Synthesis and evaluation of pyrazolone compounds as SARS-coronavirus 3C-like protease inhibitors

Bioorganic and Medicinal Chemistry

Volumn 18, Issue 22, 2010, Pages 7849-7854

  Ramajayam, R ^a   Tan, Kian Pin ^b   Liu, Hun Ge ^b   Liang, Po Huang ^a,b  

^a INSTITUTE OF BIOLOGICAL CHEMISTRY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

3CL protease; Computer modeling; Coxsackievirus; Pyrazolone; SARS CoV

Indexed keywords

3 PHENYL 1 (3 NITROPHENYL) 4 (4 CARBOXYBENZYLIDENE)PYRAZOL 5(4H) ONE; 3 PHENYL 1 (4 CYANOPHENYL) 4 (4 CARBOXYBENZYLIDENE)PYRAZOL 5(4H) ONE; 3 PHENYL 1 (4 FLUOROPHENYL) 4 (4 CARBOXYBENZYLIDENE)PYRAZOL 5(4H) ONE; PROTEINASE INHIBITOR; PYRAZOLONE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; COXSACKIE VIRUS B3; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; HUMAN; HUMAN CELL; NONHUMAN; SARS CORONAVIRUS;

ANTIVIRAL AGENTS; BINDING SITES; CATALYTIC DOMAIN; COMPUTER SIMULATION; CYSTEINE ENDOPEPTIDASES; ENTEROVIRUS B, HUMAN; HUMANS; PROTEASE INHIBITORS; PYRAZOLONES; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

COXSACKIEVIRUS; SARS CORONAVIRUS;

EID: 78449255006     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2010.09.050     Document Type: Article

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