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Volumn 20, Issue 9, 2012, Pages 1029-1038

Identification of the pathogenic pathways in osteoarthritic hip cartilage: Commonality and discord between hip and knee OA

Author keywords

Cartilage; Chondrocytes; Gene expression profiling; Microarray; Pathway analysis

Indexed keywords

RNA;

EID: 84864383496     PISSN: 10634584     EISSN: 15229653     Source Type: Journal    
DOI: 10.1016/j.joca.2012.05.006     Document Type: Article
Times cited : (80)

References (57)
  • 2
    • 63249118366 scopus 로고    scopus 로고
    • Molecular mechanisms of cartilage destruction in osteoarthritis
    • Loeser R. Molecular mechanisms of cartilage destruction in osteoarthritis. Biochem J 2008, 8(4):303-306.
    • (2008) Biochem J , vol.8 , Issue.4 , pp. 303-306
    • Loeser, R.1
  • 3
    • 33750352895 scopus 로고    scopus 로고
    • Yet more evidence that osteoarthritis is not a cartilage disease
    • Brandt K., Radin E., Dieppe P., van de Putte L. Yet more evidence that osteoarthritis is not a cartilage disease. Ann Rheum Dis 2006, 65:1261-1264.
    • (2006) Ann Rheum Dis , vol.65 , pp. 1261-1264
    • Brandt, K.1    Radin, E.2    Dieppe, P.3    van de Putte, L.4
  • 4
    • 0029583775 scopus 로고
    • The chondrocyte, architect of cartilage. Biomechanics, structure, function and molecular biology of cartilage matrix macromolecules
    • Muir H. The chondrocyte, architect of cartilage. Biomechanics, structure, function and molecular biology of cartilage matrix macromolecules. Bioessays 1995 Dec, 17(12):1039-1048.
    • (1995) Bioessays , vol.17 , Issue.12 , pp. 1039-1048
    • Muir, H.1
  • 5
    • 15844413814 scopus 로고    scopus 로고
    • Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
    • Glasson S.S., Askew R., Sheppard B., Carito B., Blanchet T., Ma H.L., et al. Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis. Nature 2005 Mar 31, 434(7033):644-648.
    • (2005) Nature , vol.434 , Issue.7033 , pp. 644-648
    • Glasson, S.S.1    Askew, R.2    Sheppard, B.3    Carito, B.4    Blanchet, T.5    Ma, H.L.6
  • 6
    • 0018877749 scopus 로고
    • The breakdown of collagen by chondrocytes
    • Jubb R.W., Fell H.B. The breakdown of collagen by chondrocytes. J Pathol 1980 Mar, 130(3):159-167.
    • (1980) J Pathol , vol.130 , Issue.3 , pp. 159-167
    • Jubb, R.W.1    Fell, H.B.2
  • 9
  • 11
    • 77950659332 scopus 로고    scopus 로고
    • Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis
    • Goldring M., Goldring S. Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis. Ann New York Acad Sci 2010, 1192:230-237.
    • (2010) Ann New York Acad Sci , vol.1192 , pp. 230-237
    • Goldring, M.1    Goldring, S.2
  • 12
    • 27944445973 scopus 로고    scopus 로고
    • Microarray analysis of differential gene expression in temporomandibular joint condylar cartilage after experimentally induced osteoarthritis
    • Meng J., Ma X., Ma D., Xu C. Microarray analysis of differential gene expression in temporomandibular joint condylar cartilage after experimentally induced osteoarthritis. Osteoarthritis Cartilage 2005, 13(12):1115-1125.
    • (2005) Osteoarthritis Cartilage , vol.13 , Issue.12 , pp. 1115-1125
    • Meng, J.1    Ma, X.2    Ma, D.3    Xu, C.4
  • 13
    • 33644915535 scopus 로고    scopus 로고
    • Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage
    • Sato T., Konomi K., Yamasaki S., Aratani S., Tsuchimochi K., Yokouchi M., et al. Comparative analysis of gene expression profiles in intact and damaged regions of human osteoarthritic cartilage. Arthritis Rheum 2006, 54(3):808-817.
