Systemic oxygenation weakens the hypoxia and hypoxia inducible factor 1α-dependent and extracellular adenosine-mediated tumor protection

Journal of Molecular Medicine

Volumn 92, Issue 12, 2014, Pages 1283-1292

  Hatfield, Stephen M ^a   Kjaergaard, Jorgen ^a   Lukashev, Dmitriy ^a   Belikoff, Bryan ^a   Schreiber, Taylor H ^c   Sethumadhavan, Shalini ^a   Abbott, Robert ^a   Philbrook, Phaethon ^a   Thayer, Molly ^a   Shujia, Dai ^a   Rodig, Scott ^d   Kutok, Jeffrey L ^d   Ren, Jin ^e   Ohta, Akio ^a   Podack, Eckhard R ^c   Karger, Barry ^a   Jackson, Edwin K ^e   Sitkovsky, Michail ^a,b  

^a NORTHEASTERN UNIVERSITY   (United States)

^b HARVARD INSTITUTES OF MEDICINE   (United States)

^c UNIVERSITY OF MIAMI MILLER SCHOOL OF MEDICINE   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

^e UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Adenosine; Cancer; CD73; HIF 1 ; Hypoxia; Immunology

Indexed keywords

5' NUCLEOTIDASE; A2AR PROTEIN; A2BR PROTEIN; ADENOSINE; ADENOSINE RECEPTOR; CD31 ANTIGEN; CD39 ANTIGEN; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; OXYGEN; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN PRESENTING CELL; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DOWN REGULATION; FEMALE; GENE PRODUCT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYPOXEMIA; HYPOXIA; IMMUNOBLOTTING; MASS SPECTROMETRY; MELANOMA B16; MICRODIALYSIS; MOUSE; NONHUMAN; OXYGEN BREATHING; OXYGEN TENSION; OXYGEN THERAPY; PATHOPHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PROTEIN EXPRESSION; PROTEIN STABILITY; PROTEIN TARGETING; PROTEOMICS; TUMOR ESCAPE; TUMOR IMMUNITY; TUMOR MICROENVIRONMENT; TUMOR REGRESSION; UPREGULATION; WESTERN BLOTTING; ANIMAL; ANOXIA; C57BL MOUSE; CELL HYPOXIA; COMPLICATION; METABOLISM; NEOPLASMS; TUMOR CELL LINE;

ADENOSINE; ANIMALS; ANOXIA; CELL HYPOXIA; CELL LINE, TUMOR; FEMALE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; MICE, INBRED C57BL; NEOPLASMS; OXYGEN; TUMOR MICROENVIRONMENT;

EID: 84914113076     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-014-1189-3     Document Type: Article

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