Evaluation of peptide-aldehyde inhibitors using R188I mutant of SARS 3CL protease as a proteolysis-resistant mutant

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 21, 2008, Pages 9400-9408

  Akaji, Kenichi ^a   Konno, Hiroyuki ^a   Onozuka, Mari ^a   Makino, Ayumi ^b   Saito, Hiroyuki ^b   Nosaka, Kazuto ^a  

^a KYOTO PREFECTURAL UNIVERSITY OF MEDICINE   (Japan)

^b KOBE PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

3CL protease; Peptide aldehyde; Protease inhibitor; SARS

Indexed keywords

ALDEHYDE; ARGININE; ISOLEUCINE; PEPTIDE; PROTEINASE; PROTEINASE INHIBITOR;

AMINO ACID SEQUENCE; ARTICLE; ENZYME ACTIVITY; MICHAELIS CONSTANT; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SARS CORONAVIRUS;

ALDEHYDES; AMINO ACID SEQUENCE; BINDING SITES; CYSTEINE ENDOPEPTIDASES; HUMANS; HYDROLYSIS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; MUTATION; PROTEASE INHIBITORS; PROTEIN CONFORMATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY; VIRAL PROTEINS;

SARS CORONAVIRUS;

EID: 53749084338     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.09.057     Document Type: Article

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