-
1
-
-
33947259319
-
Immunosuppressive strategies that are mediated by tumor cells
-
Rabinovich GA, Gabrilovich D, Sotomayor EM. Immunosuppressive strategies that are mediated by tumor cells. Annu Rev Immunol (2007) 25:267-96. doi: 10.1146/annurev.immunol.25.022106.141609.
-
(2007)
Annu Rev Immunol
, vol.25
, pp. 267-296
-
-
Rabinovich, G.A.1
Gabrilovich, D.2
Sotomayor, E.M.3
-
2
-
-
37549061827
-
Creating immune privilege: active local suppression that benefits friends, but protects foes
-
Mellor AL, Munn DH. Creating immune privilege: active local suppression that benefits friends, but protects foes. Nat Rev Immunol (2008) 8:74-80. doi:10.1038/nri2233.
-
(2008)
Nat Rev Immunol
, vol.8
, pp. 74-80
-
-
Mellor, A.L.1
Munn, D.H.2
-
3
-
-
84863594742
-
Cellular constituents of immune escape within the tumor microenvironment
-
Kerkar SP, Restifo NP. Cellular constituents of immune escape within the tumor microenvironment. Cancer Res (2012) 72:3125-30. doi:10.1158/0008-5472.CAN-11-4094.
-
(2012)
Cancer Res
, vol.72
, pp. 3125-3130
-
-
Kerkar, S.P.1
Restifo, N.P.2
-
4
-
-
20244380618
-
Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen
-
Drake CG, Doody AD, Mihalyo MA, Huang CT, Kelleher E, Ravi S, et al. Androgen ablation mitigates tolerance to a prostate/prostate cancer-restricted antigen. Cancer Cell (2005) 7:239-49. doi:10.1016/j.ccr.2005.01.027.
-
(2005)
Cancer Cell
, vol.7
, pp. 239-249
-
-
Drake, C.G.1
Doody, A.D.2
Mihalyo, M.A.3
Huang, C.T.4
Kelleher, E.5
Ravi, S.6
-
5
-
-
51349149926
-
Rapid tolerization of virus-activated tumor-specific CD8+ T cells in prostate tumors of TRAMP mice
-
Bai A, Higham E, Eisen HN, Wittrup KD, Chen J. Rapid tolerization of virus-activated tumor-specific CD8+ T cells in prostate tumors of TRAMP mice. Proc Natl Acad Sci U S A (2008) 105:13003-8. doi:10.1073/pnas.0805599105.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 13003-13008
-
-
Bai, A.1
Higham, E.2
Eisen, H.N.3
Wittrup, K.D.4
Chen, J.5
-
6
-
-
0022446727
-
Interleukin 2 activation of cytotoxic T-lymphocytes infiltrating into human metastatic melanomas
-
Itoh K, Tilden AB, Balch CM. Interleukin 2 activation of cytotoxic T-lymphocytes infiltrating into human metastatic melanomas. Cancer Res (1986) 46:3011-7.
-
(1986)
Cancer Res
, vol.46
, pp. 3011-3017
-
-
Itoh, K.1
Tilden, A.B.2
Balch, C.M.3
-
7
-
-
0028791059
-
Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
-
Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (1995) 270:985-8. doi:10.1126/science.270.5238.985.
-
(1995)
Science
, vol.270
, pp. 985-988
-
-
Waterhouse, P.1
Penninger, J.M.2
Timms, E.3
Wakeham, A.4
Shahinian, A.5
Lee, K.P.6
-
8
-
-
0035863805
-
Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3-and CTLA-4-deficient mice
-
Gozalo-Sanmillan S, McNally JM, Lin MY, Chambers CA, Berg LJ. Cutting edge: two distinct mechanisms lead to impaired T cell homeostasis in Janus kinase 3-and CTLA-4-deficient mice. J Immunol (2001) 166:727-30. doi:10.4049/jimmunol.166.2.727.
-
(2001)
J Immunol
, vol.166
, pp. 727-730
-
-
Gozalo-Sanmillan, S.1
McNally, J.M.2
Lin, M.Y.3
Chambers, C.A.4
Berg, L.J.5
-
9
-
-
84907909000
-
Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4
-
Kuehn HS, Ouyang W, Lo B, Deenick EK, Niemela JE, Avery DT, et al. Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4. Science (2014) 345:1623-7. doi:10.1126/science.1255904.
-
(2014)
Science
, vol.345
, pp. 1623-1627
-
-
Kuehn, H.S.1
Ouyang, W.2
Lo, B.3
Deenick, E.K.4
Niemela, J.E.5
Avery, D.T.6
-
10
-
-
84887862839
-
A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application
-
Okazaki T, Chikuma S, Iwai Y, Fagarasan S, Honjo T. A rheostat for immune responses: the unique properties of PD-1 and their advantages for clinical application. Nat Immunol (2013) 14:1212-8. doi:10.1038/ni.2762.
-
(2013)
Nat Immunol
, vol.14
, pp. 1212-1218
-
-
Okazaki, T.1
Chikuma, S.2
Iwai, Y.3
Fagarasan, S.4
Honjo, T.5
-
11
-
-
49249089425
-
Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways
-
Fife BT, Bluestone JA. Control of peripheral T-cell tolerance and autoimmunity via the CTLA-4 and PD-1 pathways. Immunol Rev (2008) 224:166-82. doi:10.1111/j.1600-065X.2008.00662.x.
-
(2008)
Immunol Rev
, vol.224
, pp. 166-182
-
-
Fife, B.T.1
Bluestone, J.A.2
-
12
-
-
84939793951
-
Immune checkpoint inhibitors for cancer therapy: clinical efficacy and safety
-
Azoury SC, Straughan DM, Shukla V. Immune checkpoint inhibitors for cancer therapy: clinical efficacy and safety. Curr Cancer Drug Targets (2015) 15:452-62. doi:10.2174/156800961506150805145120.
-
(2015)
Curr Cancer Drug Targets
, vol.15
, pp. 452-462
-
-
Azoury, S.C.1
Straughan, D.M.2
Shukla, V.3
-
13
-
-
0035209620
-
International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors
-
Fredholm BB, AP IJ, Jacobson KA, Klotz KN, Linden J. International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors. Pharmacol Rev (2001) 53:527-52.
-
(2001)
Pharmacol Rev
, vol.53
, pp. 527-552
-
-
Fredholm, B.B.1
Ijzerman, A.P.2
Jacobson, K.A.3
Klotz, K.N.4
Linden, J.5
-
14
-
-
49649098562
-
Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production
-
Tripmacher R, Gaber T, Dziurla R, Haupl T, Erekul K, Grutzkau A, et al. Human CD4(+) T cells maintain specific functions even under conditions of extremely restricted ATP production. Eur J Immunol (2008) 38:1631-42. doi:10.1002/eji.200738047.
-
(2008)
Eur J Immunol
, vol.38
, pp. 1631-1642
-
-
Tripmacher, R.1
Gaber, T.2
Dziurla, R.3
Haupl, T.4
Erekul, K.5
Grutzkau, A.6
-
15
-
-
84903277871
-
Integrating canonical and metabolic signalling programmes in the regulation of T cell responses
-
Pollizzi KN, Powell JD. Integrating canonical and metabolic signalling programmes in the regulation of T cell responses. Nat Rev Immunol (2014) 14:435-46. doi:10.1038/nri3701.
-
(2014)
Nat Rev Immunol
, vol.14
, pp. 435-446
-
-
Pollizzi, K.N.1
Powell, J.D.2
-
16
-
-
84894029679
-
Hypoxia-induced and A2A adenosine receptor-independent T-cell suppression is short lived and easily reversible
-
Ohta A, Madasu M, Subramanian M, Kini R, Jones G, Chouker A, et al. Hypoxia-induced and A2A adenosine receptor-independent T-cell suppression is short lived and easily reversible. Int Immunol (2014) 26:83-91. doi:10.1093/intimm/dxt045.
-
(2014)
Int Immunol
, vol.26
, pp. 83-91
-
-
Ohta, A.1
Madasu, M.2
Subramanian, M.3
Kini, R.4
Jones, G.5
Chouker, A.6
-
17
-
-
84920052826
-
Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors
-
Gnad T, Scheibler S, von Kugelgen I, Scheele C, Kilic A, Glode A, et al. Adenosine activates brown adipose tissue and recruits beige adipocytes via A2A receptors. Nature (2014) 516:395-9. doi:10.1038/nature13816.
-
(2014)
Nature
, vol.516
, pp. 395-399
-
-
Gnad, T.1
Scheibler, S.2
von Kugelgen, I.3
Scheele, C.4
Kilic, A.5
Glode, A.6
-
18
-
-
0030785819
-
The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine
-
Blay J, White TD, Hoskin DW. The extracellular fluid of solid carcinomas contains immunosuppressive concentrations of adenosine. Cancer Res (1997) 57:2602-5.
-
(1997)
Cancer Res
, vol.57
, pp. 2602-2605
-
-
Blay, J.1
White, T.D.2
Hoskin, D.W.3
-
19
-
-
33748357735
-
A2A adenosine receptor protects tumors from antitumor T cells
-
Ohta A, Gorelik E, Prasad SJ, Ronchese F, Lukashev D, Wong MK, et al. A2A adenosine receptor protects tumors from antitumor T cells. Proc Natl Acad Sci U S A (2006) 103:13132-7. doi:10.1073/pnas.0605251103.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 13132-13137
-
-
Ohta, A.1
Gorelik, E.2
Prasad, S.J.3
Ronchese, F.4
Lukashev, D.5
Wong, M.K.6
-
20
-
-
2542432162
-
Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors
-
Sitkovsky MV, Lukashev D, Apasov S, Kojima H, Koshiba M, Caldwell C, et al. Physiological control of immune response and inflammatory tissue damage by hypoxia-inducible factors and adenosine A2A receptors. Annu Rev Immunol (2004) 22:657-82. doi:10.1146/annurev.immunol.22.012703.104731.
