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Volumn 9, Issue 7, 2014, Pages

Genes involved in the osteoarthritis process identified through genome wide expression analysis in articular cartilage; the RAAK study

Author keywords

[No Author keywords available]

Indexed keywords

DECAY ACCELERATING FACTOR; NERVE GROWTH FACTOR RECEPTOR; OSTEOPROTEGERIN; TRANSCRIPTOME;

EID: 84904659936     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0103056     Document Type: Article
Times cited : (135)

References (37)
  • 1
    • 66249096001 scopus 로고    scopus 로고
    • Cartilage homeostasis in health and rheumatic diseases
    • Goldring MB, Marcu KB (2009) Cartilage homeostasis in health and rheumatic diseases. Arthritis Res Ther 11: 224.
    • (2009) Arthritis Res Ther , vol.11 , pp. 224
    • Goldring, M.B.1    Marcu, K.B.2
  • 3
    • 55249086064 scopus 로고    scopus 로고
    • New insights into osteoarthritis: Early developmental features of an ageing-related disease
    • Bos SD, Slagboom PE, Meulenbelt I (2008) New insights into osteoarthritis: early developmental features of an ageing-related disease. Curr Opin Rheumatol 20: 553-559.
    • (2008) Curr Opin Rheumatol , vol.20 , pp. 553-559
    • Bos, S.D.1    Slagboom, P.E.2    Meulenbelt, I.3
  • 4
    • 84856620553 scopus 로고    scopus 로고
    • Etiology of osteoarthritis: Genetics and synovial joint development
    • Sandell LJ (2012) Etiology of osteoarthritis: genetics and synovial joint development. Nat Rev Rheumatol 8: 77-89.
    • (2012) Nat Rev Rheumatol , vol.8 , pp. 77-89
    • Sandell, L.J.1
  • 5
    • 84884147168 scopus 로고    scopus 로고
    • Osteoarthritis year 2013 in review: Genetics and genomics
    • Gonzalez A (2013) Osteoarthritis year 2013 in review: genetics and genomics. Osteoarthritis Cartilage 21: 1443-1451.
    • (2013) Osteoarthritis Cartilage , vol.21 , pp. 1443-1451
    • Gonzalez, A.1
  • 7
    • 84864383496 scopus 로고    scopus 로고
    • Identification of the pathogenic pathways in osteoarthritic hip cartilage: Commonality and discord between hip and knee OA
    • Xu Y, Barter MJ, Swan DC, Rankin KS, Rowan AD, et al. (2012) Identification of the pathogenic pathways in osteoarthritic hip cartilage: commonality and discord between hip and knee OA. Osteoarthritis Cartilage 20: 1029-1038.
    • (2012) Osteoarthritis Cartilage , vol.20 , pp. 1029-1038
    • Xu, Y.1    Barter, M.J.2    Swan, D.C.3    Rankin, K.S.4    Rowan, A.D.5
  • 8
    • 77950021301 scopus 로고    scopus 로고
    • Genomewide expression profiling reveals new candidate genes associated with osteoarthritis
    • Karlsson C, Dehne T, Lindahl A, Brittberg M, Pruss A, et al. (2010) Genomewide expression profiling reveals new candidate genes associated with osteoarthritis. Osteoarthritis Cartilage 18: 581-592.
    • (2010) Osteoarthritis Cartilage , vol.18 , pp. 581-592
    • Karlsson, C.1    Dehne, T.2    Lindahl, A.3    Brittberg, M.4    Pruss, A.5
  • 9
    • 60249098721 scopus 로고    scopus 로고
    • Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology
    • Geyer M, Grassel S, Straub RH, Schett G, Dinser R, et al. (2009) Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology. Osteoarthritis Cartilage 17: 328-335.
    • (2009) Osteoarthritis Cartilage , vol.17 , pp. 328-335
    • Geyer, M.1    Grassel, S.2    Straub, R.H.3    Schett, G.4    Dinser, R.5
  • 10
    • 73649118465 scopus 로고    scopus 로고
    • Cytokine receptor-like factor 1 is highly expressed in damaged human knee osteoarthritic cartilage and involved in osteoarthritis downstream of TGF-beta
    • Tsuritani K, Takeda J, Sakagami J, Ishii A, Eriksson T, et al. (2010) Cytokine receptor-like factor 1 is highly expressed in damaged human knee osteoarthritic cartilage and involved in osteoarthritis downstream of TGF-beta. Calcif Tissue Int 86: 47-57.
