-
1
-
-
0031577292
-
An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
-
K. Itoh, T. Chiba, S. Takahashi, T. Ishii, K. Igarashi, Y. Katoh, T. Oyake, N. Hayashi, K. Satoh, I. Hatayama, M. Yamamoto, and Y. Nabeshima An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements Biochemical and biophysical research communications 236 1997 313 322
-
(1997)
Biochemical and Biophysical Research Communications
, vol.236
, pp. 313-322
-
-
Itoh, K.1
Chiba, T.2
Takahashi, S.3
Ishii, T.4
Igarashi, K.5
Katoh, Y.6
Oyake, T.7
Hayashi, N.8
Satoh, K.9
Hatayama, I.10
Yamamoto, M.11
Nabeshima, Y.12
-
3
-
-
84964999321
-
Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration
-
K.M. Holmstrom, L. Baird, Y. Zhang, I. Hargreaves, A. Chalasani, J.M. Land, L. Stanyer, M. Yamamoto, A.T. Dinkova-Kostova, and A.Y. Abramov Nrf2 impacts cellular bioenergetics by controlling substrate availability for mitochondrial respiration Biology open 2 2013 761 770
-
(2013)
Biology Open
, vol.2
, pp. 761-770
-
-
Holmstrom, K.M.1
Baird, L.2
Zhang, Y.3
Hargreaves, I.4
Chalasani, A.5
Land, J.M.6
Stanyer, L.7
Yamamoto, M.8
Dinkova-Kostova, A.T.9
Abramov, A.Y.10
-
4
-
-
84869076474
-
Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks
-
Y. Hirotsu, F. Katsuoka, R. Funayama, T. Nagashima, Y. Nishida, K. Nakayama, J.D. Engel, and M. Yamamoto Nrf2-MafG heterodimers contribute globally to antioxidant and metabolic networks Nucleic acids research 40 2012 10228 10239
-
(2012)
Nucleic Acids Research
, vol.40
, pp. 10228-10239
-
-
Hirotsu, Y.1
Katsuoka, F.2
Funayama, R.3
Nagashima, T.4
Nishida, Y.5
Nakayama, K.6
Engel, J.D.7
Yamamoto, M.8
-
5
-
-
84863764614
-
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
-
Y. Mitsuishi, K. Taguchi, Y. Kawatani, T. Shibata, T. Nukiwa, H. Aburatani, M. Yamamoto, and H. Motohashi Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming Cancer cell 22 2012 66 79
-
(2012)
Cancer Cell
, vol.22
, pp. 66-79
-
-
Mitsuishi, Y.1
Taguchi, K.2
Kawatani, Y.3
Shibata, T.4
Nukiwa, T.5
Aburatani, H.6
Yamamoto, M.7
Motohashi, H.8
-
6
-
-
77958125017
-
Discovery of the negative regulator of Nrf2, Keap1: A historical overview
-
K. Itoh, J. Mimura, and M. Yamamoto Discovery of the negative regulator of Nrf2, Keap1: a historical overview Antioxidants & redox signaling 13 2010 1665 1678
-
(2010)
Antioxidants & Redox Signaling
, vol.13
, pp. 1665-1678
-
-
Itoh, K.1
Mimura, J.2
Yamamoto, M.3
-
8
-
-
0032953192
-
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
-
K. Itoh, N. Wakabayashi, Y. Katoh, T. Ishii, K. Igarashi, J.D. Engel, and M. Yamamoto Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain Genes & development 13 1999 76 86
-
(1999)
Genes & Development
, vol.13
, pp. 76-86
-
-
Itoh, K.1
Wakabayashi, N.2
Katoh, Y.3
Ishii, T.4
Igarashi, K.5
Engel, J.D.6
Yamamoto, M.7
-
9
-
-
3543008924
-
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
-
A. Kobayashi, M.I. Kang, H. Okawa, M. Ohtsuji, Y. Zenke, T. Chiba, K. Igarashi, and M. Yamamoto Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2 Molecular and cellular biology 24 2004 7130 7139
-
(2004)
Molecular and Cellular Biology
, vol.24
, pp. 7130-7139
-
-
Kobayashi, A.1
Kang, M.I.2
Okawa, H.3
Ohtsuji, M.4
Zenke, Y.5
Chiba, T.6
Igarashi, K.7
Yamamoto, M.8
-
10
-
-
4544294365
-
The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: Oxidative stress sensing by a Cul3-Keap1 ligase
-
S.B. Cullinan, J.D. Gordan, J. Jin, J.W. Harper, and J.A. Diehl The Keap1-BTB protein is an adaptor that bridges Nrf2 to a Cul3-based E3 ligase: oxidative stress sensing by a Cul3-Keap1 ligase Molecular and cellular biology 24 2004 8477 8486
-
(2004)
Molecular and Cellular Biology
, vol.24
, pp. 8477-8486
-
-
Cullinan, S.B.1
Gordan, J.D.2
Jin, J.3
Harper, J.W.4
Diehl, J.A.5
-
11
-
-
10044228504
-
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
-
D.D. Zhang, S.C. Lo, J.V. Cross, D.J. Templeton, and M. Hannink Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex Molecular and cellular biology 24 2004 10941 10953
-
(2004)
Molecular and Cellular Biology
, vol.24
, pp. 10941-10953
-
-
Zhang, D.D.1
Lo, S.C.2
Cross, J.V.3
Templeton, D.J.4
Hannink, M.5
-
12
-
-
84872850686
-
Keap1/Nrf2/ARE redox-sensitive signaling system as a pharmacological target
-
N.K. Zenkov, E.B. Menshchikova, and V.O. Tkachev Keap1/Nrf2/ARE redox-sensitive signaling system as a pharmacological target Biochemistry. Biokhimiia 78 2013 19 36
-
(2013)
Biochemistry. Biokhimiia
, vol.78
, pp. 19-36
-
-
Zenkov, N.K.1
Menshchikova, E.B.2
Tkachev, V.O.3
-
13
-
-
0037015035
-
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
-
A.T. Dinkova-Kostova, W.D. Holtzclaw, R.N. Cole, K. Itoh, N. Wakabayashi, Y. Katoh, M. Yamamoto, and P. Talalay Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants Proceedings of the National Academy of Sciences of the United States of America 99 2002 11908 11913
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, pp. 11908-11913
-
-
Dinkova-Kostova, A.T.1
Holtzclaw, W.D.2
Cole, R.N.3
Itoh, K.4
Wakabayashi, N.5
Katoh, Y.6
Yamamoto, M.7
Talalay, P.8
-
14
-
-
78650509515
-
Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
-
M. McMahon, D.J. Lamont, K.A. Beattie, and J.D. Hayes Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals Proceedings of the National Academy of Sciences of the United States of America 107 2010 18838 18843
-
(2010)
Proceedings of the National Academy of Sciences of the United States of America
, vol.107
, pp. 18838-18843
-
-
McMahon, M.1
Lamont, D.J.2
Beattie, K.A.3
Hayes, J.D.4
-
15
-
-
77953460849
-
Genetic analysis of cytoprotective functions supported by graded expression of Keap1
-
K. Taguchi, J.M. Maher, T. Suzuki, Y. Kawatani, H. Motohashi, and M. Yamamoto Genetic analysis of cytoprotective functions supported by graded expression of Keap1 Molecular and cellular biology 30 2010 3016 3026
-
(2010)
Molecular and Cellular Biology
, vol.30
, pp. 3016-3026
-
-
Taguchi, K.1
Maher, J.M.2
Suzuki, T.3
Kawatani, Y.4
Motohashi, H.5
Yamamoto, M.6
-
16
-
-
84863763926
-
Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver
-
K.C. Wu, J.Y. Cui, and C.D. Klaassen Effect of graded Nrf2 activation on phase-I and -II drug metabolizing enzymes and transporters in mouse liver PloS one 7 2012 e39006
-
(2012)
PloS One
, vol.7
, pp. e39006
-
-
Wu, K.C.1
Cui, J.Y.2
Klaassen, C.D.3
-
17
-
-
84902965305
-
Role of the Keap1-Nrf2 pathway in cancer
-
H.M. Leinonen, E. Kansanen, P. Polonen, M. Heinaniemi, and A.L. Levonen Role of the Keap1-Nrf2 pathway in cancer Advances in cancer research 122 2014 281 320
-
(2014)
Advances in Cancer Research
, vol.122
, pp. 281-320
-
-
Leinonen, H.M.1
Kansanen, E.2
Polonen, P.3
Heinaniemi, M.4
Levonen, A.L.5
-
18
-
-
84885944468
-
The emerging role of the Nrf2-Keap1 signaling pathway in cancer
-
M.C. Jaramillo, and D.D. Zhang The emerging role of the Nrf2-Keap1 signaling pathway in cancer Genes & development 27 2013 2179 2191
-
(2013)
