scopus 로고    scopus 로고
    • A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis
    • Chung Y.L., Lee M.Y., Wang A.J., Yao L.F. A therapeutic strategy uses histone deacetylase inhibitors to modulate the expression of genes involved in the pathogenesis of rheumatoid arthritis. Mol Ther 2003 Nov, 8(5):707-717.
    • (2003) Mol Ther , vol.8 , Issue.5 , pp. 707-717
    • Chung, Y.L.1    Lee, M.Y.2    Wang, A.J.3    Yao, L.F.4
  • 58
    • 76649099170 scopus 로고    scopus 로고
    • Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis
    • Higashiyama R., Miyaki S., Yamashita S., Yoshitaka T., Lindman G., Ito Y., et al. Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis. Mod Rheumatol 2010 Feb, 20(1):11-17.
    • (2010) Mod Rheumatol , vol.20 , Issue.1 , pp. 11-17
    • Higashiyama, R.1    Miyaki, S.2    Yamashita, S.3    Yoshitaka, T.4    Lindman, G.5    Ito, Y.6
  • 59
    • 34247227700 scopus 로고    scopus 로고
    • Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients
    • Huber L.C., Brock M., Hemmatazad H., Giger O.T., Moritz F., Trenkmann M., et al. Histone deacetylase/acetylase activity in total synovial tissue derived from rheumatoid arthritis and osteoarthritis patients. Arthritis Rheum 2007 Apr, 56(4):1087-1093.
    • (2007) Arthritis Rheum , vol.56 , Issue.4 , pp. 1087-1093
    • Huber, L.C.1    Brock, M.2    Hemmatazad, H.3    Giger, O.T.4    Moritz, F.5    Trenkmann, M.6
  • 60
    • 78650783194 scopus 로고    scopus 로고
    • Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes
    • El Mansouri F.E., Chabane N., Zayed N., Kapoor M., Benderdour M., Martel-Pelletier J., et al. Contribution of H3K4 methylation by SET-1A to interleukin-1-induced cyclooxygenase 2 and inducible nitric oxide synthase expression in human osteoarthritis chondrocytes. Arthritis Rheum 2011 Jan, 63(1):168-179.
    • (2011) Arthritis Rheum , vol.63 , Issue.1 , pp. 168-179
    • El Mansouri, F.E.1    Chabane, N.2    Zayed, N.3    Kapoor, M.4    Benderdour, M.5    Martel-Pelletier, J.6
  • 61
    • 77951717549 scopus 로고    scopus 로고
    • SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway
    • Gagarina V., Gabay O., Dvir-Ginzberg M., Lee E.J., Brady J.K., Quon M.J., et al. SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. Arthritis Rheum 2010 May, 62(5):1383-1392.
    • (2010) Arthritis Rheum , vol.62 , Issue.5 , pp. 1383-1392
    • Gagarina, V.1    Gabay, O.2    Dvir-Ginzberg, M.3    Lee, E.J.4    Brady, J.K.5    Quon, M.J.6
  • 62
    • 61349159991 scopus 로고    scopus 로고
    • Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase
    • Dvir-Ginzberg M., Gagarina V., Lee E.J., Hall D.J. Regulation of cartilage-specific gene expression in human chondrocytes by SirT1 and nicotinamide phosphoribosyltransferase. J Biol Chem 2008 Dec 26, 283(52):36300-36310.
    • (2008) J Biol Chem , vol.283 , Issue.52 , pp. 36300-36310
    • Dvir-Ginzberg, M.1    Gagarina, V.2    Lee, E.J.3    Hall, D.J.4
  • 63
    • 78650978303 scopus 로고    scopus 로고
    • Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions
    • Fujita N., Matsushita T., Ishida K., Kubo S., Matsumoto T., Takayama K., et al. Potential involvement of SIRT1 in the pathogenesis of osteoarthritis through the modulation of chondrocyte gene expressions. J Orthop Res 2011 Apr, 29(4):511-515.
    • (2011) J Orthop Res , vol.29 , Issue.4 , pp. 511-515
    • Fujita, N.1    Matsushita, T.2    Ishida, K.3    Kubo, S.4    Matsumoto, T.5    Takayama, K.6
  • 65
    • 74049084565 scopus 로고    scopus 로고
    • Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase
    • Hong E.H., Lee S.J., Kim J.S., Lee K.H., Um H.D., Kim J.H., et al. Ionizing radiation induces cellular senescence of articular chondrocytes via negative regulation of SIRT1 by p38 kinase. J Biol Chem 2010 Jan 8, 285(2):1283-1295.
