Dissecting temporal and spatial control of cytokinesis with a myosin II inhibitor

Science

Volumn 299, Issue 5613, 2003, Pages 1743-1747

  Straight, Aaron F ^a   Cheung, Amy ^a   Limouze, John ^b   Chen, Irene ^c   Westwood, Nick J ^d   Sellers, James R ^b   Mitchison, Timothy J ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

DRUG PRODUCTS; MUSCLE; SHRINKAGE;

CYTOKINESIS;

CELLS;

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ACTIN; ALSTERPAULLONE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BLEBBISTATIN; BREFELDIN A; LATRUNCULIN A; MYOSIN II; NOCODAZOLE; OLOMOUCINE; PACLITAXEL; PROTEIN INHIBITOR; ROSCOVITINE; STAUROSPORINE; UNCLASSIFIED DRUG;

MEMBRANE; MICROBIOLOGY;

ANAPHASE; ARTICLE; CELL COMMUNICATION; CELL DIVISION; CELL MEMBRANE; CONTROLLED STUDY; CYTOKINESIS; CYTOSKELETON; INHIBITION KINETICS; MICROTUBULE; MICROTUBULE ORGANIZING CENTER; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; REGULATORY MECHANISM;

ANAPHASE; CELL DIVISION; CELL MOVEMENT; CONTRACTILE PROTEINS; CYCLIN-DEPENDENT KINASES; DNA REPLICATION; ENZYME INHIBITORS; HELA CELLS; HETEROCYCLIC COMPOUNDS WITH 4 OR MORE RINGS; HUMANS; KINESIN; LEUPEPTINS; MICROTUBULES; MITOSIS; MYOSIN TYPE II; NOCODAZOLE; PROTEIN-SERINE-THREONINE KINASES; STAUROSPORINE; UBIQUITIN;

EID: 0037436506     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1081412     Document Type: Article

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34. We thank E. M. Ostap for purified myosin Ib; J. Dantzig, A. Shaw, and Y. M. Goldman for rabbit skeletal myosin SI; L. Flanagan and T. Stossel for M2 cells; K. Pierce and M. M.-C. Lo for assistance with chiral chromatography; S. Miller and T. Kapoor for advice on chemical synthesis; T. Kapoor for assistance with aurora kinase inhibitors; and A. Farrell, W. Brieher, and R. Ward for stimulating discussion and critical review of the manuscript. This work was supported by grants from the NIH (GM62566, GM23928) to T.J.M. and from Merck & Co. and E. Merck. A.F.S. was supported by the Cancer Research Fund of the Damon Runyon-Walter Winchell Foundation.