Inhibition of spermidine/spermine N1-acetyltransferase activity: A new therapeutic concept in rheumatoid arthritis

Arthritis and Rheumatology

Volumn 66, Issue 7, 2014, Pages 1723-1733

  Neidhart, Michel ^a   Karouzakis, Emmanuel ^a   Jüngel, Astrid ^a   Gay, Renate E ^a   Gay, Steffen ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

5 METHYLCYTOSINE; ACYLTRANSFERASE; ADENOSYLMETHIONINE DECARBOXYLASE; BETA1 INTEGRIN; CHEMOKINE RECEPTOR CXCR4; DIMINAZENE ACETURATE; DNA METHYLTRANSFERASE 1; HERMES ANTIGEN; MATRIX METALLOPROTEINASE; POLYAMINE; POLYAMINE MODULATED FACTOR 1; SMALL INTERFERING RNA; SPERMIDINE; SPERMIDINE SPERMINE N1 ACETYLTRANSFERASE 1; SPERMINE; UNCLASSIFIED DRUG;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL ADHESION; CELL PROLIFERATION; CLINICAL ARTICLE; DNA METHYLATION; ENZYME ACTIVITY; ENZYME INHIBITION; FIBROBLAST; HUMAN; HUMAN CELL; METHYLATION; MIDDLE AGED; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYROSEQUENCING; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID;

ACETYLTRANSFERASES; ADENOSYLMETHIONINE DECARBOXYLASE; AGED; ANIMALS; ARTHRITIS, RHEUMATOID; CELLS, CULTURED; DIMINAZENE; DNA METHYLATION; DRUG DESIGN; ENZYME INHIBITORS; FEMALE; FIBROBLASTS; HUMANS; MALE; MICE; MICE, SCID; MIDDLE AGED; PROMOTER REGIONS, GENETIC; RNA, SMALL INTERFERING; S-ADENOSYLMETHIONINE; SYNOVIAL MEMBRANE; TRANSCRIPTION FACTORS;

EID: 84903478937     PISSN: 23265191     EISSN: 23265205     Source Type: Journal    
DOI: 10.1002/art.38574     Document Type: Article

References (38)

