Design, synthesis, and biological evaluation of novel dipeptide-type SARS-CoV 3CL protease inhibitors: Structure-activity relationship study

European Journal of Medicinal Chemistry

Volumn 65, Issue , 2013, Pages 436-447

  Thanigaimalai, Pillaiyar ^a   Konno, Sho ^a   Yamamoto, Takehito ^a   Koiwai, Yuji ^a   Taguchi, Akihiro ^a   Takayama, Kentaro ^a   Yakushiji, Fumika ^a   Akaji, Kenichi ^b   Kiso, Yoshiaki ^b   Kawasaki, Yuko ^c   Chen, Shen En ^c   Naser Tavakolian, Aurash ^c   Schön, Arne ^c   Freire, Ernesto ^c   Hayashi, Yoshio ^a  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

^c JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

Cysteine protease inhibitors; Dipeptide; Docking study; Peptidomimetics; SARS; SARS CoV 3CL protease

Indexed keywords

BENZOTHIAZOLE; PEPTIDOMIMETIC AGENT; PROTEINASE INHIBITOR;

ARTICLE; DRUG DESIGN; DRUG SYNTHESIS; HYDROGEN BOND; MOLECULAR DOCKING; SEVERE ACUTE RESPIRATORY SYNDROME; STRUCTURE ACTIVITY RELATION;

EID: 84878735186     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2013.05.005     Document Type: Article

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