-
(2004)
Annu Rev Immunol
, vol.22
, pp. 657-682
-
-
Sitkovsky, M.V.1
Lukashev, D.2
Apasov, S.3
Kojima, H.4
Koshiba, M.5
Caldwell, C.6
-
21
-
-
84930026328
-
The hypoxia-adenosinergic immunosuppression and redirection of immune response in tumor microenvironment
-
Gabrilovich DI, Hurwitz AA, editors. New York: Springer
-
Ohta A, Sitkovsky M. The hypoxia-adenosinergic immunosuppression and redirection of immune response in tumor microenvironment. In: Gabrilovich DI, Hurwitz AA, editors. Tumor-Induced Immune Suppression. New York: Springer (2014). doi:10.1007/978-0-387-69118-3.
-
(2014)
Tumor-Induced Immune Suppression
-
-
Ohta, A.1
Sitkovsky, M.2
-
22
-
-
84871048026
-
Purinergic signaling during inflammation
-
Eltzschig HK, Sitkovsky MV, Robson SC. Purinergic signaling during inflammation. N Engl J Med (2012) 367:2322-33. doi:10.1056/NEJMra1205750.
-
(2012)
N Engl J Med
, vol.367
, pp. 2322-2333
-
-
Eltzschig, H.K.1
Sitkovsky, M.V.2
Robson, S.C.3
-
23
-
-
84875700546
-
Adenosine receptors as drug targets - what are the challenges?
-
Chen JF, Eltzschig HK, Fredholm BB. Adenosine receptors as drug targets - what are the challenges? Nat Rev Drug Discov (2013) 12:265-86. doi:10.1038/nrd3955.
-
(2013)
Nat Rev Drug Discov
, vol.12
, pp. 265-286
-
-
Chen, J.F.1
Eltzschig, H.K.2
Fredholm, B.B.3
-
24
-
-
0035924320
-
Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage
-
Ohta A, Sitkovsky M. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage. Nature (2001) 414:916-20. doi:10.1038/414916a.
-
(2001)
Nature
, vol.414
, pp. 916-920
-
-
Ohta, A.1
Sitkovsky, M.2
-
25
-
-
22744450934
-
Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury
-
Thiel M, Chouker A, Ohta A, Jackson E, Caldwell C, Smith P, et al. Oxygenation inhibits the physiological tissue-protecting mechanism and thereby exacerbates acute inflammatory lung injury. PLoS Biol (2005) 3:e174. doi:10.1371/journal.pbio.0030174.
-
(2005)
PLoS Biol
, vol.3
-
-
Thiel, M.1
Chouker, A.2
Ohta, A.3
Jackson, E.4
Caldwell, C.5
Smith, P.6
-
26
-
-
34548398926
-
Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice
-
Mohsenin A, Mi T, Xia Y, Kellems RE, Chen JF, Blackburn MR. Genetic removal of the A2A adenosine receptor enhances pulmonary inflammation, mucin production, and angiogenesis in adenosine deaminase-deficient mice. Am J Physiol Lung Cell Mol Physiol (2007) 293:L753-61. doi:10.1152/ajplung.00187.2007.
-
(2007)
Am J Physiol Lung Cell Mol Physiol
, vol.293
, pp. L753-L761
-
-
Mohsenin, A.1
Mi, T.2
Xia, Y.3
Kellems, R.E.4
Chen, J.F.5
Blackburn, M.R.6
-
27
-
-
34447564893
-
Enhanced airway reactivity and inflammation in A2A adenosine receptor-deficient allergic mice
-
Nadeem A, Fan M, Ansari HR, Ledent C, Jamal Mustafa S. Enhanced airway reactivity and inflammation in A2A adenosine receptor-deficient allergic mice. Am J Physiol Lung Cell Mol Physiol (2007) 292:L1335-44. doi:10.1152/ajplung.00416.2006.
-
(2007)
Am J Physiol Lung Cell Mol Physiol
, vol.292
, pp. L1335-L1344
-
-
Nadeem, A.1
Fan, M.2
Ansari, H.R.3
Ledent, C.4
Jamal Mustafa, S.5
-
28
-
-
65449135161
-
A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence
-
Alam MS, Kurtz CC, Wilson JM, Burnette BR, Wiznerowicz EB, Ross WG, et al. A2A adenosine receptor (AR) activation inhibits pro-inflammatory cytokine production by human CD4+ helper T cells and regulates Helicobacter-induced gastritis and bacterial persistence. Mucosal Immunol (2009) 2:232-42. doi:10.1038/mi.2009.4.
-
(2009)
Mucosal Immunol
, vol.2
, pp. 232-242
-
-
Alam, M.S.1
Kurtz, C.C.2
Wilson, J.M.3
Burnette, B.R.4
Wiznerowicz, E.B.5
Ross, W.G.6
-
29
-
-
84904254163
-
Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor
-
Mittal D, Young A, Stannard K, Yong M, Teng MW, Allard B, et al. Antimetastatic effects of blocking PD-1 and the adenosine A2A receptor. Cancer Res (2014) 74:3652-8. doi:10.1158/0008-5472.CAN-14-0957.
-
(2014)
Cancer Res
, vol.74
, pp. 3652-3658
-
-
Mittal, D.1
Young, A.2
Stannard, K.3
Yong, M.4
Teng, M.W.5
Allard, B.6
-
30
-
-
38049141544
-
A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells
-
Zarek PE, Huang CT, Lutz ER, Kowalski J, Horton MR, Linden J, et al. A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells. Blood (2008) 111:251-9. doi:10.1182/blood-2007-03-081646.
-
(2008)
Blood
, vol.111
, pp. 251-259
-
-
Zarek, P.E.1
Huang, C.T.2
Lutz, E.R.3
Kowalski, J.4
Horton, M.R.5
Linden, J.6
-
31
-
-
77950249826
-
A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironments
-
Ohta A, Ohta A, Madasu M, Kini R, Subramanian M, Goel N, et al. A2A adenosine receptor may allow expansion of T cells lacking effector functions in extracellular adenosine-rich microenvironments. J Immunol (2009) 183:5487-93. doi:10.4049/jimmunol.0901247.
-
(2009)
J Immunol
, vol.183
, pp. 5487-5493
-
-
Ohta, A.1
Ohta, A.2
Madasu, M.3
Kini, R.4
Subramanian, M.5
Goel, N.6
-
32
-
-
33947698009
-
Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition
-
Sevigny CP, Li L, Awad AS, Huang L, McDuffie M, Linden J, et al. Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition. J Immunol (2007) 178:4240-9. doi:10.4049/jimmunol.178.7.4240.
-
(2007)
J Immunol
, vol.178
, pp. 4240-4249
-
-
Sevigny, C.P.1
Li, L.2
Awad, A.S.3
Huang, L.4
McDuffie, M.5
Linden, J.6
-
33
-
-
84871299189
-
The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway
-
Ohta A, Kini R, Ohta A, Subramanian M, Madasu M, Sitkovsky M. The development and immunosuppressive functions of CD4(+) CD25(+) FoxP3(+) regulatory T cells are under influence of the adenosine-A2A adenosine receptor pathway. Front Immunol (2012) 3:190. doi:10.3389/fimmu.2012.00190.
-
(2012)
Front Immunol
, vol.3
, pp. 190
-
-
Ohta, A.1
Kini, R.2
Ohta, A.3
Subramanian, M.4
Madasu, M.5
Sitkovsky, M.6
-
34
-
-
84886432843
-
Targeting CD73 enhances the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs
-
Allard B, Pommey S, Smyth MJ, Stagg J. Targeting CD73 enhances the antitumor activity of anti-PD-1 and anti-CTLA-4 mAbs. Clin Cancer Res (2013) 19:5626-35. doi:10.1158/1078-0432.CCR-13-0545.
-
(2013)
Clin Cancer Res
, vol.19
, pp. 5626-5635
-
-
Allard, B.1
Pommey, S.2
Smyth, M.J.3
Stagg, J.4
-
35
-
-
0033820684
-
Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanisms
-
Hasko G, Kuhel DG, Chen JF, Schwarzschild MA, Deitch EA, Mabley JG, et al. Adenosine inhibits IL-12 and TNF-[alpha] production via adenosine A2a receptor-dependent and independent mechanisms. FASEB J (2000) 14:2065-74. doi:10.1096/fj.99-0508com.
-
(2000)
FASEB J
, vol.14
, pp. 2065-2074
-
-
Hasko, G.1
Kuhel, D.G.2
Chen, J.F.3
Schwarzschild, M.A.4
Deitch, E.A.5
Mabley, J.G.6
-
36
-
-
0038603203
-
Adenosine affects expression of membrane molecules, cytokine and chemokine release, and the T-cell stimulatory capacity of human dendritic cells
-
Panther E, Corinti S, Idzko M, Herouy Y, Napp M, la Sala A, et al. Adenosine affects expression of membrane molecules, cytokine and chemokine release, and the T-cell stimulatory capacity of human dendritic cells. Blood (2003) 101:3985-90. doi:10.1182/blood-2002-07-2113.
-
(2003)
Blood
, vol.101
, pp. 3985-3990
-
-
Panther, E.1
Corinti, S.2
Idzko, M.3
Herouy, Y.4
Napp, M.5
la Sala, A.6
-
37
-
-
84918577973
-
Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment
-
Cekic C, Day YJ, Sag D, Linden J. Myeloid expression of adenosine A2A receptor suppresses T and NK cell responses in the solid tumor microenvironment. Cancer Res (2014) 74:7250-9. doi:10.1158/0008-5472.CAN-13-3583.
-
(2014)
Cancer Res
, vol.74
, pp. 7250-7259
-
-
Cekic, C.1
Day, Y.J.2
Sag, D.3
Linden, J.4
-
38
-
-
84918545478
-
Adenosine A2A receptors intrinsically regulate CD8+ T cells in the tumor microenvironment
-
Cekic C, Linden J. Adenosine A2A receptors intrinsically regulate CD8+ T cells in the tumor microenvironment. Cancer Res (2014) 74:7239-49. doi:10.1158/0008-5472.CAN-13-3581.