Genes & Development
, vol.27
, pp. 2179-2191
-
-
Jaramillo, M.C.1
Zhang, D.D.2
-
19
-
-
3843104763
-
Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron
-
M. McMahon, N. Thomas, K. Itoh, M. Yamamoto, and J.D. Hayes Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron The Journal of biological chemistry 279 2004 31556 31567
-
(2004)
The Journal of Biological Chemistry
, vol.279
, pp. 31556-31567
-
-
McMahon, M.1
Thomas, N.2
Itoh, K.3
Yamamoto, M.4
Hayes, J.D.5
-
20
-
-
34248593492
-
Molecular mechanism of human Nrf2 activation and degradation: Role of sequential phosphorylation by protein kinase CK2
-
J. Pi, Y. Bai, J.M. Reece, J. Williams, D. Liu, M.L. Freeman, W.E. Fahl, D. Shugar, J. Liu, W. Qu, S. Collins, and M.P. Waalkes Molecular mechanism of human Nrf2 activation and degradation: role of sequential phosphorylation by protein kinase CK2 Free radical biology & medicine 42 2007 1797 1806
-
(2007)
Free Radical Biology & Medicine
, vol.42
, pp. 1797-1806
-
-
Pi, J.1
Bai, Y.2
Reece, J.M.3
Williams, J.4
Liu, D.5
Freeman, M.L.6
Fahl, W.E.7
Shugar, D.8
Liu, J.9
Qu, W.10
Collins, S.11
Waalkes, M.P.12
-
21
-
-
28044446334
-
Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3
-
J.H. An, K. Vranas, M. Lucke, H. Inoue, N. Hisamoto, K. Matsumoto, and T.K. Blackwell Regulation of the Caenorhabditis elegans oxidative stress defense protein SKN-1 by glycogen synthase kinase-3 Proceedings of the National Academy of Sciences of the United States of America 102 2005 16275 16280
-
(2005)
Proceedings of the National Academy of Sciences of the United States of America
, vol.102
, pp. 16275-16280
-
-
An, J.H.1
Vranas, K.2
Lucke, M.3
Inoue, H.4
Hisamoto, N.5
Matsumoto, K.6
Blackwell, T.K.7
-
22
-
-
25844490465
-
The C. Elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response
-
H. Inoue, N. Hisamoto, J.H. An, R.P. Oliveira, E. Nishida, T.K. Blackwell, and K. Matsumoto The C. elegans p38 MAPK pathway regulates nuclear localization of the transcription factor SKN-1 in oxidative stress response Genes & development 19 2005 2278 2283
-
(2005)
Genes & Development
, vol.19
, pp. 2278-2283
-
-
Inoue, H.1
Hisamoto, N.2
An, J.H.3
Oliveira, R.P.4
Nishida, E.5
Blackwell, T.K.6
Matsumoto, K.7
-
23
-
-
40849118472
-
Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. Elegans
-
J.M. Tullet, M. Hertweck, J.H. An, J. Baker, J.Y. Hwang, S. Liu, R.P. Oliveira, R. Baumeister, and T.K. Blackwell Direct inhibition of the longevity-promoting factor SKN-1 by insulin-like signaling in C. elegans Cell 132 2008 1025 1038
-
(2008)
Cell
, vol.132
, pp. 1025-1038
-
-
Tullet, J.M.1
Hertweck, M.2
An, J.H.3
Baker, J.4
Hwang, J.Y.5
Liu, S.6
Oliveira, R.P.7
Baumeister, R.8
Blackwell, T.K.9
-
25
-
-
0242666198
-
Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression
-
D.A. Bloom, and A.K. Jaiswal Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression The Journal of biological chemistry 278 2003 44675 44682
-
(2003)
The Journal of Biological Chemistry
, vol.278
, pp. 44675-44682
-
-
Bloom, D.A.1
Jaiswal, A.K.2
-
26
-
-
0037044791
-
Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription
-
H.C. Huang, T. Nguyen, and C.B. Pickett Phosphorylation of Nrf2 at Ser-40 by protein kinase C regulates antioxidant response element-mediated transcription The Journal of biological chemistry 277 2002 42769 42774
-
(2002)
The Journal of Biological Chemistry
, vol.277
, pp. 42769-42774
-
-
Huang, H.C.1
Nguyen, T.2
Pickett, C.B.3
-
27
-
-
84874111758
-
The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation
-
H.K. Bryan, A. Olayanju, C.E. Goldring, and B.K. Park The Nrf2 cell defence pathway: Keap1-dependent and -independent mechanisms of regulation Biochemical pharmacology 85 2013 705 717
-
(2013)
Biochemical Pharmacology
, vol.85
, pp. 705-717
-
-
Bryan, H.K.1
Olayanju, A.2
Goldring, C.E.3
Park, B.K.4
-
28
-
-
0041742490
-
Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress
-
S. Numazawa, M. Ishikawa, A. Yoshida, S. Tanaka, and T. Yoshida Atypical protein kinase C mediates activation of NF-E2-related factor 2 in response to oxidative stress American journal of physiology. Cell physiology 285 2003 C334 C342
-
(2003)
American Journal of Physiology. Cell Physiology
, vol.285
, pp. C334-C342
-
-
Numazawa, S.1
Ishikawa, M.2
Yoshida, A.3
Tanaka, S.4
Yoshida, T.5
-
29
-
-
0141752795
-
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
-
S.B. Cullinan, D. Zhang, M. Hannink, E. Arvisais, R.J. Kaufman, and J.A. Diehl Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival Molecular and cellular biology 23 2003 7198 7209
-
(2003)
Molecular and Cellular Biology
, vol.23
, pp. 7198-7209
-
-
Cullinan, S.B.1
Zhang, D.2
Hannink, M.3
Arvisais, E.4
Kaufman, R.J.5
Diehl, J.A.6
-
30
-
-
40549121572
-
Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells
-
P.L. Apopa, X. He, and Q. Ma Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells Journal of biochemical and molecular toxicology 22 2008 63 76
-
(2008)
Journal of Biochemical and Molecular Toxicology
, vol.22
, pp. 63-76
-
-
Apopa, P.L.1
He, X.2
Ma, Q.3
-
31
-
-
34447526197
-
GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2
-
A.K. Jain, and A.K. Jaiswal GSK-3beta acts upstream of Fyn kinase in regulation of nuclear export and degradation of NF-E2 related factor 2 The Journal of biological chemistry 282 2007 16502 16510
-
(2007)
The Journal of Biological Chemistry
, vol.282
, pp. 16502-16510
-
-
Jain, A.K.1
Jaiswal, A.K.2
-
32
-
-
80051690439
-
Src subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expression
-
S.K. Niture, A.K. Jain, P.M. Shelton, and A.K. Jaiswal Src subfamily kinases regulate nuclear export and degradation of transcription factor Nrf2 to switch off Nrf2-mediated antioxidant activation of cytoprotective gene expression The Journal of biological chemistry 286 2011 28821 28832
-
(2011)
The Journal of Biological Chemistry
, vol.286
, pp. 28821-28832
-
-
Niture, S.K.1
Jain, A.K.2
Shelton, P.M.3
Jaiswal, A.K.4
-
33
-
-
0034839145
-
Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells
-
D. Martin, M. Salinas, R. Lopez-Valdaliso, E. Serrano, M. Recuero, and A. Cuadrado Effect of the Alzheimer amyloid fragment Abeta(25-35) on Akt/PKB kinase and survival of PC12 cells Journal of neurochemistry 78 2001 1000 1008
-
(2001)
Journal of Neurochemistry
, vol.78
, pp. 1000-1008
-
-
Martin, D.1
Salinas, M.2
Lopez-Valdaliso, R.3
Serrano, E.4
Recuero, M.5
Cuadrado, A.6
-
34
-
-
0038529681
-
Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner
-
M. Salinas, R. Diaz, N.G. Abraham, C.M. Ruiz de Galarreta, and A. Cuadrado Nerve growth factor protects against 6-hydroxydopamine-induced oxidative stress by increasing expression of heme oxygenase-1 in a phosphatidylinositol 3-kinase-dependent manner The Journal of biological chemistry 278 2003 13898 13904
-
(2003)
The Journal of Biological Chemistry
, vol.278
, pp. 13898-13904
-
-
Salinas, M.1
Diaz, R.2
Abraham, N.G.3
