메뉴 건너뛰기




Volumn 15, Issue 1, 2014, Pages

IUTA: A tool for effectively detecting differential isoform usage from RNA-Seq data

Author keywords

Compositional data; Isoform usage; R package; RNA seq; Tissue; Transcriptome profiling

Indexed keywords

ANIMAL TISSUE; ARTICLE; GENETIC ALGORITHM; GENETIC ANALYSIS; GENETIC PARAMETERS; GEOMETRY; INTERMETHOD COMPARISON; ISOFORM USAGE; ISOFORM USAGE TWO STEP ANALYSIS; MATHEMATICAL ANALYSIS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROBABILITY; RNA SEQUENCE; ALGORITHM; ANIMAL; BIOLOGY; COMPARATIVE STUDY; COMPUTER PROGRAM; COMPUTER SIMULATION; NUCLEIC ACID DATABASE; PROCEDURES;

EID: 84908060782     PISSN: None     EISSN: 14712164     Source Type: Journal    
DOI: 10.1186/1471-2164-15-862     Document Type: Article
Times cited : (16)

References (46)
  • 1
    • 0013394889 scopus 로고    scopus 로고
    • Mechanisms of alternative pre-messenger RNA splicing
    • 12626338
    • Black DL. Mechanisms of alternative pre-messenger RNA splicing. Annu Rev Biochem 2003, 72:291-336. 10.1146/annurev.biochem.72.121801.161720, 12626338.
    • (2003) Annu Rev Biochem , vol.72 , pp. 291-336
    • Black, D.L.1
  • 2
    • 18344364099 scopus 로고    scopus 로고
    • Understanding alternative splicing: towards a cellular code
    • 15956978
    • Matlin AJ, Clark F, Smith CW. Understanding alternative splicing: towards a cellular code. Nat Rev Mol Cell Biol 2005, 6(5):386-398. 10.1038/nrm1645, 15956978.
    • (2005) Nat Rev Mol Cell Biol , vol.6 , Issue.5 , pp. 386-398
    • Matlin, A.J.1    Clark, F.2    Smith, C.W.3
  • 3
    • 33745899048 scopus 로고    scopus 로고
    • Alternative splicing: new insights from global analyses
    • 16839875
    • Blencowe BJ. Alternative splicing: new insights from global analyses. Cell 2006, 126(1):37-47. 10.1016/j.cell.2006.06.023, 16839875.
    • (2006) Cell , vol.126 , Issue.1 , pp. 37-47
    • Blencowe, B.J.1
  • 4
    • 75849145292 scopus 로고    scopus 로고
    • Expansion of the eukaryotic proteome by alternative splicing
    • 3443858, 20110989
    • Nilsen TW, Graveley BR. Expansion of the eukaryotic proteome by alternative splicing. Nature 2010, 463(7280):457-463. 10.1038/nature08909, 3443858, 20110989.
    • (2010) Nature , vol.463 , Issue.7280 , pp. 457-463
    • Nilsen, T.W.1    Graveley, B.R.2
  • 5
    • 79960918747 scopus 로고    scopus 로고
    • RNA structure and the mechanisms of alternative splicing
    • 3149766, 21530232
    • McManus CJ, Graveley BR. RNA structure and the mechanisms of alternative splicing. Curr Opin Genet Dev 2011, 21(4):373-379. 10.1016/j.gde.2011.04.001, 3149766, 21530232.
    • (2011) Curr Opin Genet Dev , vol.21 , Issue.4 , pp. 373-379
    • McManus, C.J.1    Graveley, B.R.2
  • 6
    • 84875444381 scopus 로고    scopus 로고
    • Alternative splicing: a pivotal step between eukaryotic transcription and translation
    • 23385723
    • Kornblihtt AR, Schor IE, Allo M, Dujardin G, Petrillo E, Munoz MJ. Alternative splicing: a pivotal step between eukaryotic transcription and translation. Nat Rev Mol Cell Biol 2013, 14(3):153-165. 10.1038/nrm3525, 23385723.