    • (2010) Calcif Tissue Int , vol.86 , pp. 47-57
    • Tsuritani, K.1    Takeda, J.2    Sakagami, J.3    Ishii, A.4    Eriksson, T.5
  • 11
    • 33644915535 scopus 로고    scopus 로고
    • Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage
    • Sato T, Konomi K, Yamasaki S, Aratani S, Tsuchimochi K, et al. (2006) Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage. Arthritis Rheum 54: 808-817.
    • (2006) Arthritis Rheum , vol.54 , pp. 808-817
    • Sato, T.1    Konomi, K.2    Yamasaki, S.3    Aratani, S.4    Tsuchimochi, K.5
  • 12
    • 0345832338 scopus 로고    scopus 로고
    • A global test for groups fo genes: Testing association with a clinical outcome
    • DOI 10.1093/bioinformatics/btg382
    • Goeman JJ, van de Geer SA, de KF, van Houwelingen HC (2004) A global test for groups of genes: testing association with a clinical outcome. Bioinformatics 20: 93-99. (Pubitemid 38088346)
    • (2004) Bioinformatics , vol.20 , Issue.1 , pp. 93-99
    • Goeman, J.J.1    Van De, G.S.2    De Kort, F.3    Van Houwellingen, H.C.4
  • 13
    • 0036081355 scopus 로고    scopus 로고
    • Gene Expression Omnibus: NCBI gene expression and hybridization array data repository
    • Edgar R, Domrachev M, Lash AE (2002) Gene Expression Omnibus: NCBI gene expression and hybridization array data repository. Nucleic Acids Res 30: 207-210. (Pubitemid 34679544)
    • (2002) Nucleic Acids Research , vol.30 , Issue.1 , pp. 207-210
    • Edgar, R.1    Domrachev, M.2    Lash, A.E.3
  • 14
    • 84861115379 scopus 로고    scopus 로고
    • Comprehensive qPCR profiling of gene expression in single neuronal cells
    • Citri A, Pang ZP, Sudhof TC, Wernig M, Malenka RC (2012) Comprehensive qPCR profiling of gene expression in single neuronal cells. Nat Protoc 7: 118-127.
    • (2012) Nat Protoc , vol.7 , pp. 118-127
    • Citri, A.1    Pang, Z.P.2    Sudhof, T.C.3    Wernig, M.4    Malenka, R.C.5
  • 15
    • 0035710746 scopus 로고    scopus 로고
    • -Delta Delta CT method
    • DOI 10.1006/meth.2001.1262
    • Livak KJ, Schmittgen TD (2001) Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 25: 402-408. (Pubitemid 34164012)
    • (2001) Methods , vol.25 , Issue.4 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 16
    • 84862565364 scopus 로고    scopus 로고
    • Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues
    • Bos SD, Bovee JV, Duijnisveld BJ, Raine EV, van Dalen WJ, et al. (2012) Increased type II deiodinase protein in OA-affected cartilage and allelic imbalance of OA risk polymorphism rs225014 at DIO2 in human OA joint tissues. Ann Rheum Dis 71: 1254-1258.
    • (2012) Ann Rheum Dis , vol.71 , pp. 1254-1258
    • Bos, S.D.1    Bovee, J.V.2    Duijnisveld, B.J.3    Raine, E.V.4    Van Dalen, W.J.5
  • 17
    • 0015046195 scopus 로고
    • Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data
    • Mankin HJ, Dorfman H, Lippiello L, Zarins A (1971) Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data. J Bone Joint Surg Am 53: 523-537.
    • (1971) J Bone Joint Surg Am , vol.53 , pp. 523-537
    • Mankin, H.J.1    Dorfman, H.2    Lippiello, L.3    Zarins, A.4
  • 18
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang DW, Sherman BT, Lempicki RA (2009) Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 4: 44-57.
    • (2009) Nat Protoc , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 19
    • 78651324347 scopus 로고    scopus 로고
    • The STRING database in 2011: Functional interaction networks of proteins, globally integrated and scored
    • Szklarczyk D, Franceschini A, Kuhn M, Simonovic M, Roth A, et al. (2011) The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res 39: D561-D568.