    • (2006) Arthritis Rheum , vol.54 , Issue.3 , pp. 808-817
    • Sato, T.1    Konomi, K.2    Yamasaki, S.3    Aratani, S.4    Tsuchimochi, K.5    Yokouchi, M.6
  • 14
    • 34447509660 scopus 로고    scopus 로고
    • Global analyses of gene expression in early experimental osteoarthritis
    • Appleton C., Pitelka V., Henry J., Beier F. Global analyses of gene expression in early experimental osteoarthritis. Arthritis Rheum 2007, 56(6):1854-1868.
    • (2007) Arthritis Rheum , vol.56 , Issue.6 , pp. 1854-1868
    • Appleton, C.1    Pitelka, V.2    Henry, J.3    Beier, F.4
  • 15
    • 43949145269 scopus 로고    scopus 로고
    • Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis
    • Dell'accio F., De Bari C., Eltawil N., Vanhummelen P., Pitzalis C. Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis. Arthritis Rheum 2008, 58(5):1410-1421.
    • (2008) Arthritis Rheum , vol.58 , Issue.5 , pp. 1410-1421
    • Dell'accio, F.1    De Bari, C.2    Eltawil, N.3    Vanhummelen, P.4    Pitzalis, C.5
  • 16
    • 60249098721 scopus 로고    scopus 로고
    • Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology
    • Geyer M., Grässel S., Straub R., Schett G., Dinser R., Grifka J., et al. Differential transcriptome analysis of intraarticular lesional vs intact cartilage reveals new candidate genes in osteoarthritis pathophysiology. Osteoarthritis Cartilage 2009, 17(3):328-335.
    • (2009) Osteoarthritis Cartilage , vol.17 , Issue.3 , pp. 328-335
    • Geyer, M.1    Grässel, S.2    Straub, R.3    Schett, G.4    Dinser, R.5    Grifka, J.6
  • 17
    • 47249083842 scopus 로고    scopus 로고
    • Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes
    • Ijiri K., Zerbini L.F., Peng H., Otu H.H., Tsuchimochi K., Otero M., et al. Differential expression of GADD45beta in normal and osteoarthritic cartilage: potential role in homeostasis of articular chondrocytes. Arthritis Rheum 2008 Jul, 58(7):2075-2087.
    • (2008) Arthritis Rheum , vol.58 , Issue.7 , pp. 2075-2087
    • Ijiri, K.1    Zerbini, L.F.2    Peng, H.3    Otu, H.H.4    Tsuchimochi, K.5    Otero, M.6
  • 18
    • 33750032729 scopus 로고    scopus 로고
    • Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis
    • Aigner T., Fundel K., Saas J., Gebhard P., Haag J., Weiss T., et al. Large-scale gene expression profiling reveals major pathogenetic pathways of cartilage degeneration in osteoarthritis. Arthritis Rheum 2006, 54(11):3533-3544.
    • (2006) Arthritis Rheum , vol.54 , Issue.11 , pp. 3533-3544
    • Aigner, T.1    Fundel, K.2    Saas, J.3    Gebhard, P.4    Haag, J.5    Weiss, T.6
  • 19
    • 77955436218 scopus 로고    scopus 로고
    • Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease
    • Scott J.L., Gabrielides C., Davidson R.K., Swingler T.E., Clark I.M., Wallis G.A., et al. Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease. Ann Rheum Dis 2010, 69(8):1502-1510.
