Genome-wide profiling of bone reveals differentially methylated regions in osteoporosis and osteoarthritis

Arthritis and Rheumatism

Volumn 65, Issue 1, 2013, Pages 197-205

  Delgado Calle, Jesús ^a   Fernández, Agustín F ^b   Sainz, Jesús ^c   Zarrabeitia, María T ^a   Sañudo, Carolina ^a   García Renedo, Raúl ^d   Pérez Núñez, María I ^d   García Ibarbia, Carmen ^a   Fraga, Mario F ^b   Riancho, José A ^a  

^a UNIVERSITY OF CANTABRIA   (Spain)

^b DEPARTAMENTO DE BIOQUÍMICA Y BIOLOGÍA MOLECULAR   (Spain)

^c University of Cantabria   (Spain)

^d HOSPITAL UNIVERSITARIO MARQUÉS DE VALDECILLA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSCRIPTION FACTOR; TRANSCRIPTOME;

ADULT; AGED; ARTICLE; CELL DIFFERENTIATION; COMPUTER PROGRAM; CPG ISLAND; DNA ISOLATION; DNA METHYLATION; EMBRYO DEVELOPMENT; FEMALE; FEMUR HEAD; GENE EXPRESSION PROFILING; GENE LOCUS; GENETIC TRAIT; HIP FRACTURE; HOMEOBOX; HUMAN; MAJOR CLINICAL STUDY; OSTEOARTHRITIS; OSTEOPOROSIS; PRIORITY JOURNAL; QUALITY CONTROL; RNA EXTRACTION; RNA SEQUENCE; TRABECULAR BONE;

AGED; AGED, 80 AND OVER; BONE AND BONES; DNA METHYLATION; FEMALE; GENE EXPRESSION PROFILING; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MIDDLE AGED; MOLECULAR SEQUENCE DATA; OSTEOARTHRITIS, HIP; OSTEOPOROSIS; OSTEOPOROTIC FRACTURES; REAL-TIME POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA;

EID: 84871770976     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.37753     Document Type: Article

References (50)