-
(2014)
Cancer Res
, vol.74
, pp. 7239-7249
-
-
Cekic, C.1
Linden, J.2
-
39
-
-
84871839897
-
Adenosine A(2)A receptor agonist-mediated increase in donor-derived regulatory T cells suppresses development of graft-versus-host disease
-
Han KL, Thomas SV, Koontz SM, Changpriroa CM, Ha SK, Malech HL, et al. Adenosine A(2)A receptor agonist-mediated increase in donor-derived regulatory T cells suppresses development of graft-versus-host disease. J Immunol (2013) 190:458-68. doi:10.4049/jimmunol.1201325.
-
(2013)
J Immunol
, vol.190
, pp. 458-468
-
-
Han, K.L.1
Thomas, S.V.2
Koontz, S.M.3
Changpriroa, C.M.4
Ha, S.K.5
Malech, H.L.6
-
40
-
-
84885452753
-
Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice
-
Lee DJ, Taylor AW. Both MC5r and A2Ar are required for protective regulatory immunity in the spleen of post-experimental autoimmune uveitis in mice. J Immunol (2013) 191:4103-11. doi:10.4049/jimmunol.1300182.
-
(2013)
J Immunol
, vol.191
, pp. 4103-4111
-
-
Lee, D.J.1
Taylor, A.W.2
-
41
-
-
84905657094
-
Extracellular adenosine-mediated modulation of regulatory T cells
-
Ohta A, Sitkovsky M. Extracellular adenosine-mediated modulation of regulatory T cells. Front Immunol (2014) 5:304. doi:10.3389/fimmu.2014.00304.
-
(2014)
Front Immunol
, vol.5
, pp. 304
-
-
Ohta, A.1
Sitkovsky, M.2
-
42
-
-
84865964344
-
Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection
-
Kinsey GR, Huang L, Jaworska K, Khutsishvili K, Becker DA, Ye H, et al. Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection. J Am Soc Nephrol (2012) 23:1528-37. doi:10.1681/ASN.2012010070.
-
(2012)
J Am Soc Nephrol
, vol.23
, pp. 1528-1537
-
-
Kinsey, G.R.1
Huang, L.2
Jaworska, K.3
Khutsishvili, K.4
Becker, D.A.5
Ye, H.6
-
43
-
-
49649091999
-
Modulation of murine dendritic cell function by adenine nucleotides and adenosine: involvement of the A(2B) receptor
-
Ben Addi A, Lefort A, Hua X, Libert F, Communi D, Ledent C, et al. Modulation of murine dendritic cell function by adenine nucleotides and adenosine: involvement of the A(2B) receptor. Eur J Immunol (2008) 38:1610-20. doi:10.1002/eji.200737781.
-
(2008)
Eur J Immunol
, vol.38
, pp. 1610-1620
-
-
Ben Addi, A.1
Lefort, A.2
Hua, X.3
Libert, F.4
Communi, D.5
Ledent, C.6
-
44
-
-
52649138296
-
Adenosine receptors in regulation of dendritic cell differentiation and function
-
Novitskiy SV, Ryzhov S, Zaynagetdinov R, Goldstein AE, Huang Y, Tikhomirov OY, et al. Adenosine receptors in regulation of dendritic cell differentiation and function. Blood (2008) 112:1822-31. doi:10.1182/blood-2008-02-136325.
-
(2008)
Blood
, vol.112
, pp. 1822-1831
-
-
Novitskiy, S.V.1
Ryzhov, S.2
Zaynagetdinov, R.3
Goldstein, A.E.4
Huang, Y.5
Tikhomirov, O.Y.6
-
45
-
-
84855369818
-
Adenosine promotes alternative macrophage activation via A2A and A2B receptors
-
Csoka B, Selmeczy Z, Koscso B, Nemeth ZH, Pacher P, Murray PJ, et al. Adenosine promotes alternative macrophage activation via A2A and A2B receptors. FASEB J (2012) 26:376-86. doi:10.1096/fj.11-190934.
-
(2012)
FASEB J
, vol.26
, pp. 376-386
-
-
Csoka, B.1
Selmeczy, Z.2
Koscso, B.3
Nemeth, Z.H.4
Pacher, P.5
Murray, P.J.6
-
46
-
-
82755162136
-
Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells
-
Ryzhov S, Novitskiy SV, Goldstein AE, Biktasova A, Blackburn MR, Biaggioni I, et al. Adenosinergic regulation of the expansion and immunosuppressive activity of CD11b+Gr1+ cells. J Immunol (2011) 187:6120-9. doi:10.4049/jimmunol.1101225.
-
(2011)
J Immunol
, vol.187
, pp. 6120-6129
-
-
Ryzhov, S.1
Novitskiy, S.V.2
Goldstein, A.E.3
Biktasova, A.4
Blackburn, M.R.5
Biaggioni, I.6
-
47
-
-
84891612009
-
Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma
-
Iannone R, Miele L, Maiolino P, Pinto A, Morello S. Blockade of A2b adenosine receptor reduces tumor growth and immune suppression mediated by myeloid-derived suppressor cells in a mouse model of melanoma. Neoplasia (2013) 15:1400-9. doi:10.1593/neo.131748.
-
(2013)
Neoplasia
, vol.15
, pp. 1400-1409
-
-
Iannone, R.1
Miele, L.2
Maiolino, P.3
Pinto, A.4
Morello, S.5
-
48
-
-
50949115838
-
Host A(2B) adenosine receptors promote carcinoma growth
-
Ryzhov S, Novitskiy SV, Zaynagetdinov R, Goldstein AE, Carbone DP, Biaggioni I, et al. Host A(2B) adenosine receptors promote carcinoma growth. Neoplasia (2008) 10:987-95. doi:10.1593/neo.08478.
-
(2008)
Neoplasia
, vol.10
, pp. 987-995
-
-
Ryzhov, S.1
Novitskiy, S.V.2
Zaynagetdinov, R.3
Goldstein, A.E.4
Carbone, D.P.5
Biaggioni, I.6
-
49
-
-
84855408091
-
Adenosine A2B receptor blockade slows growth of bladder and breast tumors
-
Cekic C, Sag D, Li Y, Theodorescu D, Strieter RM, Linden J. Adenosine A2B receptor blockade slows growth of bladder and breast tumors. J Immunol (2012) 188:198-205. doi:10.4049/jimmunol.1101845.
-
(2012)
J Immunol
, vol.188
, pp. 198-205
-
-
Cekic, C.1
Sag, D.2
Li, Y.3
Theodorescu, D.4
Strieter, R.M.5
Linden, J.6
-
50
-
-
84896468409
-
Adenosine A(2B) receptor antagonist PSB603 suppresses tumor growth and metastasis by inhibiting induction of regulatory T cells
-
Kaji W, Tanaka S, Tsukimoto M, Kojima S. Adenosine A(2B) receptor antagonist PSB603 suppresses tumor growth and metastasis by inhibiting induction of regulatory T cells. J Toxicol Sci (2014) 39:191-8. doi:10.2131/jts.39.191.
-
(2014)
J Toxicol Sci
, vol.39
, pp. 191-198
-
-
Kaji, W.1
Tanaka, S.2
Tsukimoto, M.3
Kojima, S.4
-
51
-
-
33646074537
-
Ecto-5'-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury
-
Volmer JB, Thompson LF, Blackburn MR. Ecto-5'-nucleotidase (CD73)-mediated adenosine production is tissue protective in a model of bleomycin-induced lung injury. J Immunol (2006) 176:4449-58. doi:10.4049/jimmunol.176.7.4449.
-
(2006)
J Immunol
, vol.176
, pp. 4449-4458
-
-
Volmer, J.B.1
Thompson, L.F.2
Blackburn, M.R.3
-
52
-
-
36048976376
-
Lack of effect of extracellular adenosine generation and signaling on renal erythropoietin secretion during hypoxia
-
Grenz A, Zhang H, Weingart J, von Wietersheim S, Eckle T, Schnermann J, et al. Lack of effect of extracellular adenosine generation and signaling on renal erythropoietin secretion during hypoxia. Am J Physiol Renal Physiol (2007) 293:F1501-11. doi:10.1152/ajprenal.00243.2007.
-
(2007)
Am J Physiol Renal Physiol
, vol.293
, pp. F1501-F1511
-
-
Grenz, A.1
Zhang, H.2
Weingart, J.3
von Wietersheim, S.4
Eckle, T.5
Schnermann, J.6
-
53
-
-
85047685683
-
Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia
-
Synnestvedt K, Furuta GT, Comerford KM, Louis N, Karhausen J, Eltzschig HK, et al. Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. J Clin Invest (2002) 110:993-1002. doi:10.1172/JCI15337.
-
(2002)
J Clin Invest
, vol.110
, pp. 993-1002
-
-
Synnestvedt, K.1
Furuta, G.T.2
Comerford, K.M.3
Louis, N.4
Karhausen, J.5
Eltzschig, H.K.6
-
54
-
-
10244222236
-
Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism
-
Eltzschig HK, Thompson LF, Karhausen J, Cotta RJ, Ibla JC, Robson SC, et al. Endogenous adenosine produced during hypoxia attenuates neutrophil accumulation: coordination by extracellular nucleotide metabolism. Blood (2004) 104:3986-92. doi:10.1182/blood-2004-06-2066.
-
(2004)
Blood
, vol.104
, pp. 3986-3992
-
-
Eltzschig, H.K.1
Thompson, L.F.2
Karhausen, J.3
Cotta, R.J.4
Ibla, J.C.5
Robson, S.C.6
-
55
-
-
0033954723
-
Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport
-
Kobayashi S, Zimmermann H, Millhorn DE. Chronic hypoxia enhances adenosine release in rat PC12 cells by altering adenosine metabolism and membrane transport. J Neurochem (2000) 74:621-32. doi:10.1046/j.1471-4159.2000.740621.x.