    • (2010) Ann Rheum Dis , vol.69 , Issue.8 , pp. 1502-1510
    • Scott, J.L.1    Gabrielides, C.2    Davidson, R.K.3    Swingler, T.E.4    Clark, I.M.5    Wallis, G.A.6
  • 20
    • 77950021301 scopus 로고    scopus 로고
    • Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis
    • Karlsson C., Dehne T., Lindahl A., Brittberg M., Pruss A., Sittinger M., et al. Genome-wide expression profiling reveals new candidate genes associated with osteoarthritis. Osteoarthritis Cartilage 2010, 18(4):581-592.
    • (2010) Osteoarthritis Cartilage , vol.18 , Issue.4 , pp. 581-592
    • Karlsson, C.1    Dehne, T.2    Lindahl, A.3    Brittberg, M.4    Pruss, A.5    Sittinger, M.6
  • 21
    • 34848912491 scopus 로고    scopus 로고
    • Sex differences in osteoarthritis of the hip and knee
    • O'Connor M.I. Sex differences in osteoarthritis of the hip and knee. J Am Acad Orthop Surg 2007, 15(Suppl 1):S22-S25.
    • (2007) J Am Acad Orthop Surg , vol.15 , Issue.SUPPL. 1
    • O'Connor, M.I.1
  • 22
    • 33748448475 scopus 로고    scopus 로고
    • Arthroscopic validation of radiographic grading scales of osteoarthritis of the tibiofemoral joint
    • Kijowski R., Blankenbaker D., Stanton P., Fine J., De Smet A. Arthroscopic validation of radiographic grading scales of osteoarthritis of the tibiofemoral joint. Am J Roentgenol 2006, 187(3):794-799.
    • (2006) Am J Roentgenol , vol.187 , Issue.3 , pp. 794-799
    • Kijowski, R.1    Blankenbaker, D.2    Stanton, P.3    Fine, J.4    De Smet, A.5
  • 23
    • 79952675059 scopus 로고    scopus 로고
    • Arthroscopic treatment for chondral lesions of the hip
    • Sampson T.G. Arthroscopic treatment for chondral lesions of the hip. Clin Sports Med 2011 Apr, 30(2):331-348.
    • (2011) Clin Sports Med , vol.30 , Issue.2 , pp. 331-348
    • Sampson, T.G.1
  • 24
    • 0037316303 scopus 로고    scopus 로고
    • A comparison of normalization methods for high density oligonucleotide array data based on variance and bias
    • Bolstad B.M., Irizarry R.A., åstrand M., Speed T.P. A comparison of normalization methods for high density oligonucleotide array data based on variance and bias. Bioinformatics 2003, 19(2):185-193.
    • (2003) Bioinformatics , vol.19 , Issue.2 , pp. 185-193
    • Bolstad, B.M.1    Irizarry, R.A.2    åstrand, M.3    Speed, T.P.4
  • 25
    • 33845432928 scopus 로고    scopus 로고
    • Adjusting batch effects in microarray expression data using empirical Bayes methods
    • Johnson W.E., Li C., Rabinovic A. Adjusting batch effects in microarray expression data using empirical Bayes methods. Biostatistics 2007 Jan, 8(1):118-127.
    • (2007) Biostatistics , vol.8 , Issue.1 , pp. 118-127
    • Johnson, W.E.1    Li, C.2    Rabinovic, A.3
  • 26
    • 79961135005 scopus 로고    scopus 로고
    • Vienna, Austria; [updated 2011; cited]; Available from:, R Development Core Team
    • R Development Core Team R: A Language and Environment for Statistical Computing 2011, Vienna, Austria; [updated 2011; cited]; Available from:. http://www.r-project.org/.
    • (2011) R: A Language and Environment for Statistical Computing
  • 27
    • 27344435774 scopus 로고    scopus 로고
    • Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles
    • Subramanian A., Tamayo P., Mootha V., Mukherjee S., Ebert B., Gillette M., et al. Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 2005, 102(43):15545-15550.