1. Goldring SR,. The role of bone in osteoarthritis pathogenesis. Rheum Dis Clin North Am 2008; 34: 561-71.
2. Dequeker J, Aerssens J, Luyten FP,. Osteoarthritis and osteoporosis: clinical and research evidence of inverse relationship. Aging Clin Exp Res 2003; 15: 426-39.
3. Chaganti RK, Parimi N, Lang T, Orwoll E, Stefanick ML, Nevitt M, et al. Bone mineral density and prevalent osteoarthritis of the hip in older men for the Osteoporotic Fractures in Men (MrOS) Study Group. Osteoporos Int 2010; 21: 1307-16.
4. Delgado-Calle J, Sanudo C, Bolado A, Fernandez AF, Arozamena J, Pascual-Carra MA, et al. DNA methylation contributes to the regulation of sclerostin expression in human osteocytes. J Bone Miner Res 2012; 27: 926-37.
5. Delgado-Calle J, Sanudo C, Fernandez AF, Garcia-Renedo R, Fraga MF, Riancho JA,. Role of DNA methylation in the regulation of the RANKL-OPG system in human bone. Epigenetics 2012; 7: 83-91.
6. Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B,. Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 2008; 5: 621-8.
7. Hernandez JL, Garcés CM, Sumillera M, Fernandez-Aldasoro EV, Garcia-Ibarbia C, Ortiz-Gomez JA, et al. Aromatase expression in osteoarthritic and osteoporotic bone. Arthritis Rheum 2008; 58: 1696-1700.
8. Ishwaran H, Rao JS, Kogalur UB,. BAM: Java software for Bayesian analysis of variance for microarray data. BMC Bioinformatics 2006; 7: 59.
9. Benjamini Y, Yekutieli D,. Quantitative trait loci analysis using the false discovery rate. Genetics 2005; 171: 783-90.
10. Huang da W, Sherman BT, Lempicki RA,. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat Protoc 2009; 4: 44-57.
11. Raychaudhuri S, Plenge RM, Rossin EJ, Ng AC, Purcell SM, Sklar P, et al. Identifying relationships among genomic disease regions: predicting genes at pathogenic SNP associations and rare deletions. PLoS Genet 2009; 5: e1000534.
12. Panoutsopoulou K, Southam L, Elliott KS, Wrayner N, Zhai G, Beazley C, et al. Insights into the genetic architecture of osteoarthritis from stage 1 of the arcOGEN study. Ann Rheum Dis 2011; 70: 864-7.
13. Estrada K, Styrkarsdottir U, Evangelou E, Hsu YH, Duncan EL, Ntzani EE, et al. Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture. Nat Genet 2012; 44: 491-501.
14. Delgado-Calle J, Sanudo C, Sanchez-Verde L, Garcia-Renedo RJ, Arozamena J, Riancho JA,. Epigenetic regulation of alkaline phosphatase in human cells of the osteoblastic lineage. Bone 2011; 49: 830-8.
15. Cheung KS, Hashimoto K, Yamada N, Roach HI,. Expression of ADAMTS-4 by chondrocytes in the surface zone of human osteoarthritic cartilage is regulated by epigenetic DNA de-methylation. Rheumatol Int 2009; 29: 525-34.
16. Roach HI, Yamada N, Cheung KS, Tilley S, Clarke NM, Oreffo RO, et al. Association between the abnormal expression of matrix-degrading enzymes by human osteoarthritic chondrocytes and demethylation of specific CpG sites in the promoter regions. Arthritis Rheum 2005; 52: 3110-24.
17. Roach HI, Aigner T,. DNA methylation in osteoarthritic chondrocytes: a new molecular target. Osteoarthritis Cartilage 2007; 15: 128-37.
18. Reynard LN, Loughlin J,. Genetics and epigenetics of osteoarthritis. Maturitas 2012; 71: 200-4.
19. Barter MJ, Bui C, Young DA,. Epigenetic mechanisms in cartilage and osteoarthritis: DNA methylation, histone modifications and microRNAs. Osteoarthritis Cartilage 2012; 20: 339-49.
20. He JY, Jiang LS, Dai LY,. The roles of the sympathetic nervous system in osteoporotic diseases: a review of experimental and clinical studies. Ageing Res Rev 2011; 10: 253-63.
21. Geusens P, Lems WF,. Osteoimmunology and osteoporosis. Arthritis Res Ther 2011; 13: 242.
22. Cillo C, Cantile M, Faiella A, Boncinelli E,. Homeobox genes in normal and malignant cells. J Cell Physiol 2001; 188: 161-9.
23. Franceschi RT,. The developmental control of osteoblast-specific gene expression: role of specific transcription factors and the extracellular matrix environment. Crit Rev Oral Biol Med 1999; 10: 40-57.
24. Aspden RM, Scheven BA, Hutchison JD,. Osteoarthritis as a systemic disorder including stromal cell differentiation and lipid metabolism. Lancet 2001; 357: 1118-20.
25. Holroyd C, Harvey N, Dennison E, Cooper C,. Epigenetic influences in the developmental origins of osteoporosis. Osteoporos Int 2011; 22: 1277-88.
26. Javaid MK, Lane NE, Mackey DC, Lui LY, Arden NK, Beck TJ, et al. Changes in proximal femoral mineral geometry precede the onset of radiographic hip osteoarthritis: the study of osteoporotic fractures. Arthritis Rheum 2009; 60: 2028-36.