1. Muller-Ladner U, Kriegsmann J, Franklin BN, Matsumoto S, Geiler T, Gay RE, et al. Synovial fibroblasts of patients with rheumatoid arthritis attach to and invade normal human cartilage when engrafted into SCID mice. Am J Pathol 1996; 149: 1607-15.
2. Neidhart M, Seemayer CA, Hummel KM, Michel BA, Gay RE, Gay S,. Functional characterization of adherent synovial fluid cells in rheumatoid arthritis: destructive potential in vitro and in vivo. Arthritis Rheum 2003; 48: 1873-80.
3. Lefevre S, Knedla A, Tennie C, Kampmann A, Wunrau C, Dinser R, et al. Synovial fibroblasts spread rheumatoid arthritis to unaffected joints. Nat Med 2009; 15: 1414-20.
4. Neumann E, Lefevre S, Zimmermann B, Gay S, Muller-Ladner U,. Rheumatoid arthritis progression mediated by activated synovial fibroblasts. Trends Mol Med 2011; 16: 458-68.
5. Karouzakis E, Gay RE, Gay S, Neidhart M,. Epigenetic control in rheumatoid arthritis synovial fibroblasts. Nat Rev Rheumatol 2009; 5: 266-72.
6. Neidhart M, Rethage J, Kuchen S, Kunzler P, Crowl RM, Billingham ME, et al. Retrotransposable L1 elements expressed in rheumatoid arthritis synovial tissue: association with genomic DNA hypomethylation and influence on gene expression. Arthritis Rheum 2000; 43: 2634-47.
7. Kuchen S, Seemayer CA, Rethage J, von Knoch R, Kuenzler P, Beat AM, et al. The L1 retroelement-related p40 protein induces p38δ MAP kinase. Autoimmunity 2004; 37: 57-65.
8. Karouzakis E, Gay RE, Michel BA, Gay S, Neidhart M,. DNA hypomethylation in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 2009; 60: 3613-22.
9. Karouzakis E, Rengel Y, Jungel A, Kolling C, Gay RE, Michel BA, et al. DNA methylation regulates the expression of CXCL12 in rheumatoid arthritis synovial fibroblasts. Genes Immun 2011; 12: 643-52.
10. Brooks WH,. X chromosome inactivation and autoimmunity. Clin Rev Allergy Immunol 2010; 39: 20-9.
11. Karouzakis E, Gay RE, Gay S, Neidhart M,. Increased recycling of polyamines is associated with global DNA hypomethylation in rheumatoid arthritis synovial fibroblasts. Arthritis Rheum 2012; 64: 1809-17.
12. Aleman A, Cebrian V, Alvarez M, Lopez V, Orenes E, Lopez-Serra L, et al. Identification of PMF1 methylation in association with bladder cancer progression. Clin Cancer Res 2008; 14: 8236-43.
13. Furumitsu Y, Yukioka K, Yukioka M, Ochi T, Morishima Y, Matsui-Yuasa I, et al. Interleukin-1β induces elevation of spermidine/ spermine N1-acetyltransferase activity and an increase in the amount of putrescine in synovial adherent cells from patients with rheumatoid arthritis. J Rheumatol 2000; 27: 1352-7.
14. Karvonen E, Kauppinen L, Partanen T, Poso H,. Irreversible inhibition of putrescine-stimulated S-adenosyl- l -methionine decarboxylase by Berenil and pentamidine. Biochem J 1985; 231: 165-9.
15. Libby PR, Porter CW,. Inhibition of enzymes of polyamine back-conversion by pentamidine and Berenil. Biochem Pharmacol 1992; 44: 830-2.
16. Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, et al. Polyamine pathway contributes to the pathogenesis of Parkinson disease. Proc Natl Acad Sci U S A 2010; 107: 16970-5.
17. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988; 31: 315-24.
18. Altman R, Alarcon G, Appelrouth D, Bloch D, Borenstein D, Brandt K, et al. The American College of Rheumatology criteria for the classification and reporting of osteoarthritis of the hand. Arthritis Rheum 1990; 33: 1601-10.
19. Mikeska T, Felsberg JM, Hewitt CA, Dobrovic A,. Analysing DNA methylation using bisulphite pyrosequencing. In:, Tollefsbol TO, editor. Epigenetics protocols: methods in molecular biology. Vol. 791. 2nd ed. New York: Springer/Humana Press; 2011. p. 33-52.
20. Mosman T,. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 1983; 65: 55-63.
21. Badolo L, Berlaimont V, Helson-Cambier M, Hanocq M, Dubois J,. Simple and rapid enzymatic assay of ornithine decarboxylase activity. Talanta 1999; 48: 127-34.
22. Neidhart M, Zaucke F, von Knoch R, Jungel A, Michel BA, Gay RE, et al. Galectin-3 is induced in rheumatoid arthritis synovial fibroblasts after adhesion to cartilage oligomeric matrix protein. Ann Rheum Dis 2005; 64: 419-24.
23. Nakano K, Boyle DL, Firestein GS,. Regulation of DNA methylation in rheumatoid arthritis synoviocytes. J Immunol 2013; 190: 1297-303.
24. Krishan A,. Rapid flow cytofluorometric analysis of cell cycle by propidium iodide staining. J Cell Biol 1975; 66: 188-93.
25. Lee DH, Jacobs DR Jr, Porta M,. Hypothesis: a unifying mechanism for nutrition and chemicals as lifelong modulators of DNA hypomethylation. Environ Health Perspect 2009; 117: 1799-802.
26. Waterland RA,. Assessing the effects of high methionine intake on DNA methylation. J Nutr 2006; 136: 1706S-10S.
27. Gregory PJ, Sperry M, Wilson AF,. Dietary supplements for osteoarthritis. Am Fam Physician 2008; 77: 177-84.
28. Nguyen M, Gregan A,. S-adenosylmethionine and depression. Aust Fam Physician 2002; 31: 339-43.
29. Purohit V, Abdelmalek MF, Barve S, Benevenga NJ, Halsted CH, Kaplowitz N, et al. Role of S-adenosylmethionine, folate, and betaine in the treatment of alcoholic liver disease: summary of a symposium. Am J Clin Nutr 2007; 86: 14-24.
30. Cooney CA, Dave AA, Wolff GL,. Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring. J Nutr 2002; 132: 2393S-400S.
31. Greenidge PA, Jenkins TC, Neidle S,. DNA minor groove recognition properties of pentamidine and its analogs: a molecular modeling study. Mol Pharmacol 1993; 43: 982-8.
32. Oliveira LF, Schubach AO, Martins MM, Passos SL, Oliveira RV, Marzochi MC, et al. Systematic review of the adverse effects of cutaneous Leishmaniasis treatment in the New World. Acta Trop 2011; 118: 87-96.
33. Joubert KE, Kettner F, Lobetti RG, Miller DM,. The effects of diminazene aceturate on systemic blood pressure in clinically healthy adult dogs. J S Afr Vet Assoc 2003; 74: 69-71.
34. Tanyildizi S, Turk G,. The effects of diminazene aceturate and ceftriaxone on ram sperm. Theriogenology 2004; 61: 529-35.
35. Stabellini G, Moscheni C, Gagliano N, Dellavia C, Calastrini C, Ferioli ME, et al. Depletion of polyamines and increase of transforming growth factor-β1, c-myc, collagen-type I, matrix metalloproteinase-1, and metalloproteinase-2 mRNA in primary human gingival fibroblasts. J Periodontol 2005; 76: 443-9.
36. Rinaldi N, Schwarz-Eywill M, Weis D, Leppelmann-Jansen P, Lukoschek M, Keilholz U, et al. Increased expression of integrins on fibroblast-like synoviocytes from rheumatoid arthritis in vitro correlates with enhanced binding to extracellular matrix proteins. Ann Rheum Dis 1997; 56: 45-51.
37. Tsujinaka S, Soda K, Kano Y, Konishi F,. Spermine accelerates hypoxia-initiated cancer cell migration. Int J Oncol 2011; 38: 305-12.
38. Lu Q,. The critical importance of epigenetics in autoimmunity. J Autoimmun 2013; 41: 1-5.