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.43 , pp. 15545-15550
    • Subramanian, A.1    Tamayo, P.2    Mootha, V.3    Mukherjee, S.4    Ebert, B.5    Gillette, M.6
  • 29
    • 78651324347 scopus 로고    scopus 로고
    • The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored
    • Database issue
    • Szklarczyk D., Franceschini A., Kuhn M., Simonovic M., Roth A., Minguez P., et al. The STRING database in 2011: functional interaction networks of proteins, globally integrated and scored. Nucleic Acids Res 2011, 39(Database issue):D561-D568.
    • (2011) Nucleic Acids Res , vol.39
    • Szklarczyk, D.1    Franceschini, A.2    Kuhn, M.3    Simonovic, M.4    Roth, A.5    Minguez, P.6
  • 30
    • 80052296784 scopus 로고    scopus 로고
    • Mybl2, downregulated during colon epithelial cell maturation, is suppressed by miR-365
    • Papetti M., Augenlicht L.H. Mybl2, downregulated during colon epithelial cell maturation, is suppressed by miR-365. Am J Physiol Gastrointest Liver Physiol 2011 Sep, 301(3):G508-G518.
    • (2011) Am J Physiol Gastrointest Liver Physiol , vol.301 , Issue.3
    • Papetti, M.1    Augenlicht, L.H.2
  • 31
    • 54349103091 scopus 로고    scopus 로고
    • Differential toll-like receptor-dependent collagenase expression in chondrocytes
    • Zhang Q., Hui W., Litherland G.J., Barter M.J., Davidson R., Darrah C., et al. Differential toll-like receptor-dependent collagenase expression in chondrocytes. Ann Rheum Dis 2008 Nov, 67(11):1633-1641.
    • (2008) Ann Rheum Dis , vol.67 , Issue.11 , pp. 1633-1641
    • Zhang, Q.1    Hui, W.2    Litherland, G.J.3    Barter, M.J.4    Davidson, R.5    Darrah, C.6
  • 32
    • 0001677717 scopus 로고
    • Controlling the false discovery rate: a practical and powerful approach to multiple testing
    • Benjamini Y., Hochberg Y. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc B 1995, 57(1):289-300.
    • (1995) J Roy Stat Soc B , vol.57 , Issue.1 , pp. 289-300
    • Benjamini, Y.1    Hochberg, Y.2
  • 33
    • 39149115688 scopus 로고    scopus 로고
    • Bioinformatics applications for pathway analysis of microarray data
    • Werner T. Bioinformatics applications for pathway analysis of microarray data. Curr Opin Biotechnol 2008 Feb, 19(1):50-54.
    • (2008) Curr Opin Biotechnol , vol.19 , Issue.1 , pp. 50-54
    • Werner, T.1
  • 34
    • 72449208765 scopus 로고    scopus 로고
    • Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study
    • Velasco J., Zarrabeitia M., Prieto J., Perez-Castrillon J., Perez-Aguilar M., Perez-Nuñez M., et al. Wnt pathway genes in osteoporosis and osteoarthritis: differential expression and genetic association study. Osteoporos Int 2010, 21(1):109-118.
    • (2010) Osteoporos Int , vol.21 , Issue.1 , pp. 109-118
    • Velasco, J.1    Zarrabeitia, M.2    Prieto, J.3    Perez-Castrillon, J.4    Perez-Aguilar, M.5    Perez-Nuñez, M.6
  • 35
    • 84855718266 scopus 로고    scopus 로고
    • 17β-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K/Akt pathway
    • Huang J., Xia C., Zheng X., Yi T., Wang X., Song G., et al. 17β-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K/Akt pathway. Cell Mol Biol Lett 2011, 16(4):564-575.
