Pro-inflammatory monocyte-macrophage polarization imbalance in human hypercholesterolemia and atherosclerosis

Atherosclerosis

Volumn 237, Issue 2, 2014, Pages 805-808

  Fadini, Gian Paolo ^a   Simoni, Francesco ^a   Cappellari, Roberta ^a   Vitturi, Nicola ^a   Galasso, Silvia ^a   Vigili de Kreutzenberg, Saula ^a   Previato, Lorenzo ^a   Avogaro, Angelo ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Bone marrow; Foam cells; Inflammation; Plaque

Indexed keywords

ANTIGEN; CD163 ANTIGEN; CD206 ANTIGEN; CD68 ANTIGEN; CHEMOKINE RECEPTOR CCR2; CHEMOKINE RECEPTOR CX3CR1; LOW DENSITY LIPOPROTEIN CHOLESTEROL; UNCLASSIFIED DRUG;

ADULT; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CELL POLARITY; CELL POPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; FAMILIAL HYPERCHOLESTEROLEMIA; FEMALE; HUMAN; HYPERCHOLESTEROLEMIA; MACROPHAGE; MALE; MONOCYTE; PHENOTYPE; POLARIZATION;

EID: 84911396612     PISSN: 00219150     EISSN: 18791484     Source Type: Journal    
DOI: 10.1016/j.atherosclerosis.2014.10.106     Document Type: Article

References (13)

1. Weber C., Zernecke A., Libby P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat. Rev. Immunol. 2008, 8:802-815.
2. Moore K.J., Tabas I. Macrophages in the pathogenesis of atherosclerosis. Cell 2011, 145:341-355.
3. Zernecke A., Shagdarsuren E., Weber C. Chemokines in atherosclerosis: an update. Arterioscler. Thromb. Vasc. Biol. 2008, 28:1897-1908.
4. Ziegler-Heitbrock L., Ancuta P., Crowe S., et al. Nomenclature of monocytes and dendritic cells in blood. Blood 2010, 116:e74-80.
5. Mantovani A., Garlanda C., Locati M. Macrophage diversity and polarization in atherosclerosis: a question of balance. Arterioscler. Thromb. Vasc. Biol. 2009, 29:1419-1423.
6. Murray P.J., Allen J.E., Biswas S.K., et al. Macrophage activation and polarization: nomenclature and experimental guidelines. Immunity 2014, 41:14-20.
7. Murphy A.J., Akhtari M., Tolani S., et al. ApoE regulates hematopoietic stem cell proliferation, monocytosis, and monocyte accumulation in atherosclerotic lesions in mice. J.Clin. Investig. 2011, 121:4138-4149.
8. Yvan-Charvet L., Pagler T., Gautier E.L., et al. ATP-binding cassette transporters and HDL suppress hematopoietic stem cell proliferation. Science 2010, 328:1689-1693.
9. Tall A.R., Yvan-Charvet L., Westerterp M., Murphy A.J. Cholesterol efflux: a novel regulator of myelopoiesis and atherogenesis. Arterioscler. Thromb. Vasc. Biol. 2012, 32:2547-2552.
10. Watts G.F., Sullivan D.R., Poplawski N., et al. Familial hypercholesterolaemia: a model of care for Australasia. Atheroscler. Suppl. 2011, 12:221-263.
11. Fadini G.P., de Kreutzenberg S.V., Boscaro E., et al. An unbalanced monocyte polarisation in peripheral blood and bone marrow of patients with type 2 diabetes has an impact on microangiopathy. Diabetologia 2013, 56:1856-1866.
12. Tolani S., Pagler T.A., Murphy A.J., et al. Hypercholesterolemia and reduced HDL-C promote hematopoietic stem cell proliferation and monocytosis: studies in mice and FH children. Atherosclerosis 2013, 229:79-85.
13. Stoger J.L., Gijbels M.J., van der Velden S., et al. Distribution of macrophage polarization markers in human atherosclerosis. Atherosclerosis 2012, 225:461-468.