Ruiz De Galarreta, C.M.4
Cuadrado, A.5
-
35
-
-
0036436025
-
Peroxynitrite activates NF-E2-related factor 2/antioxidant response element through the pathway of phosphatidylinositol 3-kinase: The role of nitric oxide synthase in rat glutathione S-transferase A2 induction
-
K.W. Kang, S.H. Choi, and S.G. Kim Peroxynitrite activates NF-E2-related factor 2/antioxidant response element through the pathway of phosphatidylinositol 3-kinase: the role of nitric oxide synthase in rat glutathione S-transferase A2 induction Nitric oxide: biology and chemistry / official journal of the Nitric Oxide Society 7 2002 244 253
-
(2002)
Nitric Oxide: Biology and Chemistry / Official Journal of the Nitric Oxide Society
, vol.7
, pp. 244-253
-
-
Kang, K.W.1
Choi, S.H.2
Kim, S.G.3
-
37
-
-
84923265392
-
Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases
-
E. Beurel, S.F. Grieco, and R.S. Jope Glycogen synthase kinase-3 (GSK3): Regulation, actions, and diseases Pharmacology & therapeutics 148C 2015 114 131
-
(2015)
Pharmacology & Therapeutics
, vol.148 C
, pp. 114-131
-
-
Beurel, E.1
Grieco, S.F.2
Jope, R.S.3
-
38
-
-
43249106330
-
Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation
-
T.M. Thornton, G. Pedraza-Alva, B. Deng, C.D. Wood, A. Aronshtam, J.L. Clements, G. Sabio, R.J. Davis, D.E. Matthews, B. Doble, and M. Rincon Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation Science 320 2008 667 670
-
(2008)
Science
, vol.320
, pp. 667-670
-
-
Thornton, T.M.1
Pedraza-Alva, G.2
Deng, B.3
Wood, C.D.4
Aronshtam, A.5
Clements, J.L.6
Sabio, G.7
Davis, R.J.8
Matthews, D.E.9
Doble, B.10
Rincon, M.11
-
39
-
-
22544433759
-
Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin
-
Q. Ding, W. Xia, J.C. Liu, J.Y. Yang, D.F. Lee, J. Xia, G. Bartholomeusz, Y. Li, Y. Pan, Z. Li, R.C. Bargou, J. Qin, C.C. Lai, F.J. Tsai, C.H. Tsai, and M.C. Hung Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin Molecular cell 19 2005 159 170
-
(2005)
Molecular Cell
, vol.19
, pp. 159-170
-
-
Ding, Q.1
Xia, W.2
Liu, J.C.3
Yang, J.Y.4
Lee, D.F.5
Xia, J.6
Bartholomeusz, G.7
Li, Y.8
Pan, Y.9
Li, Z.10
Bargou, R.C.11
Qin, J.12
Lai, C.C.13
Tsai, F.J.14
Tsai, C.H.15
Hung, M.C.16
-
40
-
-
0027515127
-
Inactivation of glycogen synthase kinase-3 beta by phosphorylation: New kinase connections in insulin and growth-factor signalling
-
C. Sutherland, I.A. Leighton, and P. Cohen Inactivation of glycogen synthase kinase-3 beta by phosphorylation: new kinase connections in insulin and growth-factor signalling The Biochemical journal 296 Pt 1 1993 15 19
-
(1993)
The Biochemical Journal
, vol.296
, Issue.PART 1
, pp. 15-19
-
-
Sutherland, C.1
Leighton, I.A.2
Cohen, P.3
-
41
-
-
0028177965
-
The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro
-
C. Sutherland, and P. Cohen The alpha-isoform of glycogen synthase kinase-3 from rabbit skeletal muscle is inactivated by p70 S6 kinase or MAP kinase-activated protein kinase-1 in vitro FEBS letters 338 1994 37 42
-
(1994)
FEBS Letters
, vol.338
, pp. 37-42
-
-
Sutherland, C.1
Cohen, P.2
-
42
-
-
0027960448
-
Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation
-
V. Stambolic, and J.R. Woodgett Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation The Biochemical journal 303 Pt 3 1994 701 704
-
(1994)
The Biochemical Journal
, vol.303
, Issue.PART 3
, pp. 701-704
-
-
Stambolic, V.1
Woodgett, J.R.2
-
43
-
-
0032746343
-
Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells
-
M. Shaw, and P. Cohen Role of protein kinase B and the MAP kinase cascade in mediating the EGF-dependent inhibition of glycogen synthase kinase 3 in Swiss 3T3 cells FEBS letters 461 1999 120 124
-
(1999)
FEBS Letters
, vol.461
, pp. 120-124
-
-
Shaw, M.1
Cohen, P.2
-
44
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
D.A. Cross, D.R. Alessi, P. Cohen, M. Andjelkovich, and B.A. Hemmings Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B Nature 378 1995 785 789
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
45
-
-
84892956594
-
Notch-Nrf2 axis: Regulation of Nrf2 gene expression and cytoprotection by notch signaling
-
N. Wakabayashi, J.J. Skoko, D.V. Chartoumpekis, S. Kimura, S.L. Slocum, K. Noda, D.L. Palliyaguru, M. Fujimuro, P.A. Boley, Y. Tanaka, N. Shigemura, S. Biswal, M. Yamamoto, and T.W. Kensler Notch-Nrf2 axis: regulation of Nrf2 gene expression and cytoprotection by notch signaling Molecular and cellular biology 34 2014 653 663
-
(2014)
Molecular and Cellular Biology
, vol.34
, pp. 653-663
-
-
Wakabayashi, N.1
Skoko, J.J.2
Chartoumpekis, D.V.3
Kimura, S.4
Slocum, S.L.5
Noda, K.6
Palliyaguru, D.L.7
Fujimuro, M.8
Boley, P.A.9
Tanaka, Y.10
Shigemura, N.11
Biswal, S.12
Yamamoto, M.13
Kensler, T.W.14
-
46
-
-
84884903877
-
Activator or inhibitor? GSK-3 as a new drug target
-
F. Takahashi-Yanaga Activator or inhibitor? GSK-3 as a new drug target Biochemical pharmacology 86 2013 191 199
-
(2013)
Biochemical Pharmacology
, vol.86
, pp. 191-199
-
-
Takahashi-Yanaga, F.1
-
47
-
-
0037044838
-
Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B
-
D. Martin, M. Salinas, N. Fujita, T. Tsuruo, and A. Cuadrado Ceramide and reactive oxygen species generated by H2O2 induce caspase-3-independent degradation of Akt/protein kinase B The Journal of biological chemistry 277 2002 42943 42952
-
(2002)
The Journal of Biological Chemistry
, vol.277
, pp. 42943-42952
-
-
Martin, D.1
Salinas, M.2
Fujita, N.3
Tsuruo, T.4
Cuadrado, A.5
-
48
-
-
49749117926
-
Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death
-
A.I. Rojo, P. Rada, J. Egea, A.O. Rosa, M.G. Lopez, and A. Cuadrado Functional interference between glycogen synthase kinase-3 beta and the transcription factor Nrf2 in protection against kainate-induced hippocampal cell death Molecular and cellular neurosciences 39 2008 125 132
-
(2008)
Molecular and Cellular Neurosciences
, vol.39
, pp. 125-132
-
-
Rojo, A.I.1
Rada, P.2
Egea, J.3
Rosa, A.O.4
Lopez, M.G.5
Cuadrado, A.6
-
49
-
-
33744950387
-
Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2
-
M. Salazar, A.I. Rojo, D. Velasco, R.M. de Sagarra, and A. Cuadrado Glycogen synthase kinase-3beta inhibits the xenobiotic and antioxidant cell response by direct phosphorylation and nuclear exclusion of the transcription factor Nrf2 The Journal of biological chemistry 281 2006 14841 14851
-
(2006)
The Journal of Biological Chemistry
, vol.281
, pp. 14841-14851
-
-
Salazar, M.1
Rojo, A.I.2
Velasco, D.3
De Sagarra, R.M.4
Cuadrado, A.5
-
51
-
-
18944373186
-
Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism
-
M. Velichkova, and T. Hasson Keap1 regulates the oxidation-sensitive shuttling of Nrf2 into and out of the nucleus via a Crm1-dependent nuclear export mechanism Molecular and cellular biology 25 2005 4501 4513
-
(2005)
Molecular and Cellular Biology
, vol.25
, pp. 4501-4513
-
-
Velichkova, M.1
Hasson, T.2
-
52
-
-
5444269904
-
Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition
-
