Transcriptome-Wide Analysis Reveals Modulation of Human Macrophage Inflammatory Phenotype Through Alternative Splicing

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 36, Issue 7, 2016, Pages 1434-1447

  Lin, Jennie ^a   Hu, Yu ^b   Nunez, Sara ^d,e   Foulkes, Andrea S ^d   Cieply, Benjamin ^a   Xue, Chenyi ^c   Gerelus, Mark ^a   Li, Wenjun ^a   Zhang, Hanrui ^c   Rader, Daniel J ^a   Musunuru, Kiran ^a   Li, Mingyao ^b   Reilly, Muredach P ^c  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b Department of Biostatistics and Epidemiology ^*  (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d Department of Medicine   (United States)

^e MOUNT HOLYOKE COLLEGE   (United States)

Author keywords

alternative splicing; Genetics; Inflammation; Macrophages; RNA

Indexed keywords

BETA ARRESTIN 1; CD74 ANTIGEN; CELF1 PROTEIN; CYCLIN DEPENDENT KINASE 5; GLYCOGEN SYNTHASE KINASE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MITOGEN ACTIVATED PROTEIN KINASE; TOLL LIKE RECEPTOR 4; TRANSCRIPTOME; CELF1 PROTEIN, HUMAN; LIPOPOLYSACCHARIDE;

ALTERNATIVE RNA SPLICING; ARTICLE; CARDIOVASCULAR DISEASE; CELL DIFFERENTIATION; CONTROLLED STUDY; GENE EXPRESSION; GENE LOCUS; GENE SILENCING; GENETIC VARIABILITY; GENOME-WIDE ASSOCIATION STUDY; HUMAN; HUMAN CELL; INDUCED PLURIPOTENT STEM CELL; INFLAMMATION; MACROPHAGE ACTIVATION; METABOLIC DISORDER; MOLECULAR PATHOLOGY; MONOCYTE; PHENOTYPE; PRIORITY JOURNAL; REGULATORY MECHANISM; RNA SEQUENCE; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSCRIPTOMICS; CELL CULTURE; DNA MICROARRAY; DRUG EFFECTS; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORK; GENETIC TRANSFECTION; GENETICS; MACROPHAGE; METABOLISM; PROCEDURES; PROTEIN ANALYSIS; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

ALTERNATIVE SPLICING; CELF1 PROTEIN; CELL DIFFERENTIATION; CELLS, CULTURED; GENE EXPRESSION PROFILING; GENE REGULATORY NETWORKS; GENOME-WIDE ASSOCIATION STUDY; HUMANS; INDUCED PLURIPOTENT STEM CELLS; INFLAMMATION; LIPOPOLYSACCHARIDES; MACROPHAGE ACTIVATION; MACROPHAGES; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PHENOTYPE; PROTEIN INTERACTION MAPPING; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TRANSCRIPTOME; TRANSFECTION;

EID: 84970029023     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.116.307573     Document Type: Article

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