-
(2000)
J Neurochem
, vol.74
, pp. 621-632
-
-
Kobayashi, S.1
Zimmermann, H.2
Millhorn, D.E.3
-
56
-
-
47049088629
-
HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak
-
Morote-Garcia JC, Rosenberger P, Kuhlicke J, Eltzschig HK. HIF-1-dependent repression of adenosine kinase attenuates hypoxia-induced vascular leak. Blood (2008) 111:5571-80. doi:10.1182/blood-2007-11-126763.
-
(2008)
Blood
, vol.111
, pp. 5571-5580
-
-
Morote-Garcia, J.C.1
Rosenberger, P.2
Kuhlicke, J.3
Eltzschig, H.K.4
-
57
-
-
20444467085
-
Inflammatory hypoxia: role of hypoxia-inducible factor
-
Karhausen J, Haase VH, Colgan SP. Inflammatory hypoxia: role of hypoxia-inducible factor. Cell Cycle (2005) 4:256-8. doi:10.4161/cc.4.2.1407.
-
(2005)
Cell Cycle
, vol.4
, pp. 256-258
-
-
Karhausen, J.1
Haase, V.H.2
Colgan, S.P.3
-
58
-
-
19544391973
-
The 'danger' sensors that STOP the immune response: the A2 adenosine receptors?
-
Sitkovsky MV, Ohta A. The 'danger' sensors that STOP the immune response: the A2 adenosine receptors? Trends Immunol (2005) 26:299-304. doi:10.1016/j.it.2005.04.004.
-
(2005)
Trends Immunol
, vol.26
, pp. 299-304
-
-
Sitkovsky, M.V.1
Ohta, A.2
-
60
-
-
0032806312
-
Renal interstitial concentration of adenosine during endotoxin shock
-
Nishiyama A, Miura K, Miyatake A, Fujisawa Y, Yue W, Fukui T, et al. Renal interstitial concentration of adenosine during endotoxin shock. Eur J Pharmacol (1999) 385:209-16. doi:10.1016/S0014-2999(99)00716-5.
-
(1999)
Eur J Pharmacol
, vol.385
, pp. 209-216
-
-
Nishiyama, A.1
Miura, K.2
Miyatake, A.3
Fujisawa, Y.4
Yue, W.5
Fukui, T.6
-
61
-
-
0033801235
-
High adenosine plasma concentration as a prognostic index for outcome in patients with septic shock
-
Martin C, Leone M, Viviand X, Ayem ML, Guieu R. High adenosine plasma concentration as a prognostic index for outcome in patients with septic shock. Crit Care Med (2000) 28:3198-202. doi:10.1097/00003246-200009000-00014.
-
(2000)
Crit Care Med
, vol.28
, pp. 3198-3202
-
-
Martin, C.1
Leone, M.2
Viviand, X.3
Ayem, M.L.4
Guieu, R.5
-
62
-
-
0030698058
-
Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptors
-
Montesinos MC, Gadangi P, Longaker M, Sung J, Levine J, Nilsen D, et al. Wound healing is accelerated by agonists of adenosine A2 (G alpha s-linked) receptors. J Exp Med (1997) 186:1615-20. doi:10.1084/jem.186.9.1615.
-
(1997)
J Exp Med
, vol.186
, pp. 1615-1620
-
-
Montesinos, M.C.1
Gadangi, P.2
Longaker, M.3
Sung, J.4
Levine, J.5
Nilsen, D.6
-
63
-
-
0036087210
-
Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors
-
Montesinos MC, Desai A, Chen JF, Yee H, Schwarzschild MA, Fink JS, et al. Adenosine promotes wound healing and mediates angiogenesis in response to tissue injury via occupancy of A(2A) receptors. Am J Pathol (2002) 160:2009-18. doi:10.1016/S0002-9440(10)61151-0.
-
(2002)
Am J Pathol
, vol.160
, pp. 2009-2018
-
-
Montesinos, M.C.1
Desai, A.2
Chen, J.F.3
Yee, H.4
Schwarzschild, M.A.5
Fink, J.S.6
-
64
-
-
34250155915
-
Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury
-
Eckle T, Fullbier L, Wehrmann M, Khoury J, Mittelbronn M, Ibla J, et al. Identification of ectonucleotidases CD39 and CD73 in innate protection during acute lung injury. J Immunol (2007) 178:8127-37. doi:10.4049/jimmunol.178.12.8127.
-
(2007)
J Immunol
, vol.178
, pp. 8127-8137
-
-
Eckle, T.1
Fullbier, L.2
Wehrmann, M.3
Khoury, J.4
Mittelbronn, M.5
Ibla, J.6
-
65
-
-
44849106271
-
Control of IFN-alphaA by CD73: implications for mucosal inflammation
-
Louis NA, Robinson AM, MacManus CF, Karhausen J, Scully M, Colgan SP. Control of IFN-alphaA by CD73: implications for mucosal inflammation. J Immunol (2008) 180:4246-55. doi:10.4049/jimmunol.180.6.4246.
-
(2008)
J Immunol
, vol.180
, pp. 4246-4255
-
-
Louis, N.A.1
Robinson, A.M.2
MacManus, C.F.3
Karhausen, J.4
Scully, M.5
Colgan, S.P.6
-
66
-
-
77955508266
-
Ecto-5'-nucleotidase (CD73) attenuates allograft airway rejection through adenosine 2A receptor stimulation
-
Ohtsuka T, Changelian PS, Bouis D, Noon K, Harada H, Lama VN, et al. Ecto-5'-nucleotidase (CD73) attenuates allograft airway rejection through adenosine 2A receptor stimulation. J Immunol (2010) 185:1321-9. doi:10.4049/jimmunol.0901847.
-
(2010)
J Immunol
, vol.185
, pp. 1321-1329
-
-
Ohtsuka, T.1
Changelian, P.S.2
Bouis, D.3
Noon, K.4
Harada, H.5
Lama, V.N.6
-
67
-
-
79954576658
-
CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis
-
Stagg J, Divisekera U, Duret H, Sparwasser T, Teng MW, Darcy PK, et al. CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis. Cancer Res (2011) 71:2892-900. doi:10.1158/0008-5472.CAN-10-4246.
-
(2011)
Cancer Res
, vol.71
, pp. 2892-2900
-
-
Stagg, J.1
Divisekera, U.2
Duret, H.3
Sparwasser, T.4
Teng, M.W.5
Darcy, P.K.6
-
68
-
-
84860382842
-
CD73-deficient mice are resistant to carcinogenesis
-
Stagg J, Beavis PA, Divisekera U, Liu MC, Moller A, Darcy PK, et al. CD73-deficient mice are resistant to carcinogenesis. Cancer Res (2012) 72:2190-6. doi:10.1158/0008-5472.CAN-12-0420.
-
(2012)
Cancer Res
, vol.72
, pp. 2190-2196
-
-
Stagg, J.1
Beavis, P.A.2
Divisekera, U.3
Liu, M.C.4
Moller, A.5
Darcy, P.K.6
-
69
-
-
84860538096
-
Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host disease
-
Tsukamoto H, Chernogorova P, Ayata K, Gerlach UV, Rughani A, Ritchey JW, et al. Deficiency of CD73/ecto-5'-nucleotidase in mice enhances acute graft-versus-host disease. Blood (2012) 119:4554-64. doi:10.1182/blood-2011-09-375899.
-
(2012)
Blood
, vol.119
, pp. 4554-4564
-
-
Tsukamoto, H.1
Chernogorova, P.2
Ayata, K.3
Gerlach, U.V.4
Rughani, A.5
Ritchey, J.W.6
-
70
-
-
33750832563
-
T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine
-
Kobie JJ, Shah PR, Yang L, Rebhahn JA, Fowell DJ, Mosmann TR. T regulatory and primed uncommitted CD4 T cells express CD73, which suppresses effector CD4 T cells by converting 5'-adenosine monophosphate to adenosine. J Immunol (2006) 177:6780-6. doi:10.4049/jimmunol.177.10.6780.
-
(2006)
J Immunol
, vol.177
, pp. 6780-6786
-
-
Kobie, J.J.1
Shah, P.R.2
Yang, L.3
Rebhahn, J.A.4
Fowell, D.J.5
Mosmann, T.R.6
-
71
-
-
34250351459
-
Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
-
Deaglio S, Dwyer KM, Gao W, Friedman D, Usheva A, Erat A, et al. Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med (2007) 204:1257-65. doi:10.1084/jem.20062512.
-
(2007)
J Exp Med
, vol.204
, pp. 1257-1265
-
-
Deaglio, S.1
Dwyer, K.M.2
Gao, W.3
Friedman, D.4
Usheva, A.5
Erat, A.6
-
72
-
-
70350231926
-
Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancer
-
Mandapathil M, Szczepanski MJ, Szajnik M, Ren J, Lenzner DE, Jackson EK, et al. Increased ectonucleotidase expression and activity in regulatory T cells of patients with head and neck cancer. Clin Cancer Res (2009) 15:6348-57. doi:10.1158/1078-0432.CCR-09-1143.
-
(2009)
Clin Cancer Res
, vol.15
, pp. 6348-6357
-
-
Mandapathil, M.1
Szczepanski, M.J.2
Szajnik, M.3
Ren, J.4
Lenzner, D.E.5
Jackson, E.K.6
-
73
-
-
0028124867
-
Ecto-5'-nucleotidase (CD73) in multidrug-resistant cell lines generated by doxorubicin
-
Ujhazy P, Klobusicka M, Babusikova O, Strausbauch P, Mihich E, Ehrke MJ. Ecto-5'-nucleotidase (CD73) in multidrug-resistant cell lines generated by doxorubicin. Int J Cancer (1994) 59:83-93. doi:10.1002/ijc.2910590117.
