New developments for the design, synthesis and biological evaluation of potent SARS-CoV 3CLpro inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 19, Issue 10, 2009, Pages 2722-2727

  Regnier, Thomas ^a   Sarma, Diganta ^a   Hidaka, Koushi ^a   Bacha, Usman ^b   Freire, Ernesto ^b   Hayashi, Yoshio ^a,c   Kiso, Yoshiaki ^a  

^a Center for Frontier Research in Medicinal Science   (Japan)

^b JOHNS HOPKINS UNIVERSITY   (United States)

^c TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

Author keywords

Drug design; Protease inhibitors; SARS CoV; Synthesis

Indexed keywords

BENZOTHIAZOLE DERIVATIVE; FLUORINE DERIVATIVE; KETONE DERIVATIVE; METHYL GROUP; PROTEINASE INHIBITOR; THIAZOLE DERIVATIVE;

ARTICLE; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME INHIBITION; IN VITRO STUDY; NONHUMAN; QUANTUM YIELD; SARS CORONAVIRUS; STRUCTURE ACTIVITY RELATION;

AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; BENZOTHIAZOLES; CHYMASES; COMPUTER SIMULATION; CYSTEINE ENDOPEPTIDASES; DRUG DESIGN; KETONES; PEPTIDES; PROTEASE INHIBITORS; PYRROLIDINONES; SARS VIRUS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; VIRAL PROTEINS;

SARS CORONAVIRUS;

EID: 65349120140     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2009.03.118     Document Type: Article

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26. i or the inhibition constant is an indication of the compound as potency.