    • (2011) Cell Mol Biol Lett , vol.16 , Issue.4 , pp. 564-575
    • Huang, J.1    Xia, C.2    Zheng, X.3    Yi, T.4    Wang, X.5    Song, G.6
  • 36
  • 37
    • 80955151596 scopus 로고    scopus 로고
    • Effect of low-intensity pulsed ultrasound on MMP-13 and MAPKs signaling pathway in rabbit knee osteoarthritis
    • Li X., Li J., Cheng K., Lin Q., Wang D., Zhang H., et al. Effect of low-intensity pulsed ultrasound on MMP-13 and MAPKs signaling pathway in rabbit knee osteoarthritis. Cell Biochem Biophys 2011, 61(2):427-434.
    • (2011) Cell Biochem Biophys , vol.61 , Issue.2 , pp. 427-434
    • Li, X.1    Li, J.2    Cheng, K.3    Lin, Q.4    Wang, D.5    Zhang, H.6
  • 38
    • 0035041939 scopus 로고    scopus 로고
    • The angiogenic pathway 'vascular endothelial growth factor/flk-1(KDR)-receptor' in rheumatoid arthritis and osteoarthritis
    • Giatromanolaki A., Sivridis E., Athanassou N., Zois E., Thorpe P.E., Brekken R.A., et al. The angiogenic pathway 'vascular endothelial growth factor/flk-1(KDR)-receptor' in rheumatoid arthritis and osteoarthritis. J Pathol 2001, 194(1):101-108.
    • (2001) J Pathol , vol.194 , Issue.1 , pp. 101-108
    • Giatromanolaki, A.1    Sivridis, E.2    Athanassou, N.3    Zois, E.4    Thorpe, P.E.5    Brekken, R.A.6
  • 39
    • 26444473434 scopus 로고    scopus 로고
    • Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function
    • Yudoh K., Nguyen T., Nakamura H., Hongo-Masuko K., Kato T., Nishioka K. Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function. Arthritis Res Ther 2005, 7(2):R380-R391.
    • (2005) Arthritis Res Ther , vol.7 , Issue.2
    • Yudoh, K.1    Nguyen, T.2    Nakamura, H.3    Hongo-Masuko, K.4    Kato, T.5    Nishioka, K.6
  • 40
    • 47249135425 scopus 로고    scopus 로고
    • Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent
    • Litherland G.J., Dixon C., Lakey R.L., Robson T., Jones D., Young D.A., et al. Synergistic collagenase expression and cartilage collagenolysis are phosphatidylinositol 3-kinase/Akt signaling-dependent. J Biol Chem 2008 May 23, 283(21):14221-14229.
    • (2008) J Biol Chem , vol.283 , Issue.21 , pp. 14221-14229
    • Litherland, G.J.1    Dixon, C.2    Lakey, R.L.3    Robson, T.4    Jones, D.5    Young, D.A.6
  • 41
    • 75949102667 scopus 로고    scopus 로고
    • Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease
    • Onishi R.M., Gaffen S.L. Interleukin-17 and its target genes: mechanisms of interleukin-17 function in disease. Immunology 2010 Mar, 129(3):311-321.
    • (2010) Immunology , vol.129 , Issue.3 , pp. 311-321
    • Onishi, R.M.1    Gaffen, S.L.2
  • 42
    • 69249224531 scopus 로고    scopus 로고
    • CCL20/CCR6 chemokine/receptor expression in bone tissue from osteoarthritis and rheumatoid arthritis patients: different response of osteoblasts in the two groups
    • Lisignoli G., Manferdini C., Codeluppi K., Piacentini A., Grassi F., Cattini L., et al. CCL20/CCR6 chemokine/receptor expression in bone tissue from osteoarthritis and rheumatoid arthritis patients: different response of osteoblasts in the two groups. J Cell Physiol 2009 Oct, 221(1):154-160.
    • (2009) J Cell Physiol , vol.221 , Issue.1 , pp. 154-160
    • Lisignoli, G.1    Manferdini, C.2    Codeluppi, K.3    Piacentini, A.4    Grassi, F.5    Cattini, L.6
  • 43
    • 36549019912 scopus 로고    scopus 로고
    • Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model
    • Hirota K., Yoshitomi H., Hashimoto M., Maeda S., Teradaira S., Sugimoto N., et al. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J Exp Med 2007 Nov 26, 204(12):2803-2812.
