Synthesis, modification and docking studies of 5-sulfonyl isatin derivatives as SARS-CoV 3C-like protease inhibitors

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 292-302

  Liu, Wei ^a   Zhu, He Min ^b   Niu, Guo Jun ^c   Shi, En Zhi ^b   Chen, Jie ^b   Sun, Bo ^c   Chen, Wei Qiang ^c   Zhou, Hong Gang ^b   Yang, Cheng ^b,c  

^a TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b NANKAI UNIVERSITY   (China)

^c TEDA   (China)

Author keywords

Docking studies; Inhibitor; Isatin; SARS

Indexed keywords

1 BENZYL 5 [(4 METHYLPIPERAZIN 1 YL)SULFONYL] 1H INDOLE 2,3 DIONE; 1 BENZYL 5 [(4 PHENYLPIPERAZIN 1 YL)SULFONYL] 1H INDOLE 2,3 DIONE; 1 BENZYL 5 [[4 (3 CHLOROBENZYL)PIPERAZIN 1 YL]SULFONYL] 1H INDOLE 2,3 DIONE; 1 BENZYL 5 [[4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]SULFONYL] 1H INDOLE 2,3 DIONE; 1 METHYL 5 [(4 METHYLPIPERAZIN 1 YL)SULFONYL] 1H INDOLE 2,3 DIONE; 1 METHYL 5 [(4 PHENYLPIPERAZIN 1 YL)SULFONYL] 1H INDOLE 2,3 DIONE; 1,5,6,7 TETRAHYDRO CYCLOPENT[F]INDOLE 2,3 DIONE; 2,3 DIOXO INDOLINE 5 SULFONIC ACID; 3,3 DICHLORO 2 OXO INDOLINE 5 SULFONIC ACID; 5 (MORPHOLINOSULFONYL) 1H INDOLE 2,3 DIONE; 5 [(2 METHYLPIPERIDIN 1 YL)SULFONYL] 1H INDOLE 2,3 DIONE; 5 [(3,5 DIMETHYLPIPERIDIN 1 YL)SULFONYL] 1H INDOLE 2,3 DIONE; 5 [(4 METHYLPIPERAZIN 1 YL)SULFONYL] 1 BETA NAPHTHALENEMETHYL 1H INDOLE 2,3 DIONE; 5 [(4 METHYLPIPERAZIN 1 YL)SULFONYL] 1H INDOLE 2,3 DIONE; 5 [(4 METHYLPIPERIDIN 1 YL)SULFONYL] 1H INDOLE 2,3 DIONE; 5 [(4 PHENYLETHYLPIPERAZIN 1 YL)SULFONYL] 1H INDOLE 2,3 DIONE; 5 [(PIPERIDIN 1 YL)SULFONYL] 1H INDOLE 2,3 DIONE; 5 [4 (2 FUROYL)PIPERAZIN 1 YL SULFONYL] 1H INDOLE 2,3 DIONE; 5 [[4 (3 CHLOROBENZYL)PIPERAZIN 1 YL]SULFONYL] 1 BETA NAPHTHALENEMETHYL 1H INDOLE 2,3 DIONE; 5 [[4 (3 CHLOROBENZYL)PIPERAZINYL 1 YL]SULFONYL] 1H INDOLE 2,3 DIONE; 5 [[4 (3 TRIFLUOROMETHYLPHENYL)PIPERAZINYL 1 YL]SULFONYL] 1H INDOLE 2,3 DIONE; 5 [[4 (3,4,5 TRIMETHOXYBENZYL)PIPERAZINYL 1 YL]SULFONYL] 1H INDOLE 2,3 DIONE; 5 [[4 (4 FLUOROPHENYL)PIPERAZIN 1 YL]SULFONYL] 1 BETA NAPHTHALENEMETHYL 1H INDOLE 2,3 DIONE; 5 [[4 (4 FLUOROPHENYL)PIPERAZINYL 1 YL]SULFONYL] 1H INDOLE 2,3 DIONE; 5 [[4 (PYRIDIN 2 YL)PIPERAZIN 1 YL]SULFONYL] 1H INDOLE 2,3 DIONE; 5 CARBOXY 1H INDOLE 2,3 DIONE; 5 SULFONYL ISATIN DERIVATIVE; ISATIN DERIVATIVE; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ALKYLATION; ARTICLE; CONTROLLED STUDY; CYCLIZATION; DRUG ACTIVITY; DRUG POTENCY; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME MODIFICATION; HYDROGEN BOND; HYDROPHOBICITY; MOLECULAR DOCKING; NONHUMAN; SARS CORONAVIRUS; STRUCTURE ANALYSIS; SULFONATION; VIRUS REPLICATION;

PICORNAVIRIDAE; SARS CORONAVIRUS;

DOCKING STUDIES; INHIBITOR; ISATIN; SARS;

HUMANS; ISATIN; MOLECULAR STRUCTURE; PROTEASE INHIBITORS; SARS VIRUS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891482162     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.11.028     Document Type: Article

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