The genome sequence of the SARS-associated coronavirus

Science

Volumn 300, Issue 5624, 2003, Pages 1399-1404

  Marra, Marco A ^a   Jones, Steven J M ^a   Astell, Caroline R ^a   Holt, Robert A ^a   Brooks Wilson, Angela ^a   Butterfield, Yaron S N ^a   Khattra, Jaswinder ^a   Asano, Jennifer K ^a   Barber, Sarah A ^a   Chan, Susanna Y ^a   Cloutier, Alison ^a   Coughlin, Shaun M ^a   Freeman, Doug ^a   Girn, Noreen ^a   Griffith, Obi L ^a   Leach, Stephen R ^a   Mayo, Michael ^a   McDonald, Helen ^a   Montgomery, Stephen B ^a   Pandoh, Pawan K ^a   Petrescu, Anca S ^a   Robertson, A Gordon ^a   Schein, Jacqueline E ^a   Siddiqui, Asim ^a   Smailus, Duane E ^a   Stott, Jeff M ^a   Yang, George S ^a   Plummer, Francis ^b   Andonov, Anton ^b   Artsob, Harvey ^b   Bastien, Nathatie ^b   Bernard, Kathy ^b   Booth, Timothy F ^b   Bowness, Donnie ^b   Czub, Martin ^b   Drebot, Michael ^b   Fernando, Lisa ^b   Flick, Ramon ^b   Garbutt, Michael ^b   Gray, Michael ^b   Grolla, Allen ^b   Jones, Steven ^b   Feldmann, Heinz ^b   Meyers, Adrienne ^b   Kabani, Amin ^b   Li, Yan ^b   Normand, Susan ^b   Stroher, Ute ^b   Tipples, Graham A ^b   Tyler, Shaun ^b   Vogrig, Robert ^b   Ward, Diane ^b   Watson, Brynn ^b   Brunham, Robert C ^c   Krajden, Mel ^c   Petric, Martin ^c   Skowronski, Danuta M ^c   Upton, Chris ^d   Roper, Rachel L ^d   more..

^a BRITISH COLUMBIA CANCER AGENCY   (Canada)

^b PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^c UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^d UNIVERSITY OF VICTORIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; GENES; IMMUNOLOGY; PULMONARY DISEASES; VACCINES;

GENOME SEQUENCE;

VIRUSES;

COMPLEMENTARY DNA; GENE PRODUCT; MEMBRANE PROTEIN; RNA DIRECTED RNA POLYMERASE; SPIKE GLYCOPROTEIN; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN; VIRUS PROTEIN; VIRUS RNA;

GENETICS; VIRUS;

AMINO ACID SEQUENCE; ARTICLE; BASE PAIRING; CORONAVIRUS; GENOME; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN READING FRAME; PHYLOGENY; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; SARS CORONAVIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VIRUS GENOME; VIRUS INFECTION; VIRUS ISOLATION; VIRUS PARTICLE;

3' UNTRANSLATED REGIONS; 5' UNTRANSLATED REGIONS; ANIMALS; BASE SEQUENCE; CONSERVED SEQUENCE; CORONAVIRUS; DNA, COMPLEMENTARY; FRAMESHIFTING, RIBOSOMAL; GENOME, VIRAL; HUMANS; MEMBRANE GLYCOPROTEINS; NUCLEOCAPSID PROTEINS; OPEN READING FRAMES; PHYLOGENY; REGULATORY SEQUENCES, NUCLEIC ACID; RNA REPLICASE; RNA, VIRAL; SARS VIRUS; SEQUENCE ANALYSIS, DNA; SEVERE ACUTE RESPIRATORY SYNDROME; VIRAL ENVELOPE PROTEINS; VIRAL MATRIX PROTEINS; VIRAL PROTEINS;

ANIMALIA; CORONAVIRUS; RNA VIRUSES; SARS CORONAVIRUS;

EID: 0038823524     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1085953     Document Type: Article

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35. We thank all the staff at the BCCA Genome Sciences Centre for helping to facilitate the rapid sequencing of the SARS-CoV genome; R. Tellier (Hospital for Sick Children) for information on primer sequences that amplify a 216-base pair region of the Pol gene; I. Sadowski (Department of Biochemistry and Molecular Biology) and J. Hobbs and his staff (Nucleic Acid and Protien Services Unit) of the University of British Columbia for rapid synthesis of PCR primers; F. Ouellette (University of British Columbia Bioinformatics Centre) for advice and assistance; the staff at the National Center for Biotechnology Information for rapidly processing and making available our sequence data; and anonymous rewiewers for their useful suggestions. The BCCA Genome Sciences Centre is supported by the British Colombia Cancer Foundation, Genome Canada/Genome British Columbia, Western Economic Diversification, Canada Foundation for Innovation, British Columbia Knowledge Development Fund, Canadian Institutes of Health Research, Michael Smith Foundation for Health Research, and Natural Sciences and Engineering Research Council of Canada. Clones derived from the SARS virus are available from the Genome Sciences Centre (www.bcgsc.bc.ca).