    • (2010) J Biol Chem , vol.285 , Issue.2 , pp. 1283-1295
    • Hong, E.H.1    Lee, S.J.2    Kim, J.S.3    Lee, K.H.4    Um, H.D.5    Kim, J.H.6
  • 66
    • 66749129781 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1
    • Dioum E.M., Chen R., Alexander M.S., Zhang Q., Hogg R.T., Gerard R.D., et al. Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science 2009 Jun 5, 324(5932):1289-1293.
    • (2009) Science , vol.324 , Issue.5932 , pp. 1289-1293
    • Dioum, E.M.1    Chen, R.2    Alexander, M.S.3    Zhang, Q.4    Hogg, R.T.5    Gerard, R.D.6
  • 67
    • 77953183739 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction
    • Yang S., Kim J., Ryu J.H., Oh H., Chun C.H., Kim B.J., et al. Hypoxia-inducible factor-2alpha is a catabolic regulator of osteoarthritic cartilage destruction. Nat Med 2010 Jun, 16(6):687-693.
    • (2010) Nat Med , vol.16 , Issue.6 , pp. 687-693
    • Yang, S.1    Kim, J.2    Ryu, J.H.3    Oh, H.4    Chun, C.H.5    Kim, B.J.6
  • 68
    • 82355190885 scopus 로고    scopus 로고
    • Sirt1 is a regulator of bone mass and a repressor of sost encoding for sclerostin, a bone formation inhibitor
    • Cohen-Kfir E., Artsi H., Levin A., Abramowitz E., Bajayo A., Gurt I., et al. Sirt1 is a regulator of bone mass and a repressor of sost encoding for sclerostin, a bone formation inhibitor. Endocrinology 2011 Dec, 152(12):4514-4524.
    • (2011) Endocrinology , vol.152 , Issue.12 , pp. 4514-4524
    • Cohen-Kfir, E.1    Artsi, H.2    Levin, A.3    Abramowitz, E.4    Bajayo, A.5    Gurt, I.6
  • 70
    • 35348821616 scopus 로고    scopus 로고
    • MicroRNAs in vertebrate physiology and human disease
    • Chang T.C., Mendell J.T. microRNAs in vertebrate physiology and human disease. Annu Rev Genomics Hum Genet 2007, 8:215-239.
    • (2007) Annu Rev Genomics Hum Genet , vol.8 , pp. 215-239
    • Chang, T.C.1    Mendell, J.T.2
  • 71
    • 77955644289 scopus 로고    scopus 로고
    • Mammalian microRNAs predominantly act to decrease target mRNA levels
    • Guo H., Ingolia N.T., Weissman J.S., Bartel D.P. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 2010 Aug 12, 466(7308):835-840.
    • (2010) Nature , vol.466 , Issue.7308 , pp. 835-840
    • Guo, H.1    Ingolia, N.T.2    Weissman, J.S.3    Bartel, D.P.4
  • 72
    • 23344439006 scopus 로고    scopus 로고
    • The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb
    • Harfe B.D., McManus M.T., Mansfield J.H., Hornstein E., Tabin C.J. The RNaseIII enzyme Dicer is required for morphogenesis but not patterning of the vertebrate limb. Proc Natl Acad Sci U S A 2005 Aug 2, 102(31):10898-10903.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , Issue.31 , pp. 10898-10903
    • Harfe, B.D.1    McManus, M.T.2    Mansfield, J.H.3    Hornstein, E.4    Tabin, C.J.5
  • 73
  • 75
    • 33745813856 scopus 로고    scopus 로고
    • The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells
    • Tuddenham L., Wheeler G., Ntounia-Fousara S., Waters J., Hajihosseini M.K., Clark I., et al. The cartilage specific microRNA-140 targets histone deacetylase 4 in mouse cells. FEBS Lett 2006 Jul 24, 580(17):4214-4217.
    • (2006) FEBS Lett , vol.580 , Issue.17 , pp. 4214-4217
    • Tuddenham, L.1    Wheeler, G.2    Ntounia-Fousara, S.3    Waters, J.4    Hajihosseini, M.K.5    Clark, I.6
  • 76
    • 73649139221 scopus 로고    scopus 로고
    • Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes
    • Tardif G., Hum D., Pelletier J.P., Duval N., Martel-Pelletier J. Regulation of the IGFBP-5 and MMP-13 genes by the microRNAs miR-140 and miR-27a in human osteoarthritic chondrocytes. BMC Musculoskelet Disord 2009, 10:148.