    • (2007) J Exp Med , vol.204 , Issue.12 , pp. 2803-2812
    • Hirota, K.1    Yoshitomi, H.2    Hashimoto, M.3    Maeda, S.4    Teradaira, S.5    Sugimoto, N.6
  • 44
    • 77951733792 scopus 로고    scopus 로고
    • ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts
    • Prasadam I., van Gennip S., Friis T., Shi W., Crawford R., Xiao Y. ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts. Arthritis Rheum 2010 May, 62(5):1349-1360.
    • (2010) Arthritis Rheum , vol.62 , Issue.5 , pp. 1349-1360
    • Prasadam, I.1    van Gennip, S.2    Friis, T.3    Shi, W.4    Crawford, R.5    Xiao, Y.6
  • 45
    • 0034099059 scopus 로고    scopus 로고
    • Apoptosis of articular chondrocytes in rheumatoid arthritis and osteoarthritis: correlation of apoptosis with degree of cartilage destruction and expression of apoptosis-related proteins of p53 and c-myc
    • Yatsugi N., Tsukazaki T., Osaki M., Koji T., Yamashita S., Shindo H. Apoptosis of articular chondrocytes in rheumatoid arthritis and osteoarthritis: correlation of apoptosis with degree of cartilage destruction and expression of apoptosis-related proteins of p53 and c-myc. J Orthop Sci 2000, 5(2):150-156.
    • (2000) J Orthop Sci , vol.5 , Issue.2 , pp. 150-156
    • Yatsugi, N.1    Tsukazaki, T.2    Osaki, M.3    Koji, T.4    Yamashita, S.5    Shindo, H.6
  • 46
    • 78449308832 scopus 로고    scopus 로고
    • ATF3, a hub of the cellular adaptive-response network, in the pathogenesis of diseases: is modulation of inflammation a unifying component?
    • Hai T., Wolford C.C., Chang Y.S. ATF3, a hub of the cellular adaptive-response network, in the pathogenesis of diseases: is modulation of inflammation a unifying component?. Gene Expr 2010, 15(1):1-11.
    • (2010) Gene Expr , vol.15 , Issue.1 , pp. 1-11
    • Hai, T.1    Wolford, C.C.2    Chang, Y.S.3
  • 47
    • 0033680154 scopus 로고    scopus 로고
    • Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease
    • Loeser R.F., Shanker G., Carlson C.S., Gardin J.F., Shelton B.J., Sonntag W.E. Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease. Arthritis Rheum 2000 Sep, 43(9):2110-2120.
    • (2000) Arthritis Rheum , vol.43 , Issue.9 , pp. 2110-2120
    • Loeser, R.F.1    Shanker, G.2    Carlson, C.S.3    Gardin, J.F.4    Shelton, B.J.5    Sonntag, W.E.6
  • 48
    • 33947178518 scopus 로고    scopus 로고
    • Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation
    • Ivanavicius S.P., Ball A.D., Heapy C.G., Westwood F.R., Murray F., Read S.J. Structural pathology in a rodent model of osteoarthritis is associated with neuropathic pain: increased expression of ATF-3 and pharmacological characterisation. Pain 2007 Apr, 128(3):272-282.
    • (2007) Pain , vol.128 , Issue.3 , pp. 272-282
    • Ivanavicius, S.P.1    Ball, A.D.2    Heapy, C.G.3    Westwood, F.R.4    Murray, F.5    Read, S.J.6
  • 49
    • 79952118180 scopus 로고    scopus 로고
    • Joint surface defects: clinical course and cellular response in spontaneous and experimental lesions
    • Dell'accio F., Vincent T.L. Joint surface defects: clinical course and cellular response in spontaneous and experimental lesions. Eur Cell Mater 2010, 20:210-217.