-
(1994)
Int J Cancer
, vol.59
, pp. 83-93
-
-
Ujhazy, P.1
Klobusicka, M.2
Babusikova, O.3
Strausbauch, P.4
Mihich, E.5
Ehrke, M.J.6
-
74
-
-
33746116078
-
Expression of ecto-5'-nucleotidase (eN, CD73) in cell lines from various stages of human melanoma
-
Sadej R, Spychala J, Skladanowski AC. Expression of ecto-5'-nucleotidase (eN, CD73) in cell lines from various stages of human melanoma. Melanoma Res (2006) 16:213-22. doi:10.1097/01.cmr.0000215030.69823.11.
-
(2006)
Melanoma Res
, vol.16
, pp. 213-222
-
-
Sadej, R.1
Spychala, J.2
Skladanowski, A.C.3
-
75
-
-
34548435229
-
RNA interference of ecto-5'-nucleotidase (CD73) inhibits human breast cancer cell growth and invasion
-
Zhi X, Chen S, Zhou P, Shao Z, Wang L, Ou Z, et al. RNA interference of ecto-5'-nucleotidase (CD73) inhibits human breast cancer cell growth and invasion. Clin Exp Metastasis (2007) 24:439-48. doi:10.1007/s10585-007-9081-y.
-
(2007)
Clin Exp Metastasis
, vol.24
, pp. 439-448
-
-
Zhi, X.1
Chen, S.2
Zhou, P.3
Shao, Z.4
Wang, L.5
Ou, Z.6
-
76
-
-
79959450187
-
New markers for minimal residual disease detection in acute lymphoblastic leukemia
-
Coustan-Smith E, Song G, Clark C, Key L, Liu P, Mehrpooya M, et al. New markers for minimal residual disease detection in acute lymphoblastic leukemia. Blood (2011) 117:6267-76. doi:10.1182/blood-2010-12-324004.
-
(2011)
Blood
, vol.117
, pp. 6267-6276
-
-
Coustan-Smith, E.1
Song, G.2
Clark, C.3
Key, L.4
Liu, P.5
Mehrpooya, M.6
-
77
-
-
80054109170
-
Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity
-
Hausler SF, Montalban del Barrio I, Strohschein J, Anoop Chandran P, Engel JB, Honig A, et al. Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity. Cancer Immunol Immunother (2011) 60:1405-18. doi:10.1007/s00262-011-1040-4.
-
(2011)
Cancer Immunol Immunother
, vol.60
, pp. 1405-1418
-
-
Hausler, S.F.1
Montalban del Barrio, I.2
Strohschein, J.3
Anoop Chandran, P.4
Engel, J.B.5
Honig, A.6
-
78
-
-
82955217840
-
CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death
-
Serra S, Horenstein AL, Vaisitti T, Brusa D, Rossi D, Laurenti L, et al. CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death. Blood (2011) 118:6141-52. doi:10.1182/blood-2011-08-374728.
-
(2011)
Blood
, vol.118
, pp. 6141-6152
-
-
Serra, S.1
Horenstein, A.L.2
Vaisitti, T.3
Brusa, D.4
Rossi, D.5
Laurenti, L.6
-
79
-
-
84879705407
-
CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer
-
Loi S, Pommey S, Haibe-Kains B, Beavis PA, Darcy PK, Smyth MJ, et al. CD73 promotes anthracycline resistance and poor prognosis in triple negative breast cancer. Proc Natl Acad Sci U S A (2013) 110:11091-6. doi:10.1073/pnas.1222251110.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 11091-11096
-
-
Loi, S.1
Pommey, S.2
Haibe-Kains, B.3
Beavis, P.A.4
Darcy, P.K.5
Smyth, M.J.6
-
80
-
-
84870424506
-
5'-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells
-
Quezada C, Garrido W, Oyarzun C, Fernandez K, Segura R, Melo R, et al. 5'-ectonucleotidase mediates multiple-drug resistance in glioblastoma multiforme cells. J Cell Physiol (2013) 228:602-8. doi:10.1002/jcp.24168.
-
(2013)
J Cell Physiol
, vol.228
, pp. 602-608
-
-
Quezada, C.1
Garrido, W.2
Oyarzun, C.3
Fernandez, K.4
Segura, R.5
Melo, R.6
-
81
-
-
84885140969
-
Overexpression of CD73 in prostate cancer is associated with lymph node metastasis
-
Yang Q, Du J, Zu L. Overexpression of CD73 in prostate cancer is associated with lymph node metastasis. Pathol Oncol Res (2013) 19:811-4. doi:10.1007/s12253-013-9648-7.
-
(2013)
Pathol Oncol Res
, vol.19
, pp. 811-814
-
-
Yang, Q.1
Du, J.2
Zu, L.3
-
82
-
-
84954542005
-
CD73 expression is an independent prognostic factor in prostate cancer
-
Leclerc BG, Charlebois R, Chouinard G, Allard B, Pommey S, Saad F, et al. CD73 expression is an independent prognostic factor in prostate cancer. Clin Cancer Res (2016) 22:158-66. doi:10.1158/1078-0432.CCR-15-1181.
-
(2016)
Clin Cancer Res
, vol.22
, pp. 158-166
-
-
Leclerc, B.G.1
Charlebois, R.2
Chouinard, G.3
Allard, B.4
Pommey, S.5
Saad, F.6
-
83
-
-
84946599682
-
CD73 is associated with poor prognosis in high-grade serous ovarian cancer
-
Turcotte M, Spring K, Pommey S, Chouinard G, Cousineau I, George J, et al. CD73 is associated with poor prognosis in high-grade serous ovarian cancer. Cancer Res (2015) 75:4494-503. doi:10.1158/0008-5472.CAN-14-3569.
-
(2015)
Cancer Res
, vol.75
, pp. 4494-4503
-
-
Turcotte, M.1
Spring, K.2
Pommey, S.3
Chouinard, G.4
Cousineau, I.5
George, J.6
-
84
-
-
75949112218
-
Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis
-
Stagg J, Divisekera U, McLaughlin N, Sharkey J, Pommey S, Denoyer D, et al. Anti-CD73 antibody therapy inhibits breast tumor growth and metastasis. Proc Natl Acad Sci U S A (2010) 107:1547-52. doi:10.1073/pnas.0908801107.
-
(2010)
Proc Natl Acad Sci U S A
, vol.107
, pp. 1547-1552
-
-
Stagg, J.1
Divisekera, U.2
McLaughlin, N.3
Sharkey, J.4
Pommey, S.5
Denoyer, D.6
-
85
-
-
84885437317
-
Anti-human CD73 monoclonal antibody inhibits metastasis formation in human breast cancer by inducing clustering and internalization of CD73 expressed on the surface of cancer cells
-
Terp MG, Olesen KA, Arnspang EC, Lund RR, Lagerholm BC, Ditzel HJ, et al. Anti-human CD73 monoclonal antibody inhibits metastasis formation in human breast cancer by inducing clustering and internalization of CD73 expressed on the surface of cancer cells. J Immunol (2013) 191:4165-73. doi:10.4049/jimmunol.1301274.
-
(2013)
J Immunol
, vol.191
, pp. 4165-4173
-
-
Terp, M.G.1
Olesen, K.A.2
Arnspang, E.C.3
Lund, R.R.4
Lagerholm, B.C.5
Ditzel, H.J.6
-
86
-
-
77950231071
-
CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression
-
Jin D, Fan J, Wang L, Thompson LF, Liu A, Daniel BJ, et al. CD73 on tumor cells impairs antitumor T-cell responses: a novel mechanism of tumor-induced immune suppression. Cancer Res (2010) 70:2245-55. doi:10.1158/0008-5472.CAN-09-3109.
-
(2010)
Cancer Res
, vol.70
, pp. 2245-2255
-
-
Jin, D.1
Fan, J.2
Wang, L.3
Thompson, L.F.4
Liu, A.5
Daniel, B.J.6
-
87
-
-
77956134431
-
CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice
-
Sun X, Wu Y, Gao W, Enjyoji K, Csizmadia E, Muller CE, et al. CD39/ENTPD1 expression by CD4+Foxp3+ regulatory T cells promotes hepatic metastatic tumor growth in mice. Gastroenterology (2010) 139:1030-40. doi:10.1053/j.gastro.2010.05.007.
-
(2010)
Gastroenterology
, vol.139
, pp. 1030-1040
-
-
Sun, X.1
Wu, Y.2
Gao, W.3
Enjyoji, K.4
Csizmadia, E.5
Muller, C.E.6
-
88
-
-
84937874129
-
Inhibition of CD39 enzymatic function at the surface of tumor cells alleviates their immunosuppressive activity
-
Bastid J, Regairaz A, Bonnefoy N, Dejou C, Giustiniani J, Laheurte C, et al. Inhibition of CD39 enzymatic function at the surface of tumor cells alleviates their immunosuppressive activity. Cancer Immunol Res (2015) 3:254-65. doi:10.1158/2326-6066.CIR-14-0018.
-
(2015)
Cancer Immunol Res
, vol.3
, pp. 254-265
-
-
Bastid, J.1
Regairaz, A.2
Bonnefoy, N.3
Dejou, C.4
Giustiniani, J.5
Laheurte, C.6
-
89
-
-
84892958157
-
Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion
-
Hausler SF, Del Barrio IM, Diessner J, Stein RG, Strohschein J, Honig A, et al. Anti-CD39 and anti-CD73 antibodies A1 and 7G2 improve targeted therapy in ovarian cancer by blocking adenosine-dependent immune evasion. Am J Transl Res (2014) 6:129-39.
-
(2014)
Am J Transl Res
, vol.6
, pp. 129-139
-
-
Hausler, S.F.1
Del Barrio, I.M.2
Diessner, J.3
Stein, R.G.4
Strohschein, J.5
Honig, A.6
-
90
-
-
79953151458
-
Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
-
Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science (2011) 331:1565-70. doi:10.1126/science.1203486.