    • (2013) Nat Rev Mol Cell Biol , vol.14 , Issue.3 , pp. 153-165
    • Kornblihtt, A.R.1    Schor, I.E.2    Allo, M.3    Dujardin, G.4    Petrillo, E.5    Munoz, M.J.6
  • 8
    • 84871436996 scopus 로고    scopus 로고
    • Evolutionary dynamics of gene and isoform regulation in Mammalian tissues
    • 3568499, 23258891
    • Merkin J, Russell C, Chen P, Burge CB. Evolutionary dynamics of gene and isoform regulation in Mammalian tissues. Science 2012, 338(6114):1593-1599. 10.1126/science.1228186, 3568499, 23258891.
    • (2012) Science , vol.338 , Issue.6114 , pp. 1593-1599
    • Merkin, J.1    Russell, C.2    Chen, P.3    Burge, C.B.4
  • 9
    • 56749098074 scopus 로고    scopus 로고
    • Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
    • 18978789
    • Pan Q, Shai O, Lee LJ, Frey BJ, Blencowe BJ. Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing. Nat Genet 2008, 40(12):1413-1415. 10.1038/ng.259, 18978789.
    • (2008) Nat Genet , vol.40 , Issue.12 , pp. 1413-1415
    • Pan, Q.1    Shai, O.2    Lee, L.J.3    Frey, B.J.4    Blencowe, B.J.5
  • 12
    • 0028345079 scopus 로고
    • Tenascin mRNA isoforms in the developing mouse brain
    • 7513764
    • Dorries U, Schachner M. Tenascin mRNA isoforms in the developing mouse brain. J Neurosci Res 1994, 37(3):336-347. 10.1002/jnr.490370306, 7513764.
    • (1994) J Neurosci Res , vol.37 , Issue.3 , pp. 336-347
    • Dorries, U.1    Schachner, M.2
  • 13
    • 84867152375 scopus 로고    scopus 로고
    • Nutritional control of mRNA isoform expression during developmental arrest and recovery in C. elegans
    • 3460187, 22539650
    • Maxwell CS, Antoshechkin I, Kurhanewicz N, Belsky JA, Baugh LR. Nutritional control of mRNA isoform expression during developmental arrest and recovery in C. elegans. Genome Res 2012, 22(10):1920-1929. 10.1101/gr.133587.111, 3460187, 22539650.
    • (2012) Genome Res , vol.22 , Issue.10 , pp. 1920-1929
    • Maxwell, C.S.1    Antoshechkin, I.2    Kurhanewicz, N.3    Belsky, J.A.4    Baugh, L.R.5
  • 14
    • 0035143709 scopus 로고    scopus 로고
    • Differential expression of VEGF isoforms in mouse during development and in the adult
    • 11169844
    • Ng YS, Rohan R, Sunday ME, Demello DE, D'Amore PA. Differential expression of VEGF isoforms in mouse during development and in the adult. Dev Dyn 2001, 220(2):112-121. 10.1002/1097-0177(2000)9999:9999<::AID-DVDY1093>3.0.CO;2-D, 11169844.
    • (2001) Dev Dyn , vol.220 , Issue.2 , pp. 112-121
    • Ng, Y.S.1    Rohan, R.2    Sunday, M.E.3    Demello, D.E.4    D'Amore, P.A.5
  • 15
    • 79960671654 scopus 로고    scopus 로고
    • Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules
    • 3142162, 21799842
    • Park JY, Li W, Zheng D, Zhai P, Zhao Y, Matsuda T, Vatner SF, Sadoshima J, Tian B. Comparative analysis of mRNA isoform expression in cardiac hypertrophy and development reveals multiple post-transcriptional regulatory modules. PLoS ONE 2011, 6(7):e22391. 10.1371/journal.pone.0022391, 3142162, 21799842.
    • (2011) PLoS ONE , vol.6 , Issue.7 , pp. e22391
    • Park, J.Y.1    Li, W.2    Zheng, D.3    Zhai, P.4    Zhao, Y.5    Matsuda, T.6    Vatner, S.F.7    Sadoshima, J.8    Tian, B.9
  • 16
    • 0043208839 scopus 로고    scopus 로고
    • Fgfr mRNA isoforms in craniofacial bone development
    • 12919696
    • Rice DP, Rice R, Thesleff I. Fgfr mRNA isoforms in craniofacial bone development. Bone 2003, 33(1):14-27. 10.1016/S8756-3282(03)00163-7, 12919696.