B.P. Zhou, J. Deng, W. Xia, J. Xu, Y.M. Li, M. Gunduz, and M.C. Hung Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition Nature cell biology 6 2004 931 940
-
(2004)
Nature Cell Biology
, vol.6
, pp. 931-940
-
-
Zhou, B.P.1
Deng, J.2
Xia, W.3
Xu, J.4
Li, Y.M.5
Gunduz, M.6
Hung, M.C.7
-
53
-
-
0030978351
-
Beta-catenin is a target for the ubiquitin-proteasome pathway
-
H. Aberle, A. Bauer, J. Stappert, A. Kispert, and R. Kemler beta-catenin is a target for the ubiquitin-proteasome pathway The EMBO journal 16 1997 3797 3804
-
(1997)
The EMBO Journal
, vol.16
, pp. 3797-3804
-
-
Aberle, H.1
Bauer, A.2
Stappert, J.3
Kispert, A.4
Kemler, R.5
-
54
-
-
0033611567
-
The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin
-
E. Latres, D.S. Chiaur, and M. Pagano The human F box protein beta-Trcp associates with the Cul1/Skp1 complex and regulates the stability of beta-catenin Oncogene 18 1999 849 854
-
(1999)
Oncogene
, vol.18
, pp. 849-854
-
-
Latres, E.1
Chiaur, D.S.2
Pagano, M.3
-
55
-
-
0032577899
-
WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells
-
J. Papkoff, and M. Aikawa WNT-1 and HGF regulate GSK3 beta activity and beta-catenin signaling in mammary epithelial cells Biochemical and biophysical research communications 247 1998 851 858
-
(1998)
Biochemical and Biophysical Research Communications
, vol.247
, pp. 851-858
-
-
Papkoff, J.1
Aikawa, M.2
-
56
-
-
33646270662
-
Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation
-
Y. Pan, C.B. Bai, A.L. Joyner, and B. Wang Sonic hedgehog signaling regulates Gli2 transcriptional activity by suppressing its processing and degradation Molecular and cellular biology 26 2006 3365 3377
-
(2006)
Molecular and Cellular Biology
, vol.26
, pp. 3365-3377
-
-
Pan, Y.1
Bai, C.B.2
Joyner, A.L.3
Wang, B.4
-
58
-
-
0036774807
-
Regulated proteolysis of Xom mediates dorsoventral pattern formation during early Xenopus development
-
Z. Zhu, and M. Kirschner Regulated proteolysis of Xom mediates dorsoventral pattern formation during early Xenopus development Developmental cell 3 2002 557 568
-
(2002)
Developmental Cell
, vol.3
, pp. 557-568
-
-
Zhu, Z.1
Kirschner, M.2
-
59
-
-
37349094929
-
GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers
-
T. Kang, Y. Wei, Y. Honaker, H. Yamaguchi, E. Appella, M.C. Hung, and H. Piwnica-Worms GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers Cancer cell 13 2008 36 47
-
(2008)
Cancer Cell
, vol.13
, pp. 36-47
-
-
Kang, T.1
Wei, Y.2
Honaker, Y.3
Yamaguchi, H.4
Appella, E.5
Hung, M.C.6
Piwnica-Worms, H.7
-
60
-
-
15844366960
-
The FWD1/beta-TrCP-mediated degradation pathway establishes a 'turning off switch' of a Cdc42 guanine nucleotide exchange factor, FGD1
-
M. Hayakawa, H. Kitagawa, K. Miyazawa, M. Kitagawa, and K. Kikugawa The FWD1/beta-TrCP-mediated degradation pathway establishes a 'turning off switch' of a Cdc42 guanine nucleotide exchange factor, FGD1 Genes to cells: devoted to molecular & cellular mechanisms 10 2005 241 251
-
(2005)
Genes to Cells: Devoted to Molecular & Cellular Mechanisms
, vol.10
, pp. 241-251
-
-
Hayakawa, M.1
Kitagawa, H.2
Miyazawa, K.3
Kitagawa, M.4
Kikugawa, K.5
-
61
-
-
41149122298
-
Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF(FWD1/beta-TrCP)-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1
-
M. Hayakawa, M. Matsushima, H. Hagiwara, T. Oshima, T. Fujino, K. Ando, K. Kikugawa, H. Tanaka, K. Miyazawa, and M. Kitagawa Novel insights into FGD3, a putative GEF for Cdc42, that undergoes SCF(FWD1/beta-TrCP)-mediated proteasomal degradation analogous to that of its homologue FGD1 but regulates cell morphology and motility differently from FGD1 Genes to cells: devoted to molecular & cellular mechanisms 13 2008 329 342
-
(2008)
Genes to Cells: Devoted to Molecular & Cellular Mechanisms
, vol.13
, pp. 329-342
-
-
Hayakawa, M.1
Matsushima, M.2
Hagiwara, H.3
Oshima, T.4
Fujino, T.5
Ando, K.6
Kikugawa, K.7
Tanaka, H.8
Miyazawa, K.9
Kitagawa, M.10
-
62
-
-
34347350211
-
Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization
-
Q. Ding, X. He, J.M. Hsu, W. Xia, C.T. Chen, L.Y. Li, D.F. Lee, J.C. Liu, Q. Zhong, X. Wang, and M.C. Hung Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization Molecular and cellular biology 27 2007 4006 4017
-
(2007)
Molecular and Cellular Biology
, vol.27
, pp. 4006-4017
-
-
Ding, Q.1
He, X.2
Hsu, J.M.3
Xia, W.4
Chen, C.T.5
Li, L.Y.6
Lee, D.F.7
Liu, J.C.8
Zhong, Q.9
Wang, X.10
Hung, M.C.11
-
63
-
-
46749100628
-
UV-induced degradation of securin is mediated by SKP1-CUL1-beta TrCP E3 ubiquitin ligase
-
M.C. Limon-Mortes, M. Mora-Santos, A. Espina, J.A. Pintor-Toro, A. Lopez-Roman, M. Tortolero, and F. Romero UV-induced degradation of securin is mediated by SKP1-CUL1-beta TrCP E3 ubiquitin ligase Journal of cell science 121 2008 1825 1831
-
(2008)
Journal of Cell Science
, vol.121
, pp. 1825-1831
-
-
Limon-Mortes, M.C.1
Mora-Santos, M.2
Espina, A.3
Pintor-Toro, J.A.4
Lopez-Roman, A.5
Tortolero, M.6
Romero, F.7
-
64
-
-
50249171794
-
Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway
-
B. Varghese, H. Barriere, C.J. Carbone, A. Banerjee, G. Swaminathan, A. Plotnikov, P. Xu, J. Peng, V. Goffin, G.L. Lukacs, and S.Y. Fuchs Polyubiquitination of prolactin receptor stimulates its internalization, postinternalization sorting, and degradation via the lysosomal pathway Molecular and cellular biology 28 2008 5275 5287
-
(2008)
Molecular and Cellular Biology
, vol.28
, pp. 5275-5287
-
-
Varghese, B.1
Barriere, H.2
Carbone, C.J.3
Banerjee, A.4
Swaminathan, G.5
Plotnikov, A.6
Xu, P.7
Peng, J.8
Goffin, V.9
Lukacs, G.L.10
Fuchs, S.Y.11
-
65
-
-
71949128142
-
Beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt
-
X. Li, J. Liu, and T. Gao beta-TrCP-mediated ubiquitination and degradation of PHLPP1 are negatively regulated by Akt Molecular and cellular biology 29 2009 6192 6205
-
(2009)
Molecular and Cellular Biology
, vol.29
, pp. 6192-6205
-
-
Li, X.1
Liu, J.2
Gao, T.3
-
66
-
-
0030695025
-
A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p
-
R.M. Feldman, C.C. Correll, K.B. Kaplan, and R.J. Deshaies A complex of Cdc4p, Skp1p, and Cdc53p/cullin catalyzes ubiquitination of the phosphorylated CDK inhibitor Sic1p Cell 91 1997 221 230
-
(1997)
Cell
, vol.91
, pp. 221-230
-
-
Feldman, R.M.1
Correll, C.C.2
Kaplan, K.B.3
Deshaies, R.J.4
-
67
-
-
0030662523
-
F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex
-
D. Skowyra, K.L. Craig, M. Tyers, S.J. Elledge, and J.W. Harper F-box proteins are receptors that recruit phosphorylated substrates to the SCF ubiquitin-ligase complex Cell 91 1997 209 219
-
(1997)
Cell
, vol.91
, pp. 209-219
-
-
Skowyra, D.1
Craig, K.L.2
Tyers, M.3
Elledge, S.J.4
Harper, J.W.5
-
68
-
-
79952256187
-
SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner
-
P. Rada, A.I. Rojo, S. Chowdhry, M. McMahon, J.D. Hayes, and A. Cuadrado SCF/{beta}-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner Molecular and cellular biology 31 2011 1121 1133
