Antagonism of adenosine A2A receptor expressed by lung adenocarcinoma tumor cells and cancer associated fibroblasts inhibits their growth

Cancer Biology and Therapy

Volumn 14, Issue 9, 2013, Pages 860-868

  Mediavilla Varela, Melanie ^a   Luddy, Kimberly ^a   Noyes, David ^a   Khalil, Farah K ^a   Neuger, Anthony M ^a   Soliman, Hatem ^a   Antonia, Scott J ^a  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

Author keywords

Adenosine A2A receptor; Cancer associated fibroblasts; Cell death; NSCLC; SCH58261; Tumor microenvironment; ZM241385

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE A2A RECEPTOR; ADENOSINE A2A RECEPTOR ANTAGONIST; 5-AMINO-7-(2-PHENYLETHYL)-2-(2-FURYL)PYRAZOLO(4,3-E)-1,2,4-TRIAZOLO(1,5-C)PYRIMIDINE; ADENOSINE A2 RECEPTOR ANTAGONIST; PYRIMIDINE DERIVATIVE; TRIAZINE DERIVATIVE; TRIAZOLE DERIVATIVE;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER ASSOCIATED FIBROBLAST; CANCER CELL; CELL GROWTH; CELL ISOLATION; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFICACY; FIBROBLAST; FLOW CYTOMETRY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TUMOR CELL; TUMOR CELL LINE; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT; ADENOCARCINOMA; ANIMAL; DRUG EFFECTS; GENETICS; LUNG NEOPLASMS; METABOLISM; NUDE MOUSE; PATHOLOGY; XENOGRAFT;

ADENOCARCINOMA; ADENOSINE A2 RECEPTOR ANTAGONISTS; ANIMALS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; FIBROBLASTS; HETEROGRAFTS; HUMANS; LUNG NEOPLASMS; MICE, NUDE; PYRIMIDINES; RECEPTOR, ADENOSINE A2A; TRIAZINES; TRIAZOLES;

EID: 84883444641     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.25643     Document Type: Article

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