    • (2009) BMC Musculoskelet Disord , vol.10 , pp. 148
    • Tardif, G.1    Hum, D.2    Pelletier, J.P.3    Duval, N.4    Martel-Pelletier, J.5
  • 77
    • 69449103973 scopus 로고    scopus 로고
    • MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses
    • Miyaki S., Nakasa T., Otsuki S., Grogan S.P., Higashiyama R., Inoue A., et al. microRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum 2009 Sep, 60(9):2723-2730.
    • (2009) Arthritis Rheum , vol.60 , Issue.9 , pp. 2723-2730
    • Miyaki, S.1    Nakasa, T.2    Otsuki, S.3    Grogan, S.P.4    Higashiyama, R.5    Inoue, A.6
  • 78
    • 56649084972 scopus 로고    scopus 로고
    • Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks
    • Iliopoulos D., Malizos K.N., Oikonomou P., Tsezou A. Integrative microRNA and proteomic approaches identify novel osteoarthritis genes and their collaborative metabolic and inflammatory networks. PLoS One 2008, 3(11):e3740.
    • (2008) PLoS One , vol.3 , Issue.11
    • Iliopoulos, D.1    Malizos, K.N.2    Oikonomou, P.3    Tsezou, A.4
  • 79
    • 8344261349 scopus 로고    scopus 로고
    • Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis
    • Vega R.B., Matsuda K., Oh J., Barbosa A.C., Yang X., Meadows E., et al. Histone deacetylase 4 controls chondrocyte hypertrophy during skeletogenesis. Cell 2004 Nov 12, 119(4):555-566.
    • (2004) Cell , vol.119 , Issue.4 , pp. 555-566
    • Vega, R.B.1    Matsuda, K.2    Oh, J.3    Barbosa, A.C.4    Yang, X.5    Meadows, E.6
  • 80
    • 33847183440 scopus 로고    scopus 로고
    • MEF2C transcription factor controls chondrocyte hypertrophy and bone development
    • Arnold M.A., Kim Y., Czubryt M.P., Phan D., McAnally J., Qi X., et al. MEF2C transcription factor controls chondrocyte hypertrophy and bone development. Dev Cell 2007 Mar, 12(3):377-389.
    • (2007) Dev Cell , vol.12 , Issue.3 , pp. 377-389
    • Arnold, M.A.1    Kim, Y.2    Czubryt, M.P.3    Phan, D.4    McAnally, J.5    Qi, X.6
  • 81
    • 57049089111 scopus 로고    scopus 로고
    • Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140
    • Nicolas F.E., Pais H., Schwach F., Lindow M., Kauppinen S., Moulton V., et al. Experimental identification of microRNA-140 targets by silencing and overexpressing miR-140. RNA 2008 Dec, 14(12):2513-2520.
    • (2008) RNA , vol.14 , Issue.12 , pp. 2513-2520
    • Nicolas, F.E.1    Pais, H.2    Schwach, F.3    Lindow, M.4    Kauppinen, S.5    Moulton, V.6
  • 82
    • 77149122720 scopus 로고    scopus 로고
    • Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level
    • Pais H., Nicolas F.E., Soond S.M., Swingler T.E., Clark I.M., Chantry A., et al. Analyzing mRNA expression identifies Smad3 as a microRNA-140 target regulated only at protein level. RNA 2010 Mar, 16(3):489-494.
    • (2010) RNA , vol.16 , Issue.3 , pp. 489-494
    • Pais, H.1    Nicolas, F.E.2    Soond, S.M.3    Swingler, T.E.4    Clark, I.M.5    Chantry, A.6
  • 83
    • 77953067173 scopus 로고    scopus 로고
    • MicroRNA-140 plays dual roles in both cartilage development and homeostasis
    • Miyaki S., Sato T., Inoue A., Otsuki S., Ito Y., Yokoyama S., et al. microRNA-140 plays dual roles in both cartilage development and homeostasis. Genes Dev 2010 Jun 1, 24(11):1173-1185.
    • (2010) Genes Dev , vol.24 , Issue.11 , pp. 1173-1185
    • Miyaki, S.1    Sato, T.2    Inoue, A.3    Otsuki, S.4    Ito, Y.5    Yokoyama, S.6
  • 84
    • 79960365689 scopus 로고    scopus 로고
    • Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate BMP signaling
    • Nakamura Y., Inloes J.B., Katagiri T., Kobayashi T. Chondrocyte-specific microRNA-140 regulates endochondral bone development and targets Dnpep to modulate BMP signaling. Mol Cell Biol 2011 May 16.