-
(2011)
Science
, vol.331
, pp. 1565-1570
-
-
Schreiber, R.D.1
Old, L.J.2
Smyth, M.J.3
-
91
-
-
84857138799
-
Inflammation and immune surveillance in cancer
-
Chow MT, Moller A, Smyth MJ. Inflammation and immune surveillance in cancer. Semin Cancer Biol (2012) 22:23-32. doi:10.1016/j.semcancer.2011.12.004.
-
(2012)
Semin Cancer Biol
, vol.22
, pp. 23-32
-
-
Chow, M.T.1
Moller, A.2
Smyth, M.J.3
-
92
-
-
0029832135
-
Early occurrence of metastatic differentiated thyroid carcinomas in transgenic mice expressing the A2a adenosine receptor gene and the human papillomavirus type 16 E7 oncogene
-
Coppee F, Gerard AC, Denef JF, Ledent C, Vassart G, Dumont JE, et al. Early occurrence of metastatic differentiated thyroid carcinomas in transgenic mice expressing the A2a adenosine receptor gene and the human papillomavirus type 16 E7 oncogene. Oncogene (1996) 13:1471-82.
-
(1996)
Oncogene
, vol.13
, pp. 1471-1482
-
-
Coppee, F.1
Gerard, A.C.2
Denef, J.F.3
Ledent, C.4
Vassart, G.5
Dumont, J.E.6
-
93
-
-
84943448098
-
Caffeine promotes anti-tumor immune response during tumor initiation: involvement of the adenosine A2A receptor
-
Eini H, Frishman V, Yulzari R, Kachko L, Lewis EC, Chaimovitz C, et al. Caffeine promotes anti-tumor immune response during tumor initiation: involvement of the adenosine A2A receptor. Biochem Pharmacol (2015) 98:110-8. doi:10.1016/j.bcp.2015.08.092.
-
(2015)
Biochem Pharmacol
, vol.98
, pp. 110-118
-
-
Eini, H.1
Frishman, V.2
Yulzari, R.3
Kachko, L.4
Lewis, E.C.5
Chaimovitz, C.6
-
94
-
-
55649124110
-
The role of ecto-5'-nucleotidase/CD73 in glioma cell line proliferation
-
Bavaresco L, Bernardi A, Braganhol E, Cappellari AR, Rockenbach L, Farias PF, et al. The role of ecto-5'-nucleotidase/CD73 in glioma cell line proliferation. Mol Cell Biochem (2008) 319:61-8. doi:10.1007/s11010-008-9877-3.
-
(2008)
Mol Cell Biochem
, vol.319
, pp. 61-68
-
-
Bavaresco, L.1
Bernardi, A.2
Braganhol, E.3
Cappellari, A.R.4
Rockenbach, L.5
Farias, P.F.6
-
95
-
-
84883444641
-
Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth
-
Mediavilla-Varela M, Luddy K, Noyes D, Khalil FK, Neuger AM, Soliman H, et al. Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth. Cancer Biol Ther (2013) 14:860-8. doi:10.4161/cbt.25643.
-
(2013)
Cancer Biol Ther
, vol.14
, pp. 860-868
-
-
Mediavilla-Varela, M.1
Luddy, K.2
Noyes, D.3
Khalil, F.K.4
Neuger, A.M.5
Soliman, H.6
-
96
-
-
78449305587
-
RNAi-mediated CD73 suppression induces apoptosis and cell-cycle arrest in human breast cancer cells
-
Zhi X, Wang Y, Zhou X, Yu J, Jian R, Tang S, et al. RNAi-mediated CD73 suppression induces apoptosis and cell-cycle arrest in human breast cancer cells. Cancer Sci (2010) 101:2561-9. doi:10.1111/j.1349-7006.2010.01733.x.
-
(2010)
Cancer Sci
, vol.101
, pp. 2561-2569
-
-
Zhi, X.1
Wang, Y.2
Zhou, X.3
Yu, J.4
Jian, R.5
Tang, S.6
-
97
-
-
38649133357
-
Ecto-5'-nucleotidase promotes invasion, migration and adhesion of human breast cancer cells
-
Wang L, Zhou X, Zhou T, Ma D, Chen S, Zhi X, et al. Ecto-5'-nucleotidase promotes invasion, migration and adhesion of human breast cancer cells. J Cancer Res Clin Oncol (2008) 134:365-72. doi:10.1007/s00432-007-0292-z.
-
(2008)
J Cancer Res Clin Oncol
, vol.134
, pp. 365-372
-
-
Wang, L.1
Zhou, X.2
Zhou, T.3
Ma, D.4
Chen, S.5
Zhi, X.6
-
98
-
-
84900359119
-
Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis
-
Zhou JZ, Riquelme MA, Gao X, Ellies LG, Sun LZ, Jiang JX. Differential impact of adenosine nucleotides released by osteocytes on breast cancer growth and bone metastasis. Oncogene (2015) 34:1831-42. doi:10.1038/onc.2014.113.
-
(2015)
Oncogene
, vol.34
, pp. 1831-1842
-
-
Zhou, J.Z.1
Riquelme, M.A.2
Gao, X.3
Ellies, L.G.4
Sun, L.Z.5
Jiang, J.X.6
-
99
-
-
84883422236
-
Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors
-
Beavis PA, Divisekera U, Paget C, Chow MT, John LB, Devaud C, et al. Blockade of A2A receptors potently suppresses the metastasis of CD73+ tumors. Proc Natl Acad Sci U S A (2013) 110:14711-6. doi:10.1073/pnas.1308209110.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 14711-14716
-
-
Beavis, P.A.1
Divisekera, U.2
Paget, C.3
Chow, M.T.4
John, L.B.5
Devaud, C.6
-
100
-
-
84929008590
-
Immunological mechanisms of the antitumor effects of supplemental oxygenation
-
Hatfield SM, Kjaergaard J, Lukashev D, Schreiber TH, BelikoffB, Abbott R, et al. Immunological mechanisms of the antitumor effects of supplemental oxygenation. Sci Transl Med (2015) 7:277ra230. doi:10.1126/scitranslmed.aaa1260.
-
(2015)
Sci Transl Med
, vol.7
-
-
Hatfield, S.M.1
Kjaergaard, J.2
Lukashev, D.3
Schreiber, T.H.4
Belikoff, B.5
Abbott, R.6
-
101
-
-
2942590732
-
Exploiting tumour hypoxia in cancer treatment
-
Brown JM, Wilson WR. Exploiting tumour hypoxia in cancer treatment. Nat Rev Cancer (2004) 4:437-47. doi:10.1038/nrc1367.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 437-447
-
-
Brown, J.M.1
Wilson, W.R.2
-
102
-
-
34547121206
-
Hypoxia in cancer: significance and impact on clinical outcome
-
Vaupel P, Mayer A. Hypoxia in cancer: significance and impact on clinical outcome. Cancer Metastasis Rev (2007) 26:225-39. doi:10.1007/s10555-007-9055-1.
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 225-239
-
-
Vaupel, P.1
Mayer, A.2
-
103
-
-
79955960780
-
Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity
-
Deaglio S, Robson SC. Ectonucleotidases as regulators of purinergic signaling in thrombosis, inflammation, and immunity. Adv Pharmacol (2011) 61:301-32. doi:10.1016/B978-0-12-385526-8.00010-2.
-
(2011)
Adv Pharmacol
, vol.61
, pp. 301-332
-
-
Deaglio, S.1
Robson, S.C.2
-
104
-
-
28044440647
-
Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction
-
Neumann AK, Yang J, Biju MP, Joseph SK, Johnson RS, Haase VH, et al. Hypoxia inducible factor 1 alpha regulates T cell receptor signal transduction. Proc Natl Acad Sci U S A (2005) 102:17071-6. doi:10.1073/pnas.0506070102.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 17071-17076
-
-
Neumann, A.K.1
Yang, J.2
Biju, M.P.3
Joseph, S.K.4
Johnson, R.S.5
Haase, V.H.6
-
105
-
-
0026784913
-
Influence of tumour physico-chemical conditions on interleukin-2-stimulated lymphocyte proliferation
-
Loeffler DA, Juneau PL, Masserant S. Influence of tumour physico-chemical conditions on interleukin-2-stimulated lymphocyte proliferation. Br J Cancer (1992) 66:619-22. doi:10.1038/bjc.1992.326.
-
(1992)
Br J Cancer
, vol.66
, pp. 619-622
-
-
Loeffler, D.A.1
Juneau, P.L.2
Masserant, S.3
-
106
-
-
0030771005
-
Hypoxia affects cytokine production and proliferative responses by human peripheral mononuclear cells
-
Naldini A, Carraro F, Silvestri S, Bocci V. Hypoxia affects cytokine production and proliferative responses by human peripheral mononuclear cells. J Cell Physiol (1997) 173:335-42. doi:10.1002/(SICI)1097-4652(199712)173:3<335:AID-JCP5>3.0.CO;2-O.
-
(1997)
J Cell Physiol
, vol.173
, pp. 335-342
-
-
Naldini, A.1
Carraro, F.2
Silvestri, S.3
Bocci, V.4
-
107
-
-
0035575975
-
Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions
-
Caldwell CC, Kojima H, Lukashev D, Armstrong J, Farber M, Apasov SG, et al. Differential effects of physiologically relevant hypoxic conditions on T lymphocyte development and effector functions. J Immunol (2001) 167:6140-9. doi:10.4049/jimmunol.167.11.6140.
-
(2001)
J Immunol
, vol.167
, pp. 6140-6149
-
-
Caldwell, C.C.1
Kojima, H.2
Lukashev, D.3
Armstrong, J.4
Farber, M.5
Apasov, S.G.6
-
108
-
-
14844339010
-
Culturing at atmospheric oxygen levels impacts lymphocyte function
-
Atkuri KR, Herzenberg LA, Herzenberg LA. Culturing at atmospheric oxygen levels impacts lymphocyte function. Proc Natl Acad Sci U S A (2005) 102:3756-9. doi:10.1073/pnas.0409910102.