-
(2011)
Molecular and Cellular Biology
, vol.31
, pp. 1121-1133
-
-
Rada, P.1
Rojo, A.I.2
Chowdhry, S.3
McMahon, M.4
Hayes, J.D.5
Cuadrado, A.6
-
69
-
-
84866283856
-
Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/beta-TrCP axis
-
P. Rada, A.I. Rojo, N. Evrard-Todeschi, N.G. Innamorato, A. Cotte, T. Jaworski, J.C. Tobon-Velasco, H. Devijver, M.F. Garcia-Mayoral, F. Van Leuven, J.D. Hayes, G. Bertho, and A. Cuadrado Structural and functional characterization of Nrf2 degradation by the glycogen synthase kinase 3/beta-TrCP axis Molecular and cellular biology 32 2012 3486 3499
-
(2012)
Molecular and Cellular Biology
, vol.32
, pp. 3486-3499
-
-
Rada, P.1
Rojo, A.I.2
Evrard-Todeschi, N.3
Innamorato, N.G.4
Cotte, A.5
Jaworski, T.6
Tobon-Velasco, J.C.7
Devijver, H.8
Garcia-Mayoral, M.F.9
Van Leuven, F.10
Hayes, J.D.11
Bertho, G.12
Cuadrado, A.13
-
70
-
-
84907929068
-
The PTEN/Nrf2 axis promotes human carcinogenesis
-
A.I. Rojo, P. Rada, M. Mendiola, A. Ortega-Molina, K. Wojdyla, A. Rogowska-Wrzesinska, D. Hardisson, M. Serrano, and A. Cuadrado The PTEN/Nrf2 axis promotes human carcinogenesis Antioxidants & redox signaling 21 2014 2498 2514
-
(2014)
Antioxidants & Redox Signaling
, vol.21
, pp. 2498-2514
-
-
Rojo, A.I.1
Rada, P.2
Mendiola, M.3
Ortega-Molina, A.4
Wojdyla, K.5
Rogowska-Wrzesinska, A.6
Hardisson, D.7
Serrano, M.8
Cuadrado, A.9
-
71
-
-
73549095761
-
A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP)
-
B. Zhao, L. Li, K. Tumaneng, C.Y. Wang, and K.L. Guan A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF(beta-TRCP) Genes & development 24 2010 72 85
-
(2010)
Genes & Development
, vol.24
, pp. 72-85
-
-
Zhao, B.1
Li, L.2
Tumaneng, K.3
Wang, C.Y.4
Guan, K.L.5
-
72
-
-
34250027624
-
Beta-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferation
-
L. Meyer, B. Deau, H. Forejtnikova, D. Dumenil, F. Margottin-Goguet, C. Lacombe, P. Mayeux, and F. Verdier beta-Trcp mediates ubiquitination and degradation of the erythropoietin receptor and controls cell proliferation Blood 109 2007 5215 5222
-
(2007)
Blood
, vol.109
, pp. 5215-5222
-
-
Meyer, L.1
Deau, B.2
Forejtnikova, H.3
Dumenil, D.4
Margottin-Goguet, F.5
Lacombe, C.6
Mayeux, P.7
Verdier, F.8
-
73
-
-
84881476323
-
Nrf2 is controlled by two distinct beta-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
-
S. Chowdhry, Y. Zhang, M. McMahon, C. Sutherland, A. Cuadrado, and J.D. Hayes Nrf2 is controlled by two distinct beta-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity Oncogene 32 2013 3765 3781
-
(2013)
Oncogene
, vol.32
, pp. 3765-3781
-
-
Chowdhry, S.1
Zhang, Y.2
McMahon, M.3
Sutherland, C.4
Cuadrado, A.5
Hayes, J.D.6
-
74
-
-
33747728194
-
Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a tethering mechanism: A two-site interaction model for the Nrf2-Keap1 complex
-
M. McMahon, N. Thomas, K. Itoh, M. Yamamoto, and J.D. Hayes Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a tethering mechanism: a two-site interaction model for the Nrf2-Keap1 complex The Journal of biological chemistry 281 2006 24756 24768
-
(2006)
The Journal of Biological Chemistry
, vol.281
, pp. 24756-24768
-
-
McMahon, M.1
Thomas, N.2
Itoh, K.3
Yamamoto, M.4
Hayes, J.D.5
-
75
-
-
33750613056
-
Two-site substrate recognition model for the Keap1-Nrf2 system: A hinge and latch mechanism
-
K.I. Tong, A. Kobayashi, F. Katsuoka, and M. Yamamoto Two-site substrate recognition model for the Keap1-Nrf2 system: a hinge and latch mechanism Biological chemistry 387 2006 1311 1320
-
(2006)
Biological Chemistry
, vol.387
, pp. 1311-1320
-
-
Tong, K.I.1
Kobayashi, A.2
Katsuoka, F.3
Yamamoto, M.4
-
76
-
-
83255185776
-
Dual regulation of the transcriptional activity of Nrf1 by beta-TrCP- and Hrd1-dependent degradation mechanisms
-
Y. Tsuchiya, T. Morita, M. Kim, S. Iemura, T. Natsume, M. Yamamoto, and A. Kobayashi Dual regulation of the transcriptional activity of Nrf1 by beta-TrCP- and Hrd1-dependent degradation mechanisms Molecular and cellular biology 31 2011 4500 4512
-
(2011)
Molecular and Cellular Biology
, vol.31
, pp. 4500-4512
-
-
Tsuchiya, Y.1
Morita, T.2
Kim, M.3
Iemura, S.4
Natsume, T.5
Yamamoto, M.6
Kobayashi, A.7
-
77
-
-
84879407019
-
Protein tyrosine phosphatase 1B modulates GSK3beta/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity
-
M.A. Mobasher, A. Gonzalez-Rodriguez, B. Santamaria, S. Ramos, M.A. Martin, L. Goya, P. Rada, L. Letzig, L.P. James, A. Cuadrado, J. Martin-Perez, K.J. Simpson, J. Muntane, and A.M. Valverde Protein tyrosine phosphatase 1B modulates GSK3beta/Nrf2 and IGFIR signaling pathways in acetaminophen-induced hepatotoxicity Cell death & disease 4 2013 e626
-
(2013)
Cell Death & Disease
, vol.4
, pp. e626
-
-
Mobasher, M.A.1
Gonzalez-Rodriguez, A.2
Santamaria, B.3
Ramos, S.4
Martin, M.A.5
Goya, L.6
Rada, P.7
Letzig, L.8
James, L.P.9
Cuadrado, A.10
Martin-Perez, J.11
Simpson, K.J.12
Muntane, J.13
Valverde, A.M.14
-
79
-
-
84893822502
-
Nrf2 enhances cholangiocyte expansion in Pten-deficient livers
-
K. Taguchi, I. Hirano, T. Itoh, M. Tanaka, A. Miyajima, A. Suzuki, H. Motohashi, and M. Yamamoto Nrf2 enhances cholangiocyte expansion in Pten-deficient livers Molecular and cellular biology 34 2014 900 913
-
(2014)
Molecular and Cellular Biology
, vol.34
, pp. 900-913
-
-
Taguchi, K.1
Hirano, I.2
Itoh, T.3
Tanaka, M.4
Miyajima, A.5
Suzuki, A.6
Motohashi, H.7
Yamamoto, M.8
-
81
-
-
0032563295
-
Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma
-
C. Murga, L. Laguinge, R. Wetzker, A. Cuadrado, and J.S. Gutkind Activation of Akt/protein kinase B by G protein-coupled receptors. A role for alpha and beta gamma subunits of heterotrimeric G proteins acting through phosphatidylinositol-3-OH kinasegamma The Journal of biological chemistry 273 1998 19080 19085
-
(1998)
The Journal of Biological Chemistry
, vol.273
, pp. 19080-19085
-
-
Murga, C.1
Laguinge, L.2
Wetzker, R.3
Cuadrado, A.4
Gutkind, J.S.5
-
82
-
-
67650475217
-
The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: Connecting neurotransmission with neuroprotection
-
S. Espada, A.I. Rojo, M. Salinas, and A. Cuadrado The muscarinic M1 receptor activates Nrf2 through a signaling cascade that involves protein kinase C and inhibition of GSK-3beta: connecting neurotransmission with neuroprotection Journal of neurochemistry 110 2009 1107 1119
-
(2009)
Journal of Neurochemistry
, vol.110
, pp. 1107-1119
-
-
Espada, S.1
Rojo, A.I.2
Salinas, M.3
Cuadrado, A.4
-
83
-
-
84948740800
-
Neuroprotection Mediated by P2Y13 Nucleotide Receptors in Neurons
-
R. Perez-Sen, M.J. Queipo, V. Morente, F. Ortega, E.G. Delicado, and M.T. Miras-Portugal Neuroprotection Mediated by P2Y13 Nucleotide Receptors in Neurons Computational and structural biotechnology journal 13 2015 160 168
-
(2015)
Computational and Structural Biotechnology Journal
, vol.13
, pp. 160-168
-
-
Perez-Sen, R.1
Queipo, M.J.2
Morente, V.3
Ortega, F.4
Delicado, E.G.5
Miras-Portugal, M.T.6