    • (2011) Mol Cell Biol
    • Nakamura, Y.1    Inloes, J.B.2    Katagiri, T.3    Kobayashi, T.4
  • 85
    • 78650515835 scopus 로고    scopus 로고
    • The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid
    • Zou W., Chen X., Shim J.H., Huang Z., Brady N., Hu D., et al. The E3 ubiquitin ligase Wwp2 regulates craniofacial development through mono-ubiquitylation of Goosecoid. Nat Cell Biol 2010 Jan, 13(1):59-65.
    • (2010) Nat Cell Biol , vol.13 , Issue.1 , pp. 59-65
    • Zou, W.1    Chen, X.2    Shim, J.H.3    Huang, Z.4    Brady, N.5    Hu, D.6
  • 86
    • 39749151652 scopus 로고    scopus 로고
    • MicroRNA Mirn140 modulates Pdgf signaling during palatogenesis
    • Eberhart J.K., He X., Swartz M.E., Yan Y.L., Song H., Boling T.C., et al. microRNA Mirn140 modulates Pdgf signaling during palatogenesis. Nat Genet 2008 Mar, 40(3):290-298.
    • (2008) Nat Genet , vol.40 , Issue.3 , pp. 290-298
    • Eberhart, J.K.1    He, X.2    Swartz, M.E.3    Yan, Y.L.4    Song, H.5    Boling, T.C.6
  • 87
    • 79953242601 scopus 로고    scopus 로고
    • Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25
    • Nakamura Y., Yamamoto K., He X., Otsuki B., Kim Y., Murao H., et al. Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25. Nat Commun 2011 Mar, 2:251.
    • (2011) Nat Commun , vol.2 , pp. 251
    • Nakamura, Y.1    Yamamoto, K.2    He, X.3    Otsuki, B.4    Kim, Y.5    Murao, H.6
  • 88
    • 79953277185 scopus 로고    scopus 로고
    • Observation of miRNA gene expression in zebrafish embryos by in situ hybridization to microRNA primary transcripts
    • He X., Yan Y.L., Delaurier A., Postlethwait J.H. Observation of miRNA gene expression in zebrafish embryos by in situ hybridization to microRNA primary transcripts. Zebrafish 2011 Mar, 8(1):1-8.
    • (2011) Zebrafish , vol.8 , Issue.1 , pp. 1-8
    • He, X.1    Yan, Y.L.2    Delaurier, A.3    Postlethwait, J.H.4
  • 89
    • 61849173539 scopus 로고    scopus 로고
    • The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13
    • Jones S.W., Watkins G., Le Good N., Roberts S., Murphy C.L., Brockbank S.M., et al. The identification of differentially expressed microRNA in osteoarthritic tissue that modulate the production of TNF-alpha and MMP13. Osteoarthritis Cartilage 2009 Apr, 17(4):464-472.
    • (2009) Osteoarthritis Cartilage , vol.17 , Issue.4 , pp. 464-472
    • Jones, S.W.1    Watkins, G.2    Le Good, N.3    Roberts, S.4    Murphy, C.L.5    Brockbank, S.M.6
  • 91
    • 80051503652 scopus 로고    scopus 로고
    • Assessment of the profiling microRNA expression of differentiated and dedifferentiated human adult articular chondrocytes
    • Lin L., Shen Q., Zhang C., Chen L., Yu C. Assessment of the profiling microRNA expression of differentiated and dedifferentiated human adult articular chondrocytes. J Orthop Res 2011 Apr 1.
    • (2011) J Orthop Res
    • Lin, L.1    Shen, Q.2    Zhang, C.3    Chen, L.4    Yu, C.5
  • 92
    • 33747608638 scopus 로고    scopus 로고
    • NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses
    • Taganov K.D., Boldin M.P., Chang K.J., Baltimore D. NF-kappaB-dependent induction of microRNA miR-146, an inhibitor targeted to signaling proteins of innate immune responses. Proc Natl Acad Sci U S A 2006 Aug 15, 103(33):12481-12486.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.33 , pp. 12481-12486
    • Taganov, K.D.1    Boldin, M.P.2    Chang, K.J.3    Baltimore, D.4
  • 93
    • 79955890241 scopus 로고    scopus 로고
    • MicroRNA-146a is linked to pain-related pathophysiology of osteoarthritis
    • Li X., Gibson G., Kim J.S., Kroin J., Xu S., van Wijnen A.J., et al. microRNA-146a is linked to pain-related pathophysiology of osteoarthritis. Gene 2011 Jul 1, 480(1-2):34-41.