    • (2010) Eur Cell Mater , vol.20 , pp. 210-217
    • Dell'accio, F.1    Vincent, T.L.2
  • 50
    • 2342624566 scopus 로고    scopus 로고
    • Microarray reality checks in the context of a complex disease
    • Miklos G.L., Maleszka R. Microarray reality checks in the context of a complex disease. Nat Biotechnol 2004 May, 22(5):615-621.
    • (2004) Nat Biotechnol , vol.22 , Issue.5 , pp. 615-621
    • Miklos, G.L.1    Maleszka, R.2
  • 51
    • 34249811791 scopus 로고    scopus 로고
    • Collagenase gene regulation by pro-inflammatory cytokines in cartilage
    • Rowan A.D., Young D.A. Collagenase gene regulation by pro-inflammatory cytokines in cartilage. Front Biosci 2007, 12:536-550.
    • (2007) Front Biosci , vol.12 , pp. 536-550
    • Rowan, A.D.1    Young, D.A.2
  • 52
    • 33846316333 scopus 로고    scopus 로고
    • The TREM receptor family and signal integration
    • Klesney-Tait J., Turnbull I.R., Colonna M. The TREM receptor family and signal integration. Nat Immunol 2006 Dec, 7(12):1266-1273.
    • (2006) Nat Immunol , vol.7 , Issue.12 , pp. 1266-1273
    • Klesney-Tait, J.1    Turnbull, I.R.2    Colonna, M.3
  • 53
    • 73349100344 scopus 로고    scopus 로고
    • TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines
    • Kuai J., Gregory B., Hill A., Pittman D.D., Feldman J.L., Brown T., et al. TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines. Rheumatology (Oxford) 2009 Nov, 48(11):1352-1358.
    • (2009) Rheumatology (Oxford) , vol.48 , Issue.11 , pp. 1352-1358
    • Kuai, J.1    Gregory, B.2    Hill, A.3    Pittman, D.D.4    Feldman, J.L.5    Brown, T.6
  • 54
    • 84855189262 scopus 로고    scopus 로고
    • Soluble triggering receptor expressed on myeloid cells-1 as a new therapeutic molecule in rheumatoid arthritis
    • Kim T.H., Choi S.J., Lee Y.H., Song G.G., Ji J.D. Soluble triggering receptor expressed on myeloid cells-1 as a new therapeutic molecule in rheumatoid arthritis. Med Hypotheses 2012 Feb, 78(2):270-272.
    • (2012) Med Hypotheses , vol.78 , Issue.2 , pp. 270-272
    • Kim, T.H.1    Choi, S.J.2    Lee, Y.H.3    Song, G.G.4    Ji, J.D.5
  • 55
    • 23444452710 scopus 로고    scopus 로고
    • Role of the growth hormone/insulin-like growth factor-1 paracrine axis in rheumatic diseases
    • Denko C.W., Malemud C.J. Role of the growth hormone/insulin-like growth factor-1 paracrine axis in rheumatic diseases. Semin Arthritis Rheum 2005 Aug, 35(1):24-34.
    • (2005) Semin Arthritis Rheum , vol.35 , Issue.1 , pp. 24-34
    • Denko, C.W.1    Malemud, C.J.2
  • 57
    • 39049171041 scopus 로고    scopus 로고
    • Metalloproteases as potential therapeutic targets in arthritis treatment
    • Rowan A.D., Litherland G.J., Hui W., Milner J.M. Metalloproteases as potential therapeutic targets in arthritis treatment. Expert Opin Ther Targets 2008 Jan, 12(1):1-18.
    • (2008) Expert Opin Ther Targets , vol.12 , Issue.1 , pp. 1-18
    • Rowan, A.D.1    Litherland, G.J.2    Hui, W.3    Milner, J.M.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.