Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway

eLife

Volumn 2015, Issue 4, 2015, Pages 1-31

  Kumari, Sudha ^a,b   Depoil, David ^a,c   Martinelli, Roberta ^d   Judokusumo, Edward ^e   Carmona, Guillaume ^b   Gertler, Frank B ^b   Kam, Lance C ^e   Carman, Christopher V ^d   Burkhardt, Janis K ^f   Irvine, Darrell J ^b   Dustin, Michael L ^a,c  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF OXFORD   (United Kingdom)

^d HARVARD MEDICAL SCHOOL   (United States)

^e Och Spine at New York Presbyterian Hospitals   (United States)

^f UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIBODY; F ACTIN; INTERCELLULAR ADHESION MOLECULE 1; PHOSPHOLIPASE C GAMMA; T LYMPHOCYTE RECEPTOR; WISKOTT ALDRICH SYNDROME PROTEIN; ACTIN;

ACTIN FILAMENT; ACTIN POLYMERIZATION; ANIMAL CELL; ARTICLE; CALCIUM SIGNALING; CONFOCAL MICROSCOPY; CONTROLLED STUDY; FLUORESCENCE MICROSCOPY; GENE INACTIVATION; GENE SILENCING; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; IMAGE ANALYSIS; IMMUNE RESPONSE; IMMUNOHISTOCHEMISTRY; IMMUNOLOGICAL SYNAPSE; MAJOR HISTOCOMPATIBILITY COMPLEX; MOUSE; NONHUMAN; PROTEIN DEFICIENCY; PROTEIN PHOSPHORYLATION; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; WESTERN BLOTTING; ANIMAL; C57BL MOUSE; CELL CULTURE; ENZYME ACTIVATION; ENZYMOLOGY; METABOLISM; POLYMERIZATION;

ACTINS; ANIMALS; CALCIUM SIGNALING; CELLS, CULTURED; ENZYME ACTIVATION; MICE; MICE, INBRED C57BL; PHOSPHOLIPASE C GAMMA; POLYMERIZATION; T-LYMPHOCYTES; WISKOTT-ALDRICH SYNDROME PROTEIN;

EID: 84964694672     PISSN: None     EISSN: 2050084X     Source Type: Journal    
DOI: 10.7554/eLife.04953     Document Type: Article

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