    • (2011) Nucleic Acids Res , vol.39
    • Szklarczyk, D.1    Franceschini, A.2    Kuhn, M.3    Simonovic, M.4    Roth, A.5
  • 20
    • 84861422537 scopus 로고    scopus 로고
    • Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis
    • Castano Betancourt MC, Cailotto F, Kerkhof HJ, Cornelis FM, Doherty SA, et al. (2012) Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis. Proc Natl Acad Sci U S A 109: 8218-8223.
    • (2012) Proc Natl Acad Sci U S a , vol.109 , pp. 8218-8223
    • Castano Betancourt, M.C.1    Cailotto, F.2    Kerkhof, H.J.3    Cornelis, F.M.4    Doherty, S.A.5
  • 23
    • 84883445177 scopus 로고    scopus 로고
    • A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip
    • doi: 10.1136/annrheumdis-2012-203114
    • Evangelou E, Kerkhof HJ, Styrkarsdottir U, Ntzani EE, Bos SD, et al. (2013) A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip. Ann Rheum Dis, doi: 10.1136/annrheumdis-2012-203114.
    • (2013) Ann Rheum Dis
    • Evangelou, E.1    Kerkhof, H.J.2    Styrkarsdottir, U.3    Ntzani, E.E.4    Bos, S.D.5
  • 24
    • 75749110202 scopus 로고    scopus 로고
    • A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22
    • Kerkhof HJ, Lories RJ, Meulenbelt I, Jonsdottir I, Valdes AM, et al. (2010) A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22. Arthritis Rheum 62: 499-510.
    • (2010) Arthritis Rheum , vol.62 , pp. 499-510
    • Kerkhof, H.J.1    Lories, R.J.2    Meulenbelt, I.3    Jonsdottir, I.4    Valdes, A.M.5
  • 25
    • 48349105759 scopus 로고    scopus 로고
    • Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis
    • Miyamoto Y, Shi D, Nakajima M, Ozaki K, Sudo A, et al. (2008) Common variants in DVWA on chromosome 3p24.3 are associated with susceptibility to knee osteoarthritis. Nat Genet 40: 994-998.
    • (2008) Nat Genet , vol.40 , pp. 994-998
    • Miyamoto, Y.1    Shi, D.2    Nakajima, M.3    Ozaki, K.4    Sudo, A.5
  • 26
    • 78149408549 scopus 로고    scopus 로고
    • New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study
    • Nakajima M, Takahashi A, Kou I, Rodriguez-Fontenla C, Gomez-Reino JJ, et al. (2010) New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study. PLoS One 5: e9723.
    • (2010) PLoS One , vol.5
    • Nakajima, M.1    Takahashi, A.2    Kou, I.3    Rodriguez-Fontenla, C.4    Gomez-Reino, J.J.5
  • 27
    • 79953309875 scopus 로고    scopus 로고
    • Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study
    • Panoutsopoulou K, Southam L, Elliott KS, Wrayner N, Zhai G, et al. (2011) Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. Ann Rheum Dis 70: 864-867.
    • (2011) Ann Rheum Dis , vol.70 , pp. 864-867
    • Panoutsopoulou, K.1    Southam, L.2    Elliott, K.S.3    Wrayner, N.4    Zhai, G.5
  • 28
    • 84865595151 scopus 로고    scopus 로고
    • Identification of new susceptibility loci for osteoarthritis (arcOGEN): A genome-wide association study
    • Zeggini E, Panoutsopoulou K, Southam L, Rayner NW, Day-Williams AG, et al. (2012) Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet 380: 815-823.
    • (2012) Lancet , vol.380 , pp. 815-823
    • Zeggini, E.1    Panoutsopoulou, K.2    Southam, L.3    Rayner, N.W.4    Day-Williams, A.G.5
  • 29
    • 84898670941 scopus 로고    scopus 로고
    • Assessment of osteoarthritis candidate genes in a meta-analysis of 9 genome-wide association studies
    • Rodriguez-Fontenla C, Calaza M, Evangelou E, Valdes AM, Arden N, et al. (2013) Assessment of osteoarthritis candidate genes in a meta-analysis of 9 genome-wide association studies. Arthritis Rheum 66: 940-949.
    • (2013) Arthritis Rheum , vol.66 , pp. 940-949
    • Rodriguez-Fontenla, C.1    Calaza, M.2    Evangelou, E.3    Valdes, A.M.4    Arden, N.5
