Structure-based design, synthesis, and biological evaluation of peptidomimetic SARS-CoV 3CLpro inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 21, 2007, Pages 5876-5880

  Ghosh, Arun K ^a   Xi, Kai ^a   Grum Tokars, Valerie ^b   Xu, Xiaoming ^a   Ratia, Kiira ^b   Fu, Wentao ^b   Houser, Katherine V ^c   Baker, Susan C ^c   Johnson, Michael E ^b   Mesecar, Andrew D ^b  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Design; Inhibitor; SARS 3CLpro; Synthesis; X ray structure

Indexed keywords

PROTEINASE INHIBITOR; RUPINTRIVIR; SARS CORONAVIRUS CHYMOTRYPSIN LIKE PROTEASE; SARS CORONAVIRUS CHYMOTRYPSIN LIKE PROTEINASE INHIBITOR; SARS CORONAVIRUS PAPAIN LIKE PROTEASE; TERT BUTOXYCARBONYLSERINE P4 DERIVATIVE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME BINDING; EVALUATION RESEARCH; INHIBITION KINETICS; LIGAND BINDING; MOLECULAR INTERACTION; MOLECULAR MODEL; NONHUMAN; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; HYDROGEN BONDING; MODELS, MOLECULAR; MOLECULAR MIMICRY; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; VIRAL PROTEINS;

SARS CORONAVIRUS;

EID: 34548830820     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.08.031     Document Type: Article

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