    • (2011) Gene , vol.480 , Issue.1-2 , pp. 34-41
    • Li, X.1    Gibson, G.2    Kim, J.S.3    Kroin, J.4    Xu, S.5    van Wijnen, A.J.6
  • 94
    • 77951743715 scopus 로고    scopus 로고
    • MicroRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes
    • Akhtar N., Rasheed Z., Ramamurthy S., Anbazhagan A.N., Voss F.R., Haqqi T.M. microRNA-27b regulates the expression of matrix metalloproteinase 13 in human osteoarthritis chondrocytes. Arthritis Rheum 2010 May, 62(5):1361-1371.
    • (2010) Arthritis Rheum , vol.62 , Issue.5 , pp. 1361-1371
    • Akhtar, N.1    Rasheed, Z.2    Ramamurthy, S.3    Anbazhagan, A.N.4    Voss, F.R.5    Haqqi, T.M.6
  • 95
    • 77955283528 scopus 로고    scopus 로고
    • Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes
    • Dudek K.A., Lafont J.E., Martinez-Sanchez A., Murphy C.L. Type II collagen expression is regulated by tissue-specific miR-675 in human articular chondrocytes. J Biol Chem 2010 Aug 6, 285(32):24381-24387.
    • (2010) J Biol Chem , vol.285 , Issue.32 , pp. 24381-24387
    • Dudek, K.A.1    Lafont, J.E.2    Martinez-Sanchez, A.3    Murphy, C.L.4
  • 97
    • 82655181357 scopus 로고    scopus 로고
    • MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4
    • Guan Y.J., Yang X., Wei L., Chen Q. MiR-365: a mechanosensitive microRNA stimulates chondrocyte differentiation through targeting histone deacetylase 4. FASEB J 2011 Dec, 25(12):4457-4466.
    • (2011) FASEB J , vol.25 , Issue.12 , pp. 4457-4466
    • Guan, Y.J.1    Yang, X.2    Wei, L.3    Chen, Q.4
  • 98
    • 84857442548 scopus 로고    scopus 로고
    • Regulation of human chondrocyte function through direct inhibition of cartilage master-regulator SOX9 by miRNA-145
    • Martinez-Sanchez A., Dudek K.A., Murphy C.L. Regulation of human chondrocyte function through direct inhibition of cartilage master-regulator SOX9 by miRNA-145. J Biol Chem 2011 Nov 18.
    • (2011) J Biol Chem
    • Martinez-Sanchez, A.1    Dudek, K.A.2    Murphy, C.L.3
  • 99
    • 79960569238 scopus 로고    scopus 로고
    • MicroRNA-145 regulates chondrogenic differentiation of mesenchymal stem cells by targeting Sox9
    • Yang B., Guo H., Zhang Y., Chen L., Ying D., Dong S. microRNA-145 regulates chondrogenic differentiation of mesenchymal stem cells by targeting Sox9. PLoS One 2011, 6(7):e21679.
    • (2011) PLoS One , vol.6 , Issue.7
    • Yang, B.1    Guo, H.2    Zhang, Y.3    Chen, L.4    Ying, D.5    Dong, S.6
  • 101
    • 79953202200 scopus 로고    scopus 로고
    • Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma
    • Arroyo J.D., Chevillet J.R., Kroh E.M., Ruf I.K., Pritchard C.C., Gibson D.F., et al. Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma. Proc Natl Acad Sci U S A 2011 Mar 22, 108(12):5003-5008.
    • (2011) Proc Natl Acad Sci U S A , vol.108 , Issue.12 , pp. 5003-5008
    • Arroyo, J.D.1    Chevillet, J.R.2    Kroh, E.M.3    Ruf, I.K.4    Pritchard, C.C.5    Gibson, D.F.6
  • 102
    • 77952086523 scopus 로고    scopus 로고
    • Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis
    • Murata K., Yoshitomi H., Tanida S., Ishikawa M., Nishitani K., Ito H., et al. Plasma and synovial fluid microRNAs as potential biomarkers of rheumatoid arthritis and osteoarthritis. Arthritis Res Ther 2010, 12(3):R86.
