PTEN in cancer, metabolism, and aging

Trends in Endocrinology and Metabolism

Volumn 24, Issue 4, 2013, Pages 184-189

  Ortega Molina, Ana ^a   Serrano, Manuel ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

Author keywords

Aging; Brown adipose tissue; Cancer; Metabolism; PTEN; Warburg effect

Indexed keywords

ADENOSINE TRIPHOSPHATE; FORKHEAD TRANSCRIPTION FACTOR; INSULIN; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE 3 KINASE; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR FKHR; TRANSCRIPTION FACTOR FKHRL1; TRANSCRIPTION FACTOR FOXO;

AGING; BROWN ADIPOSE TISSUE; CANCER INHIBITION; CELL PROLIFERATION; CELL SURVIVAL; CHEMICAL CARCINOGENESIS; ENERGY EXPENDITURE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME REGULATION; GENE OVEREXPRESSION; GLYCOLYSIS; INSULIN RESISTANCE; INSULIN SENSITIVITY; LONGEVITY; METABOLISM; NEGATIVE FEEDBACK; NEOPLASM; NONHUMAN; OBESITY; OXIDATIVE PHOSPHORYLATION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; REVIEW; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; TRANSGENIC MOUSE; WEIGHT REDUCTION;

AGING; ANIMALS; HUMANS; NEOPLASMS; PTEN PHOSPHOHYDROLASE;

EID: 84877919960     PISSN: 10432760     EISSN: 18793061     Source Type: Journal    
DOI: 10.1016/j.tem.2012.11.002     Document Type: Review

References (51)