    • (2003) Bone , vol.33 , Issue.1 , pp. 14-27
    • Rice, D.P.1    Rice, R.2    Thesleff, I.3
  • 17
    • 0037443035 scopus 로고    scopus 로고
    • Pre-mRNA splicing and human disease
    • 12600935
    • Faustino NA, Cooper TA. Pre-mRNA splicing and human disease. Genes Dev 2003, 17(4):419-437. 10.1101/gad.1048803, 12600935.
    • (2003) Genes Dev , vol.17 , Issue.4 , pp. 419-437
    • Faustino, N.A.1    Cooper, T.A.2
  • 18
    • 0032859650 scopus 로고    scopus 로고
    • Overexpression of four-repeat tau mRNA isoforms in progressive supranuclear palsy but not in Alzheimer's disease
    • 10482263
    • Chambers CB, Lee JM, Troncoso JC, Reich S, Muma NA. Overexpression of four-repeat tau mRNA isoforms in progressive supranuclear palsy but not in Alzheimer's disease. Ann Neurol 1999, 46(3):325-332. 10.1002/1531-8249(199909)46:3<325::AID-ANA8>3.0.CO;2-V, 10482263.
    • (1999) Ann Neurol , vol.46 , Issue.3 , pp. 325-332
    • Chambers, C.B.1    Lee, J.M.2    Troncoso, J.C.3    Reich, S.4    Muma, N.A.5
  • 19
    • 34447106755 scopus 로고    scopus 로고
    • Alternative splicing in cancer: noise, functional, or systematic?
    • Skotheim RI, Nees M. Alternative splicing in cancer: noise, functional, or systematic?. Int J Biochem Cell Biol 2007, 39(7-8):1432-1449.
    • (2007) Int J Biochem Cell Biol , vol.39 , Issue.7-8 , pp. 1432-1449
    • Skotheim, R.I.1    Nees, M.2
  • 20
    • 46249106990 scopus 로고    scopus 로고
    • Mapping and quantifying mammalian transcriptomes by RNA-Seq
    • 18516045
    • Mortazavi A, Williams BA, McCue K, Schaeffer L, Wold B. Mapping and quantifying mammalian transcriptomes by RNA-Seq. Nat Methods 2008, 5(7):621-628. 10.1038/nmeth.1226, 18516045.
    • (2008) Nat Methods , vol.5 , Issue.7 , pp. 621-628
    • Mortazavi, A.1    Williams, B.A.2    McCue, K.3    Schaeffer, L.4    Wold, B.5
  • 21
    • 57749195712 scopus 로고    scopus 로고
    • RNA-Seq: a revolutionary tool for transcriptomics
    • 2949280, 19015660
    • Wang Z, Gerstein M, Snyder M. RNA-Seq: a revolutionary tool for transcriptomics. Nat Rev Genet 2009, 10(1):57-63. 10.1038/nrg2484, 2949280, 19015660.
    • (2009) Nat Rev Genet , vol.10 , Issue.1 , pp. 57-63
    • Wang, Z.1    Gerstein, M.2    Snyder, M.3
  • 22
    • 84863992953 scopus 로고    scopus 로고
    • Identifying differentially expressed transcripts from RNA-seq data with biological variation
    • 3381971, 22563066
    • Glaus P, Honkela A, Rattray M. Identifying differentially expressed transcripts from RNA-seq data with biological variation. Bioinformatics 2012, 28(13):1721-1728. 10.1093/bioinformatics/bts260, 3381971, 22563066.
