Structure-based design, synthesis, and evaluation of peptide-mimetic SARS 3CL protease inhibitors

Journal of Medicinal Chemistry

Volumn 54, Issue 23, 2011, Pages 7962-7973

  Akaji, Kenichi ^a,b   Konno, Hiroyuki ^c   Mitsui, Hironori ^b   Teruya, Kenta ^b   Shimamoto, Yasuhiro ^b   Hattori, Yasunao ^b   Ozaki, Takeshi ^d   Kusunoki, Masami ^e   Sanjoh, Akira ^f  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^b KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^c YAMAGATA UNIVERSITY   (Japan)

^d OSAKA UNIVERSITY   (Japan)

^e UNIVERSITY OF YAMANASHI   (Japan)

^f RandD Center   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE; CHYMOTRYPSIN INHIBITOR; N BROMOSUCCINIMIDE;

ARTICLE; BIOTRANSFORMATION; CARBOXY TERMINAL SEQUENCE; DRUG DESIGN; DRUG SCREENING; DRUG SYNTHESIS; IC 50; SOLID PHASE SYNTHESIS; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ALDEHYDES; CRYSTALLOGRAPHY, X-RAY; CYSTEINE ENDOPEPTIDASES; MODELS, MOLECULAR; MUTATION; PEPTIDOMIMETICS; PROTEASE INHIBITORS; SOLID-PHASE SYNTHESIS TECHNIQUES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

EID: 82555185535     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm200870n     Document Type: Article

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