Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes

Journal of Experimental Medicine

Volumn 190, Issue 9, 1999, Pages 1329-1341

  Zhang, Jinyi ^a,c   Shehabeldin, Amro ^a,c   Da Cruz, Luis A G ^a,c   Butler, Jeffrey ^a,c   Somani, Ally Khan ^a,c   McGavin, Mary ^a,c   Kozieradzki, Ivona ^a,b   Dos Santos, Antonio O ^a,b   Nagy, Andras ^a,c   Grinstein, Sergio ^a,c   Penninger, Josef M ^a,b   Siminovitch, Katherine A ^a,c  

^a UNIVERSITY OF TORONTO   (Canada)

^b AMGEN INSTITUTE   (Canada)

^c MOUNT SINAI HOSPITAL   (Canada)

Author keywords

Antigen receptor signaling; Cytoskeletal rearrangement; Immunodeficiency; Lymphocyte activation; Wiskott Aldrich syndrome protein

Indexed keywords

CALCIUM; HERMES ANTIGEN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; LYMPHOCYTE ANTIGEN RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR;

ACTIN POLYMERIZATION; ANIMAL CELL; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOSKELETON; GENE FUNCTION; HEMATOPOIETIC CELL; IMMUNE DEFICIENCY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEFICIENCY; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; T LYMPHOCYTE ACTIVATION; WISKOTT ALDRICH SYNDROME;

ACTINS; ANIMALS; ANTIGENS, CD3; B-LYMPHOCYTES; CELL COUNT; CELL DIFFERENTIATION; CYTOSKELETON; GENE TARGETING; IMMUNOLOGIC CAPPING; INTERLEUKIN-2; LYMPH NODES; LYMPHOCYTE ACTIVATION; MICE; MICE, KNOCKOUT; NEUTROPHILS; PHAGOCYTOSIS; PROTEINS; RECEPTORS, ANTIGEN, T-CELL; SIGNAL TRANSDUCTION; SPLEEN; T-LYMPHOCYTES; WISKOTT-ALDRICH SYNDROME; WISKOTT-ALDRICH SYNDROME PROTEIN;

EID: 0033230229     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.190.9.1329     Document Type: Article

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