Fused-ring structure of decahydroisoquinolin as a novel scaffold for SARS 3CL protease inhibitors

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 4, 2015, Pages 876-890

  Shimamoto, Yasuhiro ^a   Hattori, Yasunao ^a   Kobayashi, Kazuya ^a   Teruya, Kenta ^b   Sanjoh, Akira ^c   Nakagawa, Atsushi ^d   Yamashita, Eiki ^d   Akaji, Kenichi ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c RandD Center   (Japan)

^d OSAKA UNIVERSITY   (Japan)

Author keywords

Decahydroisoquinolin; Hydrophobic interaction; Inhibitor; SARS 3CL protease

Indexed keywords

(1,1' BIPHENYL) 4 YL (3 VINYLOCTAHYDROISOQUINOLIN 2(1H) YL)METHANONE; (4 BROMOPHENYL) (3 VINYLOCTAHYDROISOQUINOLIN 2(1H) YL)METHANONE; 2 [(( 2 [(1,1' BIPHENYL) 4 CARBONYL]DECAHYDROISOQUINOLIN 3 YL)METHYL)AMINO] 3 (1H IMIDAZOL 4 YL) N METHOXY N METHYLPROPANAMIDE; 2 [(( 2 [(1,1' BIPHENYL) 4 CARBONYL]DECAHYDROISOQUINOLIN 3 YL)METHYL)AMINO] 3 (1H IMIDAZOL 4 YL)PROPANAL; 2 [(( 2 [(1,1' BIPHENYL) 4 CARBONYL]DECAHYDROISOQUINOLIN 3 YL)METHYL)AMINO] N METHOXY N METHYL 3 (1 TRITYL 1H IMIDAZOL 4 YL)PROPANAMIDE; 2 [(( 2 [(1,1' BIPHENYL) 4 CARBONYL]DECAHYDROISOQUINOLIN 3 YL)METHYL)AMINO] N METHOXY N METHYL 3 (1H IMIDAZOL 4 YL)PROPANAMIDE; 2 [((2 (4 BROMOBENZOYL)DECAHYDROISOQUINOLIN 3 YL)METHYL)AMINO] 3 (1H IMIDAZOL 4 YL) N METHOXY N METHYLPROPANAMIDE; 2 [((2 (4 BROMOBENZOYL)DECAHYDROISOQUINOLIN 3 YL)METHYL)AMINO] 3 (1H IMIDAZOL 4 YL)PROPANAL; 2 [((2 (4 BROMOBENZOYL)DECAHYDROISOQUINOLIN 3 YL)METHYL)AMINO] N METHOXY N METHYL 3 (1 TRITYL 1H IMIDAZOL 4 YL)PROPANAMIDE; 2 [((2 (4 BROMOBENZOYL)DECAHYDROISOQUINOLIN 3 YL)METHYL)AMINO] N METHOXY N METHYL 3 (1H IMIDAZOL 4 YL)PROPANAMIDE; 2 [(6 ((TERT BUTYLDIPHENYLSILYL)OXY)METHYL)CYCLOHEXYL]ETHANOL; 2 [2 (((TERT BUTYLDIPHENYLSILYL)OXY)METHYL)CYCLOHEXYL]ETHANOL; 4 (2 (HYDROXYMETHYL)CYCLOHEXYL)BUT 2 EN 1 YL ACETATE; 4 BROMO N ((2 (4 HYDROXYBUT 2 EN 1 YL)CYCLOHEXYL)METHYL)BENZAMIDE; 4 [2 (((TERT BUTYLDIPHENYLSILYL)OXY)METHY)CYCLOHEXYL]BUT 2 EN 1 OL; 4 [2 (((TERT BUTYLDIPHENYLSILYL)OXY)METHY)CYCLOHEXYL]BUT 2 EN 1 YL ACETATE; 6 (2 ((4 BROMOBENZYL)OXY)ETHYL)CYCLOHEX 3 ENECARBOXYLIC ACID; CHYMOTRYPSIN INHIBITOR; DECAHYDROISOQUINOLIN INHIBITOR; ETHY 4 [2 (((TERT BUTYLDIPHENYLSILYL)OXY)METHY)CYCLOHEX 1 YL]BUT 2 ENOATE; ETHYL 6 (2 (BENZYLOXY)ETHYL)CYCLOHEX 3 ENECARBOXYLATE 7; N [(2 (4 HYDROXYBUT 2 EN 1 YL)CYCLOHEXYL)METHYL] [1,1' BIPHENYL] 4 CARBOXAMIDE; UNCLASSIFIED DRUG; [(6 (2 ((4 BROMOBENZYL)OXY)ETHYL)CYCLOHEX 3 EN 1 YL)METHOXY](TERT BUTYL)DIPHENYLSILANE; [(6 (2 (BENZYLOXY)ETHYL)CYCLOHEX 3 EN 1 YL)METHOXY](TERT BUTYL)DIPHENYLSILANE; [6 (2 ((4 BROMOBENZYL)OXY)ETHYL)CYCLOHEX 3 EN 1 YL]METHANOL; [6 (2 (BENZYLOXY)ETHYL)CYCLOHEX 3 EN 1 YL]METHANOL;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHEMICAL STRUCTURE; CONTROLLED STUDY; CYCLIZATION; DIELS ALDER REACTION; ENANTIOMER; HYDROGENATION; HYDROPHOBICITY; IC50; INHIBITION KINETICS; MOLECULAR INTERACTION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

EID: 84964199951     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2014.12.028     Document Type: Article

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