    • (2012) Bioinformatics , vol.28 , Issue.13 , pp. 1721-1728
    • Glaus, P.1    Honkela, A.2    Rattray, M.3
  • 23
    • 78649714014 scopus 로고    scopus 로고
    • Analysis and design of RNA sequencing experiments for identifying isoform regulation
    • 3037023, 21057496
    • Katz Y, Wang ET, Airoldi EM, Burge CB. Analysis and design of RNA sequencing experiments for identifying isoform regulation. Nat Methods 2010, 7(12):1009-1015. 10.1038/nmeth.1528, 3037023, 21057496.
    • (2010) Nat Methods , vol.7 , Issue.12 , pp. 1009-1015
    • Katz, Y.1    Wang, E.T.2    Airoldi, E.M.3    Burge, C.B.4
  • 25
    • 79961123152 scopus 로고    scopus 로고
    • RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome
    • 3163565, 21816040
    • Li B, Dewey CN. RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics 2011, 12:323. 10.1186/1471-2105-12-323, 3163565, 21816040.
    • (2011) BMC Bioinformatics , vol.12 , pp. 323
    • Li, B.1    Dewey, C.N.2
  • 26
    • 84872198346 scopus 로고    scopus 로고
    • Differential analysis of gene regulation at transcript resolution with RNA-seq
    • 3869392, 23222703
    • Trapnell C, Hendrickson DG, Sauvageau M, Goff L, Rinn JL, Pachter L. Differential analysis of gene regulation at transcript resolution with RNA-seq. Nat Biotechnol 2013, 31(1):46-53. 3869392, 23222703.
    • (2013) Nat Biotechnol , vol.31 , Issue.1 , pp. 46-53
    • Trapnell, C.1    Hendrickson, D.G.2    Sauvageau, M.3    Goff, L.4    Rinn, J.L.5    Pachter, L.6
  • 27
    • 79751531332 scopus 로고    scopus 로고
    • Haplotype and isoform specific expression estimation using multi-mapping RNA-seq reads
    • 3188795, 21310039
    • Turro E, Su SY, Goncalves A, Coin LJ, Richardson S, Lewin A. Haplotype and isoform specific expression estimation using multi-mapping RNA-seq reads. Genome Biol 2011, 12(2):R13. 10.1186/gb-2011-12-2-r13, 3188795, 21310039.
    • (2011) Genome Biol , vol.12 , Issue.2 , pp. R13
    • Turro, E.1    Su, S.Y.2    Goncalves, A.3    Coin, L.J.4    Richardson, S.5    Lewin, A.6
  • 28
    • 77952262437 scopus 로고    scopus 로고
    • Towards reliable isoform quantification using RNA-SEQ data
    • Howard BE, Heber S. Towards reliable isoform quantification using RNA-SEQ data. BMC Bioinformatics 2010, 11(Suppl 3):S6.
    • (2010) BMC Bioinformatics , vol.11 , Issue.SUPPL 3 , pp. S6
    • Howard, B.E.1    Heber, S.2
  • 30
    • 84883469280 scopus 로고    scopus 로고
    • Inference of alternative splicing from RNA-Seq data with probabilistic splice graphs
    • 3753571, 23846746
    • LeGault LH, Dewey CN. Inference of alternative splicing from RNA-Seq data with probabilistic splice graphs. Bioinformatics 2013, 29(18):2300-2310. 10.1093/bioinformatics/btt396, 3753571, 23846746.
    • (2013) Bioinformatics , vol.29 , Issue.18 , pp. 2300-2310
    • LeGault, L.H.1    Dewey, C.N.2
  • 31
    • 80053435328 scopus 로고    scopus 로고
    • FDM: a graph-based statistical method to detect differential transcription using RNA-seq data
    • 3179659, 21824971
    • Singh D, Orellana CF, Hu Y, Jones CD, Liu Y, Chiang DY, Liu J, Prins JF. FDM: a graph-based statistical method to detect differential transcription using RNA-seq data. Bioinformatics 2011, 27(19):2633-2640. 10.1093/bioinformatics/btr458, 3179659, 21824971.