-
(2005)
Proc Natl Acad Sci U S A
, vol.102
, pp. 3756-3759
-
-
Atkuri, K.R.1
Herzenberg, L.A.2
Herzenberg, L.A.3
-
109
-
-
84874036703
-
In vivo T cell activation in lymphoid tissues is inhibited in the oxygen-poor microenvironment
-
Ohta A, Diwanji R, Kini R, Subramanian M, Ohta A, Sitkovsky M. In vivo T cell activation in lymphoid tissues is inhibited in the oxygen-poor microenvironment. Front Immunol (2011) 2:27. doi:10.3389/fimmu.2011.00027.
-
(2011)
Front Immunol
, vol.2
, pp. 27
-
-
Ohta, A.1
Diwanji, R.2
Kini, R.3
Subramanian, M.4
Ohta, A.5
Sitkovsky, M.6
-
110
-
-
68249153389
-
Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin
-
Yang M, Ma C, Liu S, Sun J, Shao Q, Gao W, et al. Hypoxia skews dendritic cells to a T helper type 2-stimulating phenotype and promotes tumour cell migration by dendritic cell-derived osteopontin. Immunology (2009) 128:e237-49. doi:10.1111/j.1365-2567.2008.02954.x.
-
(2009)
Immunology
, vol.128
, pp. e237-e249
-
-
Yang, M.1
Ma, C.2
Liu, S.3
Sun, J.4
Shao, Q.5
Gao, W.6
-
111
-
-
55749095015
-
Divergent effects of hypoxia on dendritic cell functions
-
Mancino A, Schioppa T, Larghi P, Pasqualini F, Nebuloni M, Chen IH, et al. Divergent effects of hypoxia on dendritic cell functions. Blood (2008) 112:3723-34. doi:10.1182/blood-2008-02-142091.
-
(2008)
Blood
, vol.112
, pp. 3723-3734
-
-
Mancino, A.1
Schioppa, T.2
Larghi, P.3
Pasqualini, F.4
Nebuloni, M.5
Chen, I.H.6
-
112
-
-
72949119535
-
Reoxygenation of hypoxia-differentiated dentritic cells induces Th1 and Th17 cell differentiation
-
Wang Q, Liu C, Zhu F, Liu F, Zhang P, Guo C, et al. Reoxygenation of hypoxia-differentiated dentritic cells induces Th1 and Th17 cell differentiation. Mol Immunol (2010) 47:922-31. doi:10.1016/j.molimm.2009.09.038.
-
(2010)
Mol Immunol
, vol.47
, pp. 922-931
-
-
Wang, Q.1
Liu, C.2
Zhu, F.3
Liu, F.4
Zhang, P.5
Guo, C.6
-
113
-
-
0346753956
-
Natural killer cell-mediated basal and interferon-enhanced cytotoxicity against liver cancer cells is significantly impaired under in vivo oxygen conditions
-
Fink T, Ebbesen P, Koppelhus U, Zachar V. Natural killer cell-mediated basal and interferon-enhanced cytotoxicity against liver cancer cells is significantly impaired under in vivo oxygen conditions. Scand J Immunol (2003) 58:607-12. doi:10.1111/j.1365-3083.2003.01347.x.
-
(2003)
Scand J Immunol
, vol.58
, pp. 607-612
-
-
Fink, T.1
Ebbesen, P.2
Koppelhus, U.3
Zachar, V.4
-
114
-
-
78149330949
-
HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment
-
Corzo CA, Condamine T, Lu L, Cotter MJ, Youn JI, Cheng P, et al. HIF-1alpha regulates function and differentiation of myeloid-derived suppressor cells in the tumor microenvironment. J Exp Med (2010) 207:2439-53. doi:10.1084/jem.20100587.
-
(2010)
J Exp Med
, vol.207
, pp. 2439-2453
-
-
Corzo, C.A.1
Condamine, T.2
Lu, L.3
Cotter, M.J.4
Youn, J.I.5
Cheng, P.6
-
115
-
-
0029840035
-
Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells
-
Takagi H, King GL, Robinson GS, Ferrara N, Aiello LP. Adenosine mediates hypoxic induction of vascular endothelial growth factor in retinal pericytes and endothelial cells. Invest Ophthalmol Vis Sci (1996) 37:2165-76.
-
(1996)
Invest Ophthalmol Vis Sci
, vol.37
, pp. 2165-2176
-
-
Takagi, H.1
King, G.L.2
Robinson, G.S.3
Ferrara, N.4
Aiello, L.P.5
-
116
-
-
0032056006
-
Adenosine modulates hypoxia-induced responses in rat PC12 cells via the A2A receptor
-
Kobayashi S, Conforti L, Pun RY, Millhorn DE. Adenosine modulates hypoxia-induced responses in rat PC12 cells via the A2A receptor. J Physiol (1998) 508(Pt 1):95-107. doi:10.1111/j.1469-7793.1998.095br.x.
-
(1998)
J Physiol
, vol.508
, pp. 95-107
-
-
Kobayashi, S.1
Conforti, L.2
Pun, R.Y.3
Millhorn, D.E.4
-
117
-
-
0035196140
-
Adenosine A(2A) and A(2B) receptor activation of erythropoietin production
-
Fisher JW, Brookins J. Adenosine A(2A) and A(2B) receptor activation of erythropoietin production. Am J Physiol Renal Physiol (2001) 281:F826-32. doi:10.1152/ajprenal.0083.2001.
-
(2001)
Am J Physiol Renal Physiol
, vol.281
, pp. F826-F832
-
-
Fisher, J.W.1
Brookins, J.2
-
118
-
-
84914113076
-
Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1alpha-dependent and extracellular adenosine-mediated tumor protection
-
Hatfield SM, Kjaergaard J, Lukashev D, BelikoffB, Schreiber TH, Sethumadhavan S, et al. Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1alpha-dependent and extracellular adenosine-mediated tumor protection. J Mol Med (Berl) (2014) 92:1283-92. doi:10.1007/s00109-014-1189-3.
-
(2014)
J Mol Med (Berl)
, vol.92
, pp. 1283-1292
-
-
Hatfield, S.M.1
Kjaergaard, J.2
Lukashev, D.3
Belikoff, B.4
Schreiber, T.H.5
Sethumadhavan, S.6
-
119
-
-
34347227058
-
Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1
-
Semenza GL. Oxygen-dependent regulation of mitochondrial respiration by hypoxia-inducible factor 1. Biochem J (2007) 405:1-9. doi:10.1042/BJ20070389.
-
(2007)
Biochem J
, vol.405
, pp. 1-9
-
-
Semenza, G.L.1
-
120
-
-
78649364332
-
Hypoxia-inducible factors and the response to hypoxic stress
-
Majmundar AJ, Wong WJ, Simon MC. Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell (2010) 40:294-309. doi:10.1016/j.molcel.2010.09.022.
-
(2010)
Mol Cell
, vol.40
, pp. 294-309
-
-
Majmundar, A.J.1
Wong, W.J.2
Simon, M.C.3
-
121
-
-
84883501150
-
HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations
-
Semenza GL. HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. J Clin Invest (2013) 123:3664-71. doi:10.1172/JCI67230.
-
(2013)
J Clin Invest
, vol.123
, pp. 3664-3671
-
-
Semenza, G.L.1
-
122
-
-
33749512970
-
Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes
-
Lukashev D, Klebanov B, Kojima H, Grinberg A, Ohta A, Berenfeld L, et al. Cutting edge: hypoxia-inducible factor 1alpha and its activation-inducible short isoform I.1 negatively regulate functions of CD4+ and CD8+ T lymphocytes. J Immunol (2006) 177:4962-5. doi:10.4049/jimmunol.177.8.4962.
-
(2006)
J Immunol
, vol.177
, pp. 4962-4965
-
-
Lukashev, D.1
Klebanov, B.2
Kojima, H.3
Grinberg, A.4
Ohta, A.5
Berenfeld, L.6
-
123
-
-
58149160405
-
Enhanced interferon-gamma gene expression in T Cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice
-
Guo J, Lu W, Shimoda LA, Semenza GL, Georas SN. Enhanced interferon-gamma gene expression in T Cells and reduced ovalbumin-dependent lung eosinophilia in hypoxia-inducible factor-1-alpha-deficient mice. Int Arch Allergy Immunol (2009) 149:98-102. doi:10.1159/000189191.
-
(2009)
Int Arch Allergy Immunol
, vol.149
, pp. 98-102
-
-
Guo, J.1
Lu, W.2
Shimoda, L.A.3
Semenza, G.L.4
Georas, S.N.5
-
124
-
-
84861927253
-
HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis
-
Higashiyama M, Hokari R, Hozumi H, Kurihara C, Ueda T, Watanabe C, et al. HIF-1 in T cells ameliorated dextran sodium sulfate-induced murine colitis. J Leukoc Biol (2012) 91:901-9. doi:10.1189/jlb.1011518.
-
(2012)
J Leukoc Biol
, vol.91
, pp. 901-909
-
-
Higashiyama, M.1
Hokari, R.2
Hozumi, H.3
Kurihara, C.4
Ueda, T.5
Watanabe, C.6
-
125
-
-
0037423948
-
HIF-1alpha is essential for myeloid cell-mediated inflammation
-
Cramer T, Yamanishi Y, Clausen BE, Forster I, Pawlinski R, Mackman N, et al. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell (2003) 112:645-57. doi:10.1016/S0092-8674(03)00154-5.