-
84
-
-
37249031483
-
Gi-coupled P2Y-ADP receptor mediates GSK-3 phosphorylation and beta-catenin nuclear translocation in granule neurons
-
F. Ortega, R. Perez-Sen, and M.T. Miras-Portugal Gi-coupled P2Y-ADP receptor mediates GSK-3 phosphorylation and beta-catenin nuclear translocation in granule neurons Journal of neurochemistry 104 2008 62 73
-
(2008)
Journal of Neurochemistry
, vol.104
, pp. 62-73
-
-
Ortega, F.1
Perez-Sen, R.2
Miras-Portugal, M.T.3
-
85
-
-
84862764432
-
The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid beta toxicity
-
E. Li, M. Noda, Y. Doi, B. Parajuli, J. Kawanokuchi, Y. Sonobe, H. Takeuchi, T. Mizuno, and A. Suzumura The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid beta toxicity Journal of neuroinflammation 9 2012 148
-
(2012)
Journal of Neuroinflammation
, vol.9
, pp. 148
-
-
Li, E.1
Noda, M.2
Doi, Y.3
Parajuli, B.4
Kawanokuchi, J.5
Sonobe, Y.6
Takeuchi, H.7
Mizuno, T.8
Suzumura, A.9
-
86
-
-
84892773204
-
Fractalkine activates Nrf2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis
-
I. Lastres-Becker, N.G. Innamorato, T. Jaworski, A. Rabano, S. Kugler, F. Van Leuven, and A. Cuadrado Fractalkine activates Nrf2/NFE2L2 and heme oxygenase 1 to restrain tauopathy-induced microgliosis Brain: a journal of neurology 137 2014 78 91
-
(2014)
Brain: A Journal of Neurology
, vol.137
, pp. 78-91
-
-
Lastres-Becker, I.1
Innamorato, N.G.2
Jaworski, T.3
Rabano, A.4
Kugler, S.5
Van Leuven, F.6
Cuadrado, A.7
-
87
-
-
0037695122
-
Human herpesvirus 8-encoded vGPCR activates nuclear factor of activated T cells and collaborates with human immunodeficiency virus type 1 Tat
-
S. Pati, J.S. Foulke Jr., O. Barabitskaya, J. Kim, B.C. Nair, D. Hone, J. Smart, R.A. Feldman, and M. Reitz Human herpesvirus 8-encoded vGPCR activates nuclear factor of activated T cells and collaborates with human immunodeficiency virus type 1 Tat Journal of virology 77 2003 5759 5773
-
(2003)
Journal of Virology
, vol.77
, pp. 5759-5773
-
-
Pati, S.1
Foulke, J.S.2
Barabitskaya, O.3
Kim, J.4
Nair, B.C.5
Hone, D.6
Smart, J.7
Feldman, R.A.8
Reitz, M.9
-
88
-
-
1942489300
-
Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells
-
S.C. McAllister, S.G. Hansen, R.A. Ruhl, C.M. Raggo, V.R. DeFilippis, D. Greenspan, K. Fruh, and A.V. Moses Kaposi sarcoma-associated herpesvirus (KSHV) induces heme oxygenase-1 expression and activity in KSHV-infected endothelial cells Blood 103 2004 3465 3473
-
(2004)
Blood
, vol.103
, pp. 3465-3473
-
-
McAllister, S.C.1
Hansen, S.G.2
Ruhl, R.A.3
Raggo, C.M.4
DeFilippis, V.R.5
Greenspan, D.6
Fruh, K.7
Moses, A.V.8
-
89
-
-
37549054326
-
The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent antiangiogenic agent
-
N. Vannini, G. Lorusso, R. Cammarota, M. Barberis, D.M. Noonan, M.B. Sporn, and A. Albini The synthetic oleanane triterpenoid, CDDO-methyl ester, is a potent antiangiogenic agent Molecular cancer therapeutics 6 2007 3139 3146
-
(2007)
Molecular Cancer Therapeutics
, vol.6
, pp. 3139-3146
-
-
Vannini, N.1
Lorusso, G.2
Cammarota, R.3
Barberis, M.4
Noonan, D.M.5
Sporn, M.B.6
Albini, A.7
-
90
-
-
33744961436
-
Inhibition of heme oxygenase-1 interferes with the transforming activity of the Kaposi sarcoma herpesvirus-encoded G protein-coupled receptor
-
M.J. Marinissen, T. Tanos, M. Bolos, M.R. de Sagarra, O.A. Coso, and A. Cuadrado Inhibition of heme oxygenase-1 interferes with the transforming activity of the Kaposi sarcoma herpesvirus-encoded G protein-coupled receptor The Journal of biological chemistry 281 2006 11332 11346
-
(2006)
The Journal of Biological Chemistry
, vol.281
, pp. 11332-11346
-
-
Marinissen, M.J.1
Tanos, T.2
Bolos, M.3
De Sagarra, M.R.4
Coso, O.A.5
Cuadrado, A.6
-
91
-
-
36348990322
-
The Galpha12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus G protein-coupled receptor to heme oxygenase-1 expression and tumorigenesis
-
M.J. Martin, T. Tanos, A.B. Garcia, D. Martin, J.S. Gutkind, O.A. Coso, and M.J. Marinissen The Galpha12/13 family of heterotrimeric G proteins and the small GTPase RhoA link the Kaposi sarcoma-associated herpes virus G protein-coupled receptor to heme oxygenase-1 expression and tumorigenesis The Journal of biological chemistry 282 2007 34510 34524
-
(2007)
The Journal of Biological Chemistry
, vol.282
, pp. 34510-34524
-
-
Martin, M.J.1
Tanos, T.2
Garcia, A.B.3
Martin, D.4
Gutkind, J.S.5
Coso, O.A.6
Marinissen, M.J.7
-
92
-
-
84901716846
-
Transcription factors Nrf2 and NF-kappaB are coordinated effectors of the Rho family, GTP-binding protein RAC1 during inflammation
-
A. Cuadrado, Z. Martin-Moldes, J. Ye, and I. Lastres-Becker Transcription factors Nrf2 and NF-kappaB are coordinated effectors of the Rho family, GTP-binding protein RAC1 during inflammation The Journal of biological chemistry 289 2014 15244 15258
-
(2014)
The Journal of Biological Chemistry
, vol.289
, pp. 15244-15258
-
-
Cuadrado, A.1
Martin-Moldes, Z.2
Ye, J.3
Lastres-Becker, I.4
-
93
-
-
77956265332
-
Monocyte chemoattractant protein-1/CC chemokine ligand 2 enhances apoptotic cell removal by macrophages through Rac1 activation
-
T. Tanaka, M. Terada, K. Ariyoshi, and K. Morimoto Monocyte chemoattractant protein-1/CC chemokine ligand 2 enhances apoptotic cell removal by macrophages through Rac1 activation Biochemical and biophysical research communications 399 2010 677 682
-
(2010)
Biochemical and Biophysical Research Communications
, vol.399
, pp. 677-682
-
-
Tanaka, T.1
Terada, M.2
Ariyoshi, K.3
Morimoto, K.4
-
94
-
-
79956207794
-
MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades
-
X. Wang, F. Zhang, F. Chen, D. Liu, Y. Zheng, Y. Zhang, C. Dong, and B. Su MEKK3 regulates IFN-gamma production in T cells through the Rac1/2-dependent MAPK cascades Journal of immunology 186 2011 5791 5800
-
(2011)
Journal of Immunology
, vol.186
, pp. 5791-5800
-
-
Wang, X.1
Zhang, F.2
Chen, F.3
Liu, D.4
Zheng, Y.5
Zhang, Y.6
Dong, C.7
Su, B.8
-
95
-
-
79955671904
-
Stimulating nicotinic receptors trigger multiple pathways attenuating cytotoxicity in models of Alzheimers and Parkinsons diseases
-
J. Kawamata, and S. Shimohama Stimulating nicotinic receptors trigger multiple pathways attenuating cytotoxicity in models of Alzheimers and Parkinsons diseases Journal of Alzheimers disease: JAD 24 Suppl 2 2011 95 109
-
(2011)
Journal of Alzheimers Disease: JAD
, vol.24
, pp. 95-109
-
-
Kawamata, J.1
Shimohama, S.2
-
96
-
-
75049085215
-
Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: Role of alpha4 and alpha7 receptors in neuroprotection
-
A. Akaike, Y. Takada-Takatori, T. Kume, and Y. Izumi Mechanisms of neuroprotective effects of nicotine and acetylcholinesterase inhibitors: role of alpha4 and alpha7 receptors in neuroprotection Journal of molecular neuroscience: MN 40 2010 211 216
-
(2010)
Journal of Molecular Neuroscience: MN
, vol.40
, pp. 211-216
-
-
Akaike, A.1
Takada-Takatori, Y.2
Kume, T.3
Izumi, Y.4
-
97
-
-
62949084265
-
Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo
-
R.S. Bitner, A.L. Nikkel, S. Markosyan, S. Otte, P. Puttfarcken, and M. Gopalakrishnan Selective alpha7 nicotinic acetylcholine receptor activation regulates glycogen synthase kinase3beta and decreases tau phosphorylation in vivo Brain research 1265 2009 65 74
-
(2009)
Brain Research
, vol.1265
, pp. 65-74
-
-
Bitner, R.S.1
Nikkel, A.L.2
Markosyan, S.3
Otte, S.4
Puttfarcken, P.5
Gopalakrishnan, M.6
-
98
-
-
84882642320
-
The microglial alpha7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2
-
E. Parada, J. Egea, I. Buendia, P. Negredo, A.C. Cunha, S. Cardoso, M.P. Soares, and M.G. Lopez The microglial alpha7-acetylcholine nicotinic receptor is a key element in promoting neuroprotection by inducing heme oxygenase-1 via nuclear factor erythroid-2-related factor 2 Antioxidants & redox signaling 19 2013 1135 1148
-
(2013)
Antioxidants & Redox Signaling
, vol.19
, pp. 1135-1148
-
-
Parada, E.1
Egea, J.2
Buendia, I.3
Negredo, P.4
Cunha, A.C.5
Cardoso, S.6
Soares, M.P.7
Lopez, M.G.8
-
99
-
-
84893752602
-
Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression
-
E. Parada, I. Buendia, R. Leon, P. Negredo, A. Romero, A. Cuadrado, M.G. Lopez, and J. Egea Neuroprotective effect of melatonin against ischemia is partially mediated by alpha-7 nicotinic receptor modulation and HO-1 overexpression Journal of pineal research 56 2014 204 212
-
(2014)
Journal of Pineal Research
, vol.56
, pp. 204-212
-
-
Parada, E.1
Buendia, I.2
Leon, R.3
Negredo, P.4
Romero, A.5
Cuadrado, A.6
Lopez, M.G.7
Egea, J.8
-
100
-
-
77749336528
-
Amyloid-beta neurotoxicity in organotypic culture is attenuated by melatonin: Involvement of GSK-3beta, tau and neuroinflammation
-
J.B. Hoppe, R.L. Frozza, A.P. Horn, R.A. Comiran, A. Bernardi, M.M. Campos, A.M. Battastini, and C. Salbego Amyloid-beta neurotoxicity in organotypic culture is attenuated by melatonin: involvement of GSK-3beta, tau and neuroinflammation Journal of pineal research 48 2010 230 238
-
(2010)
Journal of Pineal Research
, vol.48
, pp. 230-238
-
-
Hoppe, J.B.1
Frozza, R.L.2
Horn, A.P.3
Comiran, R.A.4
Bernardi, A.5
Campos, M.M.6
Battastini, A.M.7
Salbego, C.8
-
101
-
-
33744495398
-
Apc tumor suppressor gene is the zonation-keeper of mouse liver
-
S. Benhamouche, T. Decaens, C. Godard, R. Chambrey, D.S. Rickman, C. Moinard, M. Vasseur-Cognet, C.J. Kuo, A. Kahn, C. Perret, and S. Colnot Apc tumor suppressor gene is the zonation-keeper of mouse liver Developmental cell 10 2006 759 770
-
(2006)
Developmental Cell
, vol.10
, pp. 759-770
-
-
Benhamouche, S.1
Decaens, T.2
Godard, C.3
Chambrey, R.4
Rickman, D.S.5
Moinard, C.6
Vasseur-Cognet, M.7
Kuo, C.J.8
Kahn, A.9
Perret, C.10
Colnot, S.11
-
102
-
-
0029800090
-
Zonation of parenchymal and nonparenchymal metabolism in liver
-
K. Jungermann, and T. Kietzmann Zonation of parenchymal and nonparenchymal metabolism in liver Annual review of nutrition 16 1996 179 203
-
(1996)
Annual Review of Nutrition
, vol.16
, pp. 179-203
-
-
Jungermann, K.1
Kietzmann, T.2
-
103
-
-
84900553531
-
Role and regulation of beta-catenin signaling during physiological liver growth
-
S.P. Monga Role and regulation of beta-catenin signaling during physiological liver growth Gene expression 16 2014 51 62
-
(2014)
Gene Expression
, vol.16
, pp. 51-62
-
-
Monga, S.P.1
-
106
-
-
78650858373
-
Critical scaffolding regions of the tumor suppressor Axin1 are natively unfolded
-
M. Noutsou, A.M. Duarte, Z. Anvarian, T. Didenko, D.P. Minde, I. Kuper, I. de Ridder, C. Oikonomou, A. Friedler, R. Boelens, S.G. Rudiger, and M.M. Maurice Critical scaffolding regions of the tumor suppressor Axin1 are natively unfolded Journal of molecular biology 405 2011 773 786
-
(2011)
Journal of Molecular Biology
, vol.405
, pp. 773-786
-
-
Noutsou, M.1
Duarte, A.M.2
Anvarian, Z.3
Didenko, T.4
Minde, D.P.5
Kuper, I.6
De Ridder, I.7
Oikonomou, C.8
Friedler, A.9
Boelens, R.10
Rudiger, S.G.11
Maurice, M.M.12
-
107
-
-
84869881653
-
Conditional disruption of Axin1 leads to development of liver tumors in mice
-
G.J. Feng, W. Cotta, X.Q. Wei, O. Poetz, R. Evans, T. Jarde, K. Reed, V. Meniel, G.T. Williams, A.R. Clarke, and T.C. Dale Conditional disruption of Axin1 leads to development of liver tumors in mice Gastroenterology 143 2012 1650 1659
-
(2012)
Gastroenterology
, vol.143
, pp. 1650-1659
-
-
Feng, G.J.1
Cotta, W.2
Wei, X.Q.3
Poetz, O.4
Evans, R.5
Jarde, T.6
Reed, K.7
Meniel, V.8
Williams, G.T.9
Clarke, A.R.10
Dale, T.C.11
-
108
-
-
84923111841
-
WNT-3A Regulates an Axin1/Nrf2 Complex That Regulates Antioxidant Metabolism in Hepatocytes
-
P. Rada, A.I. Rojo, A. Offergeld, G.J. Feng, J.P. Velasco-Martin, J.M. Gonzalez-Sancho, A.M. Valverde, T. Dale, J. Regadera, and A. Cuadrado WNT-3A Regulates an Axin1/Nrf2 Complex That Regulates Antioxidant Metabolism in Hepatocytes Antioxidants & redox signaling 22 2015 555 571
-
(2015)
Antioxidants & Redox Signaling
, vol.22
, pp. 555-571
-
-
Rada, P.1
Rojo, A.I.2
Offergeld, A.3
Feng, G.J.4
Velasco-Martin, J.P.5
Gonzalez-Sancho, J.M.6
Valverde, A.M.7
Dale, T.8
Regadera, J.9
Cuadrado, A.10
-
109
-
-
84872731930
-
Aging-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt/beta-catenin dysregulation
-
F. L'Episcopo, C. Tirolo, N. Testa, S. Caniglia, M.C. Morale, F. Impagnatiello, S. Pluchino, and B. Marchetti Aging-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt/beta-catenin dysregulation The Journal of neuroscience: the official journal of the Society for Neuroscience 33 2013 1462 1485
-
(2013)
The Journal of Neuroscience: The Official Journal of the Society for Neuroscience
, vol.33
, pp. 1462-1485
-
-
L'Episcopo, F.1
Tirolo, C.2
Testa, N.3
Caniglia, S.4
Morale, M.C.5
Impagnatiello, F.6
Pluchino, S.7
Marchetti, B.8
-
110
-
-
1542335553
-
Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol
-
D. Martin, A.I. Rojo, M. Salinas, R. Diaz, G. Gallardo, J. Alam, C.M. De Galarreta, and A. Cuadrado Regulation of heme oxygenase-1 expression through the phosphatidylinositol 3-kinase/Akt pathway and the Nrf2 transcription factor in response to the antioxidant phytochemical carnosol The Journal of biological chemistry 279 2004 8919 8929
-
(2004)
The Journal of Biological Chemistry
, vol.279
, pp. 8919-8929
-
-
Martin, D.1
Rojo, A.I.2
Salinas, M.3
Diaz, R.4
Gallardo, G.5
Alam, J.6
De Galarreta, C.M.7
Cuadrado, A.8
-
111
-
-
77957221943
-
Synthetic triterpenoids attenuate cytotoxic retinal injury: Cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN
-
I. Pitha-Rowe, K. Liby, D. Royce, and M. Sporn Synthetic triterpenoids attenuate cytotoxic retinal injury: cross-talk between Nrf2 and PI3K/AKT signaling through inhibition of the lipid phosphatase PTEN Investigative ophthalmology & visual science 50 2009 5339 5347
-
(2009)
Investigative Ophthalmology & Visual Science
, vol.50
, pp. 5339-5347
-
-
Pitha-Rowe, I.1
Liby, K.2
Royce, D.3
Sporn, M.4
-
112
-
-
84855458875
-
Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3
-
A.I. Rojo, O.N. Medina-Campos, P. Rada, A. Zuniga-Toala, A. Lopez-Gazcon, S. Espada, J. Pedraza-Chaverri, and A. Cuadrado Signaling pathways activated by the phytochemical nordihydroguaiaretic acid contribute to a Keap1-independent regulation of Nrf2 stability: Role of glycogen synthase kinase-3 Free radical biology & medicine 52 2012 473 487
-
(2012)
Free Radical Biology & Medicine
, vol.52
, pp. 473-487
-
-
Rojo, A.I.1
Medina-Campos, O.N.2
Rada, P.3
Zuniga-Toala, A.4
Lopez-Gazcon, A.5
Espada, S.6
Pedraza-Chaverri, J.7
Cuadrado, A.8
-
113
-
-
0037569694
-
Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element
-
E. Balogun, M. Hoque, P. Gong, E. Killeen, C.J. Green, R. Foresti, J. Alam, and R. Motterlini Curcumin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element The Biochemical journal 371 2003 887 895
-
(2003)
The Biochemical Journal
, vol.371
, pp. 887-895
-
-
Balogun, E.1
Hoque, M.2
Gong, P.3
Killeen, E.4
Green, C.J.5
Foresti, R.6
Alam, J.7
Motterlini, R.8
-
114
-
-
84898650544
-
Isoquercitrin inhibits the progression of liver cancer in vivo and in vitro via the MAPK signalling pathway
-
G. Huang, B. Tang, K. Tang, X. Dong, J. Deng, L. Liao, Z. Liao, H. Yang, and S. He Isoquercitrin inhibits the progression of liver cancer in vivo and in vitro via the MAPK signalling pathway Oncology reports 31 2014 2377 2384
-
(2014)
Oncology Reports
, vol.31
, pp. 2377-2384
-
-
Huang, G.1
Tang, B.2
Tang, K.3
Dong, X.4
Deng, J.5
Liao, L.6
Liao, Z.7
Yang, H.8
He, S.9
-
115
-
-
80051795536
-
2′,5′-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways
-
R. Kachadourian, S. Pugazhenthi, K. Velmurugan, D.S. Backos, C.C. Franklin, J.M. McCord, and B.J. Day 2′,5′-Dihydroxychalcone-induced glutathione is mediated by oxidative stress and kinase signaling pathways Free radical biology & medicine 51 2011 1146 1154
-
(2011)
Free Radical Biology & Medicine
, vol.51
, pp. 1146-1154
-
-
Kachadourian, R.1
Pugazhenthi, S.2
Velmurugan, K.3
Backos, D.S.4
Franklin, C.C.5
McCord, J.M.6
Day, B.J.7
-
116
-
-
18844402874
-
Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells
-
C.Y. Chen, J.H. Jang, M.H. Li, and Y.J. Surh Resveratrol upregulates heme oxygenase-1 expression via activation of NF-E2-related factor 2 in PC12 cells Biochemical and biophysical research communications 331 2005 993 1000
-
(2005)
Biochemical and Biophysical Research Communications
, vol.331
, pp. 993-1000
-
-
Chen, C.Y.1
Jang, J.H.2
Li, M.H.3
Surh, Y.J.4
-
117
-
-
37649023810
-
Upregulation of heme oxygenase-1 by brazilin via the phosphatidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury
-
B.M. Choi, and B.R. Kim Upregulation of heme oxygenase-1 by brazilin via the phosphatidylinositol 3-kinase/Akt and ERK pathways and its protective effect against oxidative injury European journal of pharmacology 580 2008 12 18
-
(2008)
European Journal of Pharmacology
, vol.580
, pp. 12-18
-
-
Choi, B.M.1
Kim, B.R.2
-
118
-
-
48049089409
-
(-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells
-
H.K. Na, E.H. Kim, J.H. Jung, H.H. Lee, J.W. Hyun, and Y.J. Surh (-)-Epigallocatechin gallate induces Nrf2-mediated antioxidant enzyme expression via activation of PI3K and ERK in human mammary epithelial cells Archives of biochemistry and biophysics 476 2008 171 177
-
(2008)
Archives of Biochemistry and Biophysics
, vol.476
, pp. 171-177
-
-
Na, H.K.1
Kim, E.H.2
Jung, J.H.3
Lee, H.H.4
Hyun, J.W.5
Surh, Y.J.6
-
119
-
-
46749135955
-
The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress
-
Y.P. Hwang, and H.G. Jeong The coffee diterpene kahweol induces heme oxygenase-1 via the PI3K and p38/Nrf2 pathway to protect human dopaminergic neurons from 6-hydroxydopamine-derived oxidative stress FEBS letters 582 2008 2655 2662
-
(2008)
FEBS Letters
, vol.582
, pp. 2655-2662
-
-
Hwang, Y.P.1
Jeong, H.G.2
-
121
-
-
45049085873
-
Redox-based regulation of signal transduction: Principles, pitfalls, and promises
-
Y.M. Janssen-Heininger, B.T. Mossman, N.H. Heintz, H.J. Forman, B. Kalyanaraman, T. Finkel, J.S. Stamler, S.G. Rhee, and A. van der Vliet Redox-based regulation of signal transduction: principles, pitfalls, and promises Free radical biology & medicine 45 2008 1 17
-
(2008)
Free Radical Biology & Medicine
, vol.45
, pp. 1-17
-
-
Janssen-Heininger, Y.M.1
Mossman, B.T.2
Heintz, N.H.3
Forman, H.J.4
Kalyanaraman, B.5
Finkel, T.6
Stamler, J.S.7
Rhee, S.G.8
Van Der Vliet, A.9
-
122
-
-
1642282736
-
Cellular mechanisms of redox cell signalling: Role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products
-
A.L. Levonen, A. Landar, A. Ramachandran, E.K. Ceaser, D.A. Dickinson, G. Zanoni, J.D. Morrow, and V.M. Darley-Usmar Cellular mechanisms of redox cell signalling: role of cysteine modification in controlling antioxidant defences in response to electrophilic lipid oxidation products The Biochemical journal 378 2004 373 382
-
(2004)
The Biochemical Journal
, vol.378
, pp. 373-382
-
-
Levonen, A.L.1
Landar, A.2
Ramachandran, A.3
Ceaser, E.K.4
Dickinson, D.A.5
Zanoni, G.6
Morrow, J.D.7
Darley-Usmar, V.M.8
-
123
-
-
84897421970
-
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
-
J.D. Hayes, and A.T. Dinkova-Kostova The Nrf2 regulatory network provides an interface between redox and intermediary metabolism Trends in biochemical sciences 39 2014 199 218
-
(2014)
Trends in Biochemical Sciences
, vol.39
, pp. 199-218
-
-
Hayes, J.D.1
Dinkova-Kostova, A.T.2
-
124
-
-
84864348569
-
Nrf2 and cancer: The good, the bad and the importance of context
-
M.B. Sporn, and K.T. Liby Nrf2 and cancer: the good, the bad and the importance of context Nature reviews. Cancer 12 2012 564 571
-
(2012)
Nature Reviews. Cancer
, vol.12
, pp. 564-571
-
-
Sporn, M.B.1
Liby, K.T.2
-
125
-
-
84924953306
-
Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a 'drug-prodrug' mechanism of action
-
J. Egea, I. Buendia, E. Parada, E. Navarro, P. Rada, A. Cuadrado, M.G. Lopez, A.G. Garcia, and R. Leon Melatonin-sulforaphane hybrid ITH12674 induces neuroprotection in oxidative stress conditions by a 'drug-prodrug' mechanism of action British journal of pharmacology 172 2015 1807 1821
-
(2015)
British Journal of Pharmacology
, vol.172
, pp. 1807-1821
-
-
Egea, J.1
Buendia, I.2
Parada, E.3
Navarro, E.4
Rada, P.5
Cuadrado, A.6
Lopez, M.G.7
Garcia, A.G.8
Leon, R.9
-
126
-
-
84925422896
-
Regulation of Nrf2 signaling and longevity in naturally long-lived rodents
-
K.N. Lewis, E. Wason, Y.H. Edrey, D.M. Kristan, E. Nevo, and R. Buffenstein Regulation of Nrf2 signaling and longevity in naturally long-lived rodents Proceedings of the National Academy of Sciences of the United States of America 112 2015 3722 3727
-
(2015)
Proceedings of the National Academy of Sciences of the United States of America
, vol.112
, pp. 3722-3727
-
-
Lewis, K.N.1
Wason, E.2
Edrey, Y.H.3
Kristan, D.M.4
Nevo, E.5
Buffenstein, R.6
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