Aging-induced Nrf2-ARE pathway disruption in the subventricular zone drives neurogenic impairment in parkinsonian mice via PI3K-Wnt/β-catenin dysregulation

Journal of Neuroscience

Volumn 33, Issue 4, 2013, Pages 1462-1485

  L'Episcopo, Francesca ^a,b   Tirolo, Cataldo ^a   Testa, Nunzio ^a   Caniglia, Salvatore ^a   Morale, Maria C ^a   Impagnatiello, Francesco ^c   Pluchino, Stefano ^d   Marchetti, Bianca ^a,b  

^a OASI RESEARCH INSTITUTE IRCCS   (Italy)

^b UNIVERSITY OF CATANIA   (Italy)

^c NicOx Research Institute   (Italy)

^d UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1, 2, 3, 6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; 2 MORPHOLINO 8 PHENYLCHROMONE; AXIN; BETA CATENIN; CASPASE 3; DOPAMINE TRANSPORTER; FLURBIPROFEN 4 NITROXYBUTYL ESTER; FRIZZLED PROTEIN; GLYCOGEN SYNTHASE KINASE 3BETA; HEME OXYGENASE 1; INDUCIBLE NITRIC OXIDE SYNTHASE; NEURON SPECIFIC NUCLEAR PROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; TRANSCRIPTION FACTOR NRF2; TUMOR NECROSIS FACTOR ALPHA; TYROSINE 3 MONOOXYGENASE; UNCLASSIFIED DRUG; WNT PROTEIN;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT RESPONSIVE ELEMENT; ARTICLE; CELL PROLIFERATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; GLIA CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOCYTOCHEMISTRY; IMMUNOFLUORESCENCE TEST; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NICK END LABELING; NONHUMAN; PARKINSONISM; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SUBVENTRICULAR ZONE; WESTERN BLOTTING;

AGING; ANIMALS; BETA CATENIN; BLOTTING, WESTERN; CELLS, CULTURED; COCULTURE TECHNIQUES; IMMUNOHISTOCHEMISTRY; IN SITU NICK-END LABELING; MALE; MESENCEPHALON; MICE; MICE, INBRED C57BL; NEURAL STEM CELLS; NEUROGLIA; NF-E2-RELATED FACTOR 2; PARKINSONIAN DISORDERS; PHOSPHATIDYLINOSITOL 3-KINASES; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WNT SIGNALING PATHWAY;

EID: 84872731930     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3206-12.2013     Document Type: Article

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