-
(2003)
Cell
, vol.112
, pp. 645-657
-
-
Cramer, T.1
Yamanishi, Y.2
Clausen, B.E.3
Forster, I.4
Pawlinski, R.5
Mackman, N.6
-
126
-
-
70249099576
-
Interdependence of hypoxic and innate immune responses
-
Nizet V, Johnson RS. Interdependence of hypoxic and innate immune responses. Nat Rev Immunol (2009) 9:609-17. doi:10.1038/nri2607.
-
(2009)
Nat Rev Immunol
, vol.9
, pp. 609-617
-
-
Nizet, V.1
Johnson, R.S.2
-
127
-
-
84908141221
-
HIF transcription factors, inflammation, and immunity
-
Palazon A, Goldrath AW, Nizet V, Johnson RS. HIF transcription factors, inflammation, and immunity. Immunity (2014) 41:518-28. doi:10.1016/j.immuni.2014.09.008.
-
(2014)
Immunity
, vol.41
, pp. 518-528
-
-
Palazon, A.1
Goldrath, A.W.2
Nizet, V.3
Johnson, R.S.4
-
128
-
-
84899753178
-
PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation
-
Noman MZ, Desantis G, Janji B, Hasmim M, Karray S, Dessen P, et al. PD-L1 is a novel direct target of HIF-1alpha, and its blockade under hypoxia enhanced MDSC-mediated T cell activation. J Exp Med (2014) 211:781-90. doi:10.1084/jem.20131916.
-
(2014)
J Exp Med
, vol.211
, pp. 781-790
-
-
Noman, M.Z.1
Desantis, G.2
Janji, B.3
Hasmim, M.4
Karray, S.5
Dessen, P.6
-
129
-
-
55249095393
-
Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha
-
Ben-Shoshan J, Maysel-Auslender S, Mor A, Keren G, George J. Hypoxia controls CD4+CD25+ regulatory T-cell homeostasis via hypoxia-inducible factor-1alpha. Eur J Immunol (2008) 38:2412-8. doi:10.1002/eji.200838318.
-
(2008)
Eur J Immunol
, vol.38
, pp. 2412-2418
-
-
Ben-Shoshan, J.1
Maysel-Auslender, S.2
Mor, A.3
Keren, G.4
George, J.5
-
130
-
-
84903905347
-
Effect of HIF1alpha on Foxp3 expression in CD4+ CD25-T lymphocytes
-
Wu J, Cui H, Zhu Z, Wang L, Li H, Wang D. Effect of HIF1alpha on Foxp3 expression in CD4+ CD25-T lymphocytes. Microbiol Immunol (2014) 58:409-15. doi:10.1111/1348-0421.12168.
-
(2014)
Microbiol Immunol
, vol.58
, pp. 409-415
-
-
Wu, J.1
Cui, H.2
Zhu, Z.3
Wang, L.4
Li, H.5
Wang, D.6
-
131
-
-
84867381718
-
Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa
-
Clambey ET, McNamee EN, Westrich JA, Glover LE, Campbell EL, Jedlicka P, et al. Hypoxia-inducible factor-1 alpha-dependent induction of FoxP3 drives regulatory T-cell abundance and function during inflammatory hypoxia of the mucosa. Proc Natl Acad Sci U S A (2012) 109:E2784-93. doi:10.1073/pnas.1202366109.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. E2784-E2793
-
-
Clambey, E.T.1
McNamee, E.N.2
Westrich, J.A.3
Glover, L.E.4
Campbell, E.L.5
Jedlicka, P.6
-
132
-
-
80052277906
-
Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1
-
Dang EV, Barbi J, Yang HY, Jinasena D, Yu H, Zheng Y, et al. Control of T(H)17/T(reg) balance by hypoxia-inducible factor 1. Cell (2011) 146:772-84. doi:10.1016/j.cell.2011.07.033.
-
(2011)
Cell
, vol.146
, pp. 772-784
-
-
Dang, E.V.1
Barbi, J.2
Yang, H.Y.3
Jinasena, D.4
Yu, H.5
Zheng, Y.6
-
133
-
-
79960369458
-
HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells
-
Shi LZ, Wang R, Huang G, Vogel P, Neale G, Green DR, et al. HIF1alpha-dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells. J Exp Med (2011) 208:1367-76. doi:10.1084/jem.20110278.
-
(2011)
J Exp Med
, vol.208
, pp. 1367-1376
-
-
Shi, L.Z.1
Wang, R.2
Huang, G.3
Vogel, P.4
Neale, G.5
Green, D.R.6
-
134
-
-
84937576224
-
E3 ubiquitin ligase VHL regulates hypoxia-inducible factor-1alpha to maintain regulatory T cell stability and suppressive capacity
-
Lee JH, Elly C, Park Y, Liu YC. E3 ubiquitin ligase VHL regulates hypoxia-inducible factor-1alpha to maintain regulatory T cell stability and suppressive capacity. Immunity (2015) 42:1062-74. doi:10.1016/j.immuni.2015.05.016.
-
(2015)
Immunity
, vol.42
, pp. 1062-1074
-
-
Lee, J.H.1
Elly, C.2
Park, Y.3
Liu, Y.C.4
-
135
-
-
84923357982
-
Deltex1 antagonizes HIF-1alpha and sustains the stability of regulatory T cells in vivo
-
Hsiao HW, Hsu TS, Liu WH, Hsieh WC, Chou TF, Wu YJ, et al. Deltex1 antagonizes HIF-1alpha and sustains the stability of regulatory T cells in vivo. Nat Commun (2015) 6:6353. doi:10.1038/ncomms7353.
-
(2015)
Nat Commun
, vol.6
, pp. 6353
-
-
Hsiao, H.W.1
Hsu, T.S.2
Liu, W.H.3
Hsieh, W.C.4
Chou, T.F.5
Wu, Y.J.6
-
136
-
-
79960393113
-
Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells
-
Facciabene A, Peng X, Hagemann IS, Balint K, Barchetti A, Wang LP, et al. Tumour hypoxia promotes tolerance and angiogenesis via CCL28 and T(reg) cells. Nature (2011) 475:226-30. doi:10.1038/nature10169.
-
(2011)
Nature
, vol.475
, pp. 226-230
-
-
Facciabene, A.1
Peng, X.2
Hagemann, I.S.3
Balint, K.4
Barchetti, A.5
Wang, L.P.6
-
137
-
-
33746491709
-
Drug penetration in solid tumours
-
Minchinton AI, Tannock IF. Drug penetration in solid tumours. Nat Rev Cancer (2006) 6:583-92. doi:10.1038/nrc1893.
-
(2006)
Nat Rev Cancer
, vol.6
, pp. 583-592
-
-
Minchinton, A.I.1
Tannock, I.F.2
-
138
-
-
44349157832
-
Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response
-
Dewhirst MW, Cao Y, Moeller B. Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. Nat Rev Cancer (2008) 8:425-37. doi:10.1038/nrc2397.
-
(2008)
Nat Rev Cancer
, vol.8
, pp. 425-437
-
-
Dewhirst, M.W.1
Cao, Y.2
Moeller, B.3
-
139
-
-
58149478525
-
HIF-1alpha and HIF-2alpha have divergent roles in colon cancer
-
Imamura T, Kikuchi H, Herraiz MT, Park DY, Mizukami Y, Mino-Kenduson M, et al. HIF-1alpha and HIF-2alpha have divergent roles in colon cancer. Int J Cancer (2009) 124:763-71. doi:10.1002/ijc.24032.
-
(2009)
Int J Cancer
, vol.124
, pp. 763-771
-
-
Imamura, T.1
Kikuchi, H.2
Herraiz, M.T.3
Park, D.Y.4
Mizukami, Y.5
Mino-Kenduson, M.6
-
140
-
-
76349095132
-
Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics
-
Semenza GL. Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics. Oncogene (2010) 29:625-34. doi:10.1038/onc.2009.441.
-
(2010)
Oncogene
, vol.29
, pp. 625-634
-
-
Semenza, G.L.1
-
141
-
-
77955750932
-
CD73: a novel target for cancer immunotherapy
-
Zhang B. CD73: a novel target for cancer immunotherapy. Cancer Res (2010) 70:6407-11. doi:10.1158/0008-5472.CAN-10-1544.
-
(2010)
Cancer Res
, vol.70
, pp. 6407-6411
-
-
Zhang, B.1
-
142
-
-
84860388676
-
CD73: a potent suppressor of antitumor immune responses
-
Beavis PA, Stagg J, Darcy PK, Smyth MJ. CD73: a potent suppressor of antitumor immune responses. Trends Immunol (2012) 33:231-7. doi:10.1016/j.it.2012.02.009.
-
(2012)
Trends Immunol
, vol.33
, pp. 231-237
-
-
Beavis, P.A.1
Stagg, J.2
Darcy, P.K.3
Smyth, M.J.4
-
143
-
-
84862317836
-
Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor
-
Waickman AT, Alme A, Senaldi L, Zarek PE, Horton M, Powell JD. Enhancement of tumor immunotherapy by deletion of the A2A adenosine receptor. Cancer Immunol Immunother (2012) 61:917-26. doi:10.1007/s00262-011-1155-7.
-
(2012)
Cancer Immunol Immunother
, vol.61
, pp. 917-926
-
-
Waickman, A.T.1
Alme, A.2
Senaldi, L.3
Zarek, P.E.4
Horton, M.5
Powell, J.D.6
-
144
-
-
84962273457
-
Adenosine receptor 2A blockade increases the efficacy of anti-PD-1 through enhanced antitumor T-cell responses
-
Beavis PA, Milenkovski N, Henderson MA, John LB, Allard B, Loi S, et al. Adenosine receptor 2A blockade increases the efficacy of anti-PD-1 through enhanced antitumor T-cell responses. Cancer Immunol Res (2015) 3:506-17. doi:10.1158/2326-6066.CIR-14-0211.
-
(2015)
Cancer Immunol Res
, vol.3
, pp. 506-517
-
-
Beavis, P.A.1
Milenkovski, N.2
Henderson, M.A.3
John, L.B.4
Allard, B.5
Loi, S.6
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