    • (2010) Arthritis Res Ther , vol.12 , Issue.3
    • Murata, K.1    Yoshitomi, H.2    Tanida, S.3    Ishikawa, M.4    Nishitani, K.5    Ito, H.6
  • 103
    • 77249137168 scopus 로고    scopus 로고
    • Principles and challenges of genome-wide DNA methylation analysis
    • Laird P.W. Principles and challenges of genome-wide DNA methylation analysis. Nat Rev Genet 2010 Feb 2, 11(3):191-203.
    • (2010) Nat Rev Genet , vol.11 , Issue.3 , pp. 191-203
    • Laird, P.W.1
  • 104
    • 39449088572 scopus 로고    scopus 로고
    • Genome-wide approaches to studying chromatin modifications
    • Schones D.E., Zhao K. Genome-wide approaches to studying chromatin modifications. Nat Rev Genet 2008 Mar, 9(3):179-191.
    • (2008) Nat Rev Genet , vol.9 , Issue.3 , pp. 179-191
    • Schones, D.E.1    Zhao, K.2
  • 105
    • 67649595548 scopus 로고    scopus 로고
    • Limitations and possibilities of small RNA digital gene expression profiling
    • Linsen S.E., de Wit E., Janssens G., Heater S., Chapman L., Parkin R.K., et al. Limitations and possibilities of small RNA digital gene expression profiling. Nat Methods 2009 Jul, 6(7):474-476.
    • (2009) Nat Methods , vol.6 , Issue.7 , pp. 474-476
    • Linsen, S.E.1    de Wit, E.2    Janssens, G.3    Heater, S.4    Chapman, L.5    Parkin, R.K.6
  • 106
    • 77957766910 scopus 로고    scopus 로고
    • Desperately seeking microRNA targets
    • Thomas M., Lieberman J., Lal A. Desperately seeking microRNA targets. Nat Struct Mol Biol 2010 Oct, 17(10):1169-1174.
    • (2010) Nat Struct Mol Biol , vol.17 , Issue.10 , pp. 1169-1174
    • Thomas, M.1    Lieberman, J.2    Lal, A.3
  • 107
    • 61449135868 scopus 로고    scopus 로고
    • Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation
    • Cheung K.S., Hashimoto K., Yamada N., Roach H.I. Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation. Rheumatol Int 2009 Mar, 29(5):525-534.
    • (2009) Rheumatol Int , vol.29 , Issue.5 , pp. 525-534
    • Cheung, K.S.1    Hashimoto, K.2    Yamada, N.3    Roach, H.I.4
  • 109
    • 61549102182 scopus 로고    scopus 로고
    • Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage
    • Loeser R.F., Im H.J., Richardson B., Lu Q., Chubinskaya S. Methylation of the OP-1 promoter: potential role in the age-related decline in OP-1 expression in cartilage. Osteoarthritis Cartilage 2009 Apr, 17(4):513-517.
    • (2009) Osteoarthritis Cartilage , vol.17 , Issue.4 , pp. 513-517
    • Loeser, R.F.1    Im, H.J.2    Richardson, B.3    Lu, Q.4    Chubinskaya, S.5
  • 110
    • 77955436218 scopus 로고    scopus 로고
    • Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease
    • Scott J.L., Gabrielides C., Davidson R.K., Swingler T.E., Clark I.M., Wallis G.A., et al. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease. Ann Rheum Dis 2010 Aug, 69(8):1502-1510.
    • (2010) Ann Rheum Dis , vol.69 , Issue.8 , pp. 1502-1510
    • Scott, J.L.1    Gabrielides, C.2    Davidson, R.K.3    Swingler, T.E.4    Clark, I.M.5    Wallis, G.A.6
  • 111
    • 61749098633 scopus 로고    scopus 로고
    • Regulation of chondrocytic phenotype by micro RNA 18a: involvement of Ccn2/Ctgf as a major target gene
    • Ohgawara T., Kubota S., Kawaki H., Kondo S., Eguchi T., Kurio N., et al. Regulation of chondrocytic phenotype by micro RNA 18a: involvement of Ccn2/Ctgf as a major target gene. FEBS Lett 2009 Mar 18, 583(6):1006-1010.
    • (2009) FEBS Lett , vol.583 , Issue.6 , pp. 1006-1010
    • Ohgawara, T.1    Kubota, S.2    Kawaki, H.3    Kondo, S.4    Eguchi, T.5    Kurio, N.6


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