    • (2011) Bioinformatics , vol.27 , Issue.19 , pp. 2633-2640
    • Singh, D.1    Orellana, C.F.2    Hu, Y.3    Jones, C.D.4    Liu, Y.5    Chiang, D.Y.6    Liu, J.7    Prins, J.F.8
  • 33
    • 77952123055 scopus 로고    scopus 로고
    • Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation
    • 3146043, 20436464
    • Trapnell C, Williams BA, Pertea G, Mortazavi A, Kwan G, van Baren MJ, Salzberg SL, Wold BJ, Pachter L. Transcript assembly and quantification by RNA-Seq reveals unannotated transcripts and isoform switching during cell differentiation. Nat Biotechnol 2010, 28(5):511-515. 10.1038/nbt.1621, 3146043, 20436464.
    • (2010) Nat Biotechnol , vol.28 , Issue.5 , pp. 511-515
    • Trapnell, C.1    Williams, B.A.2    Pertea, G.3    Mortazavi, A.4    Kwan, G.5    van Baren, M.J.6    Salzberg, S.L.7    Wold, B.J.8    Pachter, L.9
  • 36
    • 0035540295 scopus 로고    scopus 로고
    • Geometric approach to statistical analysis on the simplex
    • Pawlowsky-Glahn V, Egozcue JJ. Geometric approach to statistical analysis on the simplex. Stoch Env Res Risk A 2001, 15(5):384-398.
    • (2001) Stoch Env Res Risk A , vol.15 , Issue.5 , pp. 384-398
    • Pawlowsky-Glahn, V.1    Egozcue, J.J.2
  • 41
    • 77649330805 scopus 로고    scopus 로고
    • A two-sample test for high-dimensional data with applications to gene-set testing
    • Chen SX, Qin Y-L. A two-sample test for high-dimensional data with applications to gene-set testing. Ann Stat 2010, 38(2):808-835.
    • (2010) Ann Stat , vol.38 , Issue.2 , pp. 808-835
    • Chen, S.X.1    Qin, Y.-L.2
  • 42
    • 0347533866 scopus 로고    scopus 로고
    • Modified Nel and Van der Merwe test for the multivariate Behrens-Fisher problem
    • Krishnamoorthy K, Yu J. Modified Nel and Van der Merwe test for the multivariate Behrens-Fisher problem. Stat Probabil Lett 2004, 66(2):161-169.
    • (2004) Stat Probabil Lett , vol.66 , Issue.2 , pp. 161-169
    • Krishnamoorthy, K.1    Yu, J.2
  • 43
    • 84870267223 scopus 로고
    • The generalization of student's problem when several different population variances are involved
    • 20287819
    • Welch BL. The generalization of student's problem when several different population variances are involved. Biometrika 1947, 34(1/2):28-35. 10.2307/2332510, 20287819.
    • (1947) Biometrika , vol.34 , Issue.1-2 , pp. 28-35
    • Welch, B.L.1
  • 45
    • 84876996918 scopus 로고    scopus 로고
    • TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions
    • 4053844, 23618408
    • Kim D, Pertea G, Trapnell C, Pimentel H, Kelley R, Salzberg SL. TopHat2: accurate alignment of transcriptomes in the presence of insertions, deletions and gene fusions. Genome Biol 2013, 14(4):R36. 10.1186/gb-2013-14-4-r36, 4053844, 23618408.
    • (2013) Genome Biol , vol.14 , Issue.4 , pp. R36
    • Kim, D.1    Pertea, G.2    Trapnell, C.3    Pimentel, H.4    Kelley, R.5    Salzberg, S.L.6
  • 46
    • 24344492919 scopus 로고    scopus 로고
    • MONaKA, a novel modulator of the plasma membrane Na, K-ATPase
    • 16135750
    • Mao H, Ferguson TS, Cibulsky SM, Holmqvist M, Ding C, Fei H, Levitan IB. MONaKA, a novel modulator of the plasma membrane Na, K-ATPase. J Neurosci 2005, 25(35):7934-7943. 10.1523/JNEUROSCI.0635-05.2005, 16135750.
    • (2005) J Neurosci , vol.25 , Issue.35 , pp. 7934-7943
    • Mao, H.1    Ferguson, T.S.2    Cibulsky, S.M.3    Holmqvist, M.4    Ding, C.5    Fei, H.6    Levitan, I.B.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.