1. Cantley L.C., Neel B.G. New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:4240-4245.
2. Simpson L., Parsons R. PTEN: life as a tumor suppressor. Exp. Cell Res. 2001, 264:29-41.
3. Hollander M.C., et al. PTEN loss in the continuum of common cancers, rare syndromes and mouse models. Nat. Rev. Cancer 2011, 11:289-301.
4. Song M.S., et al. The functions and regulation of the PTEN tumour suppressor. Nat. Rev. Mol. Cell Biol. 2012, 13:283-296.
5. Alimonti A., et al. Subtle variations in Pten dose determine cancer susceptibility. Nat. Genet. 2010, 42:454-458.
6. Chalhoub N., Baker S.J. PTEN and the PI3-kinase pathway in cancer. Annu. Rev. Pathol. 2009, 4:127-150.
7. Maehama T., Dixon J.E. The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate. J. Biol. Chem. 1998, 273:13375-13378.
8. Manning B.D., Cantley L.C. AKT/PKB signaling: navigating downstream. Cell 2007, 129:1261-1274.
9. Zoncu R., et al. mTOR: from growth signal integration to cancer, diabetes and ageing. Nat. Rev. Mol. Cell Biol. 2011, 12:21-35.
10. Hay N. Interplay between FOXO, TOR, and Akt. Biochim. Biophys. Acta 2011, 1813:1965-1970.
11. de Keizer P.L., et al. Forkhead box O as a sensor, mediator, and regulator of redox signaling. Antioxid. Redox Signal. 2011, 14:1093-1106.
12. Ortega-Molina A., et al. Pten positively regulates brown adipose function, energy expenditure, and longevity. Cell Metab. 2012, 15:382-394.
13. Garcia-Cao I., et al. Systemic elevation of PTEN induces a tumor-suppressive metabolic state. Cell 2012, 149:49-62.
14. Pal A., et al. PTEN mutations as a cause of constitutive insulin sensitivity and obesity. N. Engl. J. Med. 2012, 367:1002-1011.
15. Polak P., et al. Adipose-specific knockout of raptor results in lean mice with enhanced mitochondrial respiration. Cell Metab. 2008, 8:399-410.
16. Castaneda T.R., et al. Metabolic control by S6 kinases depends on dietary lipids. PLoS ONE 2012, 7:e32631.
17. Blouet C., et al. Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis. Cell Metab. 2008, 8:459-467.
18. Selman C., et al. Evidence for lifespan extension and delayed age-related biomarkers in insulin receptor substrate 1 null mice. FASEB J. 2008, 22:807-818.
19. Taguchi A., et al. Brain IRS2 signaling coordinates life span and nutrient homeostasis. Science 2007, 317:369-372.
20. Lamming D.W., et al. Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 2012, 335:1638-1643.
21. Harrison D.E., et al. Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009, 460:392-395.
22. Selman C., et al. Ribosomal protein S6 kinase 1 signaling regulates mammalian life span. Science 2009, 326:140-144.
23. Fontana L., et al. Extending healthy life span - from yeast to humans. Science 2010, 328:321-326.
24. Kenyon C.J. The genetics of ageing. Nature 2010, 464:504-512.
25. Breese C.R., et al. Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins. J. Gerontol. 1991, 46:B180-B187.
26. Chung W.H., et al. The role of genetic variants in human longevity. Ageing Res. Rev. 2010, 9(Suppl. 1):S67-S78.
27. Carracedo A., Pandolfi P.P. The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene 2008, 27:5527-5541.
28. Um S.H., et al. Absence of S6K1 protects against age- and diet-induced obesity while enhancing insulin sensitivity. Nature 2004, 431:200-205.
29. Hanahan D., Weinberg R.A. Hallmarks of cancer: the next generation. Cell 2011, 144:646-674.
30. DeBerardinis R.J., et al. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab. 2008, 7:11-20.
31. Jones R.G., Thompson C.B. Tumor suppressors and cell metabolism: a recipe for cancer growth. Genes Dev. 2009, 23:537-548.
32. Puigserver P., Spiegelman B.M. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr. Rev. 2003, 24:78-90.
33. Sun Q., et al. Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:4129-4134.
34. Mor I., et al. Control of glycolysis through regulation of PFK1: old friends and recent additions. Cold Spring Harb. Symp. Quant. Biol. 2011, 76:211-216.
35. Bensaad K., et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell 2006, 126:107-120.
36. Gao P., et al. c-Myc suppression of miR-23a/b enhances mitochondrial glutaminase expression and glutamine metabolism. Nature 2009, 458:762-765.
37. Suzuki S., et al. Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:7461-7466.
38. Hu W., et al. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. Proc. Natl. Acad. Sci. U.S.A. 2010, 107:7455-7460.
39. Song M.S., et al. Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell 2011, 144:187-199.
40. Frontini A., Cinti S. Distribution and development of brown adipocytes in the murine and human adipose organ. Cell Metab. 2010, 11:253-256.
41. Nedergaard J., Cannon B. The changed metabolic world with human brown adipose tissue: therapeutic visions. Cell Metab. 2010, 11:268-272.
42. Cannon B., Nedergaard J. Brown adipose tissue: function and physiological significance. Physiol. Rev. 2004, 84:277-359.
43. Nicholls D.G., Locke R.M. Thermogenic mechanisms in brown fat. Physiol. Rev. 1984, 64:1-64.
44. Kozak L.P., Anunciado-Koza R. UCP1: its involvement and utility in obesity. Int. J. Obes. (Lond.) 2008, 32(Suppl. 7):S32-S38.
45. Seale P., et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J. Clin. Invest. 2011, 121:96-105.
46. Vegiopoulos A., et al. Cyclooxygenase-2 controls energy homeostasis in mice by de novo recruitment of brown adipocytes. Science 2010, 328:1158-1161.
47. Kurtz J.E., Ray-Coquard I. PI3 kinase inhibitors in the clinic: an update. Anticancer Res. 2012, 32:2463-2470.
48. van den Berg S.A., et al. Skeletal muscle mitochondrial uncoupling, adaptive thermogenesis and energy expenditure. Curr. Opin. Clin. Nutr. Metab. Care 2011, 14:243-249.
49. Nedergaard J., et al. Three years with adult human brown adipose tissue. Ann. N. Y. Acad. Sci. 2011, 1212:E20-E36.
50. Mattson M.P. Perspective: does brown fat protect against diseases of aging?. Ageing Res. Rev. 2010, 9:69-76.
51. Altarejos J.Y., Montminy M. CREB and the CRTC co-activators: sensors for hormonal and metabolic signals. Nat. Rev. Mol. Cell Biol. 2011, 12:141-151.