  • 30
    • 84942113789 scopus 로고    scopus 로고
    • A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis
    • doi: 10.1136/annrheum-dis-2013-205149
    • Ramos YF, Bos SD, van der Breggen R, Kloppenburg M, Ye K, et al. (2014) A gain of function mutation in TNFRSF11B encoding osteoprotegerin causes osteoarthritis with chondrocalcinosis. Ann Rheum Dis, doi: 10.1136/annrheum-dis- 2013-205149.
    • (2014) Ann Rheum Dis
    • Ramos, Y.F.1    Bos, S.D.2    Van Der Breggen, R.3    Kloppenburg, M.4    Ye, K.5
  • 31
    • 84895917052 scopus 로고    scopus 로고
    • Epigenetic mechanisms and non-coding RNAs in osteoarthritis
    • Barter MJ, Young DA (2013) Epigenetic mechanisms and non-coding RNAs in osteoarthritis. Curr Rheumatol Rep 15: 353.
    • (2013) Curr Rheumatol Rep , vol.15 , pp. 353
    • Barter, M.J.1    Young, D.A.2
  • 32
    • 84904667534 scopus 로고    scopus 로고
    • Characterization of the cartilage DNA methylome in knee and hip osteoarthritis
    • doi: 10.1002/art.38713
    • Rushton MD, Reynard LN, Barter MJ, Refaie R, Rankin KS, et al. (2014) Characterization of the cartilage DNA methylome in knee and hip osteoarthritis. Arthritis Rheumatol, doi: 10.1002/art.38713.
    • (2014) Arthritis Rheumatol
    • Rushton, M.D.1    Reynard, L.N.2    Barter, M.J.3    Refaie, R.4    Rankin, K.S.5
  • 33
    • 84899638695 scopus 로고    scopus 로고
    • Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31
    • Styrkarsdottir U, Thorleifsson G, Helgadottir HT, Bomer N, Metrustry S, et al. (2014) Severe osteoarthritis of the hand associates with common variants within the ALDH1A2 gene and with rare variants at 1p31. Nat Genet 46: 498-502.
    • (2014) Nat Genet , vol.46 , pp. 498-502
    • Styrkarsdottir, U.1    Thorleifsson, G.2    Helgadottir, H.T.3    Bomer, N.4    Metrustry, S.5
  • 34
    • 84887550824 scopus 로고    scopus 로고
    • Genome-wide expression profiles of subchondral bone in osteoarthritis
    • doi: 10.1186/ar4380
    • Chou CH, Wu CC, Song IW, Chuang HP, Lu LS, et al. (2013) Genome-wide expression profiles of subchondral bone in osteoarthritis. Arthritis Res Ther 15: R190; doi: 10.1186/ar4380.
    • (2013) Arthritis Res Ther , vol.15
    • Chou, C.H.1    Wu, C.C.2    Song, I.W.3    Chuang, H.P.4    Lu, L.S.5
  • 35
    • 84868466570 scopus 로고    scopus 로고
    • Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22
    • Raine EV, Wreglesworth N, Dodd AW, Reynard LN, Loughlin J (2012) Gene expression analysis reveals HBP1 as a key target for the osteoarthritis susceptibility locus that maps to chromosome 7q22. Ann Rheum Dis 71: 2020-2027.
    • (2012) Ann Rheum Dis , vol.71 , pp. 2020-2027
    • Raine, E.V.1    Wreglesworth, N.2    Dodd, A.W.3    Reynard, L.N.4    Loughlin, J.5
  • 36
    • 17044363555 scopus 로고    scopus 로고
    • The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor Dbs to enhance Schwann cell migration
    • Yamauchi J, Chan JR, Miyamoto Y, Tsujimoto G, Shooter EM (2005) The neurotrophin-3 receptor TrkC directly phosphorylates and activates the nucleotide exchange factor Dbs to enhance Schwann cell migration. Proc Natl Acad Sci U S A 102: 5198-5203.
    • (2005) Proc Natl Acad Sci U S a , vol.102 , pp. 5198-5203
    • Yamauchi, J.1    Chan, J.R.2    Miyamoto, Y.3    Tsujimoto, G.4    Shooter, E.M.5
  • 37
    • 84869186227 scopus 로고    scopus 로고
    • Control of arthritis pain with anti-nerve-growth factor: Risk and benefit
    • Seidel MF, Lane NE (2012) Control of arthritis pain with anti-nerve-growth factor: risk and benefit. Curr Rheumatol Rep 14: 583-588.
    • (2012) Curr Rheumatol Rep , vol.14 , pp. 583-588
    • Seidel, M.F.1    Lane, N.E.2


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