27. Aspden RM,. Osteoarthritis: a problem of growth not decay? Rheumatology (Oxford) 2008; 47: 1452-60.
28. Velasco J, Zarrabeitia MT, Prieto JR, Perez-Castrillon JL, Perez-Aguilar MD, Perez-Nunez MI, et al. Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study. Osteoporos Int 2010; 21: 109-18.
29. Luyten FP, Tylzanowski P, Lories RJ,. Wnt signaling and osteoarthritis. Bone 2009; 44: 522-7.
30. Corr M,. Wnt-beta-catenin signaling in the pathogenesis of osteoarthritis. Nat Clin Pract Rheumatol 2008; 4: 550-6.
31. Baker-Lepain JC, Lynch JA, Parimi N, McCulloch CE, Nevitt MC, Corr M, et al. Variant alleles of the WNT antagonist FRZB are determinants of hip shape and modify the relationship between hip shape and osteoarthritis. Arthritis Rheum 2012; 64: 1457-65.
32. Jiang LS, Zhang ZM, Jiang SD, Chen WH, Dai LY,. Differential bone metabolism between postmenopausal women with osteoarthritis and osteoporosis. J Bone Miner Res 2008; 23: 475-483.
33. Kanis JA, Borgstrom F, De Laet C, Johansson H, Johnell O, Jonsson B, et al. Assessment of fracture risk. Osteoporos Int 2005; 16: 581-9.
34. Gomez R, Lago F, Gomez-Reino J, Dieguez C, Gualillo O,. Adipokines in the skeleton: influence on cartilage function and joint degenerative diseases. J Mol Endocrinol 2009; 43: 11-8.
35. Tang ZH, Xiao P, Lei SF, Deng FY, Zhao LJ, Deng HY, et al. A bivariate whole-genome linkage scan suggests several shared genomic regions for obesity and osteoporosis. J Clin Endocrinol Metab 2007; 92: 2751-7.
36. Howard TD, Ho SM, Zhang L, Chen J, Cui W, Slager R, et al. Epigenetic changes with dietary soy in cynomolgus monkeys. PLoS One 2011; 6: e26791.
37. Grethen E, Hill KM, Jones R, Cacucci BM, Gupta CE, Acton A, et al. Serum leptin, parathyroid hormone, 1,25-dihydroxyvitamin D, fibroblast growth factor 23, bone alkaline phosphatase, and sclerostin relationships in obesity. J Clin Endocrinol Metab 2012; 97: 1655-62.
38. Gotoh M, Notoya K, Ienaga Y, Kawase M, Makino H,. Enhancement of osteogenesis in vitro by a novel osteoblast differentiation-promoting compound, TAK-778, partly through the expression of Msx2. Eur J Pharmacol 2002; 451: 19-25.
39. Cheng SL, Shao JS, Cai J, Sierra OL, Towler DA,. Msx2 exerts bone anabolism via canonical Wnt signaling. J Biol Chem 2008; 283: 20505-22.
40. Sierra OL, Towler DA,. Runx2 trans-activation mediated by the MSX2-interacting nuclear target requires homeodomain interacting protein kinase-3. Mol Endocrinol 2010; 24: 1478-97.
41. Sierra OL, Cheng SL, Loewy AP, Charlton-Kachigian N, Towler DA,. MINT, the Msx2 interacting nuclear matrix target, enhances Runx2-dependent activation of the osteocalcin fibroblast growth factor response element. J Biol Chem 2004; 279: 32913-23.
42. Gordon JA, Hassan MQ, Koss M, Montecino M, Selleri L, van Wijnen AJ, et al. Epigenetic regulation of early osteogenesis and mineralized tissue formation by a HOXA10-PBX1-associated complex. Cells Tissues Organs 2011; 194: 146-50.
43. Jin WJ, Jiang SD, Jiang LS, Dai LY,. Differential responsiveness to 17β-estradiol of mesenchymal stem cells from postmenopausal women between osteoporosis and osteoarthritis. Osteoporos Int 2012; 23: 2469-78.
44. El Serafi AT, Oreffo RO, Roach HI,. Epigenetic modifiers influence lineage commitment of human bone marrow stromal cells: Differential effects of 5-aza-deoxycytidine and trichostatin A. Differentiation 2011; 81: 35-41.
45. Vaes BL, Lute C, van der Woning SP, Piek E, Vermeer J, Blom HJ, et al. Inhibition of methylation decreases osteoblast differentiation via a non-DNA-dependent methylation mechanism. Bone 2010; 46: 514-23.
46. Dansranjavin T, Krehl S, Mueller T, Mueller LP, Schmoll HJ, Dammann RH,. The role of promoter CpG methylation in the epigenetic control of stem cell related genes during differentiation. Cell Cycle 2009; 8: 916-24.
47. Riancho J, Garcia-Ibarbia C, Perez-Nunez MI, Alonso MA, Diaz T, Perez-Castrillon JL, et al. Genetic polymorphisms of the Wnt receptor LRP5 are differentially associated with trochanteric and cervical hip fractures. Calcif Tissue Int 2012; 90: 137-43.
48. Fraga MF, Esteller M,. Epigenetics and aging: the targets and the marks. Trends Genet 2007; 23: 413-8.
49. Kaneko KJ, Rein T, Guo ZS, Latham K, DePamphilis ML,. DNA methylation may restrict but does not determine differential gene expression at the Sgy/Tead2 locus during mouse development. Mol Cell Biol 2004; 24: 1968-82.
50. Deaton AM, Webb S, Kerr AR, Illingworth RS, Guy J, Andrews R, et al. Cell type-specific DNA methylation at intragenic CpG islands in the immune system. Genome Res 2011; 21: 1074-86.